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您的检索式：作者名="Alison Rodger"
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| 1 | Expression and function of matrix metalloproteinase (MMP)-28显示文摘 | Ursula R. Rodgers Lara Kevorkian Alison K. Surridge Jasmine G. Waters Tracey E. Swingler Kirsty Culley Sara Illman Jouko Lohi Andrew E. Parker Ian M. Clark | 2009 | Matrix Biology2009，，5： | 1 |
| 2 | Direct detection and measurement of wall shear stress using a filamentous bio-nanoparticle显示文摘墙砍动人的液体在表面上施加的应力(WSS ) 关于脉管的功能包括那些影响许多过程。WSS 在正常生理学起一个重要作用(例如 angiogenesis ) 并且影响微脉管系统分子的运输的主要功能。波动的 WSS 的点在很多疾病显示出畸形;然而,为在生理的系统直接测量 WSS 没有确定的技术。所有当前的方法依靠大批从测量速度坡度获得的估计流动数据。在这个工作,我们报导能直接与亚微米在 microfluidic 房间测量 WSS 的 nanosensor 由使用病毒的一种特定的类型的空间分辨率,抗菌素 M13,它荧光灯地被标记并且抛锚到表面。nanosensor 能为生物织物被校准并且适应,这被表明,揭示 WSS 在不能从体积流动大小精确地计算的房间微域。这个方法在生物学和 microfluidics 把自己借给对许多应用程序适用的一个平台。 | Daniela P. Lobo Alan M. Wemyss David J. Smith Anne Straube Kai B. Betteridge Andrew H. J. Salmon Rebecca R. Foster Hesham E. Elhegni Simon C. Satchell Haydn A. Little Raul Pacheco-Gomez Mark J. Simmons Matthew R. Hicks David O. Bates Alison Rodger Timothy R. Dafforn Kenton P. Arkill | 2015 | Nano Research2015，8，10： | 1 |
| 3 | Shape dependent protein-induced stabilization of gold nanoparticles:From a protein corona perspective Special Collection:Distinguished Australian Researchers显示文摘Gold nanoparticles(AuNPs)are promising materials for many bioapplications.However,upon contacting with biological media,AuNPs undergo changes.The interaction with proteins results in the so-called protein corona(PC)around AuNPs,leading to the new bioidentity and optical properties.Understanding the mechanisms of PC formation and its functions can help us to utilise its benefits and avoid its drawbacks.To date,most of the previous works aimed to understand the mechanisms governing PC formation and focused on the spherical nanoparticles,although non-spherical nanoparticles are designed for a wide range of applications in biosensing.In this work,we investigated the differences in PC formation on spherical and anisotropic AuNPs(nanostars in particular)from the joint experimental(extinction spectroscopy,zeta potential and surface-enhanced Raman scattering[SERS])and computational methods(the finite element method and molecular dynamics[MD]simulations).We discovered that protein does not fully cover the surface of anisotropic nanoparticles,leaving SERS hot-spots at the tips and high curvature edges‘available’for analyte binding(no SERS signal after pre-incubation with protein)while providing protein-induced stabilization(indicated by extinction spectroscopy)of the AuNPs by providing a protein layer around the particle’s core.The findings are confirmed from our MD simulations,the adsorption energy significantly decreases with the increased radius of curvature,so that tips(adsorption energy:2762.334 kJ/mol)would be the least preferential binding site compared to core(adsorption energy:11819.263 kJ/mol).These observations will help the development of new nanostructures with improved sensing and targeting ability. | Anastasiia Tukova Yihan Nie Mohammad Tavakkoli Yaraki Ngoc Thanh Tran Jiaqiu Wang Alison Rodger Yuantong Gu Yuling Wang | 2023 | Aggregate2023，4，4： | 0 |
| 4 | Prevalence of significant liver disease in human immunodeficiency virus-infected patients exposed to Didanosine: A cross sectional study显示文摘AIM To identify significant liver disease [including nodular regenerative hyperplasia(NRH)] in asymptomatic Didanosine(DDI) exposed human immunodeficiency virus(HIV) positive patients.METHODS Patients without known liver disease and with > 6 mo previous DDI use had liver stiffness assessed by transient elastography(TE). Those with alanine transaminase(ALT) above upper limit normal and/or TE > 7.65 k Pa underwent ultrasound scan(U/S). Patients with:(1) abnormal U/S; or(2) elevated ALT plus TE > 7.65 k Pa;or(3) TE > 9.4 k Pa were offered trans-jugular liver biopsy(TJLB) with hepatic venous pressure gradient(HVPG) assessment.RESULTS Ninety-nine patients were recruited, median age 50 years(range 31-70), 81% male and 70% men who have sex with men. Ninety-five percent with VL < 50 copies on antiretroviral therapy with median CD4 count 639 IU/L. Median DDI exposure was 3.4 years(range 0.5-14.6). Eighty-one had a valid TE readings(interquartile range/score ratio < 0.3): 71(88%) < 7.65 k Pa, 6(7%) 7.65-9.4 k Pa and 4(6%) > 9.4 k Pa. Seventeen(17%) met criteria for TJLB, of whom 12 accepted. All had HVPG < 6 mm Hg. Commonest histological findings were steatosis(n = 6), normal architecture(n = 4) and NRH(n = 2), giving a prevalence of previously undiagnosed NRH of 2%(95%CI: 0.55%, 7.0%).CONCLUSION A screening strategy based on TE, liver enzymes and U/S scan found a low prevalence of previously undiagnosed NRH in DDI exposed, asymptomatic HIV positive patients. Patients were more likely to have steatosis highlighting the increased risk of multifactorial liver disease in this population. | Sarah Logan Alison Rodger Laura Maynard-Smith James O'Beirne Thomas Fernandez Filippo Ferro Colette Smith Sanjay Bhagani | 2016 | World Journal of Hepatology2016，8，36： | 0 |
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