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| 1 | Diverse Roles of Strigolactones in Plant Development显示文摘与根流出物表明那的 strigolactones 的发现触发寄生杂草种子萌芽,然后作为一个分叉的禁止者和植物荷尔蒙, strigolactone 研究的下一个阶段快速在优化植物生长和开发作为一个主要播放器揭示了这个荷尔蒙类。从植物进化的早阶段,看起来, strigolactones 涉及创新植物修改生长以便为有限资源与附近的有机体在竞争获得优点。例如,苔藓植物能响应从一位邻居发出的 strigolactones 改变它的生长。在更高的植物以内, strigolactones 看起来涉及经由生长和开发的战略修正控制资源分发的平衡。最尤其是,更高种那相遇磷酸盐缺乏增加 strigolactone 生产,它改变根生长并且支持真菌的共生提高磷酸盐吸入。射击也由 channeling 资源变化离开非本质的叶子和分支并且进主要的茎和根系统。这神经质的回答是极端地改变整个植物的建筑学以便在多样的环境条件下面优化生长和开发的关键改编。 | Philip B. Brewer Hinanit Koltai Christine A. Beveridget | 2013 | Molecular Plant2013，6，1： | 30 |
| 2 | 阿拉斯加输油管的设计和施工方式方案变更过程及其背后的原因和哲学思想(英文)显示文摘阿拉斯加输油管道公司曾经研发和使用了3种主要施工方案和技术:传统地埋式、特殊埋设和地上敷设方式,在传统地埋式施工方案中,管顶埋深变化于0.9~2.7m.这主要是考虑了地形变化,而不是沿途的岩性和土壤类型.在特殊埋设方案中,在原油管道必须埋设的地段,如大规模动物迁徙常用地段则使用通道冷液循环降(保)温系统和(或)热管(桩)降(保)温,来保护多年冻土.地上敷设方案包括桩基架设和地上洁净砾石管堤(垫护层).后者只在管道进入和离开多年冻土时采用.架设桩基横梁方案中使用有或没有热管保温的垂直支架梁(单元)(VSM),在初步规划和设计阶段,管道的业主公司(即横穿阿拉斯加管道系统,或TAPS)和随后的阿拉斯加管道服务公司(APSC)不容商量的坚决要求100%的埋设方案.但是,随着勘察工作的进展和设计方案的细化,施工设计方案在不断变化,1977年管道施工结束时,只有57%的管道采用了埋设方式.管道运行30a后的今天(考虑运行期间维护中所产生的问题),很多经验丰富的工程师认为53%的埋设可能更合理.,设计和施工方案变更的原因主要有;1)为了获得通过联邦政府所属的土地所需的许可证,政府有特殊的规定和要求;2)管道公司的设计、施工和管理人员进行了现场野外调查、研究,并积极参与了详细设计和研发;3)美国环境政策法案(NEPA)的最新要求(启用了核准制).阿拉斯加管道服务公司是7家主要石油公司的服务机构.由于这个项目的巨大规模和所涉及的高昂费用,致使各大石油公司的工程师非同寻常程度的参与.在文章中,笔者论述了与阿拉斯加管道施工有关的阿拉斯加管道服务公司、美国联邦和阿拉斯加州政府相关组织机构的形成历史,管道设计演变过程及其背后的哲学思想,以及阿拉斯加管道工程项目的经验和教训. | Max Clifton Brewer 金会军 胡万志 张欣佳 陈剑锋 | 2006 | 冰川冻土2006，28，6： | 9 |
| 3 | Genotyping-by-sequencing of pear (Pyrus spp.) accessions unravels novel patterns of genetic diversity and selection footprints显示文摘Understanding of genetic diversity and marker-trait relationships in pears(Pyrus spp.)forms an important part of gene conservation and cultivar breeding.Accessions of Asian and European pear species,and interspecific hybrids were planted in a common garden experiment.Genotyping-by-sequencing(GBS)was used to genotype 214 accessions,which were also phenotyped for fruit quality traits.A combination of selection scans and association analyses were used to identify signatures of selection.Patterns of genetic diversity,population structure and introgression were also investigated.About 15000 high-quality SNP markers were identified from the GBS data,of which 25%and 11%harboured private alleles for European and Asian species,respectively.Bayesian clustering analysis suggested negligible gene flow,resulting in highly significant population differentiation(Fst=0.45)between Asian and European pears.Interspecific hybrids displayed an average of 55%and 45%introgression from their Asian and European ancestors,respectively.Phenotypic(firmness,acidity,shape and so on)variation between accessions was significantly associated with genetic differentiation.Allele frequencies at large-effect SNP loci were significantly different between genetic groups,suggesting footprints of directional selection.Selection scan analyses identified over 20 outlier SNP loci with substantial statistical support,likely to be subject to directional selection or closely linked to loci under selection. | Satish Kumar Chris Kirk Cecilia Deng Claudia Wiedow Mareike Knaebel Lester Brewer | 2017 | Horticulture Research2017，4，1： | 8 |
| 4 | 植物A.murale和A.corsicum修复镍污染土壤显示文摘通过盆栽试验,研究了镍富集植物A.murale、A.corsicum及普通作物萝卜和芥菜,在4种不同Ni含量土壤中富集Ni的能力.A.murale和A.corsicum能够超量富集Ni,在4种土壤处理中,其地上部Ni浓度均显著高于萝卜和芥菜.在墨江土壤(Ni 1062mg/kg)中,A.murale和A.corsicum去除Ni能力明显大于萝卜和芥菜;在信宜土壤(Ni 107mg/kg)中,芥菜去除Ni能力最强;而元江土壤(Ni 2519mg/kg)中4种植物去除Ni的能力均很低.调节土壤pH值能显著改变A.murale和A.corsicum提取Ni的能力,最佳去除Ni土壤pH值在6.0左右.酸化及碱化处理蛇纹岩发育土壤均显著降低了A.murale和A.corsicum去除土壤Ni的能力. | 仇荣亮 刘凤杰 万云兵 汤叶涛 胡鹏杰 Brewer E P LI Y M | 2008 | 中国环境科学2008，28，11： | 7 |
| 5 | 地球运动的动力学模式:从板块构造到地幔柱显示文摘板块构造学说和地幔柱假说是解释地球运动的两种大地构造动力学模式。本文总结了两种构造理论的基本观点和所解决的地学问题,阐述了存在的不足和局限之处。客观引述了对德干、冰岛等原认为是典型地幔柱(或热点)的不同成因观点。认为板块构造学说和地幔柱假说各有其独到之处,两者并不矛盾,在许多方面可以互为补充、共存。但也都有其内在的缺陷,尤其缺乏了令人信服的直接证据,需要今后不断补充和完善。 | 张丽芬 张树明 BREWER T S | 2005 | 大地构造与成矿学2005，29，4： | 7 |
| 6 | Implications of Recent Clinical Trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines显示文摘 | Scott M. Grundy James I. Cleeman C. Noel Bairey Merz H. Bryan Brewer Luther T. Clark Donald B. Hunninghake Richard C. Pasternak Sidney C. Smith Neil J. Stone | 2004 | Circulation: Journal of the American Heart Association2004，，2： | 6 |
| 7 | Cellular and Molecular Requirements for Polar PIN Targeting and Transcytosis in Plants显示文摘极,大头针植物生长素流出搬运人的亚 cellular 本地化决定细胞间的植物生长素流动的方向,因此定义植物生长素发信号的空间方面。动态,大头针蛋白质的象 transcytosis 一样本地化响应外部、内部的信号发生,在植物生长素分发把这些信号集成到变化。这里,我们检验极的大头针交货和 transcytosis 的细胞、分子的机制。机制 ARFGEF 依赖的极的指向和 transcytosis 很好在调整植物开发在与他们的基本重要性一致的多样的 Arabidopsis 生态型之中被保存并且出现小变化。在细胞的水平,我们在顶端、基础的大头针指向在肌动朊细胞骨架的角色上精制以前的调查结果,并且为微导管识别一个以前未知的角色,明确地在基础指向。到房间的不同方面的大头针蛋白质交货被 ARF 依赖的 trafficking 与不同 ARFGEF 泡 trafficking 管理者的以前未知的复杂水平调停。我们的数据建议由这些不同小径的大头针蛋白质的其他的招募能响应不同信号说明类型特定的房间和极的指向的货物特定的方面,以及为极性变化。结果动态大头针放到房间的不同方面在植物纸巾以内定义植物生长素流动的一个三维的模式。 | Jurgen Kleine-Vehn tukasz tangowski Justyna Wisniewska Pankaj Dhonukshe Philip B Brewer Jiri Friml | 2008 | Molecular Plant2008，1，6： | 5 |
| 8 | PXR variants:the impact on drug metabolism and therapeutic responses显示文摘The pregnane X receptor(PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters.Several protein isoforms of PXR exist,and they have differential transcriptional activity upon target genes; transcript variants 3(PXR3) and 4(PXR4) do not induce target gene expression,whereas transcript variants 1(PXR1) and 2(PXR2) respond to agonist by activating target gene expression.PXR protein variants also display differences in protein–protein interactions; PXR1 interacts with p53,whereas PXR3 does not.Furthermore,the transcript variants of PXR that encode these protein isoforms are differentially regulated by methylation and deletions in the respective promoters of the variants,and their expression differs in various human cancers and also in cancerous tissue compared to adjacent normal tissues.PXR1 and PXR4 m RNA are downregulated by methylation in cancerous tissue and have divergent effects on cellular proliferation when ectopically overexpressed.Additional detailed and comparative mechanistic studies are required to predict the effect of PXR transcript variant expression on carcinogenesis,therapeutic response,and the development of toxicity. | C.Trent Brewer Taosheng Chen | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 5 |
| 9 | 《Science》杂志发表关于计算社会科学的文章:Computational Social Science显示文摘计算科学是一门正在兴起的综合性学科,它依赖于先进的计算机及计算技术对理论科学、大型实验、观测数据、应用科学、国防以及社会科学进行模型化、模拟与仿真、计算等。特别是对极复杂系统进行模型与程序化,然后利用计算机给出严格理论及实验无法达到的过程数据或者直接模拟出整个复杂过程的演变或者预测过程的发展趋势。对基础科学、应用科学、国防科学、社会科学以及工程技术等的发展有着不可估量的科学作用与经济效益。其中,随着信息化和网络化的不断普及与深入,社会动态变化的速度和规模已经提高到一个前所未有的水平,计算科学在社会科学中的深入应用,即计算社会科学也将成为科研信息化发展中一个新的热点。本刊对《Science》2009年2月发表的一篇关于计算社会科学的文章《Computational Social Science》进行了摘编,该文由美国多个大学及研究机构的共15名研究人员共同编写,文章从计算社会科学的数据获取、研究方法及其制约因素,以及人才的培养等几个方面,描述了计算社会科学的发展、讨论了社会科学研究的特点等。其主要目的是想借此文向广大读者介绍计算社会科学这一学科理念,推动这一对于提高社会科学研究水平和规范性的研究方法在国内的发展,并以此进一步繁荣我国社会科学研究工作。 | 张鉴 孔丽华 David Lazer Alex Pentland Lada Adamic Sinan Aral Albert-László Barabási Devon Brewer Nicholas Christakis Noshir Contractor James Fowler Myron Gutmann Tony Jebara Gary King Michael Macy Deb Roy Marshall Van Alstyne | 2010 | 科研信息化技术与应用2010，0，2： | 5 |
| 10 | Cholesterol Efflux and Atheroprotection: Advancing the Concept of Reverse Cholesterol Transport显示文摘 | Robert S. Rosenson H. Bryan Brewer W. Sean Davidson Zahi A. Fayad Valentin Fuster James Goldstein Marc Hellerstein Xian-Cheng Jiang Michael C. Phillips Daniel J. Rader Alan T. Remaley George H. Rothblat Alan R. Tall Laurent Yvan-Charvet | 2012 | Circulation2012，，15： | 4 |
| 11 | Recent advances in the study of Kaposi's sarcoma-associated herpesvirus replication and pathogenesis显示文摘It has now been over twenty years since a novel herpesviral genome was identified in Kaposi's sarcoma biopsies. Since then, the cumulative research effort by molecular biologists, virologists, clinicians, and epidemiologists alike has led to the extensive characterization of this tumor virus, Kaposi's sarcoma-associated herpesvirus(KSHV; also known as human herpesvirus 8(HHV-8)), and its associated diseases. Here we review the current knowledge of KSHV biology and pathogenesis, with a particular emphasis on new and exciting advances in the field of epigenetics. We also discuss the development and practicality of various cell culture and animal model systems to study KSHV replication and pathogenesis. | Denis Avey Brittany Brewers Fanxiu Zhu | 2015 | Virologica Sinica2015，30，2： | 3 |
| 12 | 仙人掌果提取液对卵巢癌的抑制作用显示文摘目的:研究仙人掌果提取液在动物体内和体外对卵巢癌的抑制作用。方法:用Crystalviolet方法测定、细胞周期分析及细胞凋亡TUNEL分析观察仙人掌果提取液在体外对卵巢癌细胞生长的抑制作用;仙人掌果提取液对人卵巢癌的动物模型的治疗效果。结果:2种卵巢癌细胞(OVCA420和SKOV3)对于不同浓度仙人掌果提取液反应敏感程度不同,IC50分别是0·8%和8%,正常卵巢上皮细胞(IOSE)的IC50为2%;仙人掌果提取液可以有效的抑制卵巢癌在动物体内的生长(P<0·05),与N-(4-hydroxyphernyl)retinamide(4HPR)作用相似(P>0·05)。结论:仙人掌果提取液对体外卵巢癌细胞生长和动物体内的卵巢癌生长均有明显抑制作用。 | 邹大明 刘华钢 Molly Brewer Jean M Feugang 梁秋云 Kenneth D. Hatch Changping Zou | 2008 | 广西医学院学报2008，18，2： | 3 |
| 13 | Novel Therapies Focused on the High-Density Lipoprotein Particle显示文摘 | Julian C. van Capelleveen H. Bryan Brewer John J.P. Kastelein G. Kees Hovingh | 2014 | Circulation Research2014，，1： | 2 |
| 14 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 15 | Gastrointestinal bleeding with the HeartMate II left ventricular assist device显示文摘 | Jeffrey A. Morgan Gaetano Paone Hassan W. Nemeh Scott E. Henry Rosan Patel Jessica Vavra Celeste T. Williams David E. Lanfear Cristina Tita Robert J. Brewer | 2012 | Journal of Heart and Lung Transplantation2012，，7： | 2 |
| 16 | Phytoremediation of soil metals显示文摘 | Rufus L Chaney Minnie Malik Yin M Li Sally L Brown Eric P Brewer J Scott Angle Alan JM Baker | 1997 | Current Opinion in Biotechnology1997，，3： | 2 |
| 17 | Evaluating the impact of human papillomavirus vaccines显示文摘 | Yuli Chang Noel T. Brewer Allen C. Rinas Karla Schmitt Jennifer S. Smith | 2009 | Vaccine2009，，32： | 2 |
| 18 | ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data显示文摘 | M.B. Chadwick M. Herman P. Oblo?insky M.E. Dunn Y. Danon A.C. Kahler D.L. Smith B. Pritychenko G. Arbanas R. Arcilla R. Brewer D.A. Brown R. Capote A.D. Carlson Y.S. Cho H. Derrien K. Guber G.M. Hale S. Hoblit S. Holloway T.D. Johnson T. Kawano B.C. Kiedr | 2011 | Nuclear Data Sheets2011，，12： | 2 |
| 19 | 急性胰腺炎猝死尸检分析显示文摘目的分析塞舌尔人急性胰腺炎猝死的原因及特点。方法收集32例急性胰腺炎猝死病例的尸检资料并进行组织病理学检查。结果32例中,男27例,女5例。23例胰腺质量轻度增加,切面可见散在的出血坏死灶;9例胰腺缩小并广泛出血坏死及周围脂肪坏死。结论乙醇摄入是塞舌尔人急性胰腺炎猝死的主要原因。 | 赵鹏 纪方 RUBELL BREWER | 2007 | 青岛大学医学院学报2007，43，5： | 2 |
| 20 | Neuronal plasticity and stressor toxicity during aging显示文摘 | Brewer GJ | 2000 | Experimental geronotology2000，35，910： | 1 |
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