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| 1 | Microscopic features of colorectal neoplasia in inflammatory bowel diseases显示文摘The risk of developing dysplasia leading to colorectal cancer(CRC)is increased in both ulcerative colitis and Crohn’s disease.The prognosis of CRC may be poorer in patients with inflammatory bowel disease(IBD)than in those without IBD.Most CRCs,in general,develop from a dysplastic precursor lesion.The interpretation by the pathologist of the biopsy will guide decision making in clinical practice:colonoscopic surveillance or surgical management.This review summarizes features of dysplasia(or intraepithelial neoplasia)with macroscopic and microscopic characteristics.From an endoscopic(gross)point of view,dysplasia may be classified as flat or elevated(raised);from a histological point of view,dysplasia is separated into 3 distinct categories:negative for dysplasia,indefinite for dysplasia,and positive for dysplasia with low-or high-grade dysplasia.The morphologic criteria for dysplasia are based on a combination of cytologic(nuclear and cytoplasmic)and architectural aberrations of the crypt epithelium.Immunohistochemical and molecular markers for dysplasia are reviewed and may help with dysplasia diagnosis,although diagnosis is essentially based on morphological criteria.The clinical,epidemiologic,and pathologic characteristics of IBD-related cancers are,in many aspects,different from those that occur sporadically in the general population.Herein,we summarize macroscopic and microscopic features of IBD-related colorectal carcinoma. | Aude Bressenot Virginie Cahn Silvio Danese Laurent Peyrin-Biroulet | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 2 | CD4+ T cells and natural killer cells: Biomarkers for hepatic fibrosis in human immunodeficiency virus/hepatitis C virus-coinfected patients显示文摘AIM To characterize peripheral blood natural killer(NK) cells phenotypes by flow cytometry as potential biomarker of liver fibrosis in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) coinfected patients.METHODS Peripheral mononuclear cells from 24 HIV/HCV(HBVnegative) coinfected and 5 HIV/HCV/HBV seronegative individuals were evaluated. HIV/HCV coinfected patients were divided in to groups: G1, patients with METAVIR F0-F2 and G2, patients with METAVIR F3-F4. NK surface cell staining was performed with: AntiCD3(APC/Cy7), anti-CD56(PE/Cy5), anti-CD57(APC), anti-CD25(PE), anti-CD69(FITC), anti-NKp30(PE), antiNKp46(PE/Cy7), anti-NKG2D(APC), anti-DNAM(FITC); anti-CD62L(PE/Cy7), anti-CCR7(PE), anti-TRAIL(PE), anti-Fas L(PE), anti CD94(FITC). Flow cytometry data acquisition was performed on BD FACSCanto, analyzed using Flow Jo software. Frequency of fluorescence was analyzed for all single markers. Clinical records were reviewed, and epidemiological and clinical data were obtained.RESULTS Samples from 11 patients were included in G1 and from 13 in G2. All patients were on ARV, with undetectable HIV viral load. Liver fibrosis was evaluated by transient elastography in 90% of the patients and with biopsy in 10% of the patients. Mean HCV viral load was(6.18 ± 0.7 log10). Even though, no major significant differences were observed between G1 and G2 regarding NK surface markers, it was found that patients with higher liver fibrosis presented statistically lower percentage of NK cells than individual with low to mild fibrosis and healthy controls(G2: 5.4% ± 2.3%, G1: 12.6% ± 8.2%, P = 0.002 and healthy controls 12.2% ± 2.7%, P = 0.008). It was also found that individuals with higher liver fibrosis presented lower CD4 LT count than those from G1(G2: 521 ± 312 cells/μL, G1: 770 ± 205 cells/μL; P = 0.035).CONCLUSION Higher levels of liver fibrosis were associated with lower percentage of NK cells and LTCD4+ count; and they may serve as noninvasive biomarkers of liver damage. | Natalia Laufer Diego Ojeda María Laura Polo Ana Martinez Héctor Pérez Gabriela Turk Pedro Cahn Norberto Walter Zwirner Jorge Quarleri | 2017 | World Journal of Hepatology2017，9，25： | 2 |
| 3 | Responding to emergencies:lessons learned and the need for analysis显示文摘 | Larson R C Metzger M D Cahn M F | 2006 | Interfaces2006，36，6： | 1 |
| 4 | Materials Science-Nanostructured Materials 显示文摘 | Cahn Rw | 1990 | Nature1990，348，6300： | 1 |
| 5 | Material science:Melting and the surface显示文摘 | Cahn R W | 1986 | Nature1986，323，3： | 1 |
| 6 | 查看详情显示文摘 | Shechtman D Blech I Gratias D Cahn J W | | 0，，： | 1 |
| 7 | The Impurity-Drag Effect in Grain Boundary Motion 显示文摘 | Cahn J W | 1962 | Acta Mater1962，，9： | 1 |
| 8 | In vitro susceptibility studies of cryprococcus neoformans isolated from patients with no clinical response to arnpbotericin B therapy显示文摘 | Rodero L Cordoba S Cahn P | 2000 | J Antimicrob Chemother2000，45，2： | 1 |
| 9 | Nucleation on Dislocations显示文摘 | Cahn J W | 1957 | Acta Metallurgi ca1957，5，： | 1 |
| 10 | Low dose T-cell lymphocyte infusion combined with marrow T-cell depletion as praphylaxis of acute graft-versus-host diseasefor HLA identical sibling bone marrow transplantation显示文摘 | Cahn JY Deconinck E Tiberghien P | 1999 | Hematol Cell Ther1999，41，2： | 1 |
| 11 | Spinodal decomposition显示文摘 | CAHN J W | 1968 | Trans TMS-AIME1968，242，： | 1 |
| 12 | Recovery and recrystallizati on of the deformed, orderable alloy (Co78Fe22)3V 显示文摘 | Cahn R W Takeyama M Horton J A | 1991 | Mater Res1991，6，： | 1 |
| 13 | Metallic phase with long-range orientational order and no translational symmetry显示文摘 | Shechtman D Blech I Gratias D Cahn J W | 1984 | Phys Rev Lett1984，53，： | 1 |
| 14 | Free energy of a nonuniform system(I ): Interfacial free energy 显示文摘 | Cahn J W Hilliard J E | 1958 | The Journal ofChemical Physics1958，28，： | 1 |
| 15 | Resistance profile of the new nucleoside reverse transcriptase inhibitor apricitabine显示文摘 | Cahn P Wainberg MA | 2010 | J Antimicrob Che- mother2010，65，2： | 1 |
| 16 | Pilot, Randomized Study Assessing Safety, Tolerability and Efficacy of Simplified LPV/r Maintenance Therapy in HIV Patients on the 1st PI-Based Reg- imen显示文摘 | Pedro Cahn Julio Montaner | 2011 | Plos One2011，6，23： | 1 |
| 17 | Changes in cortical thickness during the course of illness in schizophrenia 显示文摘 | van Haren NE Schnack HG Cahn W | 2011 | Arch Gen Psychiatry2011，68，： | 1 |
| 18 | Brain volume changes in first-episode schizophrenia: a 1-year follow-up study 显示文摘 | CAHN W HULSHOFF POL HE LEMS EB | 2002 | Arch Gen Psychiatry2002，59，11： | 1 |
| 19 | In vitro susceptibility studies of cryptococcus neoformans isolated from patients with no clinical response to amphoteriein B therapy 显示文摘 | Rodero L Cordoba S Cahn P | 2000 | Journal of Antimicrobial Chemotherapy2000，45，： | 1 |
| 20 | The Kinetics of Grain Boundary Nucleation Reactions显示文摘 | Cahn J W | 1956 | Acta Metall1956，4，9： | 1 |
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