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| 1 | Distribution,function and physiological role of melatonin in the lower gut显示文摘Melatonin is a hormone with endocrine, paracrine andautocrine actions. It is involved in the regulation of multiple functions, including the control of the gastroin-testinal (GI) system under physiological and pathophys-iological conditions. Since the gut contains at least 400times more melatonin than the pineal gland, a reviewof the functional importance of melatonin in the gutseems useful, especially in the context of recent clinicaltrials. Melatonin exerts its physiological effects throughspecific membrane receptors, named melatonin-1 re-ceptor (MT1), MT2 and MT3. These receptors can befound in the gut and their involvement in the regulationof GI motility, inflammation and pain has been reportedin numerous basic and clinical studies. Stable levels ofmelatonin in the lower gut that are unchanged follow-ing a pinealectomy suggest local synthesis and, further more, implicate physiological importance of endogenous melatonin in the GI tract. Presently, only a small number of human studies report possible beneficial and also possible harmful effects of melatonin in case reports and clinical trials. These human studies include patients with lower GI diseases, especially patients with irritable bowel syndrome, inflammatory bowel disease and colorectal cancer. In this review, we summarize the presently available information on melatonin effects in the lower gut and discuss available in vitro and in vivo data. We furthermore aim to evaluate whether melatonin may be useful in future treatment of symptoms or diseases involving the lower gut. | Chun-Qiu Chen Jakub Fichna Mohammad Bashashati Yong-Yu Li Martin Storr | 2011 | World Journal of Gastroenterology2011，17，34： | 13 |
| 2 | Cytokine imbalance in irritable bowel syndrome: a systematic review and meta‐analysis显示文摘 | M. Bashashati N. Rezaei A. Shafieyoun D. P. McKernan L. Chang L. ?hman E. M. Quigley M. Schmulson K. A. Sharkey M. Simrén | 2014 | Neurogastroenterol. Motil2014，，7： | 2 |
| 3 | Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta‐analysis显示文摘 | M. Bashashati N. Rezaei H. Bashashati A. Shafieyoun N. E. Daryani K. A. Sharkey M. Storr | 2012 | Neurogastroenterology & Motility2012，，12： | 2 |
| 4 | Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival 显示文摘 | Johnson N A Boyle M Bashashati A | 2009 | Blood2009，113，16： | 1 |
| 5 | Urinary metabolites as noninvasive biomarkers of gastrointestinal diseases:A clinical review显示文摘The diagnosis of gastrointestinal(GI) disorders is usually based on invasive techniques such as endoscopy.A key important factor in GI cancer is early diagnosis which warrants development of non-or lessinvasive diagnostic techniques.In addition,monitoring and surveillance are other important parts in the management of GI diseases.Metabolomics studies with nuclear magnetic resonance and mass spectrometry can measure the concentration of more than 3000 chemical compounds in the urine providing possible chemical signature in different diseases and during health.In this review,we discuss the urinary metabolomics signature of different GI diseases including GI cancer and elaborate on how these biomarkers could be used for the classification,early diagnosis and the monitoring of the patients.Moreover,we discuss future directions of this still evolving field of research. | Irene Sarosiek Rudolf Schicho Pedro Blandon Mohammad Bashashati | 2016 | World Journal of Gastrointestinal Oncology2016，8，5： | 1 |
| 6 | Cytokine gene poly- morphisms are associated with irritable bowel syndrome: a system- atic review and meta-analysis 显示文摘 | Bashashati M Rezaei N Bashashati H | 2012 | Neurogastroenterol Motil2012，24，12： | 1 |
| 7 | EMG and EOG artifacts in brain computer interface systems:a survey显示文摘 | Fatourechi M Bashashati A Ward R K | | 0，，03： | 1 |
| 8 | TOPICAL REVIEW:A survey of signal processing algorithms in brain-computer interfaces based on electrical brain signals显示文摘 | Bashashati A Fatourechi M Ward RK | 2007 | Journal of Neural Engineering2007，4，： | 1 |
| 9 | Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome显示文摘 | Elham Barkhordari Nima Rezaei Bita Ansaripour Pegah Larki Maryam Alighardashi Hamid Reza Ahmadi-Ashtiani Mahdi Mahmoudi Mohammad-Reza Keramati Peiman Habibollahi Mohammad Bashashati Naser Ebrahimi-Daryani Ali Akbar Amirzargar | 2010 | Journal of Clinical Immunology2010，，1： | 1 |
| 10 | Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival显示文摘 | Johnson NA Boyle M Bashashati A | 2009 | Blood2009，113，16： | 1 |
| 11 | A survey of signal processing algorithms in brain-computer inter- faces based on electrical brain signals 显示文摘 | Bashashati A Fatourechi M Ward R K | 2007 | J Neural Eng2007，4，2： | 1 |
| 12 | The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment显示文摘 | Schicho R Bashashati M Bawa M | 2010 | Inflamm Bowel Dis2010，17，8： | 1 |
| 13 | Cytokine imbalance in irritable bowel syndrome: a systematic review and meta-analysis显示文摘 | Bashashati M Rezaei N Shafieyoun A | 2014 | Neurogastroenterol Motil2014，26，7： | 1 |
| 14 | Cytokine imbalance in irritable bowel syndrome:a systematic review and meta-analysis 显示文摘 | Bashashati M Rezaei N Shafieyoun A | 2014 | Neurogastroenterol Moti12014，26，7： | 1 |
| 15 | Diffuse large B-cell lymphoma: reduced CD20 expression is associated with an inferior survival显示文摘 | Johnson NA Boyle M Bashashati A | 2009 | Blood2009，113，16： | 1 |
| 16 | Cytokine gene poly-morphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis显示文摘 | Bashashati M Rezaei N Bashashati H | 2012 | N eurogastroenterol Motil2012，24，12： | 1 |
| 17 | A survey of signal processing algorithms in brain-computer in- terfaces based on electrical brain signals显示文摘 | BASHASHATI A FATOURECHI M WARD R K | 2007 | J Neural Eng2007，4，2： | 1 |
| 18 | Cytokines and irritable bowel syndrome: Where do we stand?显示文摘 | Mohammad Bashashati Nima Rezaei Christopher N. Andrews Chun-Qiu Chen Nasser Ebrahimi Daryani Keith A. Sharkey Martin A. Storr | 2011 | Cytokine2011，，2： | 1 |
| 19 | Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta‐analysis显示文摘 | M. Bashashati N. Rezaei H. Bashashati A. Shafieyoun N. E. Daryani K. A. Sharkey M. Storr | 2012 | Neurogastroenterology & Motility2012，，12： | 1 |
| 20 | Activation of neuro- nal P2X7 receptor-pannexin-I mediates death of enteric neurons during colitis 显示文摘 | Gulbransen BD Bashashati M Hirota SA | 2012 | Nat Med2012，18，4： | 1 |
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