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| 1 | Irsogladine maleate and rabeprazole in non-erosive reflux disease: A double-blind, placebo-controlled study显示文摘AIM:To evaluate the efficacy of adding irsogladine maleate(IM) to proton-pump inhibitor(PPI) therapy in non-erosive reflux disease(NERD) treatment.METHODS:One hundred patients with NERD were recruited and randomized to receive rabeprazole plus IM(group I) or rabeprazole plus placebo(group P).The efficacy of the treatment was assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease(FSSG) and the short form(SF)-36 quality of life questionnaires after four weeks of treatment.We also assessed whether patients with NERD with minimal changes(grade M) had different responses to the therapies compared with patients who did not have minimal changes(grade N).RESULTS:Group I and group P showed significant improvements in their FSSG scores after the treatment(from 17.9 ± 7.9 to 9.0 ± 7.6, and from 17.7 ± 7.3 to 11.2 ± 7.9, respectively, P = 0.0001), but there was no statistically significant difference between the FSSG scores in group I and those in group P.Subgroup analysis showed that significant improvements in the FSSG scores occurred in the patients in group I who had NERD grade N(modified Los Angeles classification)(7.8 ± 7.4 vs 12.5 ± 9.8, P = 0.041).The SF-36 scores for patients with NERD grade N who had received IM and rabeprazole were significantly improved in relation to their vitality and mental health scores.CONCLUSION:The addition of IM to rabeprazole significantly improves gastroesophageal reflux diseasesymptoms and the quality of the lives of patients with NERD grade N. | Takayoshi Suzuki Masashi Matsushima Aya Masui Shingo Tsuda Jin Imai Jun Nakamura Yoko Tsukune Tetsufumi Uchida Hiroki Yuhara Muneki Igarashi Jun Koike Tetsuya Mine | 2015 | World Journal of Gastroenterology2015，21，16： | 8 |
| 2 | The deep-space multi-object orbit determination system and its application to Hayabusa2’s asteroid proximity operations显示文摘The deep-space multi-object orbit determination system(DMOODS)and its application in the asteroid proximity operation of the Hayabusa2 mission are described.DMOODS was developed by the Japan Aerospace Exploration Agency(JAXA)for the primary purpose of determining the trajectory of deep-space spacecraft for JAXA’s planetary missions.The weighted least-squares batch filter is used for the orbit estimator of DMOODS.The orbit estimator supports more than 10 data types,some of which are used for relative trajectory measurements between multiple space objects including natural satellites and small bodies.This system consists of a set of computer programs running on Linux-based consumer PCs on the ground,which are used for orbit determination and the generation of radiometric tracking data,such as delta differential one-way ranging and doppler tracking data.During the asteroid proximity phase of Hayabusa2,this system played an essential role in operations that had very strict navigation requirements or operations in which few optical data were obtained owing to special constraints on the spacecraft attitude or distance from the asteroid.One example is orbit determination during the solar conjunction phase,in which the navigation accuracy is degraded by the effect of the solar corona.The large range bias caused by the solar corona was accurately estimated with DMOODS by combining light detection and ranging(LIDAR)and ranging measurements in the superior solar conjunction phase of Hayabusa2.For the orbiting operations of target markers and the MINERVA-II2 rover,the simultaneous estimation of six trajectories of four artificial objects and a natural object was made by DMOODS.This type of simultaneous orbit determination of multi-artificial objects in deep-space has never been accomplished before. | Hiroshi Takeuchi Kent Yoshikawa Yuto Takei Yusuke Oki Shota Kikuchi Hitoshi Ikeda Stefania Soldini Naoko Ogawa Yuya Mimasu Go Ono Fuyuto Terui Naoya Sakatani Manabu Yamada Toru Kouyama Shingo Kameda Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 2 |
| 3 | Purification of human blood eosinophils by a combination method using anti-CD16 monoclonal antibody, immunobeads, and Nycodenz density gradient显示文摘 | Minoru Miyasato Shingo Tsuda Naohisa Kitamura Kano Shirouzu Takekuni Nakama Yoichiro Sasai | 1995 | Journal of Dermatological Science1995，，2： | 1 |
| 4 | Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu显示文摘This paper describes the orbit design of the deployable payload Rover 2 of MINERVA-II,installed on the Hayabusa2 spacecraft.Because Rover 2 did not have surface exploration capabilities,the operation team decided to experiment with a new strategy for its deployment to the surface.The rover was ejected at a high altitude and made a semi-hard landing on the surface of the asteroid Ryugu after several orbits.Based on the orbital analysis around Ryugu,the expected collision speed was tolerable for the rover to function post-impact.Because the rover could not control its position,its motion was entirely governed by the initial conditions.Thus,the largest challenge was to insert the rover into a stable orbit(despite its large release uncertainty),and avoid its escape from Ryugu due to an environment strongly perturbed by solar radiation pressure and gravitational irregularities.This study investigates the solution space of the orbit around Ryugu and evaluates the orbit’s robustness by utilizing Monte Carlo simulations to determine the orbit insertion policy.Upon analyzing the flight data of the rover operation,we verified that the rover orbited Ryugu for more than one period and established the possibility of a novel method for estimating the gravity of an asteroid. | Yusuke Oki Kent Yoshikawa Hiroshi Takeuchi Shota Kikuchi Hitosi Ikeda Daniel JScheeres Jay WMcMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa Go Ono Fuyuto Terui Manabu Yamada Toru Kouyama Shingo K ameda Kazuya Yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda | 2020 | Astrodynamics2020，4，4： | 1 |
| 5 | Correction to: Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu显示文摘Correction to:Oki,Y.,Yoshikawa,K.,Takeuchi,H.et al.Orbit insertion strategy of Hayabusa2's rover with large release uncertainty around the asteroid Ryugu.Astrodynamics 2020,4(4):309-329 http://gffzzd3cc09b8251d45dfsf9ocpf6vx9cc6p0f.ffgz.tsg.suse.edu.cn/10.1007/s42064-020-0080-y The article“Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu”written by Yusuke Oki,Kent Yoshikawa,Hiroshi Takeuchi et al.,was originally published electronically on the publisher’s internet portal(currently SpringerLink)on 05 November 2020 without open access.After publication in Volume 4,Issue 4,page 309–329,the author(s)decided to opt for Open Choice and to make the article an open access publication. | Yusuke Oki Kent Yoshikawa Hiroshi Takeuchi Shota Kikuchi Hitosi Ikeda Daniel J.Scheeres Jay W.McMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa Go Ono Fuyuto Terui Manabu Yamada Toru Kouyama Shingo Kameda Kazuya Yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda | 2021 | Astrodynamics2021，5，2： | 0 |
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