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| 1 | Translational approaches: From fatty liver to non-alcoholic steatohepatitis显示文摘Over the past few decades, non-alcoholic fatty liver disease(NAFLD) has become one, if not the most common,cause of chronic liver disease affecting both adults and children. The increasing number of cases at an early age is the most worrying aspect of this pathology, since it provides more time for its evolution. The spectrum of this disease ranges from liver steatosis to steatohepatitis, fibrosis and in some cases, hepatocellular carcinoma. NAFLD may not always be considered a benign disease and hepatologists must be cautious in the presence of fatty liver. This should prompt the use of the available experimental models to understand better the pathogenesis and to develop a rational treatment of a disease that is dangerously increasing. In spite of the growing efforts, the pathogenesis of NAFLD is still poorly understood. In the present article we review the most relevant hypotheses and evidence that account for the progression of NAFLD to non-alcoholic steatohepatitis(NASH) and fibrosis. The available in vitro and in vivo experimental models of NASH are discussed and revised in terms of their validity in translational studies. These studies must be aimed at the discovery of the still unknown triggers or mediators that induce the progression of hepatic inflammation, apoptosis and fibrosis. | Natalia Rosso Norberto C Chavez-Tapia Claudio Tiribelli Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，27： | 14 |
| 2 | A position statement on NAFLD/NASH based on the EASL 2009 special conference显示文摘 | Vlad Ratziu Stefano Bellentani Helena Cortez-Pinto Chris Day Giulio Marchesini | 2010 | Journal of Hepatology2010，，2： | 9 |
| 3 | Alimentary regimen in non-alcoholic fatty liver disease:Mediterranean diet显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide.The mechanisms of the underlying disease development and progression are awaiting clarification.Insulin resistance and obesity-related inflammation status,among other possible genetic,dietary,and lifestyle factors,are thought to play the key role.There is no consensus concerning the pharmacological treatment.However,the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy.On the basis of its components,the literature reports on the effectiveness of the Mediterranean diet in reducing cardiovascular risk and in preventing major chronic diseases,including obesity and diabetes.New evidence supports the idea that the Mediterranean diet,associated with physical activity and cognitive behaviour therapy,may have an important role in the prevention and the treatment of NAFLD. | Ludovico Abenavoli Natasa Milic Valentina Peta Francesco Alfieri Antonino De Lorenzo Stefano Bellentani | 2014 | World Journal of Gastroenterology2014，20，45： | 7 |
| 4 | Stage of change and motivation to healthier lifestyle in non-alcoholic fatty liver disease显示文摘 | Elena Centis Simona Moscatiello Elisabetta Bugianesi Stefano Bellentani Anna Ludovica Fracanzani Simona Calugi Salvo Petta Riccardo Dalle Grave Giulio Marchesini | 2012 | Journal of Hepatology2012，，： | 5 |
| 5 | From NAFLD in clinical practice to answers from guidelines显示文摘 | Fabio Nascimbeni Raluca Pais Stefano Bellentani Christopher Paul Day Vlad Ratziu Paola Loria Amedeo Lonardo | 2013 | Journal of Hepatology2013，，： | 3 |
| 6 | Practice guidelines for the diagnosis and management of nonalcoholic fatty liver disease显示文摘 | P. Loria L.E. Adinolfi S. Bellentani E. Bugianesi A. Grieco S. Fargion A. Gasbarrini C. Loguercio A. Lonardo G. Marchesini F. Marra M. Persico D. Prati G. Svegliati- Baroni | 2010 | Digestive and Liver Disease2010，，4： | 2 |
| 7 | 非酒精性脂肪肝的发病率及危险因素:饮酒与肝脏的研究 | Bedogni G. Miglioli L. Masutti F. S. Bellentani 李翔 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，10： | 2 |
| 8 | Epidemiology of non-alco- holic fatty liver disease 显示文摘 | Bellentani S Scaglioni F Marino M | 2010 | J Dig Dis2010，28，1： | 1 |
| 9 | Nonalcoholic fatty liver disease(NAFLD)and cardiovascular disease:an open question显示文摘 | Loria P Lonardo A Bellentani S | | 0，，： | 1 |
| 10 | Familial clustering of helcoacter pylori infection:population based study显示文摘 | DOMINICI P BELLENTANI S BIASE ARD | 1999 | BMJ1999，319，： | 1 |
| 11 | The epidemiology of fatty liver显示文摘 | Bellentani S Bedogni G Miglioli L | 2004 | Eur J Gastroenterol Hepatol2004，16，11： | 1 |
| 12 | Epidemiology and naturalhistory of non-alcoholic fatty liver disease(NAFLD)显示文摘 | Bellentani S Mariano Marino | 2009 | Ann Hepatol2009，8，： | 1 |
| 13 | High Prevalence of Celiac Disease in Italian General Population显示文摘 | Umberto Volta Stefano Bellentani Francesco Bianco Bianchi Giovanni Brandi Lucia De Franceschi Lucia Miglioli Alessandro Granito Fiorella Balli Claudio Tiribelli | 2001 | Digestive Diseases and Sciences2001，，7： | 1 |
| 14 | Moderate alcohol use and health: A consensus document显示文摘 | A. Poli F. Marangoni A. Avogaro G. Barba S. Bellentani M. Bucci R. Cambieri A.L. Catapano S. Costanzo C. Cricelli G. de Gaetano A. Di Castelnuovo P. Faggiano F. Fattirolli L. Fontana G. Forlani S. Frattini R. Giacco C. La Vecchia L. Lazzaretto L. Loffredo | 2013 | Nutrition, Metabolism and Cardiovascular Diseases2013，，6： | 1 |
| 15 | Fatty liver:how frequent is it and why显示文摘 | Bedogni G Bellentani S | 2004 | Ann Hepatol2004，3，2： | 1 |
| 16 | Non - alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question显示文摘 | Loria P Lonardo A Bellentani S | 2007 | Nutr Metab Cardiovasc Dis2007，17，9： | 1 |
| 17 | A posi- tion statement on NAFLD/NASH based on the EA- SL 2009 special conference显示文摘 | Ratziu V Bellentani S Cortez-Pinto H | 2010 | J Hepatol2010，53，2： | 1 |
| 18 | Nonalcoholicfattyliverdisease(NAFLD)andcardiovasculardisease:anopenquestion显示文摘 | LoriaP LonardoA BellentaniS etal | 2007 | NutrMetabCardiovascDis2007，17，9： | 1 |
| 19 | A position statement on NAFLD/NASH based on the EASL 2009 special conference显示文摘 | Ratziu V Bellentani S Cortez-pinto H | 2010 | J Hepatol2010，53，： | 1 |
| 20 | Epidemiology and natural history of non-alcoholic fatty liver disease(NAFLD)显示文摘 | Bellentani S Marino M | | 0，，： | 1 |
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