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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Supply chain coordination with demand disruptions显示文摘 | Xiangtong Qi Jonathan F. Bard Gang Yu | 2004 | Omega2004，，4： | 5 |
| 3 | Is in vivo measurement of size of polyps during colonoscopy accurate?显示文摘 | Narasimh Gopalswamy Vishwanath N. Shenoy Umesh Choudhry Ronald J. Markert Nancy Peace Manoop S. Bhutani Christopher J. Barde | 1997 | Gastrointestinal Endoscopy1997，，6： | 3 |
| 4 | Post‐stroke depression: mechanisms, translation and therapy显示文摘 | Isabelle Loubinoux Golo Kronenberg Matthias Endres Pascale Schumann‐Bard Thomas Freret Robert K. Filipkowski Leszek Kaczmarek Aurel Popa‐Wagner | 2012 | J. Cell. Mol. Med2012，，9： | 3 |
| 5 | Lipoprotein (a) as a predictor of coronary heart disease: the PRIME Study显示文摘 | LUC G BARD J M ARVEILER D | 2001 | Atherosclerosis2001，163，2： | 2 |
| 6 | How low does ethical leadership flow? Test of a trickle-down model显示文摘 | David M. Mayer Maribeth Kuenzi Rebecca Greenbaum Mary Bardes Rommel (Bombie) Salvador | 2008 | Organizational Behavior and Human Decision Processes2008，，1： | 2 |
| 7 | Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer ' s disease显示文摘 | Bard F Cannon C Barbour R | 2000 | Nat Med2000，6，8： | 2 |
| 8 | Analysis of cymnastics judges visoal search显示文摘 | Bard C FlcuryM | 1980 | Vision and sport1980，51，： | 1 |
| 9 | Chemiluminescence of Anodized and Etched Silicon:Evidence for a luminescent Siloxene-Like Layer on Porous Silicon显示文摘 | McCord P Yau S L Bard A J | 1992 | Science1992，257，5066： | 1 |
| 10 | Heterogenerous photoeatalytic oxida- tion of cyanide and sulfite in aqueous solutions at semiconductor powder显示文摘 | Nfrank S N Bard A J | 1977 | J Phys Chem1977，81，： | 1 |
| 11 | A Branch and Bound Algorithm for the Bilevel Programming Problem显示文摘 | Bard J F Moore J T | 1990 | SIAM Journal of Scientific and Statistical Computing1990，18，： | 1 |
| 12 | Spectral sensitization of the heterogeneous photocatalytic oxidation of hydroquinone in aqueous solutions at phthalocyanine - coated titanium dioxide powders显示文摘 | Fu - Ren F Fan Allen J Bard | 1979 | J Am Chem Soc1979，101，20： | 1 |
| 13 | Some properties of the bilevel programming problem显示文摘 | Bard J F | 1991 | Journal of Optimization Theory and Applications1991，68，： | 1 |
| 14 | Tuna food habits related to the micronekton distribution in French Polynesia显示文摘 | Bertrand A Bard F X Josse E | 2002 | Marine Biology2002，140，： | 1 |
| 15 | Optimizing aircraft routing in response to groundings and delays显示文摘 | Jonathan Bard Yu G | 2001 | IIE Transaction2001，33，： | 1 |
| 16 | Algorithms for parallelmachine scheduling: a case study of the tracking and data relay satellite system显示文摘 | Rojanasoonthon S Bard J F Reddy S D | 2003 | Journal of Operational Research Society2003，54，8： | 1 |
| 17 | Supply chain coordination with demand disruptions显示文摘 | Qi X T Bard J F Yu G | 2004 | Omega2004，32，4： | 1 |
| 18 | Hydrogen peroxide pro- duction in the oxygen reduction reaction at different eleetrocatalysts as quantified by scanning electrochemical microscopy 显示文摘 | SANCHEZ-SANCHEZ C M BARD A J | 2009 | Anal Chem2009，81，19： | 1 |
| 19 | Plasma cystatin - C and devel- opment of coronary heart disease: The PRIME Study 显示文摘 | Lue G Bard JM Lesueur C | 2006 | Athero- sclerosis2006，185，2： | 1 |
| 20 | ELectrochemical in-vestigation of the energetics of particulate titanium dioxide photocatalysts: the methyl viologen-acetate system 显示文摘 | Ward M D White J R Bard A J | 1983 | Journal of American Chemical Society1983，105，： | 1 |
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