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| 1 | Modern approach to the clinical management of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common and emerging form of chronic liver disease worldwide.It includes a wide spectrum of liver diseases ranging from simple fatty liver to steatohepatitis,which may progress to cirrhosis,liver cancer,and liver mortality.Common metabolic diseases,which are well established cardiovascular risk factors,have been associated to NAFLD and cardiovascular disease is the single most important cause of morbidity and mortality in this patient population.The pathogenesis of NAFLD appears multifactorial and many mechanisms have been proposed as possible causes of fatty liver infiltration.Management of fatty liver has become a major challenge to healthcare systems as the consequence of the increasing rates of obesity worldwide.First-line management focuses on lifestyle modifications.Moderate weight reduction either by dietary restriction or by increased habitual physical activity is safe and highly recommended.Several therapeutic interventions have been proposed.These include insulin sensitizer agents,lipid lowering drugs,antioxidants such as vitamin E and supplementation of vitamin D3.However,therapeutic strategies have been largely empirical so far,and experimental trials have mostly been carried out in uncontrolled settings with small sample sizes.Metabolic conditions such as diabetes mellitus,obesity,hypertension and hyperlipidemia,should be strongly considered and a multidisciplinary approach should be personalized for individual patients.Treatment of co-morbidities should be regarded as of paramount importance in the management of these patients.The purpose of this review is to examine different approaches for the clinical management of non-alcoholic fatty liver disease. | Maria Del Ben Licia Polimeni Francesco Baratta Daniele Pastori Lorenzo Loffredo Francesco Angelico | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 2 | Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy显示文摘 | Francesco S. Loffredo Matthew L. Steinhauser Steven M. Jay Joseph Gannon James R. Pancoast Pratyusha Yalamanchi Manisha Sinha Claudia Dall’Osso Danika Khong Jennifer L. Shadrach Christine M. Miller Britta S. Singer Alex Stewart Nikolaos Psychogios Robert | 2013 | Cell2013，，4： | 2 |
| 3 | Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions:A single-center study显示文摘BACKGROUND Currently,there is insufficient data about the accuracy in the diagnosing of pancreatic cystic lesions(PCLs),especially with novel endoscopic techniques such as with direct intracystic micro-forceps biopsy(mFB)and needle-based confocal laser-endomicroscopy(nCLE).AIM To compare the accuracy of endoscopic ultrasound(EUS)and associated techniques for the detection of potentially malignant PCLs:EUS-guided fine needle aspiration(EUS-FNA),contrast-enhanced EUS(CE-EUS),EUS-guided fiberoptic probe cystoscopy(cystoscopy),mFB,and nCLE.METHODS This was a single-center,retrospective study.We identified patients who had undergone EUS,with or without additional diagnostic techniques,and had been diagnosed with PCLs.We determined agreement among malignancy after 24-mo follow-up findings with detection of potentially malignant PCLs via the EUSguided techniques and/or EUS-guided biopsy when available(EUS malignancy detection).RESULTS A total of 129 patients were included, with EUS performed alone in 47/129. In 82/129 patients,EUS procedures were performed with additional EUS-FNA (21/82), CE-EUS (20/82), cystoscopy(27/82), mFB (36/82), nCLE (44/82). Agreement between EUS malignancy detection and the 24-mo follow-up findings was higher when associated with additional diagnostic techniques thanEUS alone [62/82 (75.6%) vs 8/47 (17%);OR 4.35, 95%CI: 2.70-7.37;P < 0.001]. The highestmalignancy detection accuracy was reached when nCLE and direct intracystic mFB were bothperformed, with a sensitivity, specificity, positive predictive value, negative predictive value andobserved agreement of 100%, 89.4%, 77.8%, 100% and 92.3%, respectively (P < 0.001 comparedwith EUS-alone).CONCLUSIONThe combined use of EUS-guided mFB and nCLE improves detection of potentially malignantPCLs compared with EUS-alone, EUS-FNA, CE-EUS or cystoscopy. | Carlos Robles-Medranda Juan I Olmos Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Martha Arevalo-Mora Raquel Del Valle Zavala Joao Autran Nebel Daniel Calle Loffredo Hannah Pitanga-Lukashok | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，3： | 2 |
| 4 | Structure and evolution of the world trade network显示文摘 | Garlaschelli D Loffredo M I | 2005 | Physica A2005，355，： | 1 |
| 5 | Association of Transposition of the Grest Arteries in infants with Maternal Exposures to Herbicides and Rodenticieles显示文摘 | Loffredo CA Silbergeld EK Ferencz C Zhang J | 2001 | Am J Epidemiol2001，6，1： | 1 |
| 6 | Treatment of a patient with congenital analbuminemia with atorvastatin and albumin infusion显示文摘Congenital analbuminemia is a rare autosomic recessive inherited disorder characterized by low plasma albumin and hypercholesterolemia, which may increase cardiovascular risk. Patients are essentially asymptomatic, apart from ease of fatigue, minimal ankle oedema and hypotension. There is no accepted strategy for safely treating both hypercholesterolemia and analbuminemia in order to eventually decrease the atherosclerotic risk. We report a case of congenital analbuminemia(1.0 g/dL) in a 38-year-old male with hypercholesterolemia(range: 406-475 mg/dL) and severe arterial dysfunction [no brachial artery flow-mediated dilation(FMD)]. Long-term, cholesterol-lowering treatment with atorvastatin was associated with the appearance of peripheral edema. Twomonths of infusion with albumin improved FMD(7%) and reduced serum cholesterol(273 mg/dL), supporting the hypothesis of a compensatory role of hypercholesterolemia. Statin treatment, together with periodical albumin infusions, may contribute to the safe reduction of cardiovascular risk. | Maria Del Ben Francesco Angelico Lorenzo Loffredo Francesco Violi | 2013 | World Journal of Clinical Cases2013，1，1： | 1 |
| 7 | The association between fibrillation显示文摘 | Loffredo L Violi F Fimognari FL | | 0，，07： | 1 |
| 8 | Structure and evolution of the word trade network显示文摘 | Garlaschelli D Loffredo M I | 2005 | Physica A2005，355，1： | 1 |
| 9 | Palate cleft显示文摘 | Loffredo LC Souza JM Freitas Jet | 2002 | Craniofac J2002，43，1： | 1 |
| 10 | Soluble CD40 ligand predicts ischemic stroke and myocardial infarction in patients with nonvalvular atrial fibrillation显示文摘 | Ferro D Loffredo L Polimeni L | 2007 | Arterioscler Thromb Vasc Biol2007，27，12： | 1 |
| 11 | Moderate alcohol use and health: A consensus document显示文摘 | A. Poli F. Marangoni A. Avogaro G. Barba S. Bellentani M. Bucci R. Cambieri A.L. Catapano S. Costanzo C. Cricelli G. de Gaetano A. Di Castelnuovo P. Faggiano F. Fattirolli L. Fontana G. Forlani S. Frattini R. Giacco C. La Vecchia L. Lazzaretto L. Loffredo | 2013 | Nutrition, Metabolism and Cardiovascular Diseases2013，，6： | 1 |
| 12 | Marnu-B*08-positive macaques control simian immunodeficiency virus replication 显示文摘 | Loffredo J T Maxwell J Qi Y | 2007 | J Virol2007，81，16： | 1 |
| 13 | On the variability of sea drag in finite water depth显示文摘 | Toffoli A Loffredo L Roy P L | 2012 | J Geophys Res2012，117，11： | 1 |
| 14 | Hyperho- moeysteinaemia and poor vitamin B status in chronic ob- structive pulmonary disease 显示文摘 | Fimognari FL Loffredo L Di simone S | 2009 | Nutr Metab Cardiovasc Dis2009，19，9： | 1 |
| 15 | STEP into NC显示文摘 | Martin Hardwick David Loffredo | 2001 | Manufacturing Engineering2001，2，1： | 1 |
| 16 | Interrupted aortic arch:an epidemiologic study显示文摘 | Loffredo CA Ferencz C Wilson PD | 2000 | Teratology2000，61，5： | 1 |
| 17 | C-reactive protein is released in the coronary circulation and causes endothelial dysfunction in patients with acute coronary syndromes显示文摘 | Forte L Cimmino G Loffredo F | | 0，，01： | 1 |
| 18 | Soluble CD40 ligand predicts ischemic stroke and myocardial infarction in patients with nonvalvular atrial fibrillation显示文摘 | Ferro D Loffredo L Polimeni L | | 0，，： | 1 |
| 19 | Patterns of link reciprocity in directed networks 显示文摘 | Garlaschelli D Loffredo M I | 2004 | Physical Review Letters2004，93，26： | 1 |
| 20 | STEP into NC显示文摘 | Martin Hardwick David Loffredo | 2001 | Manufacturing Engineering2001，，1： | 1 |
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