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| 1 | Primary sclerosing cholangitis associated colitis: Characterization of clinical, histologic features, and their associations with liver transplantation显示文摘BACKGROUND Primary sclerosing cholangitis(PSC)associated inflammatory bowel disease(IBD)is a unique form of IBD(PSC-IBD)with distinct clinical and histologic features from ulcerative colitis(UC)and Crohn disease(CD).In patients with PSC and IBD,the severity of the two disease processes may depend on each other.AIM To study the histologic and clinical features of PSC patients with and without IBD.METHODS We assessed specimens from patients with UC(n=28),CD(n=10),PSC and UC(PSC-UC;n=26);PSC and CD(PSC-CD;n=6);and PSC and no IBD(PSC-no IBD;n=4)between years 1999-2013.PSC-IBD patients were matched to IBD patients without PSC by age and colitis duration.Clinical data including age,gender,age at IBD and PSC diagnoses,IBD duration,treatment,follow-up,orthotopic liver transplantation(OLT)were noted.RESULTS PSC-UC patients had more isolated right-sided disease(P=0.03),and less active inflammation in left colon,rectum(P=0.03 and P=0.0006),and overall(P=0.0005)compared to UC.They required less steroids(P=0.01)and fewer colectomies(P=0.03)than UC patients.The PSC-CD patients had more ileitis and less rectal involvement compared to PSC-UC and CD.No PSC-CD patients required OLT compared to 38%of PSC-UC(P=0.1).PSC-IBD(PSC-UC and PSCCD)patients with OLT had severe disease in the left colon and rectum(P=0.04).CONCLUSION PSC-UC represents a distinct form of IBD.The different disease phenotype in PSC-IBD patients with OLT may support liver-gut axis interaction,however warrants clinical attention and further research. | John Aranake-Chrisinger Themistocles Dassopoulos Yan Yan ILKe Nalbantoglu | 2020 | World Journal of Gastroenterology2020，26，28： | 3 |
| 2 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，： | 2 |
| 3 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，5： | 2 |
| 4 | Acute pancreatitis in human immunodeficiency virus–infected patients: a review显示文摘 | Themistocles Dassopoulos Eli D Ehrenpreis | 1999 | The American Journal of Medicine1999，，1： | 1 |
| 5 | Acute pancreatitis in human immunodeficiency virus-infected patients: a review显示文摘 | Dassopoulos T Ehrenpreis ED | 1999 | Am J Med1999，107，1： | 1 |
| 6 | Optimizing immunomodulators andanti-TNF agents in the therapy of Crohn disease显示文摘 | Dassopoulos T Sninsky C A | 2012 | Gastroen-terol Clin N2012，41，2： | 1 |
| 7 | Evolving treatment strategies for inflammatory bowel disease显示文摘 | Hanauer S Dassopoulos T | 2001 | Annu Rev Med2001，52，： | 1 |
| 8 | Identification of microRNAs associated with ileal and colonic Crohn's disease 显示文摘 | Wu F Zhang S Dassopoulos T | 2010 | Inflamm Bowel Dis2010，16，10： | 1 |
| 9 | Thiopu- rine methyltransferase activity influences clinical response to azathio- prine in inflammatory bowel disease显示文摘 | CUFFARI C DASSOPOULOS T TURNBOUGH Lf | 2004 | Clin Gastroenterol Hepatol2004，2，5： | 1 |
| 10 | Evolving treatment strategies for inflammatory bowel disease显示文摘 | Hananer S Dassopoulos T | 2001 | Annu Rev Med2001，52，： | 1 |
| 11 | Identification of microRNAsassociated with ileal and colonic Crohn's disease显示文摘 | Wu F Zhang S Dassopoulos T | 2010 | InflammBowel Dis2010，16，10： | 1 |
| 12 | Thalidomide treatment for refractory Crohn' s disease: a review of the history, pharmacologieal mechanisms and clinical literature 显示文摘 | Ginsburg PM Dassopoulos T Ehrenpreis ED | 2001 | Ann Med2001，33，8： | 1 |
| 13 | Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies:insights into distinctive pathogenesis显示文摘 | WU F DASSOPOULOS T COPE L | 2007 | Inflamm Bowel Dis2007，13，7： | 1 |
| 14 | American Gastroenterological Association Institute Technical Review on the Use of Thiopurines,Methotrexate,and anti-TNF-c~ Biologic Drugs for the Induction and Maintenance of Remission in inflmnmatory Crohn' s Disease 显示文摘 | Dassopoulos T Sultan S Falck-Ytter YT | 2013 | C astroen-terology2013，145，6： | 1 |
| 15 | Genome-wide gene expres- sion differences in Crons disease and ulcerative colitis from endo- scopic pinch biopsies: insights into distinctive pathogenesis 显示文摘 | Wu F Dassopoulos T Cope L | 2007 | Inflamm Bowel Dis2007，13，7： | 1 |
| 16 | Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies:insights into distinctive pathogenesis显示文摘 | Wu F Dassopoulos T Cope L | 2007 | Inflamm Bowel Dis2007，13，7： | 1 |
| 17 | Identification of microRNAsassociated with ileal and colonic Crohn’s disease显示文摘 | Wu F Zhang S Dassopoulos T | 2010 | Inflamm BowelDis2010，16，10： | 1 |
| 18 | Thalidomide treatment for refractory Crohn's disease: a review of the history, pharmacological mechanisms and clinical literature 显示文摘 | Ginsburg PM Dassopoulos T Ehrenpreis ED | 2001 | Ann Med2001，33，8： | 1 |
| 19 | Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease显示文摘 | Carmen Cuffari Themistocles Dassopoulos Lisa Turnbough Richard E Thompson Theodore M Bayless | 2004 | Clinical Gastroenterology and Hepatology2004，，： | 1 |
| 20 | MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α显示文摘 | Feng Wu Michelle Zikusoka Anil Trindade Themistocles Dassopoulos Mary L. Harris Theodore M. Bayless Steven R. Brant Shukti Chakravarti John H. Kwon | 2008 | Gastroenterology2008，，5： | 1 |
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