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| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Natural(ghrelin) and synthetic(hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation显示文摘 | Pettersson I Granata R Ghigo E | 2002 | J Endocrinol2002，175，： | 1 |
| 3 | A new evaluation of our life-support system显示文摘 | TOUSSAINT A GHIGO J GEORGE P C | 2003 | EMBO Journal2003，4，9： | 1 |
| 4 | Hypo- thalamopituitary dysfunction following traumatic brain injury andan- eurysmal subarachnoid hemorrhage 显示文摘 | Schneider HJ Kreitschmann-Andermahr I Ghigo E | 2007 | JAMA2007，298，12： | 1 |
| 5 | Finding gene-expression patterns in bacterial biofilms显示文摘 | Beloin C Ghigo J M | 2005 | Trends in Microbiology2005，13，1： | 1 |
| 6 | Growth hormone-releasing peptides 显示文摘 | Ghigo E Arvat E Muccioli G | 1999 | Eur J Endocrinol1999，136，： | 1 |
| 7 | The IGF system显示文摘 | Annunziata M Granata R Ghigo E | 2011 | Acta Diabetol2011，48，1： | 1 |
| 8 | Growth hormone- releasing peptides and their analogs显示文摘 | Camanni F Ghigo E Arvat E | 1998 | Front Neuroendocrinol1998，19，1： | 1 |
| 9 | Natural conjugative plasmids induce bacterial bio-film development显示文摘 | Ghigo JM | 2001 | Nature2001，412，6845： | 1 |
| 10 | A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans 显示文摘 | Chaveroche MK Ghigo JM d'Enfert C | 2000 | Nucleic Acids Res2000，28，22： | 1 |
| 11 | Taming the PI3K team to hold inflammation and cancer at bay 显示文摘 | Hirsch E Ciraolo E Ghigo A | 2008 | Pharmacol Ther2008，118，2： | 1 |
| 12 | Consensus guidelines on screening for hypopituitarism following traumatic brain injury 显示文摘 | Ghigo E Masel B Aimaretti G | 2005 | Brain injury2005，19，9： | 1 |
| 13 | Natural eonjugative plasmids induce bacterial biofihn development显示文摘 | Ghigo J M | 2001 | Nature2001，412，： | 1 |
| 14 | A CsgD-independent pathway for cellulose production and biofilm formation in Escherichia coli显示文摘 | DARE S GHIGO J M | 2006 | J Bacteriol2006，188，8： | 1 |
| 15 | Analysis of air quality monitoring networks by functional clustering显示文摘 | Ignaccolo R Ghigo S Giovenali E | 2008 | Environmetrics2008，19，7： | 1 |
| 16 | A CsgD-independent pathway for cellulose production and biofilm formation in Escherichia coli显示文摘 | Da Re S Ghigo J M | 2006 | J Bacteriol2006，188，8： | 1 |
| 17 | Natural conjugative plasmids induce bacterial biofilm development显示文摘 | Ghigo JM | 2001 | Nature2001，412，6845： | 1 |
| 18 | Cortistatin , but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland显示文摘 | Deghenghi R Papotti M Ghigo E | 2001 | J Endocrinol Invest2001，24，1： | 1 |
| 19 | Traumatic brain in jury and hypopituitarism 显示文摘 | Aimaretti G Ghigo E | 2005 | ScientificWorldJoumal2005，5，： | 1 |
| 20 | BapA, a large secreted protein required for biofilm formation and host colonization of Salmonella enterica serovar Enteritidis 显示文摘 | Latasa C Roux A Toledo-Arana A Ghigo JM Gamazo C Penads JR Lasa I | 2005 | Mol Microbiol2005，58，5： | 1 |
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