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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | 酸乳发酵凝乳过程中的理化性质和生物活性显示文摘全脂牛奶在室温发酵制作酸乳过程中 ,其酸度随着发酵时间的延续和微生物添加量的增加而上升 ,pH值则逐渐降低 ;而酸乳粘度则随着发酵时间的延续上升达到最高点开始下降 .当微生物添加量为 4 %~ 5% ,发酵 1 2h时 ,酸乳凝乳良好 ,口感适宜 ,活性乳酸菌总数达到 1 0 7数量级 . | 沈辉 Celestin SAB UMUKAMA Etienne NZEYI MANA Felicien NIBRKORO | 2000 | 无锡轻工业学院学报2000，19，5： | 24 |
| 3 | 抑郁症动物模型的研究进展(英文)显示文摘抑郁症是一种慢性的、具有高复发率的精神性疾病,往往会危及到病人的生命。尽管其全球发病率高达20%,但人们对其病理生理机制了解甚少,这主要归因于缺乏有效可靠的动物模型。此外,抑郁症的核心症状,例如抑郁心境、无价值感和反复出现自杀念头等,均无法在实验动物上得以模拟。目前,大部分动物模型的建立主要参照以下两个原则之一:对于已知抗抑郁药的作用或者是对应激的反应。本综述主要介绍目前最常用的几个抑郁症动物模型,包括获得性无助、慢性温和应激和社会失败应激,以及一些用于筛选有抗抑郁活性药物的行为学检测方法(如强迫游泳实验和悬尾实验),并对它们的优点与不足进行讨论。最后,对动物模型和行为学检测方法的发展方向进行展望。 | 严华成 曹雄 Manas Das 朱心红 高天明 | 2010 | Neuroscience Bulletin2010，26，4： | 11 |
| 4 | Potentially fatal haemobilia due to inappropriate use of an expanding biliary stent显示文摘AIM: To highlight the fatal complication caused by expanding biliary stents and the importance of avoiding use of expanding stent in potentially curable diseases.METHODS: Arteriobiliary fistula is an uncommon cause of haemobilia. We describe a case of right hepatic artery pseudoaneurysm causing arteriobiliary fistula and presenting as severe malena and cholangitis, in a patient with a mesh metal biliary stent. The patient had lymphoma causing bile duct obstruction.RESULTS: Gastroduodenoscopy failed to establish the exact source of bleeding and hepatic artery angiography and selective embolisation of the pseudo aneurysm successfully controlled the bleeding.CONCLUSION: Bleeding from the pseudo aneurysm of the hepatic artery can be fatal. Mesh metal stents in biliary tree can cause this complication as demonstrated in this case.So mesh metal stent insertion should be avoided in potentially benign or in curable conditions. Difficulty in diagnosis and management is discussed along with the review of the literature. | Rakesh Rai John Rose Derek Manas | 2003 | World Journal of Gastroenterology2003，9，10： | 9 |
| 5 | Biliary cast syndrome:literature review and a single centre experience in liver transplant recipients显示文摘BACKGROUND:Biliary cast syndrome(BCS)is an unusual complication of orthotopic liver transplantation (OLTx),and its management is difficult.Limited success using endoscopic retrograde cholangiopancreatography (ERCP)or open exploration to clear casts has been reported, but failure usually results in re-transplantation.We aimed to review our experience with BCS and highlight a novel combined percutaneous and endoscopic approach for duct clearance.A brief review of the literature is given. METHODS:We retrospectively reviewed our experience of managing BCS using case notes review.Details were also gathered from radiology,where interventional procedures were carried out. RESULTS:We had a total of three cases of BCS reported between 2002 and 2005.Multiple attempts were made to remove these casts.All three were treated in a variety of ways.Management is discussed along with highlighting a novel combined percutaneous and endoscopic approach for duct clearance. CONCLUSIONS:BCS is a potential complication of OLTx. Surgical and endoscopic methods of removing casts are used.However,in circumstances where these methods are technically difficult,a percutaneous endoscopic approach with serial dilatation of the cutaneous port and surgical removal of casts can be done. | Narasimhaiah Srinivasaiah Mettu Srinivas Reddy Schlok Balupuri David Talbot Bryon Jaques Derek Manas | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 8 |
| 6 | Influence of oxygen gas content on the structural and optical properties of ZnO thin films deposited by RF magnetron sputtering at room temperature显示文摘Zinc oxide (ZnO) thin films were deposited on sapphire (0001) substrates at room temperature by radiofrequency (RF) magnetron sputtering at oxygen gas contents of 0%,25%,50% and 75%,respectively.The influence of oxygen gas content on the structural and optical properties of ZnO thin films was studied by a surface profile measuring system,X-ray diffraction analysis,atomic force microscopy,and UV spectrophotometry.It is found that the size of ZnO crystalline grains increases first and then decreases with the increase of oxygen gas content,and the maximum grain size locates at the 25% oxygen gas content.The crystalline quality and average optical transmittance (>90%) in the visible-light region of the ZnO film prepared at an oxygen gas content of 25% are better than those of ZnO films at the other contents.The obtained results can be attributed to the resputtering by energetic oxygen anions in the growing process. | LIU Baoting ZHOU Yang ZHENG Hongfang LI Mana GUO Zhe HAO Qingxun PENG Yingcai | 2011 | Rare Metals2011，30，2： | 6 |
| 7 | Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases显示文摘The gene encoding bone morphogenetic protein-7(BMP7) is expressed in the developing kidney in embryos and also in the mature organ in adults. During kidney development, expression of BMP7 is essential to determine the final number of nephrons in and proper size of the organ. The secreted BMP7 acts on the nephron progenitor cells to exert its dual functions: To maintain and expand the progenitor population and to provide them with competence to respond to differentiation cues, each relying on distinct signaling pathways. Intriguingly, in the adult organ, BMP7 has been implicated in protection against and regeneration from injury. Exogenous administration of recombinant BMP7 to animal models of kidney diseases has shown promising effects in counteracting inflammation, apoptosis and fibrosis evoked upon injury. Although the expression pattern of BMP7 has been well described, the mechanisms by which it is regulated have remained elusive and the processes by which the secretion sites of BMP7 impinge upon its functions in kidney development and diseases have not yet been assessed. Understanding the regulatory mechanisms will pave the way towards gaining better insight into the roles of BMP7, and to achieving desired control of the gene expression as a therapeutic strategy for kidney diseases. | Taro Tsujimura Mana Idei Masahiro Yoshikawa Osamu Takase Keiichi Hishikawa | 2016 | World Journal of Stem Cells2016，8，9： | 6 |
| 8 | Lymphomatoidgastropathy mimicking extranodal NK/T cell lymphoma,nasal type:A case report显示文摘Extranodal natural killer(NK)/T-cell lymphoma,nasal type,exhibits aggressive tumor behavior and carries a poor prognosis.Recently,lymphomatoid gastropathy with NK/T cell infiltration into gastric mucosa has been recognized as a pseudo-malignant disease which regresses without treatment.Because the conventional immunohistochemical criteria of lymphomatoid gastropathy is similar to that of extranodal NK/T-cell lymphoma nasal type,it is difficult to distinguish between the two conditions by histopathological evaluation only.Here,we report a rare case of lymphomatoid gastropathy in a 57-year-old female.Gastroendoscopy on routine check-up revealed elevated reddish lesions < 1 cm in diameter in the gastric fornix and body.Although repeat endoscopies at 1 and 6 mo later revealed no gastric lesions at any locations without any treatments,at 12 mo later gastric lymphomatoid lesions recurred at gastric fornix and body.Histological examination of endoscopic biopsy specimens at 12 mo showed atypical NK cell infiltration with CD3+,CD4-,CD5-,CD7+,CD8-,CD20-,CD30-,CD56+,CD79a-and T-cell-restricted intracellular antigen-1+ into gastric mucosa.After treatment for Helicobacter pylori(H.pylori) eradication,the lesions disappeared in all locations of the gastric fornix and body over the subsequent 12 mo.Here,we report a case of H.pylori-positive lymphomatoid gastropathy with massive NK-cell proliferation,and also review the literature concerning newly identified lymphomatoid gastropathy based on comparison of extra nodal NK/T-cell lymphoma nasal type.In any case,these lesions are evaluated with biopsy specimens,the possibility of this benign entity should be considered,and excessive treatment should be carefully avoided.Close follow-up for this case of lymphomatoid gastropathy is necessary to exclude any underlying malignancy. | Tomohiro Terai Mitsushige Sugimoto Hiroki Uozaki Tetsushi Kitagawa Mana Kinoshita Satoshi Baba Takanori Yamada Satoshi Osawa Ken Sugimoto | 2012 | World Journal of Gastroenterology2012，18，17： | 5 |
| 9 | Analyzing cytokines as biomarkers to evaluate severity of glaucoma显示文摘AIM: To analyze cytokines as biomarkers for evaluation of severity of glaucoma.METHODS: This was a prospective case-control study including 29 eyes with glaucoma. Besides, 28 eyes with senile cataract were used as control. Patients were classified into four groups: acute angle closure glaucoma(AACG), chronic angle closure glaucoma(CACG), primary open angle glaucoma(POAG) and senile cataract. Undiluted vitreous samples were collected, then vitreous concentrations of 9 types of cytokines were determined by cytometric bead assay system: γ-interferon(IFNg), interleukin(IL)-10, IL-2, IL-4, IL-5, interferon-γ-inducible protein(IP)-10, monocyte chemoattractant protein(MCP)-1, tumor necrosis factor(TNF)-α, and vascular endothelial growth factor(VEGF). We also recorded the intraocular pressure(IOP) of patients in each group and Pearson correlated analysis was performed to analysis the correlation between each type of cytokine with IOP.RESULTS: Vitreous levels of IL-2, IL-5, MCP-1, TNF-α and IP-10 were significantly higher(P<0.05) in AACG group. Patients with AACG, CACG and POAG have higher IOP than senile cataract, but we didn't find any significant correlation between IOP with any type of the cytokines.CONCLUSION: Inflammation and immune reaction have a strong link with the pathology of glaucoma especially AACG. Some cytokines may act as biomarkers to evaluate the severity of glaucoma. Anti-inflammatory treatments and controlling of IOP are necessary for the therapy of glaucoma. | Yao Tong Ya-Li Zhou Yan Zheng Manas Biswal Pei-Quan Zhao Zhao-Yang Wang | 2017 | International Journal of Ophthalmology(English edition)2017，10，6： | 5 |
| 10 | A systematic investigation of secondary phase dissolution in Mg-Sn alloys显示文摘As-cast Mg-Sn alloys(3,6,and 9 wt%Sn)were solution treated at 653,703 and 753 K(380,430 and 480℃)for 1,4,8,12 and 24 h to determine the variation of secondary phase with respect to Sn content,temperature and time.Mg-3 wt%Sn exhibits Mg2Sn dissolution at all solution treatment temperatures whereas Mg-6 and 9 wt%Sn alloy displays Mg2Sn reprecipitation and dissolution depending on the heat treatment temperature.In addition,a combined mathematical model that predicts the secondary phase dissolution and solute redistribution as a function of temperature and time is presented in this work.This model is a significant improvement compared to the previous studies where the dissolution and homogenization processes are considered independently.The effect of grain size and solute mobility upon the dissolution and homogenization kinetics is discussed as well. | Arushi Dev Niladri Naskar Nishant Kumar Ashutosh Jena Manas Paliwal | 2019 | Journal of Magnesium and Alloys2019，7，4： | 5 |
| 11 | Antibody engineering: facing new challenges in cancer therapy显示文摘Antibody-based therapeutics are beginning to realize the promise enclosed in their early denomination as “magic bullets”. Initial disappointment has turned into clinical and commercial success, and engineered antibodies currently represent over 30% of biopharmaceuticals in clinical trials. Recent structural and functional data have allowed the design of a new generation of therapeutic antibodies, with strategies ranging from complement-mediated and antibody-dependant cellular cytotoxicity enhancement to improved cytotoxic payloads using toxins, drugs,radionucleids and viral delivery. This review considers the structure of different types of recombinant antibodies, their mechanism of action and how their efficacy has been increased using a broad array of approaches. We will also focus on the additional benefits offered by the use of gene therapy methods for the in vivo production of therapeutic antibodies. | Laura S■NZ ■ngel M CUESTA Mana COMPTE Luis ■LVAREZ-VALLINA | 2005 | Acta Pharmacologica Sinica2005，26，6： | 5 |
| 12 | Clinical-radiological-pathological correlation of cavernous sinus hemangioma: Incremental value of diffusion-weighted imaging显示文摘AIM To elucidate the clinical, magnetic resonance imaging(MRI), pathological features of these lesions and asses the incremental value of diffusion-weighted imaging(DWI) in diagnosing them.METHODS Fifteen consecutive patients(11 females and 4 males; mean age 40.93 years; age range 13-63 years) with cavernous sinus hemangiomas(CSH) who underwent examination between November 2008 and May 2016 were included for the analysis. MRI, clinical and surgical findings of each patient was retrospectively reviewed. DWI were also analysed and mean-apparent diffusion coefficient(ADC) value was calculated. Eleven patients underwent surgical removal of the lesion and 2 patients had biopsy only. Diagnosis of CSH was confirmed histologically in 13 patients.RESULTS Eleven patients(73%) presented with headaches and 10(66%) had cranial nerve involvement. Extra cavernous sinus extension was noted in 14(94%). Surgery was performed in 13(87%) and post-operative radiation was given to 4(28%) patients. Thirteen patients remained asymptomatic on follow up. Three conspicuous imaging features were highly suggestive of the diagnosis: Lack of diffusion restriction(100%), homogeneous hyperintensity on T2 weighted image sequences(93.3%) and intense post-contrast enhancement(100%). The mean ADC was 1.82 × 10-3 ± 0.2186 cm2/s.CONCLUSION T1-weighted hypointensity with homogeneous hyperintensity on T2-weighted sequences, intense enhancement and absence of hemosiderin within the lesion on GRE sequence favour the diagnosis. Facilitated diffusion on DWI differentiates CSH from other solid cavernous sinus lesions and significantly improves the diagnostic accuracy, a critical factor for planning surgery. | Abhishek Mahajan Vedula Rajni Kanth Rao Gudipati Anantaram Ashwin M Polnaya Sandeep Desai Paresh Desai Rammohan Vadapalli Manas Panigrahi | 2017 | World Journal of Radiology2017，9，8： | 4 |
| 13 | Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management显示文摘Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using 'top-down' care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. | Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 4 |
| 14 | Radiofrequency ablation of recurrent cholangiocarcinoma after orthotopic liver transplantation—a case report显示文摘AIM: To report the use of radiofrequency ablation in the treatment of recurrenct cholangiocarcinoma in the transplanted liver.METHODS: A lady who underwent orthotopic liver transplantation (OLT) for intrahepatic cholangiocarcinoma recurrence of tumour 13 mo after tralsplantation inspite of adjuvant chemotherapy. Her recurrent tumour was treated with radiofrequency ablation.RESULTS: She survived for 18 mo following the recurrence of her tumour.CONCLUSION: Radiofrequency ablation can be used safely in the transplanted liver to treat recurrent tumour. | Rakesh Rai Derek Manas John Rose | 2005 | World Journal of Gastroenterology2005，11，4： | 4 |
| 15 | Application of artificial intelligence to forecast hydrocarbon production from shales显示文摘Artificial intelligence(AI)methods and applications have recently gained a great deal of attention in many areas,including fields of mathematics,neuroscience,economics,engineering,linguistics,gaming,and many others.This is due to the surge of innovative and sophisticated AI techniques applications to highly complex problems as well as the powerful new developments in high speed computing.Various applications of AI in everyday life include machine learning,pattern recognition,robotics,data processing and analysis,etc.The oil and gas industry is not behind either,in fact,AI techniques have recently been applied to estimate PVT properties,optimize production,predict recoverable hydrocarbons,optimize well placement using pattern recognition,optimize hydraulic fracture design,and to aid in reservoir characterization efforts.In this study,three different AI models are trained and used to forecast hydrocarbon production from hydraulically fractured wells.Two vastly used artificial intelligence methods,namely the Least Square Support Vector Machine(LSSVM)and the Artificial Neural Networks(ANN),are compared to a traditional curve fitting method known as Response Surface Model(RSM)using second order polynomial equations to determine production from shales.The objective of this work is to further explore the potential of AI in the oil and gas industry.Eight parameters are considered as input factors to build the model:reservoir permeability,initial dissolved gas-oil ratio,rock compressibility,gas relative permeability,slope of gas oil ratio,initial reservoir pressure,flowing bottom hole pressure,and hydraulic fracture spacing.The range of values used for these parameters resemble real field scenarios from prolific shale plays such as the Eagle Ford,Bakken,and the Niobrara in the United States.Production data consists of oil recovery factor and produced gas-oil ratio(GOR)generated from a generic hydraulically fractured reservoir model using a commercial simulator.The Box-Behnken experiment design was used to minimize the number of simulations for this study.Five time-based models(for production periods of 90 days,1 year,5 years,10 years,and 15 years)and one rate-based model(when oil rate drops to 5 bbl/day/fracture)were considered.Particle Swarm Optimization(PSO)routine is used in all three surrogate models to obtain the associated model parameters.Models were trained using 80%of all data generated through simulation while 20%was used for testing of the models.All models were evaluated by measuring the goodness of fit through the coefficient of determination(R2)and the Normalized Root Mean Square Error(NRMSE).Results show that RSM and LSSVM have very accurate oil recovery forecasting capabilities while LSSVM shows the best performance for complex GOR behavior.Furthermore,all surrogate models are shown to serve as reliable proxy reservoir models useful for fast fluid recovery forecasts and sensitivity analyses. | Palash Panja Raul Velasco Manas Pathak Milind Deo | 2018 | Petroleum2018，4，1： | 4 |
| 16 | Comparison of the efficacy of anti-VEGF monotherapy versus PDT and intravitreal anti-VEGF combination treatment in AMD: a Meta-analysis and systematic review显示文摘AIM:To compare the effect of anti-vascular endothelial growth factor(VEGF) monotherapy versus photodynamic therapy(PDT) and anti-VEGF combination treatment in age-related macular degeneration(AMD).METHODS:A computerized online search was performed using PubMed,Web of Science and the Cochrane Library.Studies that compared anti-VEGF monotherapy with PDT and anti-VEGF combination treatment of AMD and were designed as randomized controlled trials were included.The means and standard deviations of the best-corrected visual acuity(BCVA),central retinal thickness(CRT),number of treatments and proportions of patients who gained BCVA ≥15,10,5,or 0 letters at 12^(th) month were extracted.A systematic review and Meta-analysis of the comparison of the two approaches was conducted using Review Manager 5.2.Subgroup.A sensitivity analysis was also performed.RESULTS:Eight studies were included.When the subgroup and sensitivity analysis was conducted,the results indicated that in the findings that included the monotherapy group and PDT(standard fluence,SF)group of Kaiser's study,the patients in the monotherapy group had a better BCVA compared with the combination group at 12^(th) month in the PDT(SF) subgroup[weighted mean difference(WMD):3.54;95% Cl:0.36 to 6.73;P=0.03],and there were more patients who gained ≥15 letters of BCVA in the monotherapy group compared with the combination group in the total result[odds ratio(OR):1.41;95% Cl:1.02 to 1.95;P=0.04].The same conclusion was obtained in the total result that included the monotherapy group and PDT(reduced fluence,RF)group of Kaiser's study(OR:1.56;95% CI:1.13 to 2.15;P=0.007).However,there were no significant differences in the other indexes between the two therapies.CONCLUSION:We found that anti-VEGF monotherapy is more effective on the recovery of visual acuity than combination therapy and more researches with lager sample size should be performed to study on the effect of the two therapy approaches on CRT and number of injections. | Yao Tong Ke-ke Zhao Dong Feng Manas Biswal Pei-Quan Zhao Zhao-Yang Wang Yun Zhang | 2016 | International Journal of Ophthalmology(English edition)2016，9，7： | 3 |
| 17 | Effect of TiB2 and Al3Ti on the microstructure,mechanical properties and fracture behaviour of near eutectic Al−12.6Si alloy显示文摘A near eutectic Al−12.6Si alloy was developed with 0.0wt%,2.0wt%,4.0wt%,and 6.0wt%Al−5Ti−1B master alloy.The micro-structural morphology,hardness,tensile strength,elongation,and fracture behaviour of the alloys were studied.The unmodified Al−12.6Si al-loy has an irregular needle and plate-like eutectic silicon(ESi)and coarse polygonal primary silicon(PSi)particles in the matrix-likeα-Al phase.The P_(Si),E_(Si),andα-Al morphology and volume fraction were changed due to the addition of the Al−5Ti−1B master alloy.The hardness,UTS,and elongation improved due to the microstructural modification.Nano-sized in-situ Al3Ti particles and ex-situ TiB_(2)particles caused the mi-crostructural modification.The fracture images of the developed alloys exhibit a ductile and brittle mode of fracture at the same time.The Al−5Ti−1B modified alloys have a more ductile mode of fracture and more dimples compared to the unmodified alloy. | Surajit Basak Prosanta Biswas Surajit Patra Himadri Roy Manas Kumar Mondal | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，7： | 3 |
| 18 | Oncological Feasibility of Laparoscopic Distal Pancreatectomy for Adenocarcinoma: A Single-Institution Comparative Study显示文摘 | S. Rehman S. K. P. John R. Lochan B. C. Jaques D. M. Manas R. M. Charnley J. J. French S. A. White | 2014 | World Journal of Surgery2014，，2： | 3 |
| 19 | Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET显示文摘Paradoxical reduction of cerebral blood flow(CBF)after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction(OEF).In this study,we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume(CBV)as a marker of regional cerebral perfusion pressure(CPP).In 37patients with unilateral internal carotid or middle cerebral arterial(MCA)steno-occlusive disease and8 normal controls,the baseline CBF(CBF_b),CBV,OEF,cerebral oxygen metabolic rate(CMRO_2),and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by^(15)O positron emission tomography.Paradoxical CBF_b reduction was found in 28 of 74 regions(18of 37 patients)in the ipsilateral hemisphere.High CBF_b(>47.6 mL/100 mL/min,n=7)was associated with normal CBF_b/CBV,increased CBV,decreased OEF,and normal CMRO_2.Low CBF_b(<31.8 mL/100mL/min,n=9)was associated with decreased CBF_b/CBV,increased CBV,increased OEF,and decreased CMRO_2.These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP,but partly includes highCBF_b regions with normal CPP,which has not been described in previous studies. | Tadashi Watabe Eku Shimosegawa Hiroki Kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine Jun Hatazawa | 2014 | Neuroscience Bulletin2014，30，5： | 3 |
| 20 | Evaluation of fatigue and rutting properties of asphalt binderand mastic modified by synthesized polyurethane显示文摘Fatigue and rutting phenomena are major distresses in asphalt pavements.Asphalt mixture properties are highly dependent upon the asphalt binder and the mastic behavior.The purpose of this study was to investigate the behavior of the asphalt binder and the mastic,modified by the synthesized polyurethane,at high and intermediate temperatures.The filler/asphalt binder ratio(by weight)was 1.0.The dynamic shear rheometer(DSR)was used to measure fatigue(G^(*)sinδ)and rutting(G^(*)/sinδ)parameters.In this study,the multiple stress creepandrecovery(MSCR)testwasalso utilizedto calculate the ruttingpotential of theasphalt binder and themastic.Parameters of the non-recoverable compliance(Jnr)and the percentage recovery(%)were evaluated at high temperatures.The obtained results indicated that the synthesizedpolyurethaneimproved the ruttingandfatigue properties.Therewasa significant correlation between the asphalt binder and the mastic in terms of the complex modulus(R^(2)=0.9958),rutting(R^(2)=0.9944),and the non-recoverable compliance(R^(2)=0.9707).For the fatigue parameter(R^(2)=0.9852),the complex modulus(R^(2)=0.9855),and the phase angle(R^(2)=0.8262),significant relationships were observed between the asphalt binder and mastic samples at intermediate temperatures.Overall,the chemical reaction between the filler and the asphalt binder could be effective in different behaviors of the mastic and asphalt binder.Therewasa 112%-164%increase in the G^(*)sinδparameter formastics,compared to that of the asphalt binder.The complex modulus was 6 times higher by adding the filler content. | Mana Motamedi Gholamali Shafabakhsh Mohammad Azadi | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 3 |
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