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| 1 | Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis显示文摘Peritonitis continues to be a major complication of peritoneal dialysis(PD), and adequate treatment is crucial for a favorable outcome. There is no consensus regarding the optimal therapeutic regimen, and few prospective controlled studies have been published. The objective of this manuscript is to review the results of PD peritonitis treatment reported in narrative reviews, systematic reviews, and proportional meta-analyses. Two narrative reviews, the only existing systematic review and its update published between 1991 and 2014 were included. In addition, we reported the results of a proportional metaanalysis published by our group. Results from systematic reviews of randomized control trials(RCT) and quasiRCT were not able to identify any optimal antimicrobial treatment, but glycopeptide regimens were more likely to achieve a complete cure than a first generation cephalosporin. Compared to urokinase, simultaneous catheter removal and replacement resulted in better outcomes. Continuous and intermittent IP antibiotic use had similar outcomes. Intraperitoneal antibiotics were superior to intravenous antibiotics in reducing treatment failure. In the proportional meta-analysis of RCTs and the case series, the resolution rate(86%) of ceftazidime plus glycopeptide as initial treatment was significantly higher than first generation cephalosporin plus aminoglycosides(66%) and glycopeptides plus aminoglycosides(75%). Other comparisons of regimens used for either initial treatment or treatment of gram-positive rods or gramnegative rods did not show statistically significant differences. The superiority of a combination of a glycopeptide and a third generation cephalosporin was also reported by a narrative review study published in 1991, which reported an 88% resolution rate. | Pasqual Barretti Joo Vitor Pereira Doles Douglas Gonalves Pinotti Regina Paolucci El Dib | 2015 | World Journal of Nephrology2015，4，2： | 9 |
| 2 | Hepatic resection beyond barcelona clinic liver cancer indication:When and how显示文摘Hepatocellular carcinoma(HCC)is the main common primary tumour of the liver and it is usually associated with cirrhosis.The barcelona clinic liver cancer(BCLC)classification has been approved as guidance for HCC treatment algorithms by the European Association for the Study of Liver and the American Association for the Study of Liver Disease.According to this algorithm,hepatic resection should be performed only in patients with small single tumours of 2-3 cm without signs of portal hypertension(PHT)or hyperbilirubinemia.BCLC classification has been criticised and many studies have shown that multiple tumors and large tumors,as wide as those with macrovascular infiltration and PHT,could benefit from liver resection.Consequently,treatment guidelines should be revised and patients with intermediate/advanced stage HCC,when technically resectable,should receive the opportunity to be treated with radical surgical treatment.Nevertheless,the surgical treatment of HCC on cirrhosis is complex:The goal to be oncologically radical has always to be balanced with the necessity to minimize organ damage.The aim of this review was to analyze when and how liver resection could be indicated beyond BCLC indication.In particular,the role of multidisciplinary approach to assure a proper indication,of the intraoperative ultrasound for intraoperative restaging and resection guidance and of laparoscopy to minimize surgical trauma have been enhanced. | Mattia Garancini Enrico Pinotti Stefano Nespoli Fabrizio Romano Luca Gianotti Vittorio Giardini | 2016 | World Journal of Hepatology2016，8，11： | 8 |
| 3 | 胃的癌症的多模式的治疗显示文摘 Gastric cancer is the second leading cause of death from malignant disease worldwide.Although complete surgical resection remains the only curative modality for early stage gastric cancer,surgery alone only provides long-term survival in 20%of patients with advancedstage disease.To improve current results,it is necessary to consider multimodality treatment,including chemotherapy,radiotherapy and surgery.Recent clinical trials have shown survival benefit of combining different neoadjuvant or adjuvant protocols compared with surgery with curative intent.Furthermore,the implementation of chemotherapy with novel targeted agents could play an important role in the multimodal management of advanced gastric cancer.In this paper,we focus on a multidisciplinary approach in the treatment of gastric cancer and discuss future strategies to improve the outcome for these patients. | Ilaria Proserpio Stefano Rausei Sabrina Barzaghi Francesco Frattini Federica Galli Domenico Iovino Francesca Rovera Luigi Boni Gianlorenzo Dionigi Graziella Pinotti | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 8 |
| 4 | Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?显示文摘BACKGROUND Distant metastases are found in approximately 35%of patients with gastric cancer at their first clinical observation,and of these,4%-14%involves the liver.Unfortunately,only 0.4%-2.3%of patients with metastatic gastric cancer are eligible for radical surgery.Although surgical resection for gastric cancer metastases is still debated,there have been changes in recent years,although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The study protocol was based on identifying studies with clearly defined purpose,eligibility criteria,methodological analysis,and patient outcome.RESULTS We selected 47 studies pertaining to the purpose of the review,which involved a total of 2304 patients.Median survival was 7-52.3 mo,median disease-free survival was 4.7-18 mo.The 1-,2-,3-,and 5-year overall survival(OS)was 33%-90.1%,10%-60%,6%-70.4%,and 0%-40.1%,respectively.Only five papers reported the 10-year OS,which was 5.5%–31.5%.The general recurrence rate was between 55.5%and 96%,and that for hepatic recurrence was between 15%and 94%.CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis,while the presence of single metastasis or≤3 metastases associated with a size of<5 cm may be considered data that do not contraindicate liver resection. | Fabio Uggeri Lorenzo Ripamonti Enrico Pinotti Mauro Alessandro Scotti Simone Famularo Mattia Garancini Luca Gianotti Marco Braga Fabrizio Romano | 2020 | World Journal of Clinical Oncology2020，11，7： | 3 |
| 5 | The westward lithospheric drift,its role on the subduction and transform zones surrounding Americas:Andean to cordilleran orogenic types cyclicity显示文摘We investigate the effect of the westerly rotation of the lithosphere on the active margins that surround the Americas and find good correlations between the inferred easterly-directed mantle counterflow and the main structural grain and kinematics of the Andes and Sandwich arc slabs.In the Andes,the subduction zone is shallow and with low dip,because the mantle flow sustains the slab;the subduction hinge converges relative to the upper plate and generates an uplifting doubly verging orogen.The Sandwich Arc is generated by a westerly-directed SAM(South American) plate subduction where the eastward mantle flow is steepening and retreating the subduction zone.In this context,the slab hinge is retreating relative to the upper plate,generating the backarc basin and a low bathymetry single-verging accretionary prism.In Central America,the Caribbean plate presents a more complex scenario:(a) To the East,the Antilles Arc is generated by westerly directed subduction of the SAM plate,where the eastward mantle flow is steepening and retreating the subduction zone.(b) To the West,the Middle America Trench and Arc are generated by the easterly-directed subduction of the Cocos plate,where the shallow subduction caused by eastward mantle flow in its northern segment gradually steepens to the southern segment as it is infered by the preexisting westerly-directed subduction of the Caribbean Plateau.In the frame of the westerly lithospheric flow,the subduction of a divergent active ridge plays the role of introducing a change in the oceanic/continental plate’s convergence angle,such as in NAM(North American)plate with the collision with the Pacific/Farallon active ridge in the Neogene(Cordilleran orogenic type scenario).The easterly mantle drift sustains strong plate coupling along NAM,showing at Juan de Fuca easterly subducting microplate that the subduction hinge advances relative to the upper plate.This lower/upper plate convergence coupling also applies along strike to the neighbor continental strike slip fault systems where subduction was terminated(San Andreas and Queen Charlotte).The lower/upper plate convergence coupling enables the capture of the continental plate ribbons of Baja California and Yakutat terrane by the Pacific oceanic plate,transporting them along the strike slip fault systems as para-autochthonous terranes.This Cordilleran orogenic type scenario,is also recorded in SAM following the collision with the Aluk/Farallon active ridge in the Paleogene,segmenting SAM margin into the eastwardly subducting Tupac Amaru microplate intercalated between the proto-LiquineOfqui and Atacama strike slip fault systems,where subduction was terminated and para-autochthonous terranes transported.In the Neogene,the convergence of Nazca plate with respect to SAM reinstalls subduction and the present Andean orogenic type scenario. | Eugenio Aragon Fernando D'Eramo Marco Cuffaro Carlo Doglioni Eleonora Ficini Lucio Pinotti Silvina Nacif Manuel Demartis Irene Hernando Tomas Fuentes | 2020 | Geoscience Frontiers2020，11，4： | 2 |
| 6 | 胆碱与乳牛营养显示文摘乳牛需要胆碱用于合成一定数量的磷脂,而且胆碱是乙酰胆碱的前体.同时,胆碱也是不稳定甲基体的重要来源,胆碱和蛋氨酸均可提供不稳定甲基体,两者具有可以互换的性质.因此,提供不稳定甲基体的胆碱、蛋氨酸和甜菜碱(be-taine),和为合成甲基体的叶酸和维生素B12在饲粮中的供应,在满足胆碱的需要量方面均有相关.这样,当饲粮中蛋氨酸和叶酸盐没有多余时,胆碱实际上是哺乳动物的一种基本营养(Zeisel,2000). | Luciano Pinotti 王永康 | 2002 | 乳业科学与技术2002，25，1： | 2 |
| 7 | Testing Feed Quality: The 'artificial Senses' 显示文摘 | Cheli F Campagnoli A Pinotti L | 2007 | Feed International2007，6，： | 1 |
| 8 | Modulation of factor Ⅶ levels byintron 7 polymorphlsm: populantion and in vitro stodles显示文摘 | Pinotti M Toso R Girelli D | 2000 | Blood2000，95，11： | 1 |
| 9 | Kefiran films plasticized with sugars and polyols: water vapor bamer and mechanical properties in relation to their microstructure analyzed by ATR/FT-IR spectroscopy显示文摘 | PIERMARIA J BOSCH A PINOTTI A | 2011 | Food Hydrocolloids2011，25，5： | 1 |
| 10 | Choline metabolism in high-producing dairy cows:Metabolic and nutritional basis显示文摘 | Baldi A Pinotti L | 2006 | Journal of Dairy Science2006，86，： | 1 |
| 11 | Clinical features treatment outment in a series of 93 patients with lowgrade gastric MALT lymphoma 显示文摘 | Pinotti G Zucca E Roggero E | 1997 | Leukmia and Lymphoma1997，26，： | 1 |
| 12 | Clinical features, treatment and outcome in a series of 93 patients with low-grade gastric MALT lymphoma显示文摘 | PINOTTI G ZUCCA E ROGGERO E | 1997 | Leuk Lymphoma1997，26，： | 1 |
| 13 | Diffusion of sodium chloride in pork tissue显示文摘 | GRAIVER N PINOTTI A CALIFANO A | 2006 | Journal of Food Engineering2006，77，4： | 1 |
| 14 | Comparison of the per-formance of chitosan and a cationic polyacrylamide as floccu-lants of emulsion systems显示文摘 | Pinotti A Bevilacqua A Zaritzky N | 2001 | Journal of Surfactants and Deter-gents2001，，1： | 1 |
| 15 | The effects of systemic hormonal replacement therapy on the skin of postmenopausal women显示文摘 | A.V.D Sauerbronn A.M Fonseca V.R Bagnoli P.H Saldiva J.A Pinotti | 2000 | International Journal of Gynecology and Obstetrics2000，，1： | 1 |
| 16 | Comparative mammalian choline metabolism with emphasis on the high-yielding dairy cow显示文摘 | Pinotti L Baldi A Dell'Orto V | 2002 | Nutr Res Reviews2002，15，： | 1 |
| 17 | A transverse thora- coabdominal skin flap for closure after radical mastectomy 显示文摘 | Baroudi R Pinotti JA Keppke EM | 1978 | Plast Reconstr Surg1978，61，4： | 1 |
| 18 | Rumen-protected choline administration to transition cows:Effects on milk production and vitamin E status显示文摘 | Pinotti L | 2003 | Journal of Veterinary Medicine Series A2003，50，1： | 1 |
| 19 | Factor Ⅶ gene polymorphisms contribute about one third of the factor Ⅶ level variation in plasma显示文摘 | Bernardi F Marchetti G Pinotti M Arcieri P Baroncini C Papacchini M | 1996 | Arterioscler Thromb Vasc Biol1996，16，1： | 1 |
| 20 | Effect of aluminum sulfate and cationic polyelectrolytes on the destabilization of emulsified wastes 显示文摘 | ZARITZKY N | 2001 | Waste Management2001，21，： | 1 |
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