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| 1 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 2 | 放电等离子烧结添加TiC开孔钛基复合材料的磨损模式(英文)显示文摘采用放电等离子烧结法制备具有开孔隙的钛基复合材料(TMCs),研究添加TiC增强颗粒对材料摩擦性能的影响。材料中含有同等摩尔比的Ti和TiH2以及不同体积分数的TiC(0、3%、10%和30%),烧结温度为850℃。采用纳米压痕和磨损试验评估材料的纳米硬度和耐磨性能,摩擦试验采用球-平面接触往复滑动模式。结果显示,随着TiC含量的增加,材料的纳米硬度从5 GPa增加到14 GPa。当TiC含量为10%时,材料的摩擦因数最低(0.2),磨损率也最低。当TiC含量较低时,样品发生粘着磨损,并伴随严重的塑性变形;当TiC含量适中时,样品表面形成机械混合层(MML);当TiC含量较高时,样品的主要磨损机制为磨粒磨损。总之,随着TiC含量的变化,材料的磨损机制、摩擦因数和磨损量也随之变化。 | I. FARíAS L. OLMOS O. JIMéNEZ M. FLORES A. BRAEM J. VLEUGELS | 2019 | Transactions of Nonferrous Metals Society of China2019，29，8： | 5 |
| 3 | Role of platelets and breast cancer stem cells in metastasis显示文摘The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression capacity.In recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and radiotherapy.The tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one response.Platelets can ingest and release RNA,proteins,cytokines and growth factors.After the platelets interact with the tumor microenvironment,they are called'tumor-educated platelets.'Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic tumors.It has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell characteristics.Cancer stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site colonization.Tumor-educated platelets support all these processes. | Gretel Mendoza-Almanza Luis Burciaga-Hernandez Vilma Maldonado Jorge Melendez-Zajgla Jorge Olmos | 2020 | World Journal of Stem Cells2020，12，11： | 2 |
| 4 | Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis显示文摘 | Juan A.del Olmo Andrés Pe?a Miguel A Serra Abdallah H Wassel Adolfo Benages José M Rodrigo | 2000 | Journal of Hepatology2000，，1： | 2 |
| 5 | Optimization and implementation of the integer wavelet transform for image coding显示文摘 | GRANGETTO M MAGLI E MARTINA M OLMO G | 2002 | IEEE Trans2002，11，6： | 2 |
| 6 | Endoscopic ultrasound-guided through-the-needle microforceps biopsy and needle-based confocal laser-endomicroscopy increase detection of potentially malignant pancreatic cystic lesions:A single-center study显示文摘BACKGROUND Currently,there is insufficient data about the accuracy in the diagnosing of pancreatic cystic lesions(PCLs),especially with novel endoscopic techniques such as with direct intracystic micro-forceps biopsy(mFB)and needle-based confocal laser-endomicroscopy(nCLE).AIM To compare the accuracy of endoscopic ultrasound(EUS)and associated techniques for the detection of potentially malignant PCLs:EUS-guided fine needle aspiration(EUS-FNA),contrast-enhanced EUS(CE-EUS),EUS-guided fiberoptic probe cystoscopy(cystoscopy),mFB,and nCLE.METHODS This was a single-center,retrospective study.We identified patients who had undergone EUS,with or without additional diagnostic techniques,and had been diagnosed with PCLs.We determined agreement among malignancy after 24-mo follow-up findings with detection of potentially malignant PCLs via the EUSguided techniques and/or EUS-guided biopsy when available(EUS malignancy detection).RESULTS A total of 129 patients were included, with EUS performed alone in 47/129. In 82/129 patients,EUS procedures were performed with additional EUS-FNA (21/82), CE-EUS (20/82), cystoscopy(27/82), mFB (36/82), nCLE (44/82). Agreement between EUS malignancy detection and the 24-mo follow-up findings was higher when associated with additional diagnostic techniques thanEUS alone [62/82 (75.6%) vs 8/47 (17%);OR 4.35, 95%CI: 2.70-7.37;P < 0.001]. The highestmalignancy detection accuracy was reached when nCLE and direct intracystic mFB were bothperformed, with a sensitivity, specificity, positive predictive value, negative predictive value andobserved agreement of 100%, 89.4%, 77.8%, 100% and 92.3%, respectively (P < 0.001 comparedwith EUS-alone).CONCLUSIONThe combined use of EUS-guided mFB and nCLE improves detection of potentially malignantPCLs compared with EUS-alone, EUS-FNA, CE-EUS or cystoscopy. | Carlos Robles-Medranda Juan I Olmos Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Martha Arevalo-Mora Raquel Del Valle Zavala Joao Autran Nebel Daniel Calle Loffredo Hannah Pitanga-Lukashok | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，3： | 2 |
| 7 | Anatomy and physiology of lymphatic drainage of the breast from the perspective of sentinel node biopsy 显示文摘 | Tanis PJ Nieweg OE Valdes Olmos RA | 2001 | J Am Coll Surg2001，192，3： | 1 |
| 8 | Delivery to macrophages and toxic action of etoposide carried in mouse red blood cells显示文摘 | Olmos G Diez JC | 2003 | Biochim Biophys Acta2003，1620，13： | 1 |
| 9 | Effect of bio-optical parameter variability on the remote estimation of chlorophyll a concentration in turbid productive waters: experimental results 显示文摘 | Dall' Olmo G Gitelson A | 2005 | Appl Opt2005，44，3： | 1 |
| 10 | 查看详情显示文摘 | del Olmo E Barboza B Ybarra M.I Lopez-Perez J.L Carron R Sevilla M.A Boselli C Feliciano A.S | | 0，，： | 1 |
| 11 | C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy显示文摘 | Olmos P Bastías MJ Vollrath V | | 0，，02： | 1 |
| 12 | Protein expression of estrogen receptorsαandβand aromatase in myometrium and uterine leiomyoma显示文摘 | Olmos Grings A Lora V Dias Ferreira G | 2012 | Gynecol Obstet Invest2012，73，： | 1 |
| 13 | Bile duct reconstruction using 3-dimensional collagen tubes 显示文摘 | Pérez Alonso AJ Del Olmo Rivas C Machado Romero I | 2013 | Cir Esp2013，91，9： | 1 |
| 14 | Delivery to macrophages of Interleukin 3 loaded in mouse erythrocytes显示文摘 | Lotero LA Tejedor MC | 2000 | Biosci Rep2000，20，5： | 1 |
| 15 | Experimental determination of the drag coefficient in aswarm of bubbles显示文摘 | SIMONNET M GENTRIC C OLMOS E | 2007 | Chemical Engineering Science2007，62，： | 1 |
| 16 | Overcoming modal bandwidth limitation in radio-over-multimode fiber links 显示文摘 | Larrode M G Koonen A M J Olmos J J V | 2006 | IEEE Photonies Technology Letters2006，18，22： | 1 |
| 17 | Phase I trial of a selective p-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies 显示文摘 | Yap T A Olmos D Brunetto AT | 2011 | J Clin Oncol2011，29，10： | 1 |
| 18 | 显示文摘 | I. Vizcaíno A. Torregrosa V. Higueras V. Morote A. Cremades V. Torres S. Olmos C. Molins | 2001 | European Radiology2001，，9： | 1 |
| 19 | Development of a sky imager for cloud cover assessment 显示文摘 | Cazorla A Olmo F J Alados-Arboledas L | 2008 | Journal of the Optical Society of America A2008，25，1： | 1 |
| 20 | Methodological principles of T wave altemans analysis: A unified framework 显示文摘 | Martinez JP Olmos S | 2005 | IEEE Transactions on Biomedical Engineering2005，52，4： | 1 |
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