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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Single-cell transcriptomic analysis defines the interplay between tumor cells,viral infection,and the microenvironment in nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma(NPC)is an Epstein-Barr virus(EBV)-associated malignancy with a complex tumor ecosystem.How the interplay between tumor cells,EBV,and the microenvironment contributes to NPC progression and immune evasion remains unclear.Here we performed single-cell RNA sequencing on^104,000 cells from 19 EBV^+NPCs and 7 nonmalignant nasopharyngeal biopsies,simultaneously profiling the transcriptomes of malignant cells,EBV,stromal and immune cells.Overall,we identified global upregulation of interferon responses in the multicellular ecosystem of NPC.Notably,an epithelial–immune dual feature of malignant cells was discovered and associated with poor prognosis.Functional experiments revealed that tumor cells with this dual feature exhibited a higher capacity for tumorigenesis.Further characterization of the cellular components of the tumor microenvironment(TME)and their interactions with tumor cells revealed that the dual feature of tumor cells was positively correlated with the expression of co-inhibitory receptors on CD8^+tumor-infiltrating T cells.In addition,tumor cells with the dual feature were found to repress IFN-γproduction by T cells,demonstrating their capacity for immune suppression.Our results provide new insights into the multicellular ecosystem of NPC and offer important clinical implications. | Shanzhao Jin Ruoyan Li Ming-Yuan Chen Chao Yu Lin-Quan Tang Yan-Min Liu Jiang-Ping Li Yi-Na Liu Yi-Ling Luo Yifan Zhao Yu Zhang Tian-Liang Xia Shang-Xin Liu Qi Liu Guan-Nan Wang Rui You Jing-Yun Peng Jiang Li Feng Han Jianwei Wang Qiu-Yan Chen Li Zhang Hai-Qiang Mai Benjamin E.Gewurz Bo Zhao Lawrence S.Young Qian Zhong Fan Bai Mu-Sheng Zeng | 2020 | Cell Research2020，30，11： | 16 |
| 3 | Three-dimensional graphene framework with ultra-high sulfur content for a robust lithium-sulfur battery显示文摘 | Benjamin Papandrea Xu Xu Yuxi Xu Chih-Yen Chen Zhaoyang Lin Gongming Wang Yanzhu Luo Matthew Liu yu Huang Liqiang Mai Xiangfeng Duan | 2016 | Nano Research2016，9，1： | 13 |
| 4 | A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION显示文摘Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGA fibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similar conditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain more crystallinity and higher Tg than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate of degradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretching stages was released in the post-annealing stage for all PGA and PGA-co-PLA samples. During earlier stages ofin vitro degradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. The heat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLA samples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, most likely due to relaxation of the cleaved chains. | Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier | 2003 | Chinese Journal of Polymer Science2003，21，2： | 9 |
| 5 | Nanoprinted high-neuron-density optical linear perceptrons performing near-infrared inference on a CMOS chip显示文摘Optical machine learning has emerged as an important research area that,by leveraging the advantages inherent to optical signals,such as parallelism and high speed,paves the way for a future where optical hardware can process data at the speed of light.In this work,we present such optical devices for data processing in the form of single-layer nanoscale holographic perceptrons trained to perform optical inference tasks.We experimentally show the functionality of these passive optical devices in the example of decryptors trained to perform optical inference of single or whole classes of keys through symmetric and asymmetric decryption.The decryptors,designed for operation in the near-infrared region,are nanoprinted on complementary metal-oxide-semiconductor chips by galvo-dithered two-photon nanolithography with axial nanostepping of 10 nm achieving a neuron density of>500 million neurons per square centimetre.This power-efficient commixture of machine learning and on-chip integration may have a transformative impact on optical decryption3,sensing4,medical diagnostics5 and computing6,7. | Elena Goi Xi Chen Qiming Zhang Benjamin P.Cumming Steffen schoenhardt Haitao Luan Min Gu | 2021 | Light(Science & Applications)2021，10，3： | 8 |
| 6 | 人为气溶胶排放导致最近80年东亚夏季风在过去四个世纪以来空前减弱显示文摘亚洲夏季风(Asian Summer Monsoon,ASM)对亚洲数十亿人口的生存、亚洲生态系统和生物多样性的分布、以及农业生产(粮食安全)和工业活动影响严重。因此了解ASM过去时空变化及其动力学过程对陆地生态系统、水资源、森林和景观研究至关重要。近几十年,器测记录显示以降水量为代表的ASM强度一直在减弱,但这一减弱趋势的起始时间和动力学过程尚不清楚。为此,第一次集成了ASM西部-中部边缘带10个对降水敏感的树木年轮宽度年表,重建了公元1566年以来反映ASM强度变化的降水序列。重建结果不仅捕捉到了ASM过去4个世纪以来强弱变化历史,也反映出历史上蝗灾与弱季风的关联。特别是发现了最近80年具有过去448年中前所未有的、最为强烈的、显著且持续时间最长的ASM强度减弱趋势。这一减弱趋势与在温室效应影响下ASM本该增强的预期大相庭径。耦合气候模型实验表明,北半球人为硫酸盐气溶胶排放的逐渐增加,对ASM减弱起了决定性作用。 | 刘禹 蔡文炬 孙长峰 宋慧明 Kim MCobb 李建平 Steven WLeavitt 吴立新 蔡秋芳 刘若时 Benjamin Ng Paolo Cherubini Ulf Büntgen 宋怡 王国建 雷莺 晏利斌 李强 马永永 方丛羲 孙军艳 李旭祥 Deliang Chen Hans WLinderholm | 2019 | 地球环境学报2019，10，6： | 7 |
| 7 | Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples显示文摘目的: 与膀胱癌 recurrence.Methods 调查 nucleophosmin/B23 表示的可能的关联: 将切除得通过手术的膀胱肿瘤上演了磅 a 到 pT4 被学习组织的 immunohistochemistry.The 为 nucleophosmin/B23 表示检验由通过手术在 Chang Gung 对待的 132 个连续病人组成了在 1998 年 12 月和 1999 年 11 月之间的纪念物医院。平均数列在后面在上面是 72 个月(range:48-84 月).Results : 染色的原子 nucleophosmin/B23 在 96% 晚期和糟糕区分的肿瘤被检测。更高的 nucleophosmin/B23 层次被连接到复发的更先进的肿瘤阶段,等级,差的预后,和可能性(P < 0.05 ) 。艇长多,变量分析为肿瘤作为独立指示物显示了 nucleophosmrn/B23 表示复发(P=0.009 ).Conclusion : 结果建议 nucleophosmin/B23 是有利预示的指示物因为膀胱 cancer.Nucleophosmin/B23 能是为预言膀胱癌症的一个有用分子的肿瘤标记复发。 | Ke-hung TSUI Homg-heng JUANG Tsong-hai LEE Phei-lang CHANG Chien-lun CHEN Benjamin Yat-ming YUNG | 2008 | Acta Pharmacologica Sinica2008，29，3： | 7 |
| 8 | Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions显示文摘Brain tumors are dynamic complex ecosystems with multiple cell types.To model the brain tumor microenvironment in a reproducible and scalable system,we developed a rapid three-dimensional(3D)bioprinting method to construct clinically relevant biomimetic tissue models.In recurrent glioblastoma,macrophages/microglia prominently contribute to the tumor mass.To parse the function of macrophages in 3D,we compared the growth of glioblastoma stem cells(GSCs)alone or with astrocytes and neural precursor cells in a hyaluronic acid-rich hydrogel,with or without macrophage.Bioprinted constructs integrating macrophage recapitulate patient-derived transcriptional profiles predictive of patient survival,maintenance of stemness,invasion,and drug resistance.Whole-genome CRISPR screening with bioprinted complex systems identified unique molecular dependencies in GSCs,relative to sphere culture.Multicellular bioprinted models serve as a scalable and physiologic platform to interrogate drug sensitivity,cellular crosstalk,invasion,context-specific functional dependencies,as well as immunologic interactions in a species-matched neural environment. | Min Tang Qi Xie Ryan C.Gimple Zheng Zhong Trevor Tam Jing Tian Reilly L.Kidwell Qiulian Wu Briana C.Prager Zhixin Qiu Aaron Yu Zhe Zhu Pinar Mesci Hui Jing Jacob Schimelman Pengrui Wang Derrick Lee Michael H.Lorenzini Deobrat Dixit Linjie Zhao Shruti B.hargava Tyler E.Miller Xueyi Wan Jing Tang Bingjie Sun Benjamin F.Cravatt Alysson R.Muotri Shaochen Chen Jeremy N.Rich | 2020 | Cell Research2020，30，10： | 6 |
| 9 | OsSERK1 regulates rice development but not immunity to Xanthomonas oryzae pv. oryzae or Magnaporthe oryzae显示文摘Somatic embryogenesis receptor kinase(SERK)proteins play pivotal roles in regulation of plant development and immunity. The rice genome contains two SERK genes,OsSerk1 and OsSerk2. We previously demonstrated that OsSerk2 is required for rice Xa21-mediated resistance to Xanthomonas oryzae pv. oryzae(Xoo) and for normal development. Here we report the molecular characterization of OsSerk1. Overexpression of OsSerk1 results in a semi-dwarf phenotype whereas silencing of OsSerk1 results in a reduced angle of the lamina joint. OsSerk1 is not required for rice resistance to Xoo or Magnaporthe oryzae. Overexpression of Os Serk1 in OsSerk2-silenced lines complements phenotypes associated with brassinosteroid(BR) signaling defects, but not the disease resistance phenotype mediated by Xa21. In yeast, OsSERK1 interacts with itself forming homodimers, and also interacts with the kinase domains of OsSERK2 and BRI1, respectively.OsSERK1 is a functional protein kinase capable of auto-phosphorylation in vitro. We conclude that, whereas OsSERK2 regulates both rice development and immunity, OsSERK1 functions in rice development but not immunity to Xoo and M. oryzae. | Shimin Zuo Xiaogang Zhou Mawsheng Chen Shilu Zhang Benjamin Schwessinger Deling Ruan Can Yuan Jing Wang Xuewei Chen Pamela C.Ronald | 2014 | Journal of Integrative Plant Biology2014，56，12： | 4 |
| 10 | Reduced graphene oxide/silicon nanowire hetero- structures with enhanced photoactivity and superior photoelectrochemical stability显示文摘Silicon nanowires (SiNWs) have been widely studied as light harvesting antennas in photocatalysts due to their ability to absorb broad-spectrum solar radiation, but they are typically limited by poor photoelectrochemical stability. Here, we report the synthesis of reduced graphene oxide-SiNW (rGO-SiNW) heterostructures to achieve greatly improved photocatalytic activity and stability. The SiNWs were synthesized through a metal-assisted electroless etching process and functionalized with reduced graphene oxide (rGO) flakes through a chemical absorption process. Here, the rGO not only functions as a physical protection layer to isolate the SiNWs from the harsh electrochemical environment but also serves as a charge mediator to facilitate the charge separation and transport processes. Furthermore, the rGO may also function as a redox catalyst to ensure efficient utilization of photo-carriers for the desired chemical reactions. Photocatalytic dye degradation studies show that the photoactivity of the heterostructures can be significantly enhanced with an initial activation process and maintained without apparent decay over repeated reaction cycles. Electrochemical and photo- electrochemical studies indicate that the enhanced photoactivity and photostability can be attributed to the more efficient separation of photoexcited charge carriers in SiNWs and the reduced self-oxidation of the surface of the SiNWs during the photocatalytic dye degradation process. The ability to significantly improve the photocatalytic activity and stability in rGO-SiNW heterostructures can not only lead to more opportunities for the application of silicon-based photocatalysts/ photoelectrodes for solar energy harvesting but also provide new insights into the stabilization of other unstable photocatalytic | Xing Zhong Gongming wang Benjamin Papandrea Mufan Li Yuxi Xu Yu Chen Chih-Yen Chen Hailong Zhou Teng Xue Yongjia Li Dehui Li Yu Huang Xiangfeng Duan | 2015 | Nano Research2015，8，9： | 4 |
| 11 | Ag@Au core/shell triangular nanoplates with dual enzyme-like properties for the colorimetric sensing of glucose显示文摘Due to the serious harm of diabetes to human health,development of sensitive assays for glucose level is of high significance for early prevention and treatment of diabetes.Currently,most conventional enzyme-based glucose sensors suffer from high cost and low stability due to the inherent defects of natural enzymes.Herein,we develop a pure nanozyme-based glucose detection method using Ag@Au core/shell triangular nanoplates(TNPs),which combines glucose oxidase(GOD)-and horseradish peroxidase(HRP)-like activities of the Au shell and inherent plasmonic properties of Ag TNPs.The sensing mechanism is based on the fact that the Au shell possessed GOD-like activity,enabling the oxidation of glucose to produce H2O2,which can further etch the silver core,leading to the decrease of absorbance at 800 nm and the color change from blue to colorless.Compared with the previous nanozymes-based glucose sensors,our method avoids the use of enzymes and organic chromogenic agent.Moreover,the stability of the Ag@Au core/shell TNPs is much better than that of Ag TNPs due to the protection by the coating of the Au shell.This method was successfully applied to the detection of urine samples from patients with diabetes,indicating its practical applicability for real sample analysis. | Ao Liu Mengmeng Li Jingxiang Wang Fan Feng Yu Zhang Zhiwei Qiu Yuzhu Chen Benjamin Edem Meteku Congying Wen Zifeng Yan Jingbin Zeng | 2020 | Chinese Chemical Letters2020，31，5： | 3 |
| 12 | Fractional Modeling and Analysis of Coupled MR Damping System显示文摘The coupled magnetorheological(MR) damping system addressed in this paper contains rubber spring and magnetorheological damper. The device inherits the damping merits of both the rubber spring and the magnetorheological damper.Here a fractional-order constitutive equation is introduced to study the viscoelasticity of the combined damper. An introduction to the definitions of fractional calculus, and the transfer function representation of a fractional-order system are given. The fractional-order system model of a magnetorheological vibration platform is set up using fractional calculus, and the function of displacement is presented. It is indicated that the fractional-order constitutive equation and the transfer function are feasible and effective means for investigating of magnetorheological vibration device. | Bingsan Chen Chunyu Li Benjamin Wilson Yijian Huang | 2016 | IEEE/CAA Journal of Automatica Sinica2016，3，3： | 3 |
| 13 | Optical force-induced nonlinearity and self-guiding of light in human red blood cell suspensions显示文摘Osmotic conditions play an important role in the cell properties of human red blood cells(RBCs),which are crucial for the pathological analysis of some blood diseases such as malaria.Over the past decades,numerous efforts have mainly focused on the study of the RBC biomechanical properties that arise from the unique deformability of erythrocytes.Here,we demonstrate nonlinear optical effects from human RBCs suspended in different osmotic solutions.Specifically,we observe self-trapping and scattering-resistant nonlinear propagation of a laser beam through RBC suspensions under all three osmotic conditions,where the strength of the optical nonlinearity increases with osmotic pressure on the cells.This tunable nonlinearity is attributed to optical forces,particularly the forward-scattering and gradient forces.Interestingly,in aged blood samples(with lysed cells),a notably different nonlinear behavior is observed due to the presence of free hemoglobin.We use a theoretical model with an optical force-mediated nonlocal nonlinearity to explain the experimental observations.Our work on light self-guiding through scattering biosoft-matter may introduce new photonic tools for noninvasive biomedical imaging and medical diagnosis. | Rekha Gautam Yinxiao Xiang Josh Lamstein Yi Liang Anna Bezryadina Guo Liang Tobias Hansson Benjamin Wetzel Daryl Preece Adam White Matthew Silverman Susan Kazarian Jingjun Xu Roberto Morandotti Zhigang Chen | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 14 | LiF@SiO2 nanocapsules for controlled lithium release and osteoarthritis treatment显示文摘 | Trever Todd Zhenhui Lu Jinmin Zhao Benjamin Cline Weizhong Zhang Hongmin Chen Anil Kumar Wen Jiang Franklin West Samuel Franklin Li Zheng Jin Xie | 2018 | Nano Research2018，11，10： | 3 |
| 15 | Detection of Hypermethylated Vimentin in Urine of Patients with Colorectal Cancer显示文摘 | Benjamin P. Song Surbhi Jain Selena Y. Lin Quan Chen Timothy M. Block Wei Song Dean E. Brenner Ying-Hsiu Su | 2012 | The Journal of Molecular Diagnostics2012，，2： | 2 |
| 16 | Study of the impacts of upstream natural gas market reform in China on infrastructure deployment and social welfare using an SVM-based rolling horizon stochastic game analysis显示文摘Natural gas is expected to play a much more important role in China in future decades, and market reform is crucial for its rapid market penetration. At present, the main gas fields, pipelines and liquefied natural gas(LNG) infrastructure are mainly monopolized by large state-owned companies, and one of the important market reform policies is to open up LNG import rights to smaller private companies and traders. Therefore, in the present study, a game theoretical model is proposed to analyze and compare the impacts of different market structures on infrastructure deployment and social welfare. Moreover, a support vector machine-based rolling horizon stochastic method is adopted in the model to simulate real LNG price fluctuations. Four market reform scenarios are proposed considering different policies such as business separation, third-party access(TPA) and their combinations. The results indicate that, with third-party access(TPA)entrance into the LNG market, the construction of LNG infrastructure will be promoted and more gas will be provided at lower prices, and thus the total social welfare will be improved greatly. | Yan Li Ge Wang Benjamin Mclellan Si-Yuan Chen Qi Zhang | 2018 | Petroleum Science2018，15，4： | 2 |
| 17 | Implications of CO2 emissions trading for short-run electricity market outcomes in northwest Europe显示文摘 | Yihsu Chen Jos Sijm Benjamin F. Hobbs Wietze Lise | | Journal of Regulatory Economics0，，： | 2 |
| 18 | Macrophage Migration Inhibitory Factor Is an Important Mediator in the Pathogenesis of Gastric Inflammation in Rats显示文摘 | Xiao Ru Huang Connie Wun Chun Hui Yong-Xiong Chen Benjamin Chun Yu Wong Peter C.W. Fung Christine Metz Chi Hin Cho Wai Mo Hui Richard Bucala Shiu-Kum Lam Hui Y. Lan | 2001 | Gastroenterology2001，，3： | 2 |
| 19 | Integrated dynamic wet spinning of core-sheath hydrogel fibers for optical-to-brain/tissue communications显示文摘Hydrogel optical light-guides have received substantial interest for applications such as deep-tissue biosensors,optogenetic stimulation and photomedicine due to their biocompatibility,(micro)structure control and tissue-like Young’s modulus.However,despite recent developments,large-scale fabrication with a continuous synthetic methodology,which could produce core-sheath hydrogel fibers with the desired optical and mechanical properties suitable for deep-tissue applications,has yet to be achieved.In this study,we report a versatile concept of integrated light-triggered dynamic wet spinning capable of continuously producing core-sheath hydrogel optical fibers with tunable fiber diameters,and mechanical and optical propagation properties.Furthermore,this concept also exhibited versatility for various kinds of core-sheath functional fibers.The wet spinning synthetic procedure and fabrication process were optimized with the rational design of the core/sheath material interface compatibility[core=poly(ethylene glycol diacrylate-co-acrylamide);sheath=Ca-alginate],optical transparency,refractive index and spinning solution viscosity.The resulting hydrogel optical fibers exhibited desirable low optical attenuation(0.18±0.01 d B cm^(-1) with 650 nm laser light),excellent biocompatibility and tissue-like Young’s modulus(<2.60 MPa).The optical waveguide hydrogel fibers were successfully employed for deep-tissue cancer therapy and brain optogenetic stimulation,confirming that they could serve as an efficient versatile tool for diverse deep-tissue therapy and brain optogenetic applications. | Guoyin Chen Gang Wang Xinrong Tan Kai Hou Qingshuo Meng Peng Zhao Shun Wang Jiayi Zhang Zhan Zhou Tao Chen Yanhua Cheng D Benjamin S.Hsiao Elsa Reichmanis Meifang Zhu | 2021 | National Science Review2021，8，9： | 2 |
| 20 | Cell polarity protein Par3 complexes with DNA-PK via Ku70 and regulates DNA double-strand break repair显示文摘分区有缺陷者 3 (Par3 ) ,在 conservedPar3/Par6/aPKC 建筑群的一个关键部件,在房间极性的戏基础角色。此处,我们报导 Ku70 和通过试管内绑定试金的蛋白质由液体层析双人脚踏车质谱法跟随了的 Ku80 同样新奇的交往 Par3 的鉴定。Ku70/Ku80 蛋白质是 DNA 依赖的蛋白激酶(DNA-PK ) 的二个关键规章的子单元,它在修理双海滨脱氧核糖核酸裂缝(DSB ) 起一个必要作用。我们决定 Par3 withKu70/Ku80 的原子协会被 y 照耀(红外) 提高,有势力 DSB inducer。而且, DNA-PKcs, DNA-PK 的催化子单元,响应红外与 Par3/Ku70/Ku80 建筑群交往了。Par3over 表示或击倒分别地能够 up- 或 downregulat-ing DNA-PK 活动。而且, Par3 击倒的房间被发现在随机的原生质标志集成有缺点,在 DSB 修理追随者红外有缺点、对射线敏感,类似于 Ku70knockdown 房间的显型。这些调查结果作为 DNA-PK 建筑群的一个新奇部件识别 Par3 并且含有到 DSB 修理的房间极性的一个意外连接。 | Longhou Fang YiGuo Wang Dan Du Guang Yang Tim Tak Kwok Siu Kai Kong Benjamin Chen David J Chen Zhengjun Chen | 2007 | Cell Research2007，17，2： | 2 |
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