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| 1 | Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker显示文摘AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer patients.METHODS: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient plasma.MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers.We conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up patients.Findings were controlled by using plasma samples from 54 tumor-free volunteers.Plasma was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative RT-PCR.RESULTS: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),respectively.Importantly,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Levels of circulating MACC1 transcripts in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival in a prospective study. | Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser Klaus-Dieter Wernecke Ulrike Stein | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Pathologic explanation for hypoechoic halo seen on sonograms of malignant liver tumors: An in vitro correlative study显示文摘 | Wernecke K Henke L Vassallo P | 1992 | AJR1992，158，11： | 1 |
| 3 | Arandomized outcomes trial of ureteral stents for extracorporeal shock wave lithotripsy of solitary kidney or proximal ureteral stones显示文摘 | Chandhoke PS Barqawi AZ Wernecke C | 2002 | J Urol2002，167，： | 1 |
| 4 | Differentiation of benign from malignant superficial lymphadenopathy:the role of high-resolution US显示文摘 | Vassall P Wernecke K Roos N | 1992 | Radiology1992，183，： | 1 |
| 5 | Detection of hepatic masses in patients with car-cinoma:Compartive sensitivities of Sonography, CT and MR imaging 显示文摘 | Wernecke K | 1991 | A JR1991，157，： | 1 |
| 6 | Pneumothorax:evaluation byultrasound preliminary results显示文摘 | Wernecke K Galanski M Peters PE | 1987 | J Thorac Imaging1987，2，2： | 1 |
| 7 | Comparative analysis of PCR-delection detection and immunohistochemistry in Brazilian Duchenne and Becker muscular dystrophy patients显示文摘 | Werneck LC Scola RH Maegawa GHB | 2001 | Am J Med Gene2001，103，： | 1 |
| 8 | Detection of hepatic masses in patients with carcinoma: comparative sensitivities of sonography, CT, and MR imaging 显示文摘 | Wernecke K Rummeny E Bongartz G | 1991 | Am J Roentgenol1991，157，4： | 1 |
| 9 | Differentiation of benign from malignant superficial lympholenopathy the role of high - resolution US 显示文摘 | VASSALLO P WERNECKE K ROAS N | 1992 | Radiology1992，183，： | 1 |
| 10 | Differentiation of benign from malignant superficial lymphadenopathy:the role of high-resolution US显示文摘 | Vassallo P Wernecke K Roos N | 1992 | Radiology1992，183，1： | 1 |
| 11 | Abdominal vs vagihal hysterectomy:a comparative study of the postoperative quality of life and satisfaction显示文摘 | Silva-Filho AL Werneck RA de Magalh(a)es RS | 2006 | Arch Gynecol Obstet2006，274，1： | 1 |
| 12 | Myasthenic crisis : report of 24 cases 显示文摘 | Werneck LC Scola RH Germiniani FM | 2002 | Arq Neuropsiquiatr2002，60，3： | 1 |
| 13 | Therapeu- tic effects of a horse riding simulator in children with cerebral pal- sy显示文摘 | Silva e Borges MB Werneck MJ da Silva Mde L | 2011 | Arq Neuropsiquiatr2011，69，5： | 1 |
| 14 | Ultrasound study of the pleura显示文摘 | K. Wernecke | 2000 | European Radiology2000，，10： | 1 |
| 15 | Dynamics of a dry forest fragment after the exclusion of human disturbance in southeastern Brazil显示文摘 | Márcio de Souza Werneck Edivani Villaron Franceschinelli | 2004 | Plant Ecology2004，，2： | 1 |
| 16 | A fast swap- based local search procedure for location problems 显示文摘 | RESENDE M G C WERNECK R C | 2007 | Annals of Operations Research2007，150，： | 1 |
| 17 | Current and emerging molecular diagnostic technologies applicable to bacterial food safety 显示文摘 | GLYNN B LAHIFF S WERNECKE M E | 2006 | International Journal of Dairy Technology2006，59，： | 1 |
| 18 | Angioscopic evaluation of atherosclerotic plaques validation by histomorphologic analysis and association with stable and unstable coronary syndromes显示文摘 | Thieme T Wernecke KD Meyer R | 1996 | J Am Coll Cardiol1996，28，1： | 1 |
| 19 | A method to extract morphological traits of plant organs from 3D point clouds as a database for an architectural plant model 显示文摘 | Dombusch T Wernecke P Diepenbrock W | 2007 | Ecological Modelling2007，200，： | 1 |
| 20 | Highly sulfated dermatan sulfates from ascidiand: Structure versus anticoagulant activity of these glycosaminoglycans显示文摘 | Pavao Mauro S G Aiekko Karin R M Werneck Claudio C | 1998 | J Biol Chem1998，273，27： | 1 |
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