|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non-invasive means of measuring hepatic fat content显示文摘Hepatic steatosis affects 20% to 30% of the general adult population in the western world. Currently, the technique of choice for determining hepatic fat deposition and the stage of fibrosis is liver biopsy. However, it is an invasive procedure and its use is limited, particularly in children. It may also be subject to sampling error. Non-invasive techniques such as ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS) can detect hepatic steatosis, but currently cannot distinguish between simple steatosis and steatohepatitis, or stage the degree of fibrosis accurately. Ultrasound is widely used to detect hepatic steatosis, but its sensitivity is reduced in the morbidly obese and also in those with small amounts of fatty infiltration. It has been used to grade hepatic fat content, but this is subjective. CT can detect hepatic steatosis, but exposes subjects to ionising radiation, thus limiting its use in longitudinal studies and in children. Recently, magnetic resonance (MR) techniques using chemical shift imaging have provided a quantitative assessment of the degree of hepatic fatty infiltration, which correlates well with liver biopsy results in the same patients. Similarly, in vivo 1H MRS is a fast, safe, non-invasive method forthe quantification of intrahepatocellular lipid (IHCL) levels. Both techniques will be useful tools in future longitudinal clinical studies, either in examining the natural history of conditions causing hepatic steatosis (e.g. non-alcoholic fatty liver disease), or in testing new treatments for these conditions. | Sanjeev R Mehta E Louise Thomas Jimmy D Bell Desmond G Johnston Simon D Taylor-Robinson | 2008 | World Journal of Gastroenterology2008，14，22： | 21 |
| 2 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 3 | 6 舌癌与其他部位口腔癌患者的生存率是否不同?显示文摘口腔鳞癌治疗技术的发展,使依照发病部位判断患者预后变得愈加闲惑。该文旨在回顾口腔鳞癌患者的治疗效果.并确定发病部位是否为患者生存率或无瘤生存率的预后因素。方法:对1993~2003年间233例手术切除的OSCC患者进行回顾性研究,将病例分为2组,舌癌73例,其他部位152例,应用Cox模型对2组的生存率进行比较。对切缘阳性、低分化、侵袭性和晚期患者术后辅助放疗或放化疗。对患者的人口统计学资料、发病部位、肿瘤分期、病理学特点、治疗方法及生存资料进行记录,并应用描述性及Kaplan—Meier曲线进行分析,以确定肿瘤局部控制率和患者无瘤生存率的预后因素。 | Bell RB Kademani D Homer L | 2007 | 中国口腔颌面外科杂志2007，5，2： | 11 |
| 4 | Assessment of large aperture lightweight imaging concepts 显示文摘 | BELL K D BOUCHER R H | 1999 | IEEE1999，，： | 3 |
| 5 | Municipal solid waste composition studies显示文摘 | MCCAULEY BELL REINHART D SEIR H | 1997 | ASCE Practice Periodical of Hazardous and Radioactive Waste1997，1，4： | 2 |
| 6 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 2 |
| 7 | IL 28 B genotype is not useful for predicting treatment outcome in A sian chronic hepatitis B patients treated with pegylated interferon‐α显示文摘 | Jacinta A Holmes Tin Nguyen Dilip Ratnam Neel M Heerasing Jane V Tehan Sara Bonanzinga Anouk Dev Sally Bell Stephen Pianko Robert Chen Kumar Visvanathan Rachel Hammond David Iser Ferry Rusli William Sievert Paul V Desmond D Scott Bowden Alexander J Thomps | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 8 | Effect of catalyst structure on oxidative dehydrogenation of ethane and propane on alumina-supported vanadia显示文摘 | Morris D Argyle Kaidong Chen Alexis T Bell | 2002 | J Catal2002，208，： | 2 |
| 9 | Rough computational methods for information systems 显示文摘 | Guan J W Bell D A | 1998 | Artificial Intelligences1998，105，12： | 2 |
| 10 | Adefovir nephrotoxicity: Possible role of mitochondrial DNA depletion显示文摘 | Nozomu Tanji Kurenai Tanji Neeraja Kambham Glen S Markowitz Alvin Bell Vivette D D’Agati | 2001 | Human Pathology2001，，7： | 2 |
| 11 | 英国医学院医学伦理学的教学、学习与评估显示文摘国际伦理快递
[引言]伦理学涵盖内容极其广泛,伦理学不同层次及其内容组成生动的学科树。一般的伦理学概念、基础和基本原则是所有伦理学的基础,是伦理学的主干;不同主题领域的伦理学,如生命伦理学(人类,包括起源)、社会伦理学(社会关系)、医学伦理学(医疗和科技)、职业伦理学(专业领域)等是伦理学对某一领域的深入,构成伦理学的各大分支;各分支领域互有交叉,相互联系,各有侧重。每一分支还可以细化分解,如医学伦理学进一步划分临床医学伦理学、研究医学伦理学等。 | Brooks L Bell D | 2017 | 中国医学伦理学2017，30，3： | 2 |
| 12 | Effects of purified dies containing different combinations of arachidonic and docosahexaenoic acid on survival, growth and fatty acid composition of juvenile turbot (Scophthalmus maximus) 显示文摘 | Castell J D Bell J G Tocher D R | 1994 | Aquaculture1994，1，： | 2 |
| 13 | Dendritic cells 显示文摘 | Bell D Young JW Banchereau J | 1999 | Adv Immunol1999，72，： | 1 |
| 14 | Abundance and partitioning of OH in a hlgh-pressure magmatic system: Megacrysts from the Monastery kimberlite, South Africa显示文摘 | Bell D B Rossman G R Moore R O | 2004 | J Petrol2004，45，： | 1 |
| 15 | The resources for enhancing Alzheimerl s caregiver health (REACH): project design and baseline characteristics 显示文摘 | Wisniewski S R Belle S H Coon D W | 2003 | Psychol Aging2003，18，3： | 1 |
| 16 | Steady-state studies显示文摘 | Michael D Rhodes Bell Alexis T The effects of zirconia morphology on methanol synthesis from CO and H2 over Cu/ZrO2 catalysts Part I | 2005 | Journal of Catalysis2005，233，： | 1 |
| 17 | Synthesis and characterization of polypyrrole-magnetite-silica particles显示文摘 | Btterworth M D Bell S A Armes S P Simpson A W | 1996 | J Colloid Interf Sci1996，183，： | 1 |
| 18 | A physicochemical study of the aging of colloidal sillica gels used in zeolite Y synthesis显示文摘 | Ginter D M Went G T Bell A T | 1992 | Zeolites1992，12，： | 1 |
| 19 | High-speed gated X-ray imaging for ICF target experiments显示文摘 | Bradley D K Bell P M Kilkenny J D | 1992 | Rev Sci Instrum1992，63，： | 1 |
| 20 | Thiazolidinedione use, fluid retention, and eongestive heart failure : a eonsensus statement from the American Heart Association and American Diabetes Association 显示文摘 | Nesto RW Bell D Bonow RO | 2004 | Diabetes Care2004，27，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员