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| 1 | 无先兆偏头痛患者颈内静脉血中的促炎细胞因子、黏附分子和淋巴细胞整合素在头痛发作时的表达显示文摘Objective. -The aim of the present research was to verify the levels of the soluble adhesion molecules sL-and sE-selectins, intercellular adhesion molecule (sICAM)-1, and vascular cell adhesion molecule-1 in serial samples of internal jugular venous blood taken from migraine patients without aura (MWoA) during attacks. The expression of leukocyte function antigen (LFA)-1 and very late activation antigen (VLA)-4 was also assessed on lymphocytes obtained from jugular venous blood. Levels of certain proinflammatory cytokines (tumor necrosis factor-α[TNF-α], interleukin-1β[IL-1β], IL-4, and IL6) were also determined and correlated with those of adhesion molecules. Patients and Methods. -Seven MWoA patients were admitted in the hospital during attacks and blood samples were taken immediately after catheter insertion, at 1, 2, and 4 hours after attack onset, and within 2 hours after its termination. The levels of adhesion molecules and cytokines were measured with ELISA method. The expression of LFA-1 and VLA-4 was assessed by flow cytometry. Results. -A parallel transient increase of sICAM-1, TNF-α, and IL-6 was observed in the first 2 hours after attack onset compared with the time of catheter insertion (P< .0001, < .001, and < .003, respectively). The proportion of CD4+and CD8+T-cells expressing high levels of LFA-1 showed instead a progressive down-regulation with significantly lower percentages at 2 and 4 hours after attack onset (P < .01 and < .022, respectively). No variation in the percentage of VLA-4 expressing cells was observed at any time of the study. Conclusions. -The transient increase in sICAM-1 and TNF-αfound in the internal jugular blood of MWoA patients assessed ictally can be induced by sensory neuropeptides released from activated trigeminal endings. The progressive decrease in sICAM-1 levels during attacks and the down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks. | Sarchielli P. Alberti A. Baldi A. 张慧(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 5 |
| 2 | Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms显示文摘 | E. Bugianesi A. Gastaldelli E. Vanni R. Gambino M. Cassader S. Baldi V. Ponti G. Pagano E. Ferrannini M. Rizzetto | 2005 | Diabetologia2005，，4： | 3 |
| 3 | Changes in awakening Cortisol response and midnight salivary Cortisol are sensitive markers of strenuous training-induced fatigue显示文摘 | M. A. Minetto F. Lanfranco A. Tibaudi M. Baldi A. Termine E. Ghigo | 2008 | Journal of Endocrinological Investigation2008，，1： | 1 |
| 4 | Polyunsaturated fatty acids and choline in dairy goats nutrition: Production and health benefits显示文摘 | G. Savoini A. Agazzi G. Invernizzi D. Cattaneo L. Pinotti A. Baldi | 2010 | Small Ruminant Research2010，，2： | 1 |
| 5 | Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms显示文摘 | E. Bugianesi A. Gastaldelli E. Vanni R. Gambino M. Cassader S. Baldi V. Ponti G. Pagano E. Ferrannini M. Rizzetto | 2005 | Diabetologia2005，，4： | 1 |
| 6 | Liver Transplantation in Defects of Cholesterol Biosynthesis: The Case of Lathosterolosis显示文摘 | P. L. Calvo A. Brunati M. Spada R. Romagnoli G. Corso G. Parenti M. Rossi M. Baldi G. Carbonaro E. David A. Pucci A. Amoroso M. Salizzoni | 2014 | American Journal of Transplantation2014，，4： | 1 |
| 7 | Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms显示文摘 | E. Bugianesi A. Gastaldelli E. Vanni R. Gambino M. Cassader S. Baldi V. Ponti G. Pagano E. Ferrannini M. Rizzetto | 2005 | Diabetologia2005，，4： | 1 |
| 8 | Pattern of Expression of Adiponectin Receptors in Human Liver and its Relation to Nonalcoholic Steatohepatitis显示文摘 | M. Nannipieri F. Cecchetti M. Anselmino E. Mancini G. Marchetti A. Bonotti S. Baldi B. Solito M. Giannetti A. Pinchera F. Santini E. Ferrannini | 2009 | Obesity Surgery2009，，4： | 1 |
| 9 | Crystal structural and optical properties of Cr-doped Y 2 Ti 2 O 7 and Y 2 Sn 2 O 7 pyrochlores显示文摘 | F. Matteucci G. Cruciani M. Dondi G. Baldi A. Barzanti | 2006 | Acta Materialia2006，，7： | 1 |
| 10 | Long-standing mild hypertransaminasaemia caused by congenital disorder of glycosylation (CDG) type IIx显示文摘 | P. L. Calvo S. Pagliardini M. Baldi A. Pucci L. Sturiale D. Garozzo T. Vinciguerra C. Barbera J. Jaeken | 2008 | Journal of Inherited Metabolic Disease2008，，2： | 1 |
| 11 | CagA antigen of helicobacter pylori and coronary instability: Insight from a clinico-pathological study and a meta-analysis of 4241 cases显示文摘 | Francesco Franceschi Giampaolo Niccoli Giuseppe Ferrante Antonio Gasbarrini Alfonso Baldi Marcello Candelli Florinda Feroce Nathalie Saulnier Micaela Conte Davide Roccarina Gaetano A. Lanza Giovanni Gasbarrini Silveri Nicolò Gentiloni Filippo Crea | 2008 | Atherosclerosis2008，，2： | 1 |
| 12 | 儿童和成人的黑色素瘤是否有区别:对33例来自单一研究机构儿童黑色素瘤的回顾性分析显示文摘Objective. To ascertain whether childhood melanoma presents any peculiar clinical features or differences in prognosis with respect to adults, we retrospectively analyzed the data from 33 patients who were up to 14 years of age and treated for cutaneous melanoma at the Istituto Nazionale Tumori, Milan, over a 25-year period. Methods. Primary lesions were amelanotic in half of the cases and raised in 73%. Lower extremities were the most common primary sites. Histologically, 9 cases were classified as nodular type, and median thickness was 2.5 mm. Nine children had nodal involvement at diagnosis, 2 in-transit metastases, and 1 distant spread. Surgery was the mainstay of treatment; 9 patients underwent lymph node dissection, 3 received chemotherapy, and 2 received radiotherapy. Results. With a median follow-up of 122 months, 5-year event-free survival and overall survival were 60%and 70%, respectively. Age seemed to correlate with survival,event-free survival being 90%in children under 10 and 47%in older patients, although the initial microstaging seemed worse in the former. Conclusion. By comparisonwith adult cases, childhood melanoma can have a higher percentage of atypical clinical features (amelanotic and raised lesions), nodular histotype, and thick lesions. Although we have no data to support any suggestion of biological differences between young children and adolescents or adults, our findings give the impression that melanoma behaves differently in the younger age group. | Ferrari A. Bono A. Baldi M. 唐彦 | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，0，11： | 0 |
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