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| 1 | Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection显示文摘AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. | Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar Basu Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 2 | Regulation of microRNA by hepatitis B virus infection and their possible association with control of innate immunity显示文摘Hepatitis B virus(HBV)chronically infects more than350 million people worldwide.HBV causes acute and chronic hepatitis,and is one of the major causes of cirrhosis and hepatocellular carcinoma.There exist complex interactions between HBV and the immune system including adaptive and innate immunity.Tolllike receptors(TLRs)and TLR-signaling pathways are important parts of the innate immune response in HBV infections.It is well known that TLR-ligands could suppress HBV replication and that TLRs play important roles in anti-viral defense.Previous immunological studies demonstrated that HBV e antigen(HBeAg)is more efficient at eliciting T-cell tolerance,including production of specific cytokines IL-2 and interferon gamma,than HBV core antigen.HBeAg downregulates cytokine production in hepatocytes by the inhibition of MAPK or NF-κB activation through the interaction with receptor-interacting serine/threonine protein kinase.MicroRNAs(miRNAs)are also able to regulate various biological processes such as the innate immune response.When the expressions of approximately 1000 miRNAs were compared between human hepatoma cells HepG2 and HepG2.2.15,which could produce HBV virion that infects chimpanzees,using real-time RT-PCR,we observed several different expression levels in miRNAs related to TLRs.Although we and others have shown that HBV modulates the host immune response,several of the miRNAs seem to be involved in the TLR signaling pathways.The possibility that alteration of these miRNAs during HBV infection might play a critical role in innate immunity against HBV infection should be considered.This article is intended to comprehensively review the association between HBV and innate immunity,and to discuss the role of miRNAs in the innate immune response to HBV infection. | Xia Jiang Tatsuo Kanda Shuang Wu Masato Nakamura Tatsuo Miyamura Shingo Nakamoto Arup Banerjee Osamu Yokosuka | 2014 | World Journal of Gastroenterology2014，20，23： | 6 |
| 3 | Distribution of hepatitis B virus genotypes:Phylogenetic analysis and virological characteristics of Genotype C circulating among HBV carriers in Kolkata,Eastern India显示文摘AIM: To evaluate the genotype distribution of hepatitis B virus (HBV) in Eastern India and to clarify the phyloge- netic origin and virological characteristics of the recently identifi ed genotype C in this region. METHODS: Genotype determination, T1762/A1764 mutation in the basal core promoter (BCP) and A1896 mutation in the precore region of 230 subjects were de- termined by restriction fragment length polymorphism method (RFLP) and the result was confi rmed by direct sequencing. RESULTS: The predominant genotypes D (HBV/D) and A (HBV/A) were detected in 131/230 (57%) and 57/230 (25%) samples. In addition, genotype C (HBV/C) was detected in 42/230 (18%) isolates. Surface gene region was sequenced from 45 isolates (27 HBV/C, 9 HBV/A and 9 HBV/D). Phylogenetic analysis revealed that all of the HBV/C sequences clustered with South East Asian subgenotype (HBV/Cs). The sequence data showed re- markable similarity with a Thai strain (AF068756) (99.5% ± 0.4% nucleotide identities) in 90% of the genotype C strains analyzed. T1762/A1764 mutation in BCP re- gion, associated with high ALT was signifi cantly higher in HBeAg negative isolates than HBeAg positive isolates. Frequency of A1896 mutation leading to HBeAg negativ- ity was low.CONCLUSION: The present study reports the genotypic distribution and the characteristics of partial genome sequences of HBV/C isolates from Eastern India. Low genetic diversity and confi nement of HBV/C in Eastern India possibly indicate a recent, limited, spread in this region. Genotype C with T1762/A1764 mutation has been reported to increase the risk for hepatocellular car- cinoma; therefore genotype C carriers in Eastern India should be carefully monitored. | Arup Banerjee Sibnarayan Datta Partha K Chandra Susanta Roychowdhury Chinmoy Kumar Panda Runu Chakravarty | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 4 | Frequency and significance of hepatitis B virus surface gene variant circulating among ‘antiHBc only’ individuals in Eastern India显示文摘 | Arup Banerjee Partha K. Chandra Sibnarayan Datta Avik Biswas Prasun Bhattacharya Subhasis Chakraborty Sekhar Chakrabarti Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | Journal of Clinical Virology2007，，4： | 2 |
| 5 | Seamless SIP Based Mobility for Multimedia Applications显示文摘 | Nilanjan Banerjee Arup Acharya Sajal K Das | 2006 | IEEE Network2006，2006，： | 1 |
| 6 | Hepatitis C virus E1 envelope glycoprotein interacts with apolipoproteins in facilitating entry into hepatocytes显示文摘 | Budhaditya Mazumdar Arup Banerjee Keith Meyer Ranjit Ray | 2011 | Hepatology2011，，4： | 1 |
| 7 | Silicene beyond mono-layers—different stacking configurations and their properties显示文摘 | C Kamal Aparna Chakrabarti Arup Banerjee S K Deb | 2013 | Journal of Physics: Condensed Matter2013，，： | 1 |
| 8 | Analysis of hepatitis B virus X gene phylogeny, genetic variability and its impact on pathogenesis: Implications in Eastern Indian HBV carriers显示文摘 | Sibnarayan Datta Arup Banerjee Partha Kumar Chandra Avik Biswas Rajesh Panigrahi Pradip Kumar Mahapatra Chinmoy Kumar Panda Shekhar Chakrabarti Sujit Kumar Bhattacharya Runu Chakravarty | 2008 | Virology2008，，2： | 1 |
| 9 | Ab initio investigation on hybrid graphite-like structure made up of silicene and boron nitride显示文摘 | C. Kamal Aparna Chakrabarti Arup Banerjee | 2014 | Physics Letters A . 2014 (16-1)2014，，： | 1 |
| 10 | Seamless SIP-Based Mobility for Multimedia Applications 显示文摘 | Nilanjan Banerjee Arup Acharya Sajal K Das | 2006 | IEEE Network2006，2006，： | 1 |
| 11 | Subgenotype D5, BCP and MHR mutations in hepatic complications among hepatitis B virus infected patients from Orissa, India显示文摘 | Rajesh Panigrahi Avik Biswas Arup Banerjee Shivaram Prasad Singh Manas K. Panigrahi Anne Marie Roque-Afonso Haribhakti Seba Das Pradip K. Mahapatra Sekhar Chakrabarti Runu Chakravarty | 2012 | Infection Genetics and Evolution2012，，8： | 1 |
| 12 | Variations in the functional domain of basal core promoter of hepatitis B virus among eastern indian patients with prevalence of genotypes A,C,and D among the same ethnic population显示文摘 | Avik Biswas Arup Banerjee Partha Kumar | 2011 | Medi Virol2011，，83： | 1 |
| 13 | Differential pattern of pre-S mutations/deletions and its association with hepatitis B virus genotypes in Eastern India显示文摘 | Avik Biswas Rajesh Panigrahi Arup Banerjee Manisha Pal Binay Krishna De Sekhar Chakrabarti Runu Chakravarty | 2012 | Infection Genetics and Evolution2012，，2： | 1 |
| 14 | Designing of intelligent expert control system using Petri net for grinding mill operation显示文摘 | Bhaumik Arup Banerjee Suman sil Jaya | 2005 | WSEAS Transactions on Information Science and Applications2005，2，4： | 1 |
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