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| 1 | Current and future molecular diagnostics in colorectal cancer and colorectal adenoma显示文摘Colorectal cancer(CRC)is one of the most prevalent cancers in developed countries.On the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or sigmoidoscopy.Since CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the disease.Fecal occult blood test is a widely used non-invasive screening tool for CRC.Although fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the test.Genetic dysregulations have been found to play an important role in CRC development.With better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for CRC.In this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were discussed.This review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma. | Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | 中国露天生物质燃烧的温室气体排放及秸秆禁燃政策的协同减排效应显示文摘露天生物质燃烧是温室气体(CO_(2)、CH_(4)、N_(2)O)的重要排放源之一,这些排放可影响本地、区域和全球的大气化学和气候变化,并带来一系列生态环境问题,进而对人类及其他生物的生存环境产生影响.本研究采用卫星火点排放清单(FINN),对2010-2019年中国露天生物质燃烧温室气体排放进行研究,并分析秸秆禁燃政策对温室气体排放的影响,对后续秸秆禁燃政策的制定具有重要参考价值.结果表明,我国2010-2019年平均年温室气体排放量为1.53×10^(8) t(将CH_(4)和N_(2)O的温室效应换算为同等效应的CO_(2)当量单位),总体呈波动性下降趋势.温室气体排放量最大的植被类型是森林(7.43×10^(7) t)和农作物(3.19×10^(7) t),分别占总排放量的48.7%和20.9%.从月分布来看,露天生物质燃烧排放的温室气体集中在2-6月,3月是高峰值.从空间分布上看,排放主要集中在华南、西南和华东地区,占总排放量的72.9%.从2013年以来,秸秆禁燃政策的加强在一定程度上降低了露天农作物秸秆燃烧排放的温室气体和PM_(2.5).从变化量看,28个省份实现了秸秆燃烧排放的温室气体与PM_(2.5)同步下降. | 朱永慧 黄凌 李瑜敏 段炼 王杨君 Maggie Chel Gee Ooi Andy Chan 李莉 | 2022 | 环境科学学报2022，42，10： | 3 |
| 3 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 4 | Dynamic cluster formation using level set methods显示文摘 | Yip Andy M Ding Chris Chan Tony F | 2006 | IEEE Trans on Pattern Analysis and Machine Intelligence2006，28，6： | 1 |
| 5 | Commitment tothe union : a survey of research and implications for industri- al relations and trade unions 显示文摘 | Ed Snape Torn Redman Andy W Chan | 2000 | International Journal of Management Reviews2000，2，3： | 1 |
| 6 | Bayesian networks in manufacturing显示文摘 | Ken McNaught Andy Chan | | 0，，06： | 1 |
| 7 | Strategic Lessons of Value Migration in IT Industry 显示文摘 | Andy Ng P T Lu D W Li C K Harry Chan H Y | 2005 | Technovation2005，，25： | 1 |
| 8 | Strategic guidelines for street canyon geometry to achieve sustainable street air quality--part II: multiple canopies and canyons 显示文摘 | Andy T Chan William T W Au Ellen S P So | 2003 | Atmospheric Environment2003，37，： | 1 |
| 9 | Microbial resistance to nanotechnologies:An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants显示文摘Microbial resistance to current antibiotics therapies is a major cause of implant failure and adverse clinical outcomes in orthopaedic surgery.Recent developments in advanced antimicrobial nanotechnologies provide numerous opportunities to effective remove resistant bacteria and prevent resistance from occurring through unique mechanisms.With tunable physicochemical properties,nanomaterials can be designed to be bactericidal,antifouling,immunomodulating,and capable of delivering antibacterial compounds to the infection region with spatiotemporal accuracy.Despite its substantial advancement,an important,but under-explored area,is potential microbial resistance to nanomaterials and how this can impact the clinical use of antimicrobial nanotechnologies.This review aims to provide a better understanding of nanomaterial-associated microbial resistance to accelerate bench-to-bedside translations of emerging nanotechnologies for effective control of implant associated infections. | Zhuoran Wu Brian Chan Jessalyn Low Justin Jang Hann Chu Hwee Weng Dennis Hey Andy Tay | 2022 | Bioactive Materials2022，7，10： | 1 |
| 10 | Strategic guidelines for street canyon geometry to achieve sustainable street air quality-partⅡ: multiple canopies and canyons 显示文摘 | Andy T Chan William T W Au Ellen S P So | 2003 | Atmos Environ2003，37，： | 1 |
| 11 | Expression of C-terminal truncated and full-length Babesia bigemina rhoptry-associated protein 1 and their potential use in enzyme-linked immunosorbent assay显示文摘 | Suthisak Boonchit Andy Alhassan Bun Chan Xuenan Xuan Naoaki Yokoyama Mamoru Ooshiro Will L. Goff Suryakant D. Waghela Gale Wagner Ikuo Igarashi | 2006 | Veterinary Parasitology2006，，1： | 1 |
| 12 | Strategic guidelines for street canyon geometry to achieve sustainable street air quality显示文摘 | Andy T Chan Ellen S P So Subash C Samad | 2001 | Atmos Environ2001，35，： | 1 |
| 13 | Dynamic cluster formation using level set methods显示文摘 | Andy M Yip Chris Ding Tony F Chan | 2006 | IEEE Transactions on Pattern Analysis and Machine Intelligence2006，28，6： | 1 |
| 14 | Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis: Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial显示文摘 | Kwan Leung Chan Koon Teo Jean G. Dumesnil Andy Ni James Tam | 2010 | Circulation2010，，2： | 1 |
| 15 | Strategic guidelines for street canyon geometry to achieve sustainable street air quality part Ⅱ:multiple canopies and canyons显示文摘 | Andy T Chan Willian T W Au Ellen S PSo | 2003 | Atmos Environ2003，37，： | 1 |
| 16 | Effect of Lipid Lowering With Rosuvastatin on Progression of Aortic Stenosis: Results of the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) Trial显示文摘 | Kwan Leung Chan Koon Teo Jean G. Dumesnil Andy Ni James Tam | 2010 | Circulation2010，，2： | 1 |
| 17 | Strategic lessons of value migration in IT industry显示文摘 | Andy Ng P T Dawei L Li C K Harry Chan H Y | 2005 | Technovation2005，25，： | 1 |
| 18 | Detection of antibodies specific to an antigenic cell wall galactomannoprote in for serodiagnosis of Aspergillus fumigatus Aspergillosis显示文摘 | Che - man Chan Patrick C Y Woo Andy S P Leung | 2002 | J Clin Microbiol2002，40，6： | 1 |
| 19 | Strategic Guidelines for Street Canyon Geometry to Achieve Sustainable Street Air Quality显示文摘 | Andy T Chan Ellen S P So Subash C Samad | | 0，，35： | 1 |
| 20 | Living and dying with dig- nity in Chinese society :perspectives of older palliative care patients in Hong Kong显示文摘 | Andy HYH Chan C Leung PPY | 2013 | Age and ageing2013，42，4： | 1 |
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