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| 1 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 2 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum‐/xeno‐free culture media显示文摘 | Irina N. Sim?es Joana S. Boura Francisco dos Santos Pedro Z. Andrade Carla M. P. Cardoso Jeffrey M. Gimble Cláudia L. da Silva Joaquim M. S. Cabral | 2013 | Biotechnology Journal2013，，4： | 1 |
| 3 | Root healing after horizontal fracture: a case report with a 13 - year follow up 显示文摘 | Andrade ES de Campos Sobrinho AL | 2008 | Dent Traumatol2008，24，4： | 1 |
| 4 | Mutation rates at 14 STR loci in the population from Pernambuco, Northeast Brazil显示文摘 | Andrade ES Comes EV Raposo G | 2009 | Forensic Sci Int Genet2009，3，4： | 1 |
| 5 | Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest显示文摘在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。 | José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de Andrade Elcida de Lima Araújo | 2020 | Journal of Plant Ecology2020，13，3： | 1 |
| 6 | Assessing arsenic, cadmium, and lead contents in major crops in Brazil for food safety purposes显示文摘 | Ana Paula Branco Corguinha Guilherme Amaral de Souza Veridiana Cardoso Gon?alves Camila de Andrade Carvalho Willian Eduardo Amaral de Lima Fábio Aurélio Dias Martins Celso Hideto Yamanaka Eros Artur Bohac Francisco Luiz Roberto Guimar?es Guilherme | 2014 | Journal of Food Composition and Analysis2014，，： | 1 |
| 7 | Endoscopic Detection of Early Esophageal Squamous Cell Carcinoma in Patients with Achalasia: Narrow-Band Imaging versus Lugol’s Staining显示文摘 | Edson Ide Fred Olavo Arag?o Andrade Carneiro Mariana Souza Varella Fraz?o Dalton Marques Chaves Rubens Ant?nio Aissar Sallum Eduardo Guimar?es Hourneaux de Moura Paulo Sakai Ivan Cecconello Fauze Maluf-Filho Everson L. A. Artifon | 2013 | Journal of Oncology2013，，： | 1 |
| 8 | Effect of exogenous melatonin on sleep and motor dysfunction in Parkinson’s disease显示文摘 | Camila Andrade Mendes Medeiros Pedro Felipe Carvalhedo de Bruin Lívia Ariane Lopes Maria Cecília Magalh?es Maria de Lourdes Seabra Veralice Meireles Sales de Bruin | 2007 | Journal of Neurology2007，，4： | 1 |
| 9 | Abdominal vs vaginal hysterectomy: a comparative study of the postoperative quality of life and satisfaction显示文摘 | Agnaldo L. Silva-Filho Rogéria Andrade Werneck Rúbia Sena Magalh?es Andrezza V. Belo Sérgio A. Triginelli | 2006 | Archives of Gynecology and Obstetrics2006，，1： | 1 |
| 10 | Experimental evaluation of extended endplate beam-to-column joints subjected to bending and axial force显示文摘 | L.R.O. de Lima L. Sim?es da Silva P.C.G.da S. Vellasco S.A.L. de Andrade | 2004 | Engineering Structures2004，，10： | 1 |
| 11 | Experimental evaluation of extended endplate beam-to-column joints subjected to bending and axial force显示文摘 | L.R.O. de Lima L. Sim?es da Silva P.C.G.da S. Vellasco S.A.L. de Andrade | 2004 | Engineering Structures2004，，10： | 1 |
| 12 | Predictive compli- cation factors for CT-guided fine needle aspiration biopsy of pulmo- nary lesions 显示文摘 | Guimar~es MD Andrade MQ Fonte AC | 2010 | Clinics ( Sao Paulo )2010，65，9： | 1 |
| 13 | The insulin receptor translocates to the nucleus to regulate cell proliferation in liver显示文摘 | Maria J. Amaya André G. Oliveira Erika S. Guimar?es Marisa C.F. Casteluber Sandhra M. Carvalho Lidia M. Andrade Mauro C.X. Pinto Albert Mennone Cleida A. Oliveira Rodrigo R. Resende Gustavo B. Menezes Michael H. Nathanson M. Fatima Leite | 2014 | Hepatology2014，，1： | 1 |
| 14 | Inter- and intraobserver agreement in computed tomography enterography in inflammatory bowel disease显示文摘AIM To evaluate intra- and interobserver agreement in imaging features in inflammatory bowel disease and comparison with fecal calprotectin(FC) levels.METHODS Our institutional computed tomography enterography(CTE) database was retrospectively queried to identify patients who underwent CTE from January 2014 to June 2015. Patient inclusion criteria were confirmed inflammatory bowel disease(IBD) and FC collected < 4 mo after CTE without any change in clinical treatment or surgical treatment during this interval. The exclusion criterion was poor image quality. Two blinded abdominal radiologists, with 12 and 3 years of experience analyzed the CTE regarding localization(small bowel, colonic, both, or no disease detected);type of IBD(inflammatory, stenosing, fistulizing, > 1 pattern, or normal); and signs of active disease(present or absent). In 42 of 44 patients evaluated, routine CTE reports were made by one of the readers who reevaluated the CTEs ≥ 6 mo later, to determine the intraobserver agreement. FC was considered a sign of disease activity when it was higher than 250 μg/g.RESULTS Forty-four patients with IBD(38 with Crohn's disease and 6 with ulcerative colitis) were included. There was a moderate interobserver agreement regarding localization of IBD(k = 0.540), type of disease(k = 0.410) and the presence of active signs in CTE(k = 0.419). There was almost perfect intraobserver agreement regarding localization, type and signs of active disease in IBD. The k values were 0.902, 0.937 and 0.830, respectively. After a consensus between both radiologists regarding inflammatory activity in CTE, we found that 24(85.7%) of 28 patients who were classified with active disease had elevated FC, and six(37.5%) of 16 patients without inflammatory activity in CTE had elevated FC(P = 0.003). The correlation between elevated FC and the presence of active disease in CTE was significant(k = 0.495, P = 0.001).CONCLUSION We found almost perfect intraobserver and moderate interobserver agreement in the signs of active disease in CTE with concurrence of high FC levels. | Natally Horvat Camila Carlos Tavares Adriana Ribas Andrade Julia Campos Sim?es Cabral Hilton Muniz Le?o Filho Angela Hissae Motoyama Caiado Serli Kiyomi Nakao Ueda André Zonetti de Arruda Leite Aytan Miranda Sipahi Manoel de Souza Rocha | 2016 | World Journal of Gastroenterology2016，22，45： | 1 |
| 15 | Ameloblastoma and adenomatoid odontogenic tumor:the role of alpha2beta1,alpha3beta1,and alpha5beta1 integrins in local invasivenes and architectural characteristics显示文摘 | DA COSTA MIGUEL MC PINTO LP | 2007 | Ann Diagn Pathol2007，11，3： | 1 |
| 16 | Immunoexpression of integrins in ameloblastoma,adenomatoid odontogenic tumor,and human tooth germs显示文摘 | MIGUEL MC DE ALMEIDA FREITAS R | 2008 | Int J Surg Pathol2008，16，3： | 1 |
| 17 | Role of 5-HT in stress, anxiety, and depression显示文摘 | Frederico G. Graeff Francisco S. Guimar?es Telma G.C.S. De Andrade John F.W. Deakin | 1996 | Pharmacology Biochemistry and Behavior1996，，1： | 1 |
| 18 | Behaviour of flush end-plate beam-to-column joints under bending and axial force 显示文摘 | Luís Sim?es da Silva L R O de Lima P C G das Vellasco S A L de Andrade | 2004 | Steel and Composite Structures2004，4，2： | 1 |
| 19 | Histological comparison of demineralized bone matrix and the Ricinus communis polymer on bone regeneration显示文摘 | Laureano Filho JR Castelo Branco Bde L Andrade ES | | 0，，02： | 1 |
| 20 | Calcium bentonite as reinforcing nanofiller for thermoplastic starch显示文摘 | Magalh~es N F Andrade C T | 2010 | Journal of the Brazilian Chemical Society2010，21，2： | 1 |
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