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| 1 | Prognosis and feasibility of en-bloc vascular resection in stage Ⅱ pancreatic adenocarcinoma显示文摘AIM:To establish the prognosis and feasibility of en-bloc vascular resection of stage pancreatic adenocarcinoma of the head and uncinate process.METHODS:We retrospectively analyzed 87 patients with stage pancreatic adenocarcinoma,who were subjected to pancreaticoduodenectomy (PD) and pylo-rus-preserving PD (PPPD) between 1996 and 2006 in Chang Gung Memorial Hospital,Taiwan. Twelve and 75 patients underwent PD/PPPD with and without resection of portal vein/superior mesenteric vein (PV/SMV),respectively.RESULTS:The overall 1-and 3-year survival rates of patients undergoing PD/PPPD with and without vas-cular resection were 50.0% and 16.7%,and 44.4% and 12.2%,respectively. Morbidity and mortality rates in the PV/SMV resection vs non-resection group were 50.0% and 0.0%,and 40.0% and 2.7%,respectively. In multivariate analysis,serum bilirubin,histological differentiation and adjuvant chemotherapy were independent prognostic factors that influenced survival.CONCLUSION:In stage adenocarcinoma of the pancreatic head and uncinate process,serum bilirubin,histological differentiation and adjuvant chemotherapy were independent prognostic factors,and en-bloc vascular resection is a feasible option in carefully selected patients. | K Dilip Chakravarty Jun-Te Hsu Chun-Nan Yeh Ta-Sen Yeh Tsann-Long Hwang Miin-Fu Chen | 2010 | World Journal of Gastroenterology2010，16，8： | 11 |
| 2 | Mid-infrared silicon photonic waveguides and devices [Invited]显示文摘Silicon has been the material of choice of the photonics industry over the last decade due to its easy integration with silicon electronics, high index contrast, small footprint, and low cost, as well as its optical transparency in the nearinfrared and parts of mid-infrared(MIR) wavelengths(from 1.1 to 8 μm). While considerations of micro-and nano-fabrication-induced device parameter deviations and a higher-than-desirable propagation loss still serve as a bottleneck in many on-chip data communication applications, applications as sensors do not require similar stringent controls. Photonic devices on chips are increasingly being demonstrated for chemical and biological sensing with performance metrics rivaling benchtop instruments and thus promising the potential of portable, handheld,and wearable monitoring of various chemical and biological analytes. In this paper, we review recent advances in MIR silicon photonics research. We discuss the pros and cons of various platforms, the fabrication procedures for building such platforms, and the benchmarks demonstrated so far, together with their applications. Novel device architectures and improved fabrication techniques have paved a viable way for realizing low-cost, high-density,multi-function integrated devices in the MIR. These advances are expected to benefit several application domains in the years to come, including communication networks, sensing, and nonlinear systems. | YI ZOU SWAPNAJIT CHAKRAVARTY CHI-JUI CHUNG XIAOCHUAN XU RAY T.CHEN | 2018 | Photonics Research2018，6，4： | 9 |
| 3 | Significant increase in HBV, HCV, HIV and syphilis infections among blood donors in West Bengal, Eastern India 2004-2005: Exploratory screening reveals high frequency of occult HBV infection显示文摘AIM: To evaluate the prevalence of markers of hepatitis B virus (HBV) and hepatitis C virus (HCV) and human immunodeficiency virus (HIV) among blood donors in Kolkata, Eastern India for two consecutive years and to conduct a pilot study to explore the presence of HBV DNA among hepatitis B surface antigen (HBsAg) negative but anti-HBc positive blood donors. METHODS: Seroprevalence of HBsAg, anti-HCV and anti-HIV was studied among 113 051 and 106 695 voluntary blood donors screened in 2004 and 2005, respectively. Moreover, a pilot study on 1027 HBsAg negative donors was carried out for evaluating the presence of HBV DNA by PCR on HBsAg negative/anti- HBc positive donors. RESULTS: A statistically significant increase in the prevalence of HBV (1448 vs 1768, P < 0.001), HIV (262 vs 374, P < 0.001), HCV (314 vs 372, P = 0.003) and syphilis (772 vs 853, P = 0.001) infections was noted among blood donors of Kolkata West Bengal in 2005 as compared to 2004. Moreover, the exploratory study on 1027 HBsAg negative donors revealed that 188 (18.3%)of them were anti-HBc positive out of which 21% were positive for HBV DNA. CONCLUSION: The findings of this study underscore the significantly increasing endemicity of hepatitis viruses, syphilis and HIV among the voluntary blood donors of our community. The pilot study indicates a high rate of prevalence of HBV DNA among HBsAg negative/anti-HBc positive donors and thus emphasizes the need for a more sensitive and stringent screening algorithm for blood donations. | Prasun Bhattacharya Partha Kumar Chandra Sibnarayan Datta Arup Banerjee Subhashish Chakraborty Krishnan Rajendran Subir Kumar Basu Sujit Kumar Bhattacharya Runu Chakravarty | 2007 | World Journal of Gastroenterology2007，13，27： | 9 |
| 4 | Discrete element approach for mine dump stability analysis显示文摘Mine overburden dumps have posed significant safety issues in the operations of various unit operations of open pit min-ing especially the external dumps. The external dumps are composed of a mixture of fragmented rocks and loose soil. Their charac-teristic is comparable to heavily discontinuous solid mass. The conventional approach of limit equilibrium methods provide safety factors for the slope but nothing about the stress-strain characteristics of the large dump mass. The designs of dump location and their respective geometry are integrated for the know-how of the stability characteristics of these dumps. The discrete element method uses a circular disk to represent the granular solid mass and their interactions are described by the Newton’s third law of motion. The displacement is described by the sliding of the circular disk. This work is focused on the modeling efficiency of the discrete element methods to represent the behaviour of mine dump masses with the specified joint plane for the limit equilibrium method. The advantage of the work lies on the ease of information retrieval at any point at the dump mass concerning the stress and strain histories, displacement, failures etc. which when integrated produces a better understanding of the stability of the dump masses. | RADHAKANTA Koner DEBASHISH Chakravarty | 2010 | Mining Science and Technology2010，20，6： | 8 |
| 5 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 6 | Changes in organic structure and mineral phases transformation of coal during heat treatment on laboratory scale显示文摘 | Vivek Mishra Mamta Sharma Sanchita Chakravarty Amit Banerjee | 2016 | International Journal of Coal Science & Technology2016，3，4： | 8 |
| 7 | Molecular Biology of the Hepatitis B Virus for Clinicians显示文摘 | Sibnarayan Datta Soumya Chatterjee Vijay Veer Runu Chakravarty | 2012 | Journal of Clinical and Experimental Hepatology2012，，4： | 5 |
| 8 | Pyruvate kinase M2 regulates homologous recombination- mediated DNA double-strand break repair显示文摘到 genotoxic 治疗的抵抗是治疗失败和肿瘤复发的一个主要原因。激活 DNA 损坏反应(DDR ) 并且允许癌症房间逃离 genotoxic 治疗的致命的效果的内在的机制仍然保持不清楚。这里,我们揭开通过的意外机制 pyruvate kinase M2 (PKM2 ) ,在癌症房间的高度表示的 PK isoform 和癌症的一个主人管理者新陈代谢的 reprogramming,与 DDR 集成直接支持 DNA 双海滨裂缝(DSB ) 修理。响应电离放射和氧化应力,在导致它的原子累积的 T328 的 ATM phosphorylates PKM2。pT328-PKM2 被要求并且对足够支持通过到在 DNA 的 DSB 和切除术的增加 CtIPs 招募的 T126 上的交往 CtBP 蛋白质(CtIP ) 的 phosphorylation 的调停的 DNA DSB 修理结束的相应再结合(HR ) 。ATM-PKM2-CtIP 轴的混乱敏化癌症房间到许多损坏 DNA 代理人和 PARP1 抑制。而且,增加了原子 pT328-PKM2 水平在 glioblastoma 病人与显著地更坏的幸存被联系。联合,这些数据倡导者是的指向 PKM2 策略的使用不仅破坏癌症新陈代谢而且禁止抵抗的重要机制到 genotoxic 治疗的一个工具。 | Steven T. Sizemore Manchao Zhang Ju Hwan Cho Gina M. Sizemore Brian Hurwitz Balveen Kaur Norman L. Lehman Michael C. Ostrowski Pierre A. Robe Weili Miao Yinsheng Wang Arnab Chakravarti Fen Xia | 2018 | Cell Research2018，28，11： | 5 |
| 9 | Distribution of mineral species in different coal seams of Talcher coalfield and its transformation behavior at varying temperatures显示文摘 | Amit Banerjee P. R. Mishra Ashok Mohanty K. Chakravarty R. Das Biswas R. Sahu S. Chakravarty | 2016 | International Journal of Coal Science & Technology2016，3，2： | 4 |
| 10 | A new finite element model for welding heat sources显示文摘 | John Goldak Aditya Chakravarti Malcolm Bibby | 1984 | Metallurgical Transactions B1984，，2： | 4 |
| 11 | Physico-chemical and elemental investigation of aqueous leaching of high sulfur coal and mine overburden from Ledo coalfield of Northeast India显示文摘 | Madhulika Dutta Puja Khare Sanchita Chakravarty Durlov Saikia Binoy K. Saikia | 2018 | International Journal of Coal Science & Technology2018，5，3： | 4 |
| 12 | Quantification of organic carbon and primary nutrients in litter and soil in a foothill forest plantation of eastern Himalaya显示文摘The present study was an effort to understand the amount of litter fall and its subsequent decomposition and quantify the release of available nutrients and soil physicochemical characteristics in plantations of four forest tree species(Lagerstroemia parviflora, Tectona grandis, Shorea robusta and Michelia champaca) in the Chilapatta Reserve Forest of the Cooch Behar Wildlife Division in the Terai zone of West Bengal, India. The most litter(5.61 Mg ha^(-1))was produced by T. grandis plantation and the least(4.72 Mg ha^(-1)) by L. parviflora. The material turnover rate to the soil through decomposition from total litter was fastest during the first quarter of the year and subsequently decreased during the next two quarters. The material turnover rate was only 1 year, which indicates that more than90% of the total litter produced decomposed within a year.The available primary nutrient content in litter varied across the four plantations over the year. The plantations generally did not significantly influence the soil physical characteristics but did significantly influence the availability of primary nutrients and organic carbon at two depths(1–15 and16–30 cm) over the year. The availability of soil primary nutrients in the four plantations also increased gradually from the first quarter of the year to the third quarter and then decreased during the last quarter to the same level as in the first quarter of the year at both depths. The availability for soil organic carbon in the plantations followed a similar trend. The amount of litter produced and the material turnover in the soil in the different plantations differed, influencing the nutrient availability and organic carbon at the plantations. The amount of soil organic carbon was highest for T. grandis(2.52 Mg ha^(-1)) and lowest for L. parviflora(2.12 Mg ha^(-1)). Litter is the source of soil organic matter,and more the litter that is produced by the plantations, the higher will be the content and amount of soil organic carbon in the plantation. | Gopal Shukla Nazir A. Pala Sumit Chakravarty | 2017 | Journal of Forestry Research2017，28，6： | 4 |
| 13 | Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study显示文摘AIM Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4(TLR4) in hepatitis B virus(HBV) infection.METHODS Real time PCR was used to analyze the transcription of TLR4 signaling molecules, cell cycle regulators and HBV DNA viral load after triggering the Hep G2.2.15 cells with TLR4 specific ligand. Nuclear factor(NF)-κB translocation on TLR4 activation was analyzed using microscopic techniques. Protein and cell cycle analysis was done using Western Blot and FACS respectively.RESULTS The present study shows that TLR4 activation represses HBV infection. As a result of HBV suppression, there are several changes in host factors which include partial release in G1/S cell cycle arrest and changes in host epigenetic marks. Finally, it was observed that anti-viral action of TLR4 takes place through the NF-κB pathway.CONCLUSION The study shows that TLR4 activation in HBV infection brings about changes in hepatocyte microenvironment and can be used for developing a promising therapeutic target in future. | Dipanwita Das Neelakshi Sarkar Isha Sengupta Ananya Pal Debraj Saha Manikankana Bandopadhyay Chandrima Das Jimmy Narayan Shivram Prasad Singh Runu Chakravarty | 2016 | World Journal of Gastroenterology2016，22，47： | 4 |
| 14 | Distribution of hepatitis B virus genotypes:Phylogenetic analysis and virological characteristics of Genotype C circulating among HBV carriers in Kolkata,Eastern India显示文摘AIM: To evaluate the genotype distribution of hepatitis B virus (HBV) in Eastern India and to clarify the phyloge- netic origin and virological characteristics of the recently identifi ed genotype C in this region. METHODS: Genotype determination, T1762/A1764 mutation in the basal core promoter (BCP) and A1896 mutation in the precore region of 230 subjects were de- termined by restriction fragment length polymorphism method (RFLP) and the result was confi rmed by direct sequencing. RESULTS: The predominant genotypes D (HBV/D) and A (HBV/A) were detected in 131/230 (57%) and 57/230 (25%) samples. In addition, genotype C (HBV/C) was detected in 42/230 (18%) isolates. Surface gene region was sequenced from 45 isolates (27 HBV/C, 9 HBV/A and 9 HBV/D). Phylogenetic analysis revealed that all of the HBV/C sequences clustered with South East Asian subgenotype (HBV/Cs). The sequence data showed re- markable similarity with a Thai strain (AF068756) (99.5% ± 0.4% nucleotide identities) in 90% of the genotype C strains analyzed. T1762/A1764 mutation in BCP re- gion, associated with high ALT was signifi cantly higher in HBeAg negative isolates than HBeAg positive isolates. Frequency of A1896 mutation leading to HBeAg negativ- ity was low.CONCLUSION: The present study reports the genotypic distribution and the characteristics of partial genome sequences of HBV/C isolates from Eastern India. Low genetic diversity and confi nement of HBV/C in Eastern India possibly indicate a recent, limited, spread in this region. Genotype C with T1762/A1764 mutation has been reported to increase the risk for hepatocellular car- cinoma; therefore genotype C carriers in Eastern India should be carefully monitored. | Arup Banerjee Sibnarayan Datta Partha K Chandra Susanta Roychowdhury Chinmoy Kumar Panda Runu Chakravarty | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 15 | A new finite element model for welding heat sources显示文摘 | John Goldak Aditya Chakravarti Malcolm Bibby | | Metallurgical Transactions B0，，： | 3 |
| 16 | Existence of spatiotemporal patterns in the reaction-diffusion predator-prey model incorporating prey refuge显示文摘 | Lakshmi Narayan Guin Benukar Mondal Santabrata Chakravarty | 2016 | International Journal of Biomathematics2016，9，6： | 3 |
| 17 | Design of crown pillar thickness using finite element method and multivariate regression analysis显示文摘Minerals are now being extracted from deep mines due to drying up of resource in shallow ground. The need for suitable supports and ground control mechanisms for safe mining necessitates proper pillar design with filling technology. In addition, high horizontal stress may cause collapse of hanging wall and footwall rocks, hence designing of suitable crown pillars is absolutely necessary for imposing overall safety of the stopes. This paper provides a methodology for the evaluation of the required thickness of crown pillars for safe operation at depth ranging from 600 m to 1000 m. Analyses are conducted with the results of 108 non-linear numerical models considering Drucker-Prager material model in plane strain condition. Material properties of ore body rock and thickness of crown pillars are varied and safety factors of pillars estimated. Then, a generalized statistical relationship between the safety factors of crown pillars with the various input parameters is developed. The developed multivariate regression model is utilized for generating design/stability charts of pillars for different geo-mining conditions.These design charts can be used for the design of crown pillar thickness with the depth of the working,taking into account the changes of the rock mass conditions in underground metal mine. | Kumar Hemant Deb Debasis Chakravarty D. | 2017 | International Journal of Mining Science and Technology2017，27，6： | 3 |
| 18 | Development of a mass model in estimating weight-wise particle size distribution using digital image processing显示文摘Particle size distribution of coarse aggregates through mechanical sieving gives results in terms of cumulative mass percent. But digital image processing generated size distribution of particles, while being fast and accurate, is often expressed in terms of area function or number of particles. In this paper, a mass model is developed which converts the image obtained size distribution to mass-wise distribution, making it readily comparable to mechanical sieving data. The concept of weight/particle ratio is introduced for mass reconstruction from 2D images of particle aggregates. Using this mass model, the effects of several particle shape parameters(such as major axis, minor axis, and equivalent diameter) on sieve-size of the particles is studied. It is shown that the sieve-size of a particle strongly depend upon the shape parameters, 91% of its variation being explained by major axis, minor axis, bounding box length and equivalent diameter. Furthermore, minor axis gives an overall accurate estimate of particle sieve-size, error in mean size(D-50) being just 0.4%. However, sieve-size of smaller particles(<20 mm) strongly depends upon the length of the smaller arm of the bounding box enclosing them and sieve-sizes of larger particles(>20 mm) are highly correlated to their equivalent diameters. Multiple linear regression analysis has been used to generate overall mass-wise particle size distribution, considering the influences of all these shape parameters on particle sieve-size. Multiple linear regression generated overall mass-wise particle size distribution shows a strong correlation with sieve generated data. The adjusted R-square value of the regression analysis is found to be 99 percent(w.r.t cumulative frequency). The method proposed in this paper provides a time-efficient way of producing accurate(up to 99%) mass-wise PSD using digital image processing and it can be used effectively to replace the mechanical sieving. | Maiti Abhik Chakravarty Debashish Biswas Kousik Halder Arpan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 3 |
| 19 | 系统性红斑狼疮孕妇早产及先兆子痫发病的预测因子 | Chakravarty E.F Colón I Langen E.S 朱国栋 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，10： | 2 |
| 20 | Nosocomial diarrhea in children:is astrovirus the leading pathogen?显示文摘Objective:To screen for the presence of mixed infection with rotavirus.Methods:The present study included 140 children aged less than 2 years with acute diarrhea.Fecal samples of all these patients were analyzed for the presence of astroviral antigen by enzyme immunoassay.Also 40 rotavirus positive fecal samples were screened for the presence of astrovirus.Results:In case of acute diarrhea in children the prevalence of astrovirus was around 34% (48/140).It was seen that even in rotavirus positive cases astrovirus co infection was 25% .Conclusions:Astrovirus is a growing problem which is often underrecognised.With the rotavirus vaccine licensure being imminent astrovirus will emerge out as the single most important cause of viral | Anita Chakravarti Manisha Jain Mayank Singh Chauhan Anju Sharma Sayani Tewari | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，5： | 2 |
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