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您的检索式：作者名="Graham Spicer"
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| 1 | Single capillary oximetry and tissue ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography显示文摘Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor a microvascular niche and better understand crucial biological mechanisms.However,capillary oximetry and pericapillary ultrastructure are challenging to measure in vivo.Here we demonstrate a novel optical imaging system,dual-band dual-scan inverse spectroscopic optical coherence tomography(D2-ISOCT),that,for the first time,can simultaneously obtain the following metrics in vivo using endogenous contrast:(1)capillary-level oxygen saturation and arteriolar-level blood flow rates,oxygen delivery rates,and oxygen metabolic rates;(2)spatial characteristics of tissue structures at length scales down to 30 nm;and(3)morphological images up to 2mm in depth.To illustrate the capabilities of D2-ISOCT,we monitored alterations to capillaries and the surrounding pericapillary tissue(tissue between the capillaries)in the healing response of a mouse ear wound model.The obtained microvascular and ultrastructural metrics corroborated well with each other,showing the promise of D2-ISOCT for becoming a powerful new non-invasive imaging tool. | Rongrong Liu James A.Winkelmann Graham Spicer Yunxiao Zhu Aya Eid Guillermo A.Ameer Vadim Backman Ji Yi | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging显示文摘Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location.We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast.We demonstrate the molecular sensitivity of this method,which enables lymphatic vessel,blood,and tissue discrimination. | James A.Winkelmann Aya Eid Graham Spicer Luay M.Almassalha The-Quyen Nguyen Vadim Backman | 2019 | Light(Science & Applications)2019，8，1： | 0 |
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