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| 1 | Insight into the biology of Macrophage Migration Inhibitory Factor (MIF) revealed by the cloning of its cell surface receptor显示文摘MIF 受体的最近的克隆在我们分子的生物学的理解和 MIF 的免疫学充满重要差距。MIF 受体象 MIF 一样,不掉进蛋白质调停人的任何确定的家庭,提供为 MIF 信号 transduction 的结构、功能的分析的新挑战和机会。 | Lin Leng Richard Bucala | 2006 | Cell Research2006，16，2： | 10 |
| 2 | CD74 is a survival receptor on colon epithelial cells显示文摘AIM: To investigate the expression and function of CD74 in normal murine colon epithelial cells (CEC) and colon carcinoma cells. METHODS: Expression of CD74 mRNA and protein were measured by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and fluorescence-activated cell sorter (FACS). The effect of migration inhibitory factor (MIF) on the survival of normal CEC from C57BL/6, NOD/SCID, and CD74 def icient mice both in vitro and in vivo, and on the CT26 carcinoma cell line was analyzed by (quantitative) qRT-PCR, RTPCR, Western blotting and FACS. RESULTS: CD74 was found to be expressed on normalCEC. Stimulation of CD74 by MIF induced a signaling cascade leading to up-regulation of Bcl-2 expression, resulting in a signif icant increased survival of CEC. CD74 was also expressed on the CT26 colon carcinoma cell line and its stimulation by MIF resulted in enhanced cell survival, up-regulation of Akt phosphorylation and Bcl-2 expression. | Nitsan Maharshak Sivan Cohen Frida Lantner Gili Hart Richard Bucala Idit Shachar | 2010 | World Journal of Gastroenterology2010，16，26： | 9 |
| 3 | Macrophage Migration Inhibitory Factor Is an Important Mediator in the Pathogenesis of Gastric Inflammation in Rats显示文摘 | Xiao Ru Huang Connie Wun Chun Hui Yong-Xiong Chen Benjamin Chun Yu Wong Peter C.W. Fung Christine Metz Chi Hin Cho Wai Mo Hui Richard Bucala Shiu-Kum Lam Hui Y. Lan | 2001 | Gastroenterology2001，，3： | 2 |
| 4 | Pathogenic effects of advanced glycosylation: biochemical, biologic and clinical implications for diabetes and aging 显示文摘 | Vlassara H Bucala R Striker L | 1994 | Lab Invest1994，70，2： | 1 |
| 5 | Identification of the major site of apolipoprotein B modification by advanced glycosylation end products blocking uptake by the low density lipoprotein receptor显示文摘 | Bucala R Mitchell R Arnold K | 1995 | J Biol Chem1995，270，10： | 1 |
| 6 | Reactive glycosylation endproducts in diabetic uraemia and treatment of renal failure显示文摘 | Makita Z Bucala R Rayfield EJ | 1994 | Lancet1994，343，： | 1 |
| 7 | Macrophage migration inhibitory factor显示文摘 | Lolis E Bucala R | 2003 | Expert Opin Ther Targets2003，7，： | 1 |
| 8 | Fibrocytes in health and disease 显示文摘 | Herzog EL Bucala R | 2010 | Exp Hematol2010，38，7： | 1 |
| 9 | Macrophage migration inhibitory factor (MIF): a glucocorticoid counter-regulator within the immune system显示文摘 | Calandra T Bucala R | 1997 | Crit Rev Immunol1997，17，1： | 1 |
| 10 | The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis显示文摘 | Bucala R Shachar I | 2014 | Mini Rev Med Chem2014，14，14： | 1 |
| 11 | Non-adiabatics radial-flow reactor for styrene production显示文摘 | Savoretti A A Borio D O Bucala V | 1999 | Chemical Engineering Science1999，54，2： | 1 |
| 12 | Advanced glycosylation end products in diabetic renal and vascular disease显示文摘 | Bucala R Vlasaam H | 1995 | Am J Kidney Dis1995，26，6： | 1 |
| 13 | Neurotoxicity of advanced glycation end-products for cultured cortical neurons显示文摘 | TakeuchiM Bucala R Suzuki T | 2000 | J Neuropathol Exp Neurol2000，59，12： | 1 |
| 14 | Macrophage migration inhibitory factor 显示文摘 | Baugh JA Bucala R | 2002 | Crit Care Med2002，30，1： | 1 |
| 15 | Macrophage migration inhibitory factor (MIF) :a glucocorticoid counter-regulator within the immune system显示文摘 | Calandra T Bucala R | 1997 | Crit Rev Immunol1997，17，1： | 1 |
| 16 | Endotoxin-indueed myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization显示文摘 | Chagnon F Metz CN Bucala R | 2005 | Circ Res2005，96，10： | 1 |
| 17 | The role of circulating fibrocytes in fibrosis显示文摘 | COWPER S E BUCALA R | 2006 | Curr Rheumatol Rep2006，8，2： | 1 |
| 18 | Transposition of an Alu-containing element induced by DNA-advanced glycosylation endproducts显示文摘 | BUCALA R LEE A T ROURKE L | 1993 | Proc Natl Acad Sci1993，90，7： | 1 |
| 19 | Macrophage migration inhibitory factor:a regulator of glucocorticoid activity with a critical role in inflammatory disease显示文摘 | Donnelly SC Bucala R | 1997 | Mol Med Today1997，3，11： | 1 |
| 20 | Crystal structure at2, 6-A resolution of human macrophage migration in- hibitory factory显示文摘 | Sun HW Bernhaagen J Bucala R | 1996 | PNAS1996，93，5： | 1 |
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