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| 1 | miR-27b inhibits gastric cancer metastasis by targeting NR2F2显示文摘增加的注意在癌症过程集中于 miRNAs 的下面规定。原子受体亚科 2 (NR2F2,也作为 COUP-TFII 知道) 涉及癌症的许多类型的发展,但是它在胃的癌症的角色留下逃犯。在这个实验, oncomine 和 Kaplan-meier 数据库表明 NR2F2 在胃的癌症是起来调整的并且高 NR2F2 表示贡献了差的幸存。MicroRNA-27b 被指向并且由在人的胃的癌症纸巾和房间的 NR2F2 下面调整。miR-27b 的宫外的表示在 vitro 并且在 vivo 禁止了胃的癌症房间增长和肿瘤生长。试金建议 miR-27b 的 overexpression 能支持 MGC-803 房间移植和侵略并且延迟他们的转移到肝。另外, miR-27b 的下面规定在 vitro 提高了 GES-1 房间增长和转移。这些调查结果表明 miR-27b 为改进病人是在胃的癌症和 biomarker 的肿瘤 suppressor 幸存。 | Qingzhao Feng Xionglin Wu Fuchao Li Beibei Ning Xiaofeng Lu Yin Zhang Ying Pan Wenxian Guan | 2017 | Protein & Cell2017，8，2： | 16 |
| 2 | Chemical comparison of dried rehmannia root and prepared rehmannia root by UPLC-TOF MS and HPLC-ELSD with multivariate statistical analysis显示文摘To identify the chemical differences which lead to the different therapeutic effects of dried rehmannia root(DRR)and prepared rehmannia root(PRR),we compared the chemical composition of decoctions of randomly purchased DRR and PRR using ultra performance liquid chromatography(UPLC)coupled with time-of-fight mass spectrometry and high performance liquid chromatography(HPLC)coupled with evaporative light scattering detection(ELSD)with the aid of multivariate statistical analysis.Both approaches clearly revealed compositional and quantitative differences between DRR and PRR.UPLC-MS data indicated stachyose,rehmaiono-side A(or rehmaionoside B),acteoside(or forsythiaside,or isoacteoside),6-O-coumaroylajugol(or 6-O-E-feruloylajugol,or 6-O-Z-feruloylajugol)as important discriminators between DRR and PRR decoctions.HPLC-ELSD analysis showed that the content of fructose in the decoctions of PRR was about four times greater than that of DRR(P<10^(-5)),while sucrose content in the decoctions of PRR was only about one seventh of that in DRR(P<0.01).Our results suggest that some compounds,such as fructose,stachyose and rehmaionoside,may be responsible for the differing therapeutic effects of DRR and PRR.Furthermore,improvements in quality control for PRR,which is currently lacking in the Chinese Pharmacopoeia,are recommended. | Qiande Liang Jing Ma Zengchun Ma Yuguang Wang Hongling Tan Chengrong Xiao Ming Liu Beibei Lu Boli Zhang Yue Gao | 2013 | Acta Pharmaceutica Sinica B2013，3，1： | 8 |
| 3 | The temporal and spatial patterns and potential evaluation of China's energy resources development显示文摘The issue of China's energy supply security is not only the key problem which affects China's rapid and sustainable development in the 21st century,but also the one which international attention focuses on.Based on the notable characteristic of spatial imbalance between energy production and consumption in China,this paper takes the evolution of China's primary energy resources development(excluding hydropower) from 1949 to 2007 as the study object,with the aim to sum up the evolutive characteristics and laws of China's energy resources development in the past nearly 60 years.Then,based on comprehensive considerations of coal's,oil's and natural gas's basic reserves,qualities,geological conditions,production status,and ecological service function of every province,this paper adopts development potential index(DP)to evaluate the development potential of every province's energy resources,and divide them into different ranks.Conclusions are drawn as follows:(1) Generally speaking,China's gross energy production was increasing in waves from 1949 to 2007.From the viewpoint of spatial patterns,China's energy resources development has shown a characteristic of 'concentrating to the north and central areas,and evolving from linear-shaped to 'T-shaped' pattern gradually since 1949.(2) The structure evolution of China's energy resources development in general has shown a trend of 'coal proportion is dominant but decreasing,while oil and gas proportions are increasing' since 1949.(3) At the provincial scale,China's energy resources development potential could be divided into large,sub-large,general and small ranks,four in all.In the future,the spatial pattern of China's energy production will evolve from 'T-shaped' to '∏-shaped pattern'.These conclusions will help to clarify the temporal and spatial characteristics and laws of China's energy resources development,and will be beneficial for China to design scientific and rational energy development strategies and plans,coordinate spatial imbalance of energy production and consumption,ensure national energy supply,avoid energy resources waste and disorderly development,and promote regional sustainable development under the globalization background with changeful international energy market. | MA Beibei LU Chunxia ZHANG Lei CHENG Xiaoling | 2010 | Journal of Geographical Sciences2010，20，3： | 8 |
| 4 | Preparation of high-purity monodisperse silica microspheres by the sol-gel method coupled with polymerization-induced colloid aggregation显示文摘Ultra-pure mesoporous silica microspheres with good monodispersity were synthesized in two steps:nanometer-sized silica sol was produced by the sol-gel process,then micrometer-sized silica microspheres were synthesized by polymerization-induced colloid aggregation of the silica sol.The total metal content of the microspheres was extremely low,which eliminated the tailing of chromatographic peaks by chelating reagents.The pore structure of the silica microspheres could be controlled by altering the sol-gel conditions.The silica microsphere particle size could be adjusted by using different polymerizationinduced colloid aggregation conditions. | Beibei Zhao Yan Zhang Tao Tang Fengyun Wang Tong Li Qiyu Lu | 2015 | Particuology2015，13，5： | 7 |
| 5 | Hypertensive stretch regulates endothelial exocytosis of WeibeI-Palade bodies through VEGF receptor 2 signaling pathways显示文摘Weibel-Palade 身体(WPB ) 的调整 endothelial exocytosis,在白血球 trafficking 的第一个阶段,在发炎和损害起一个枢轴的作用。尖锐的机械段仔细与脉管的发炎被联系了,尽管精确机制是未知的。这里,我们证明那高血压的段通过 VEGF 受体 2 调整 endothelial 房间(EC ) 的 WPB 的 exocytosis (VEGFR2 ) 表明小径。段触发一个快速的版本(在分钟以内) 从在有教养的人的 EC 的 WPB 的 von Willebrand 因素和 interleukin-8,通过 P-selectin 的 translocation 把在白血球和 EC 之间的相互作用提升到房间膜。我们进一步证明那高血压的段显著地导致未经触动的 EC 的 P-selectin translocation 并且两个都提高白血球粘附前 vivo 并且在 vivo。导致段的 endothelial exocytosis 经由 VEGFR2/PLCγ 被调停; 1/calcium 小径。有趣地,段也经由一条 VEGFR2/Akt/nitric 氧化物小径导致否定反馈。如此的双效果在颈动脉动脉片断,以及在尖锐高血压的老鼠模型用药理学和基因途径被证实。这些研究为 endothelial exocytosis 作为有势力收缩筋揭示机械段,它被 VEGFR2 发信号调制。因此, VEGFR2 发信号小径可以在限制高血压的段相关的发炎代表新奇治疗学的目标。 | Yan Xiong Zhenqian Hu Xiaofan Han Beibei Jiang Rongli Zhan Xiaoyu Zhang Yao Lu Chenyang Geng Wei Li Yulong He Yingqing Huo Masabuml Shlbuya Jincai Luo | 2013 | Cell Research2013，23，6： | 7 |
| 6 | Adjuvant treatment for triple-negative breast cancer: a retrospective study of immunotherapy with autologous cytokine-induced killer cells in 294 patients显示文摘Objective: To examine the efficacy and safety of a sequential combination of chemotherapy and autologous cytokine-induced killer(CIK) cell treatment in triple-negative breast cancer(TNBC) patients.Methods: A total of 294 post-surgery TNBC patients participated in the research from January 1, 2009 to January 1, 2015. After adjuvant chemotherapy, autologous CIK cells were introduced in 147 cases(CIK group), while adjuvant chemotherapy alone was used to treat the remaining 147 cases(control group). The major endpoints of the investigation were the disease-free survival(DFS) and overall survival(OS). Additionally, the side effects of the treatment were evaluated.Results: In the CIK group, the DFS and OS intervals of the patients were significantly longer than those of the control group(DFS:P = 0.047;OS: P = 0.007). The multivariate analysis demonstrated that the TNM(tumor-node-metastasis) stage and adjuvant CIK treatment were independent prognostic factors for both DFS [hazard ratio(HR)= 0.520, 95% confidence interval(CI):0.271-0.998, P = 0.049;HR = 1.449, 95% CI:1.118-1.877, P = 0.005, respectively] and OS(HR=0.414, 95% CI:0.190-0.903, P = 0.027;HR= 1.581, 95% CI:1.204-2.077, P = 0.001, respectively) in patients with TNBC. Additionally, longer DFS and OS intervals were associated with increased number of CIK treatment cycles(DFS: P = 0.020;OS: P = 0.040). The majority of the patients who benefitted from CIK cell therapy were relatively early-stage TNBC patients.Conclusion: Chemotherapy in combination with adjuvant CIK could be used to lower the relapse and metastasis rate, thus effectively extending the survival time of TNBC patients, especially those at early stages. | Yuhan Zhang Shuaibing Wang Beibei Yang Su Lu Yiyi Du Hong Liu | 2019 | Cancer Biology & Medicine2019，16，2： | 6 |
| 7 | Synthesis of high-purity silver nanorods with tunable plasmonic properties and sensor behavior显示文摘Through anisotropic Ag overgrowth on the surface of Au nanobipyramids(Au NBPs), high-purity and sizecontrolled Ag nanorods(Au/Ag NRs) are obtained by a simplified purification process. The diameters of the Au/Ag NRs are determined by the size of the as-prepared Au NBPs, and the lengths of the Au/Ag NRs are tunable using different amounts of Ag precursor in the growth solution. Surface-enhanced Raman scattering(SERS) studies using Rhodamine-6G(R6G) as a test molecule indicate that the Au/Ag NRs have excellent sensing potential. The tunable optical properties and strong electromagnetic effect of the Au/Ag NRs, along with their superior SERS signal enhancement, show that Au/Ag NRs are promising for further applications in plasmon sensing and biomolecular detection. | Haiying Xu Caixia Kan Changzong Miao Changshun Wang Jingjing Wei Yuan Ni Beibei Lu Daning Shi | 2017 | Photonics Research2017，5，1： | 4 |
| 8 | A detail preserving neural network model for Monte Carlo denoising显示文摘Monte Carlo based methods such as path tracing are widely used in movie production. To achieve low noise, they require many samples per pixel,resulting in long rendering time. To reduce the cost,one solution is Monte Carlo denoising, which renders the image with fewer samples per pixel(as little as128) and then denoises the resulting image. Many Monte Carlo denoising methods rely on deep learning:they use convolutional neural networks to learn the relationship between noisy images and reference images,using auxiliary features such as position and normal together with image color as inputs. The network predicts kernels which are then applied to the noisy input. These methods show powerful denoising ability,but tend to lose geometric or lighting details and to blur sharp features during denoising.In this paper, we solve this issue by proposing a novel network structure, a new input feature—light transport covariance from path space—and an improved loss function. Our network separates feature buffers from the color buffer to enhance detail effects. The features are extracted separately and then integrated into a shallow kernel predictor. Our loss function considers perceptual loss, which also improves detail preservation.In addition, we use a light transport covariance feature in path space as one of the features, which helps to preserve illumination details. Our method denoises Monte Carlo path traced images while preserving details much better than previous methods. | Weiheng Lin Beibei Wang Lu Wang Nicolas Holzschuch | 2020 | Computational Visual Media2020，6，2： | 4 |
| 9 | Significantly improved hydrogen storage behaviors in MgH_(2) with Nb nanocatalyst显示文摘The study explores the excellent modification effect of Nb nanocatalyst prepared via surfactant assisted ball milling technique(SABM)on the hydrogen storage properties of MgH_(2).Optimal catalyst doping concentration was determined by comparing onset decomposition temperature,released hydrogen capacity,and reaction rate for different MgH_(2)-ywt%Nb(y=0,3,5,7,9)composites.The MgH_(2)-5wt%Nb composite started releasing hydrogen at 186.7℃ and a total of 7.0wt%hydrogen was released in the dehydrogenation process.In addition,5wt%Nb doped MgH_(2) also managed to release 4.2wt%H_(2) within 14 min at 250℃ and had the ability to absorb 4.0wt%hydrogen in 30 min at 100℃.Cycling tests revealed that MgH_(2)-5wt%Nb could retain 6.3wt%H_(2) storage capacity(89.2%)after 20 cycles.Dehydrogenation and hydrogenation activation energy values were decreased from 140.51±4.74 and 70.67±2.07 kJ·mol^(−1) to 90.04±2.83 and 53.46±3.33 kJ·mol^(−1) after doping MgH_(2) with Nb,respectively.Microstructure analysis proved that homogeneously distributed NbH acted as active catalytic unit for improving the hydrogen storage performance of MgH_(2).These results indicate SABM can be considered as an option to develop other nanocatalysts for energy related areas. | Farai Michael Nyahuma Liuting Zhang Mengchen Song Xiong Lu Beibei Xiao Jiaguang Zheng Fuying Wu | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 3 |
| 10 | Mapping a leaf senescence gene els1 by BSR-Seq in common wheat显示文摘Leaf senescence is normally the last stage of plant development. Early senescence of functional leaves significantly reduces the photosynthetic time and efficiency, seriously affecting grain yield and quality in wheat. Discovering genes responsible for early leaf senescence(els) are necessary for developing novel germplasms and cultivars with delayed leaf-senescence through molecular manipulation and marker assisted selection. In this study, we identified an early leaf senescence line M114 in a derivative of a wheat breeding population. Genetic analysis indicated that early leaf senescence in M114 is controlled by a single recessive gene, provisionally designated els1. By applying bulked segregant analysis and RNA-Seq(BSR-Seq), seven polymorphic markers linked to els1 were developed and the gene was located on chromosome arm 2 BS in a 1.5 c M genetic interval between markers WGGB303 and WGGB305. A co-segregating marker, WGGB302, provide a starting point for fine mapping and map-based cloning of els1. | Miaomiao Li Beibei Li Guanghao Guo Yongxing Chen Jingzhong Xie Ping Lu Qiuhong Wu Deyun Zhang Huaizhi Zhang Jian Yang Panpan Zhang Yan Zhang Zhiyong Liu | 2018 | The Crop Journal2018，6，3： | 3 |
| 11 | Numerical study of ambient pressure for laser-induced bubble near a rigid boundary显示文摘The dynamics of the laser-induced bubble at different ambient pressures was numerically studied by Finite Volume Method (FVM). The velocity of the bubble wall, the liquid jet velocity at collapse, and the pressure of the water hammer while the liquid jet impacting onto the boundary are found to increase nonlinearly with increasing ambient pressure. The collapse time and the formation time of the liquid jet are found to decrease nonlinearly with increasing ambient pressure. The ratios of the jet formation time to the collapse time, and the displacement of the bubble center to the maximal radius while the jet formation stay invariant when ambient pressure changes. These ratios are independent of ambient pressure. | LI BeiBei ZHANG HongChao HAN Bing LU Jian | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，7： | 3 |
| 12 | Exploring single atom catalysts of transition-metal doped phosphorus carbide monolayer for HER:A first-principles study显示文摘Hydrogen has been identified as one of the most promising sustainable and clean energy. Developing hydrogen evolution reaction(HER) catalyst with high activity is essential for satisfying the future requirements. Considering novel advantages of two-dimensional materials and high catalytic activity of atomic transition metal, in this study, using density functional theory calculation, the HER on single transitionmetal(23 different TM atoms) doped phosphorus carbide monolayer(α-PC) has been investigated. The Volmer–Tafel and Volmer–Heyrovsky reaction mechanisms, and the stability of the most promising HER catalyst are also included. The results show that Ir-αPC with high physical and thermal stability has the most optimal value of Gibbs free adsorption energy for H atom. The relationship of d band center and the HER activity shows a volcano-like curve. The calculation of reaction energy barrier indicates that the Volmer-Heyrovsky step is more favorable than the Volmer-Tafel step. | Dachang Chen Zhiwen Chen Xiaoxing Zhang Zhuole Lu Song Xiao Beibei Xiao Chandra Veer Singh | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 13 | Ligand assisted copper-catalyzed Ullmann cross coupling reaction of bromaminic acid with amines显示文摘Three types of ligands have been developed for copper-catalyzed Ullmann cross coupling reaction of bromaminic acid with amines in aqueous solution. Ligands with large steric hindrance and strong electron-donating capacity were beneficial to the reaction. UV–Vis and CV analyses demonstrated that these ligands had strong coordination with copper(I), implying the effect of ligand coordination ability on the stability and catalytic activity of catalytic system. | Beibei Shao Hongying Du Xinyu Hao Rongwen Lu Yi Luo Shufen Zhang | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 2 |
| 14 | CD4+T cells memorize obesity and promote weight regain显示文摘Body weight regain often causes failure of obesity therapies while the underlying mechanism remains largely unknown.In this study,we report that immune cells,especially CD4+T cells,mediate the‘memory’of previous obese status.In a weight gain-loss-regain model,we found that C57BL/6J mice with an obesity history showed a much faster rate of body weight regain.This obesity memory could last for at least 2 months after previously obese mice were kept at the same body weight as non-obese mice.Surprisingly,such obesity memory was abrogated by dexamethasone treatment,whereas immunodeficient Rag1−/−and H2A−/−mice failed to establish such memory.Rag1−/−mice repossessed the obesity memory when immune cells or CD4+T cells isolated from previously obese mice were transferred.Furthermore,depletion of CD4+T cells led to obesity memory ablation.Taken together,we conclude that CD4+T cells mediate obesity memory and promote weight regain. | Jianghuan Zou Beibei Lai Mingzhu Zheng Qin Chen Shujun Jiang Anying Song Zan Huang Peiliang Shi Xin Tu Di Wang Linrong Lu Zhaoyu Lin Xiang Gao | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 15 | Distribution of perfluorinated compounds in surface water from Hanjiang River in Wuhan, China显示文摘 | Beibei Wang Menghua Cao Hudi Zhu Jing Chen Linling Wang Guanghong Liu Xiaoman Gu Xiaohua Lu | 2013 | Chemosphere2013，，： | 2 |
| 16 | Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection显示文摘Dear Editor,In recent years,the incidence of human infections caused by emerging or re-emerging pathogens has rapidly increased.Diseases that were once regional now have the ability to spread globally in a short amount of time and pose a wider threat to public health(Weaver et al.2018).Yellow fever virus(YFV,family Flaviviridae,genus Flavivirus)is a mosquito-borne flavivirus that causes yellow fever in humans and has been endemic in Africa and Latin America for many years(Domingo et al.2018). | Meng Li Beibei Wang Liqiang Li Gary Wong Yingxia Liu Jinmin Ma Jiandong Li Hongzhou Lu Mifang Liang Ang Li Xiuqing Zhang Yuhai Bi Hui Zeng | 2019 | Virologica Sinica2019，34，3： | 1 |
| 17 | A genome-wide comparison of genes responsive to autopolyploidy inIsatis indigotica usingArabidopsis thaliana Affymetrix genechips显示文摘 | Beibei Lu Xinzhu Pan Lei Zhang Beibei Huang Lianna Sun Bin Li Bo Yi Shuiqing Zheng Xiaojing Yu Ruxian Ding Wansheng Chen | 2006 | Plant Molecular Biology Reporter2006，，2： | 1 |
| 18 | A facile design for multifunctional AIEgen based on tetraaniline derivatives显示文摘Aniline oligomers have been widely used in many fields due to their excellent physicochemical properties. Owing to strong intermolecular interactions, their emission is always weakened or quenched when they are in high concentration or aggregated state, which greatly limits their fluorescent applications. Inspired by the concept of aggregation-induced emission(AIE), herein we introduced large steric groups onto the aniline oligomer to prevent the formation of packing structure. In particular, diphenyl vinyl group was bonded with oligomeric tetraaniline by a facile synthetic procedure with high yield. The obtained aniline oligomer derivative exhibited typical AIE features, which was also confirmed by density functional theoretical calculation. More importantly, this AIE oligomer was able to detect Fe^(3+) ions selectively and quantitatively. The fluorescence intensity decreased linearly along with the increment of Fe^(3+) concentration. Moreover, we demonstrated that this AIE oligomer could stain live bacteria, such as E. coli and S. aureus efficiently. All these results suggest that such a readily accessible and multifunctional tetraaniline derivative provides a new platform for the construction of fluorescent materials. | Beibei Liu Wei He Hao Lu Kun Wang Mingming Huang Ryan Tsz Kin Kwok Jacky Wing Yip Lam Longcheng Gao Jiping Yang Benzhong Tang | 2019 | Science China Chemistry2019，62，6： | 1 |
| 19 | Folate-conjugated pH-responsive nanocarrier designed for active tumor targeting and controlled release of doxorubicin显示文摘 | Lulu WEI Beibei LU Lin CUI Xueying PENG Jianning wu Deqiang LI Zhiyong LIU Xuhong GUO | 2017 | Frontiers of Materials Science2017，11，4： | 1 |
| 20 | Seven new 3,4-dihydro-furanocoumarin derivatives from Angelica dahurica显示文摘Objective:To study the chemical constituents of the roots of Angelica dahurica,a well-known Chinese herbal medicine named Baizhi in Chinese.Methods:Compounds were separated by various chromatographies,and the structures of new compounds were elucidated based on the analysis of their spectroscopic and spectrometric data(1D,2D NMR,HRESI MS,IR,and UV).The absolute configurations of new compounds were determined by the calculated electronic circular dichroism and chemical derivatization.The inhibitory activities of all isolates against nitric oxide(NO)production were evaluated using lipopolysaccharide-activated RAW 264.7macrophage cells.Results:Seven new 3,4-dihydro-furanocoumarin derivatives(1a/1b,2a/2b,3a/3b,4)together with a known furanocoumarin(5)were isolated from the roots of A.dahurica.The new compounds included three pairs of enantiomers,(4S,2’’R)-angelicadin A(1a)/(4R,2’’S)-angelicadin A(1b),(4S,2’’S)-angelicadin A(2a)/(4R,2’’R)-angelicadin A(2b),and(4S,2’’S)-secoangelicadin A(3a)/(4R,2’’R)-secoangelicadin A(3b),together with(4R,2’’R)-secoangelicadin A methyl ester(4).The known xanthotoxol(5)inhibited the NO production with the half-maximal inhibitory concentration(IC50)value of(32.8±0.8)μmol/L,but all the new compounds showed no inhibitory activities at the concentration of100μmol/L.Conclusion:This is the first report of the discovery of 3,4-dihydro-furanocoumarins from A.dahurica.The results are not only meaningful for the understanding of the chemical constituents of A.dahurica,but also enrich the reservoir of natural products. | Yang Wang Fanyu Shi Zihan Lu Mingliang Zhang Zekun Zhang Fangfang Jia Beibei Zhang Lishan Ouyang Zhixiang Zhu Shepo Shi | 2023 | Chinese Herbal Medicines2023，15，3： | 1 |
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