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| 1 | Research progress of aluminum alloy automotive sheet and application technology显示文摘Pretreatment technology is deeply discussed to explain its importance in guaranteeing properties and formability of aluminum alloy automotive sheet. Some typical applications of aluminum alloy automotive sheet to automotive industry are listed. Based on the author's knowledge and recognition and research progress presently, the important research contents about aluminum alloy automotive sheet are emphasized. Reducing cost and price of sheet and going deeply into application research are the main work for expending the application of aluminum alloy automotive sheet in the automobile. | Ma Mingtu You Jianghai Lu Hongzhou Wang Zhiwen | 2012 | Engineering Sciences2012，10，4： | 10 |
| 2 | On the automobile lightweight显示文摘The significance,description parameters,evaluation method,implement way and design for lightweight of automobile are comprehensively reviewed.The relationship among the performances of auto parts & components,the properties of materials and application of advanced technologies is also elaborated.According to recently related progress of lightweight and authors' research and developing work,lightweight of automobile is comprehensively and systematically overviewed. | Ma Mingtu Yi Hongliang Lu Hongzhou Wan Xinming | 2012 | Engineering Sciences2012，10，2： | 8 |
| 3 | Analysis of surface orange peel of aluminum-alloy automobile sheet by using of EBSD and X-ray diffraction显示文摘The formation cause of orange peel of aluminum-alloy automotive sheet after tensile deformation was analysed by using X-ray diffraction and electron back-scattered diffraction(EBSD).The test results showed that formation cause of surface orange peel after tensile deformation related to product texture and nonuniform deformation during the tensile process.The grain size has significant effect on deformation uniform and texture formation.Coarse grains were easy to produce nonuniform deformation and texture,which would produce surface orange peel after tensile deformation. | Ma Mingtu Sun Zhifu Wang Zhiwen Lu Hongzhou Zhou Mingbo | 2012 | Engineering Sciences2012，10，6： | 7 |
| 4 | An antiretroviral regimen containing 6 months of stavudine followed by long-term zidovudine for first-fine HIV therapy is optimal in resource-limited settings: a prospective, multicenter study in China显示文摘 | Li Taisheng Guo Fuping Li Yijia Zhang Chengda Han Yang Lye Wei He Yun Lu Hongzhou Xie Jing Huang Aiqiong Li Yanling Tang Xiaoping Wang Hui Zhang Tong Gao Guiju Lei Junkang Zhang Xiaoying Wu Xinhua Sun Yongtao Bai Jinsong Luo Ling Wang Huanlmg | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 5 | Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection显示文摘The ongoing pandemic of coronavirus disease 19(COVID-19)is caused by a newly discoveredβcoronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination.Here we examined,using ELISA,the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6–7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection.All samples were positive for IgGs against the S-and N-proteins of SARS-CoV-2.Notably,14 samples available at 6–7 months post-infection all showed significant neutralizing activities in a pseudovirus assay,with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2.Furthermore,in 10 blood samples from cases at 6–7 months post-infection used for memory T-cell tests,we found that interferonγ-producing CD4+and CD8+cells were increased upon SARS-CoV-2 antigen stimulation.Together,these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population,and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2. | Yun Tan Feng Liu Xiaoguang Xu Yun Ling Weijin Huang Zhaoqin Zhu Mingquan Guo Yixiao Lin Ziyu Fu Dongguo Liang Tengfei Zhang Jian Fan Miao Xu Hongzhou Lu Saijuan Chen | 2020 | Frontiers of Medicine2020，14，6： | 6 |
| 6 | Dent Resistance for Automobile Body Panels显示文摘Dent resistance of automobile body panels is an important property for automobile design and manufacture, but the study on this aspect is not still profound. This study is to summarize the testing methods and physical significations of static and dynamic dent resistance of automobile body panels combined with the author's study, and to analyze the dent behaviors in the round. Several influence factors on dent resistance are expatiated including the mechanical properties of materials, stress states after forming, bake hardening ability, modulus, methods of testing, and structure of specimens and so on. The automotive lightweight and application of high strength steel sheets and aluminum alloys sheets are analyzed, and the significance of testing of dent resistance, especially for dynamic dent resistance of auto-panels, and the finite element simulation analysis are emphasized. To explain the physical phenomenon of dent behaviors, the latest and concerned study results are also discussed. According to this study, a dent resistance test and evaluation standard of Society of Automotive Engineers of China for automotive body panel is presented and is being carried out, and an industry conference is hold to discuss the working-out of the standard, a primary schedule of this standard is confirmed now. The study can guide the further testing and study of dent resistant of auto-panels. | LU Hongzhou MA Mingm YOU Jianghai LI Zhigang | 2009 | Chinese Journal of Mechanical Engineering2009，22，6： | 5 |
| 7 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 8 | Discovery process, clinical characteristics, and treatment of patients infected with avian influenza virus (H7N9) in Shanghai显示文摘During the spring of 2013,a novel avian-origin influenza A (H7N9) virus emerged and spread in Shanghai.On May 9,2013,33 lab-confirmed cases (2 children and 31 adults) have been reported,among whom 13 died.Among the 31 adult cases of H7N9 avian influenza A virus infections in humans,80.6% (25/31) were older men (average age 65 years).Clear history of poultry exposure was found in eight patients (8/33,24.3%) and the remaining 21 cases had been suspected poultry exposure.Clustered cases were found in two families (two cases from a father and his son,and the other two cases from a wife and her husband).However,no evidence of human-to-human transmission had been identified.Avian influenza is one of the most dangerous contagions in poultry worldwide,and avian influenza A virus is the major pathogen responsible.Transmission from poultry to humans has now been proven.Some gene segments of the strain have mutated,and further mutations might result in human-to-human transmission. | Sun Yang Shen Yinzhong Lu Hongzhou | 2014 | Chinese Medical Journal2014，，1： | 4 |
| 9 | Morphology observation for surface orange peel and fracture in tension sample of aluminum-alloy sheet and characterization of nano hardness显示文摘The tension property of aluminum-alloy sheet with different microstructures is measured,and the surface and tension fracture morphology of tension sample with and without orange peel are observed by using scanning electron microscope(SEM).Surface roughness and nano hardness of tension sample are measured.The results show that the average elongation of the samples with orange peel is lower than that without orange peel;especially the r value of perpendicular to the rolling direction is much lower than that without orange peel.The tension surface of the orange peel samples is very rough;various parameters of surface roughness are higher.Under the observation of SEM,a wider sliding band with a micro crack on the surface of orange peel sample can be found.The various parameters of surface roughness without orange peel sample are near to zero,the sliding band is narrow and without micro cracks.The dimple width in tensile fracture of orange peel sample is larger than that without orange peel sample,but shear lip is narrower.The nano hardness testing results show that samples with orange peel behave high elastic modulus,high hardness,and high maximum load,but low plastic deformation depth.These mentioned features can completely describe surface and fracture morphology of tension samples with orange peel. | Ma Mingtu Mei Huasheng Lu Hongzhou Yang Hongya Wu Emei Zhou Mingbo | 2012 | Engineering Sciences2012，10，6： | 4 |
| 10 | Human infection with avian influenza A(H7N9) virus in Shanghai: current status and future trends显示文摘Avian influenza A(H7N9) virus is one subgroup among the larger group of H7 viruses,which normally circulate among birds.The H7N9 subtype of avian influenza viruses has not been known to infect humans until only recently.On March 31,2013,China confirmed the first three human cases of novel avian influenza A(H7N9)infection in Shanghai and Anhui,two of these patients died.1 As of February 27,2014,367 laboratory-confirmed human cases have been reported from 15 provinces/municipalities in China's Mainland,the most (136) from China's Zhejiang province.2 H7N9 virus transmission and infection continue endash 127 confirmed human H7N9 cases were reported in January 2014. | Shen Yinzhong Lu Hongzhou | 2014 | Chinese Medical Journal2014，，10： | 3 |
| 11 | Characteristics of SARS-CoV-2 Delta variant-infected individuals with intermittently positive retest viral RNA after discharge显示文摘SARS-CoV-2-infected patients will be discharged when viral ribonucleic acid(RNA)is consecutively negative at least twice over a 24-h interval.However,we have demonstrated that positive retest viral RNA,a particular clinical phenomenon initially observed in discharged SARS-CoV-2-infected patients in early 2020[1,2],is the occasional reoccurrence of Polymerase Chain Reaction(PCR)-detectable viral RNA but not reinfection[3]. | Lu Li Jingyan Tang Zhiwei Xie Qingxin Gan Guofang Tang Zhongwei Hu Huimin Zeng Jingrong Shi Jiaojiao Li Yan Li Changwen Ke Min Kang Dan Liang Huan Lu Yuwei Tong Xilong Deng Jinxin Liu Hongzhou Lu Fuxiang Wang Fengyu Hu Feng Li Nanshan Zhong Xiaoping Tang | 2022 | National Science Review2022，9，10： | 3 |
| 12 | Evaluation of Epstein-Barr Virus Salivary Shedding in HIV/AIDS Patients and HAART Use: A Retrospective Cohort Study显示文摘Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus(EBV) in saliva and relationship with highly active antiretroviral therapy(HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients who were treated in the hospitals for infectious diseases in Wuxi and Shanghai, China from May 2016 to April 2017. The EBV-seropositive samples were identified by ELISA. EBV-specific primers and probes were used for the quantitative detection of viral DNA from saliva via quantitative real-time polymerase chain reaction. CD4 cell counts of the HIV/AIDS patients were detected by a flow cytometry. A total of 372 HIV/AIDS patients were ultimately selected and categorized for this retrospective cohort study. For EBV IgG and IgM, the HIV/AIDS HAART use(H) and non-HAART use(NH) groups had significantly higher seropositive rates than the HIV-negative control group. The HIV/AIDS(NH) group had the highest seropositive rate(IgG, 94.27%; IgM, 68.98%) and the highest incidence of EBV reactivation or infection. For salivary EBV DNA-positive rates and quantities, the HIV/AIDS(H)(73.69%) and the HIV/AIDS(NH)(100%) groups showed significantly higher values than the HIV-negative control group(35.79%,[ twofold). Further, the salivary EBV DNA-negative population had significantly higher CD4 cell counts than the EBV DNA-positive population in the HIV/AIDS(H) group and the HIV/AIDS(NH) groups. Thus, HAART use is beneficial in decreasing the EBV salivary shedding in HIV/AIDS patients and indirectly decreases EBV transmission risk. | Yan Yan Yong Ren Renfang Chen Jing Hu Yongjia Ji Junyang Yang Jiayin Shen Lvyin Hu Hao Pei Jun Wang Yuanwang Qiu Hongzhou Lu Lihua Huang | 2018 | Virologica Sinica2018，33，3： | 3 |
| 13 | Satb2 expression in Foxci-promoted osteogenic differentiation of MC3T3-E1 cells is negatively regulated by microRNA-103-3p显示文摘The forkhead tran scripti on factor C1 (Foxci) is a cell-fate-determining factor that controls cranial bone development and osteogenic differentiation. Previously, it was demonstrated that various microRNAs (miRNAs) play important roles in osteogenesis and regulate the complex process of osteogenic differentiation. However, it remains unclear how miRNA expression changes during Foxci-promoted osteogenic differentiation. In this study, we successfully overexpressed the Foxci gene in MC3T3-E1 cells and investigated the alterations in the miRNA expression profile on day 3 after osteogenic induction by using a miRNA microarray. Nine downregulated miRNAs and eight upregulated miRNAs were found to be differentially expressed. Among these miRNAs, miR-103-3p was consistently downregulated in the Foxc7-overexpressing MC3T3-E1 cells and was identified as a negative regulator of osteogenic differentiation by using a gain-and Iose-of-funotion assay. The special AT-rich sequence-binding protein 2 (Satb2), a pivotal osteogenic transcription factor, was identified as the miR-103-3p targeting gene and was verified by real-time polymerase chain reaction, western blot analysis, and luciferase assay. Overexpression of miR-103-3p markedly inhibited the expression of Satb2 and attenuated Foxci-promoted osteogenic differentiation. Taken together, our results elucidated the miRNA expression profiles of MC3T3-E1 cells in the early stage of Foxc 1-promoted osteogenic differentiation and suggested that miR-103-3p acts as a negative regulator of the osteogenic differentiation of MC3T3-E1 cells by directly targeting Satb2. | Hongzhou Shen Chenpei Lu Jun Shi Hongliang Li Jiawen Si Guofang Shen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，6： | 3 |
| 14 | 2014 update of the Chinese guidelines for diagnosis and treatment of avian influenza A(H7N9) virus infection显示文摘The National Health and Family Planning Commission of China published an updated guidance (2014 version) on clinical management in Chinese on January 26,2014.1The guidelines come as human cases of avian influenza A(H7N9) virus infection undergo a seasonal spike.As of February 26,2014,237 cases have been detected in the outbreak's second wave,which began in October,compared with 136 in the first wave last spring.2 As of April 21,2014,a total of 414 human cases of avian influenza A(H7N9) have been confirmed in the mainland of China,including Zhejiang (138 cases),Guangdong (103 cases),Jiangsu (52 cases),Shanghai (41 cases),Fujian (22 cases),Hunan (22 cases),Anhui (13 cases),Jiangxi (six cases),Beijing (four cases),Henan (four cases),Guangxi (three cases),Shandong (three cases),Guizhou (one case,imported from Zhejiang),Hebei (one case) and Jilin (one case). | Shen Yinzhong Lu Hongzhou | 2014 | Chinese Medical Journal2014，，13： | 2 |
| 15 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 16 | En- terococcus faecium-related outbreak with molecular evidence of transmission from pigs to humans显示文摘 | LU Hongzhou WANG Xinhua LI Haijing | 2002 | J Clin Microbiol2002，40，3： | 1 |
| 17 | Rift Valley Fever Virus and Yellow Fever Virus in Urine: A Potential Source of Infection显示文摘Dear Editor,In recent years,the incidence of human infections caused by emerging or re-emerging pathogens has rapidly increased.Diseases that were once regional now have the ability to spread globally in a short amount of time and pose a wider threat to public health(Weaver et al.2018).Yellow fever virus(YFV,family Flaviviridae,genus Flavivirus)is a mosquito-borne flavivirus that causes yellow fever in humans and has been endemic in Africa and Latin America for many years(Domingo et al.2018). | Meng Li Beibei Wang Liqiang Li Gary Wong Yingxia Liu Jinmin Ma Jiandong Li Hongzhou Lu Mifang Liang Ang Li Xiuqing Zhang Yuhai Bi Hui Zeng | 2019 | Virologica Sinica2019，34，3： | 1 |
| 18 | The 4Rs approach to COVID-19 emergency management during the post-pandemic period:What lessons can be learned from Shenzhen,China?显示文摘The Omicron variant of SARS-CoV-2(or Omicron)is extremely contagious and has swept the world in a short period.Shenzhen—a new international city in China with a permanent population of 17.56 million and covering nearly 2000 square kilometers—was attacked by Omicron in 2022.However,the pandemic was controlled in a very short time as a result of prompt government reaction that prevented the variant’s further spread.The total number of cases in this wave of the pandemic was more than 2600.Shenzhen’s successful experience in tackling the Omicron wave deserves in-depth discussion.Proposed by American scholar Robert Heath,the 4Rs model aims to reduce the harm from a crisis through the measures of reduction,readiness,response,and recovery.This article presents the successful experience of Shenzhen’s local government and the Third People’s Hospital of Shenzhen,the only hospital in Shenzhen designated to use the 4Rs emergency management model for the treatment of COVID-19 during the 2022 Omicron wave of the pandemic. | Rongfeng Zhou Hongzhou Lu | 2022 | Infectious Medicine2022，1，4： | 1 |
| 19 | Recycle technology for recovering resources and products from waste printed circuit boards显示文摘 | Jia Li Hongzhou Lu Jie Guo | 2007 | Environmental Science and Technology2007，41，6： | 1 |
| 20 | Recycle technology for recovering resources and products from waste printed circuit boards 显示文摘 | Li Jia Lu Hongzhou Guo Jie | 2007 | Environmental Science & Technology2007，41，6： | 1 |
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