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| 1 | Hypertensive stretch regulates endothelial exocytosis of WeibeI-Palade bodies through VEGF receptor 2 signaling pathways显示文摘Weibel-Palade 身体(WPB ) 的调整 endothelial exocytosis,在白血球 trafficking 的第一个阶段,在发炎和损害起一个枢轴的作用。尖锐的机械段仔细与脉管的发炎被联系了,尽管精确机制是未知的。这里,我们证明那高血压的段通过 VEGF 受体 2 调整 endothelial 房间(EC ) 的 WPB 的 exocytosis (VEGFR2 ) 表明小径。段触发一个快速的版本(在分钟以内) 从在有教养的人的 EC 的 WPB 的 von Willebrand 因素和 interleukin-8,通过 P-selectin 的 translocation 把在白血球和 EC 之间的相互作用提升到房间膜。我们进一步证明那高血压的段显著地导致未经触动的 EC 的 P-selectin translocation 并且两个都提高白血球粘附前 vivo 并且在 vivo。导致段的 endothelial exocytosis 经由 VEGFR2/PLCγ 被调停; 1/calcium 小径。有趣地,段也经由一条 VEGFR2/Akt/nitric 氧化物小径导致否定反馈。如此的双效果在颈动脉动脉片断,以及在尖锐高血压的老鼠模型用药理学和基因途径被证实。这些研究为 endothelial exocytosis 作为有势力收缩筋揭示机械段,它被 VEGFR2 发信号调制。因此, VEGFR2 发信号小径可以在限制高血压的段相关的发炎代表新奇治疗学的目标。 | Yan Xiong Zhenqian Hu Xiaofan Han Beibei Jiang Rongli Zhan Xiaoyu Zhang Yao Lu Chenyang Geng Wei Li Yulong He Yingqing Huo Masabuml Shlbuya Jincai Luo | 2013 | Cell Research2013，23，6： | 7 |
| 2 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | Effective removal of Cd^2+ and Pb^2+ pollutants from wastewater by dielectrophoresis-assisted adsorption显示文摘Dielectrophoresis(DEP)was combined with adsorption(ADS)to simultaneously and effectively remove Cd^2+ and Pb^2+ species from aqueous solution.To implement the process,bentonite particles of submicro-meter size were used to first adsorb the heavy metal ions.These particles were subsequently trapped and removed by DEP.The effects of the adsorbent dosage,DEP cell voltage and the capture pool numbers on the removal rate were investigated in batch processes,which allowed us to determine the optimal experimental conditions.The high removal efficiency,97.3% and 99.9% for Cd^2+ and Pb^2+,respectively,were achieved when the ions are coexisting in the system.The microstructure of bentonite particles before and after ADS/DEP was examined by scanning electron microscopy.Our results suggest that the dielectrophoresis-assisted adsorption method has a high capability to remove the heavy metals from wastewater. | Qinghao Jin Chenyang Cui Huiying Chen Jing Wu Jing Hu Xuan Xing Junfeng Geng Yanhong Wu | 2019 | Frontiers of Environmental Science & Engineering2019，13，2： | 1 |
| 4 | TaTIP41 and TaTAP46 positively regulate drought tolerance in wheat by inhibiting PP2A activity显示文摘Drought is a major environmental stress limiting global wheat(Triticum aestivum)production.Exploring drought tolerance genes is important for improving drought adaptation in this crop.Here,we cloned and characterized TaTIP41,a novel drought tolerance gene in wheat.TaTIP41 is a putative conserved component of target of rapamycin(TOR)signaling,and the Ta TIP41 homoeologs were expressed in response to drought stress and abscisic acid(ABA).The overexpression of Ta TIP41 enhanced drought tolerance and the ABA response,including ABA-induced stomatal closure,while its downregulation using RNA interference(RNAi)had the opposite effect.Furthermore,Ta TIP41 physically interacted with TaTAP46,another conserved component of TOR signaling.Like TaTIP41,TaTAP46 positively regulated drought tolerance.Furthermore,TaTIP41 and TaTAP46 interacted with type-2A protein phosphatase(PP2A)catalytic subunits,such as TaPP2A-2,and inhibited their enzymatic activities.Silencing TaPP2A-2 improved drought tolerance in wheat.Together,our findings provide new insights into the roles of TaTIP41 and TaTAP46 in the drought tolerance and ABA response in wheat,and their potential application in improving wheat environmental adaptability. | Jianhui Ma Yuke Geng Hong Liu Mengqi Zhang Shujuan Liu Chenyang Hao Jian Hou Youfu Zhang Daijing Zhang Weijun Zhang Xueyong Zhang Tian Li | 2023 | Journal of Integrative Plant Biology2023，65，9： | 0 |
| 5 | Protective effects and microarray-based mechanism of sea cucumber hydrolysates against high-glucose induced nephrotoxicity in mouse glomerulus mesangial cells显示文摘Diabetic nephropathy(DN)is a common type of end-stage renal disease and glomerular mesangial cells(GMCs)are widely used as a cell model for DN.This study firstly investigated the inhibitory effects of the Apostichopus japonicus and Acaudina leucoprocta hydrolysates on cellular growth under high-glucose treatment,better inhibitory effect of A.japonicus hydrolysate was observed compared to that of A.leucoprocta hydrolysate.Subsequently,the global transcription profiles obtained via microarray analysis showed that 6070 and 7015 genes were identified in the A.japonicus and A.leucoprocta groups compared with the model group,respectively.Among them,transcriptions of the slc30a4,slc35dl,tppp3,tp53inpl,bcl-2,apafl,alox12b and adrala genes were restored from the levels of the model group to those of the control group,contributed to cell mitosis and proliferation in both treatment groups.In addition,other apoptosis-related genes,such as bcl-6,clu,foxo3 and akt,showed opposite trends between two groups,which might cause the difference in inhibitory effect.We preliminarily proposed that the regulation effects of A.japonicus and A.leucoprocta on the genes involved in cellular mitosis,proliferation and apoptosis,might contribute to their inhibitory activity on GMCs under high-glucose environment. | Lingxin Geng Jiaojiao Han Jun Zhou Ye Li Tinghong Ming Zhen Zhang Chenyang Lu Xiurong Su | 2024 | Journal of Future Foods2024，4，3： | 0 |
| 6 | Physiological mechanisms underlying reduced photosynthesis in wheat leaves grown in the field under conditions of nitrogen and water deficiency显示文摘Reduced photosynthesis results directly from nitrogen or water deficiency in wheat plants,and leads to a decrease in grain yield.In this study,by measuring the effects of water and N deficiencies,both individually and combined,we characterized the responses of wheat(Triticum aestivum L.Yumai 49-198)plants to these two deficiencies using physiological measurements and comparative proteomics.Significant decreases in grain yield and leaf photosynthetic performance were observed in all deficiency conditions,and 106 photosynthetic proteins that showed responses were identified.Nitrogen deficiency induced the least change in photosynthetic proteins,and similar changes in most of these proteins were also observed for the combined nitrogen and water deficiencies.Water deficiency induced the largest change in photosynthetic proteins and resulted in the lowest 1000-kernel weight.Severe decreases in photosynthesis in both the water-deficiency and combined N and water deficiency groups were reflected mainly in an imbalanced ATP/NADPH ratio associated with the light reaction,which influences carbon metabolism in the Calvin cycle.Photorespiration was respectively stimulated or inhibited by N or water deficiency,while suppression of photorespiratory flux and activation of nitrogen recycling were observed in the combined N and water deficiency treatments.Comparison of photosynthetic proteins between experimental sites suggested that precipitation affected linear electron flow in the photoreaction,and thus photosynthetic efficiency.Our results provide a baseline for future studies of the roles of these photosynthetic proteins in the response to N or water deficiency and their effect on 1000-kernel weight. | Juan Kang Yingying Chu Geng Ma Yanfei Zhang Xiaoyan Zhang Mao Wang Hongfang Lu Lifang Wang Guozhang Kang Dongyun Ma Yingxin Xie Chenyang Wang | 2023 | The Crop Journal2023，11，2： | 0 |
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