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| 1 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 2 | Could sport be part of pediatric obesity prevention and treatment? Expert conclusions from the 28th European Childhood Obesity Group Congress显示文摘The prevalence of pediatric obesity continues to increase worldwide,bringing with it various metabolic,functional,social,and psychological complications.1 Both the prevention and treatment of childhood obesity must be based on multidisciplinary approaches combining nutrition,physical activity(PA),and psychological support.2 As an essential element of these multicomponent strategies,regular physical activity has been acknowledged as having beneficial effects on children's and adolescents,body composition,physical fitness,and metabolic profile,as well as on their health-related quality of life,social and psychological health,and academic achievement.3,4 Given that only a relatively small proportion of children and adolescents meet the public health recommendations for PA,5 and given that weight loss exercise-based interventions suffer from a high attrition rate,there is a clear need for appropriate PAs. | Susanne Ring-Dimitriou Peter Krustrup Manuel J Coelho-E-Silva Jorge Mota Andera Seabra Carla Rego Artur Mazur Elpis Vlachopapadopoulou Margerita Caroli Marie-Laure Frelut Eva Erhardt Anders Forslund Ema Boyland Daniel Weghuber David Thivel | 2019 | Journal of Sport and Health Science2019，8，4： | 3 |
| 3 | The influence of processing parameters on the ultrasonic degassing of molten AlSi9Cu3 aluminium alloy显示文摘 | Hélder Puga Joaquim Barbosa E. Seabra S. Ribeiro M. Prokic | 2009 | Materials Letters2009，，9： | 2 |
| 4 | Timing of renal replacement ther-apy initiation in acute renal failure:a meta-analysis显示文摘 | Seabra VF Balk EM Liangos O | 2008 | Am J Kidney Dis2008，52，： | 1 |
| 5 | Timing of renal replace- ment therapy initiation in acute renal failure : a meta - analysis 显示文摘 | Seabra VF Balk EM Liangos O | 2008 | Am J Kidney Dis2008，52，： | 1 |
| 6 | Timing of renal replace- ment therapy initiation in acute renal failure:a meta-analysis显示文摘 | Seabra VF Balk EM Liangos O | 2008 | Am J Kidney Dis2008，52，： | 1 |
| 7 | Poly (Vinyl Alcohol) and Poly( vinyl Pyrrolidone) Blended Films fore Thromboresistant via Nitric Oxide Release 显示文摘 | Amedea Barozzi Seabra Marcelo Ganzarolli de Oliveira | 2000 | Bioma- terials2000，21，1： | 1 |
| 8 | Computer aided learning versus standard lecture for undergraduate education in urology显示文摘 | Seabra D Srougi M Baptista R | 2004 | Journal Urology2004，171，3： | 1 |
| 9 | Sensitivity to cis-diamminedichloroplatinum in human cancer cells is related to expression of cyclin D1but not to c-raf-1 protein显示文摘 | Wareniur HM Seabra L Maw P | 1996 | Int J Cancer1996，67，： | 1 |
| 10 | Influenee of multimode universal adhesives and zirconia primer application techniques on zirconia repair 显示文摘 | Seabra B Arantes-Oliveira S Portugal J | 2014 | J Prosthet Dent2014，112，2： | 1 |
| 11 | Rab GTPases and myosin motors in organe- lie motility显示文摘 | Seabra MC Coudrier E | 2004 | Traffic2004，5，： | 1 |
| 12 | Thein vivo andin vitro protective properties of taurine 显示文摘 | Timbrell JA Seabra V Waterfield CJ | 1995 | Gen Pharmac1995，26，3： | 1 |
| 13 | Toxoplasma gondii prevents neuron degeneration by interferon-gamma-activated microglia in a mechanism involving inhibition of inducible nitric oxide synthase and transforming growth factor-beta1 production by infected microglia 显示文摘 | Roznfeld C Martinez R Seabra S | 2005 | Am J Pathol2005，167，4： | 1 |
| 14 | The in vivo and in vitro protective properties of taurine 显示文摘 | Timbrell JA Seabra V Waterfield LJ | 1995 | Gen Pharmac1995，263，： | 1 |
| 15 | Randomized,double-blind Clinical trial,controlled with placebo,of the toxicology of chronic melatonin treatment显示文摘 | Seabra M D L V Bingnotto M Pinto J R | 2000 | J Pineal Res2000，29，： | 1 |
| 16 | Friction coefficient in FZG gears lubricated with industrial gear oil: biodegra-dable ester vs mineral oil 显示文摘 | Martins R Seabra J Brito A | 2006 | Tribology International2006，39，7： | 1 |
| 17 | The Melanosome as a Model to Study Organelle Motility in Mammals显示文摘 | Duarte C Barral Miguel C Seabra | 2004 | Pigment Cell Res2004，17，： | 1 |
| 18 | Expression of the VLDL receptor in endothelial cells显示文摘 | WYNE K L PATHA R K SEABRA M C | 1996 | Arteriosclerosis Thrombosis and Vascular Biology1996，16，3： | 1 |
| 19 | Pure and (zinc or iron) doped titania powders prepared by sol -gel and used as photocatalyst显示文摘 | Seabra M P Miranda Salvado I M Labrincha J A | 2011 | Ceramic Internation- al2011，37，7： | 1 |
| 20 | Impact dynamics of muhibody sys- tems with frictional contact using joint coordinates and canoni- cal equations of motion 显示文摘 | Seabra M Nikravesh P | 1996 | Nonlinear Dynamics1996，9，： | 1 |
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