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| 1 | Inflammatory pathways in the early steps of colorectal cancer development显示文摘Colorectal cancer is a major cause of cancer-related death in many countries.Colorectal carcinogenesis is a stepwise process which,from normal mucosa leads to malignancy.Many factors have been shown to influence this process,however,at present,several points remain obscure.In recent years some hypotheses have been considered on the mechanisms involved in cancer development,expecially in its early stages.Tissue injury resulting from infectious,mechanical,or chemical agents may elicit a chronic immune response resulting in cellular proliferation and regeneration.Chronic inflammation of the large bowel(as in inflammatory bowel diseases),has been associated with the subsequent development of colorectal cancer.In this review we examine the inflammatory pathways involved in the early steps of carcinogenesis,with particular emphasis on colorectal.Firstly,we describe cells and proteins recently suggested as central in the mechanism leading to tumor development.Macrophages and neutrophils are among the cells mostly involved in these processes and proteins,as cyclooxygenases and resolvins,are crucial in these inflammatory pathways.Indeed,the activation of these pathways establishes an oxidative and anaerobic microenvironment with DNA damage to epithelial cells,and shifting from an aerobic to an anaerobic metabolism.Many cellular mechanisms,such as proliferation,apoptosis,and autophagy are altered causing failure to control normal mucosa repair and renewal. | Francesco Mariani Paola Sena Luca Roncucci | 2014 | World Journal of Gastroenterology2014，20，29： | 13 |
| 2 | Self-assembled multifunctional DNA nanoflowers for the circumvention of multidrug resistance in targeted anticancer drug delivery显示文摘癌症化疗被它的副作用和 multidrug 抵抗(MDR ) 限制了。因此,指向了能围绕 MDR 的药交货系统被需要。这里,我们向 chemosensitive 和在白血病和乳癌房间模型围绕了 MDR 的 MDR 癌症房间为指向的药交货汇报多功能的 DNA nanoflowers (NF ) 。NF 经由卷圆复制, NF 为特定的癌症房间识别,为 bioimaging 的 fluorophores,和 doxorubicin (纪录影片) 用 aptamers 在期间被合并产生的 DNA 和镁焦磷酸盐的潜在的一起沉淀是自我装配的为药交货的有约束力的 DNA。NF 尺寸是悦耳的(在直径击倒 nm 到 200 ) ,并且浓密地包装的药绑定主题和多孔的 intrastructures 赋予 NF 以一个高装载药的能力(71.4% , wt/wt ) 。尽管 Doxloaded NF (NF 纪录影片) 在生理的 pH 是稳定的,药版本在酸或基本的条件下面被便于。NF 交付纪录影片进目标 chemosensitive 和 MDR 癌症房间,阻止药流出并且提高在 MDR 房间的药保留。NF 纪录影片在两个目标 chemosensitive 房间和 MDR 房间,然而并非在 nontarget 房间导致有势力 cytotoxicity,并发地因此围绕 MDR 并且减少副作用。总的来说,这些 NF 为在指向的癌症治疗围绕 MDR 正在答应工具。 | Lei Mei Guizhi Zhu Liping Qiu Cuichen Wu Huapei Chen Hao Liang Sena Cansiz Yifan Lv Xiaobing Zhang Weihong Tan | 2015 | Nano Research2015，8，11： | 8 |
| 3 | Physiological Roles of Mitochondrial Reactive Oxygen Species显示文摘 | Laura A. Sena Navdeep S. Chandel | 2012 | Molecular Cell2012，，2： | 3 |
| 4 | 动物实验和临床试验疗效的比较:系统评价显示文摘目的:评价动物实验和临床试验治疗效果的一致性。研究设计:系统评价。数据来源:Medline、Embase、SIGLE、NTIS、Science Citation Index、CAB、BIOSIS。研究项目选择:关于在临床试验中疗效(有益或不利)明确的干预措施的动物实验,包括头部外伤、出血性疾病抗纤溶治疗、急性缺血性脑卒中的溶栓治疗与自由基清除剂替拉扎特治疗、出生前皮质激素预防新生儿呼吸窘迫综合征、二膦酸盐防治骨质疏松症等。评价方法:收集有关研究设计、分配隐藏、随机分组动物数量、动物模型类型、干预措施和结果的数据。 | Perel P. Roberts I. Sena E. 黄浙勇 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，3，7： | 3 |
| 5 | Predictors and consequences of pneumonia in critically ill patients with stroke显示文摘 | Anupama Upadya Natalya Thorevska Kanaga N Sena Constantine Manthous Yaw Amoateng-Adjepong | 2004 | Journal of Critical Care2004，，1： | 3 |
| 6 | Modified versus standard D2 lymphadenectomy in total gastrectomy for nonjunctional gastric carcinoma with lymph node metastasis显示文摘 | Gennaro Galizia Eva Lieto Ferdinando De Vita Paolo Castellano Francesca Ferraraccio Anna Zamboli Andrea Mabilia Annamaria Auricchio Gabriele De Sena Lorenzo De Stefano Francesca Cardella Alfonso Barbarisi Michele Orditura | 2014 | Surgery2014，，： | 2 |
| 7 | Therapeutic potential of Lovastatin in mulliple sclerosis显示文摘 | Sena A pedrosa R Grace Morais M | 2005 | J Neurol2005，250，6： | 1 |
| 8 | On the nanostructuring and catalytic Promotion of intermediate temperature solid oxide fuel cell (IT-SOFC) cathodes显示文摘 | Sena J M Buchkremer H P | 2007 | J Power Sources2007，172，： | 1 |
| 9 | Related articles, links polymorphisms in MHC - DRA and - DRB alleles of water buf- falo ( Bubalus bubalis) reveal different features from cattle DR alleles 显示文摘 | SENA L SCHNEIDER M P BRENIG B | 2003 | Anim Genet2003，34，1： | 1 |
| 10 | Kappa-casein gene study with molecular markers in female buffaloes (Bubalus bubalis)显示文摘 | Otaviano A R Tonhati H Sena J | 2005 | Genetics and Molecular Biology2005，28，2： | 1 |
| 11 | Predictors and consequ-ences of pneumonia in critically ill patients with stroke显示文摘 | Upadya A Thorevska N Sena KN | 2004 | J CritCare2004，19，1： | 1 |
| 12 | Comparison of treatment effects between animal experiments and clinical trials : Systematic review显示文摘 | Perel P Roberts I Sena E | 2007 | MED2007，3347，586： | 1 |
| 13 | Bond between near-surface mounted carbon- fiber- reinforced polymer laminate strips and concrete显示文摘 | Jose Manuel de Sena Cruz Joaquim Antenio Oliveira de Barros | 2004 | Journal of Composites for Construction2004，8，6： | 1 |
| 14 | Predictors of serological cure and serofast state after treatment in HIV-negative persons with early syphilis显示文摘 | Sena AC Wolff M Martin DH | 2011 | Clin Infect Dis2011，53，11： | 1 |
| 15 | Synthesis and hypolipidemic activity of N-substituted phthalimides part V 显示文摘 | Sena V M Srivastava R M Silva R O | 2003 | IL Farmaco2003，58，： | 1 |
| 16 | A Multi- disciplinary Approach to the Development of a Cervical Spine Clearance Protocol : Process, Rati- onale,and Initial Results显示文摘 | Steven LL Matthew Sena | 2003 | Elsevier Science2003，10，38： | 1 |
| 17 | Effects of alpha-lipoic acid onendothelial function in aged diabetic and high-fat fed rats显示文摘 | Sena CM Nunes E Louro T | 2008 | Br JPharmacol2008，153，5： | 1 |
| 18 | Neuropharmacological Activity of the Pericarp of Passiflora edulis flavicarpa Degener:Putative Involvement of C - Glycosylflavonoids显示文摘 | SENA ET AL | 2009 | the Society for Experimental Biology and Medicine2009，，： | 1 |
| 19 | Effect of immediate fluid resuscitation on the rate,volume,and duration of pulmonary vascular hemorrhage in a sheep model of penetrating thoracic trauma显示文摘 | Sakles JC Sena MJ Knight DA | 1997 | Ann Emerg Med1997，29，3： | 1 |
| 20 | Chemical epigenetics alters the secondary metabolite composition of guttate excreted by ~n atlantic-forest-soil-derived Penicillium citreonigrum显示文摘 | Wang X Sena F J G Hoover A R | 2010 | Jour- aal of Natural Products2010，73，5： | 1 |
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