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| 1 | Urine-derived stem/progenitor cells:A focus on their characterization and potential显示文摘Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized medicine.Among the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(USCs)have aroused interest in the past years.USCs display classical features of mesenchymal stem cells such as differentiation capacity and immunomodulation.Importantly,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive procedure.Moreover,USCs can be differentiated into renal cell types.This is of high interest for renal cell therapy-based regenerative approaches.This review will firstly describe the isolation and characterization of USCs.We will specifically present USC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation capacity.In the second part of this review,we will present and discuss the main applications of USCs.These include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of USCs for cell therapy approaches with a detailed analysis depending on the targeted organ or system.Importantly,we will also focus on the applications that rely on the use of USC-derived products such as microvesicles including exosomes,which is a strategy being increasingly employed.In the last section,we will discuss the remaining barriers and challenges in the field of USC-based regenerative medicine. | Perrine Burdeyron Sébastien Giraud Thierry Hauet Clara Steichen | 2020 | World Journal of Stem Cells2020，12，10： | 6 |
| 2 | Memristive Artificial Synapses for Neuromorphic Computing显示文摘Neuromorphic computing simulates the operation of biological brain function for information processing and can potentially solve the bottleneck of the von Neumann architecture.This computing is realized based on memristive hardware neural networks in which synaptic devices that mimic biological synapses of the brain are the primary units.Mimicking synaptic functions with these devices is critical in neuromorphic systems.In the last decade,electrical and optical signals have been incorporated into the synaptic devices and promoted the simulation of various synaptic functions.In this review,these devices are discussed by categorizing them into electrically stimulated,optically stimulated,and photoelectric synergetic synaptic devices based on stimulation of electrical and optical signals.The working mechanisms of the devices are analyzed in detail.This is followed by a discussion of the progress in mimicking synaptic functions.In addition,existing application scenarios of various synaptic devices are outlined.Furthermore,the performances and future development of the synaptic devices that could be significant for building efficient neuromorphic systems are prospected. | Wen Huang Xuwen Xia Chen Zhu Parker Steichen Weidong Quan Weiwei Mao Jianping Yang Liang Chu Xing’ao Li | 2021 | Nano-Micro Letters2021，13，5： | 4 |
| 3 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 4 | A single-amino acid substitution inγ-aminobutyric acid subtype A receptor locus is associated with cyclodiene insecticide resistance in Drosophila populations 显示文摘 | Ffrench Constant R H Steichen J C RocheleauT A | 1993 | Proc Natl Acad Sci USA1993，90，5： | 1 |
| 5 | A possible association between primary aldosteronism and a lower beta-cell functian显示文摘 | Steichen O | 2008 | j Hypertens2008，26，3： | 1 |
| 6 | Galectin-3 functions as an alarmin: pathogenic role for sepsis development in murine respiratory tularemia 显示文摘 | Mishra BB Li Q Steichen AL | 2013 | PLoS One2013，8，59： | 1 |
| 7 | A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics 显示文摘 | Steichen SD Caldorera-Moore M Peppas NA | 2013 | Eur J Pharm Sci2013，48，3： | 1 |
| 8 | Alternative operative techniques in laparoscopic Roux-en-Y gastric bypass for morbid obesity显示文摘 | Borao FJ Thomas TA Steichen FM | 2001 | JSLS2001，5，2： | 1 |
| 9 | A point mutation in a Drosophila GABA receptor confers insecticide resistance 显示文摘 | Ffrench-Constant Richard H Rocheleau Thomas A Steichen Jessica C Chalmers Alison E | 1993 | Nature (London)1993，363，： | 1 |
| 10 | A point mutation in a Drosophila GABA receptor confers insecticide resistance显示文摘 | FFRENCH -- CONSTANT RH ROCHELEAU TA STEICHEN JC | 1993 | Nature1993，363，3： | 1 |
| 11 | Catheter-based radiofrequency renal-nerve ablation in patients with resistant hypertension显示文摘 | Azizi M Steichen O Frank M | | 0，，03： | 1 |
| 12 | Effects of rabepra- zole on the antiplatelet effects and PHarmacokinetics of clopidogrel in healthy volunteers 显示文摘 | Funck-Brentano C Szymezak J Steichen O | 2013 | Arch Cardiovasc Dis2013，106，12： | 1 |
| 13 | Gas extravasation complicating laparoscopic extraperitoneal inguinal hernia repair显示文摘 | E. J. Hagopian F. M. Steichen K. F. Lee D. B. Earle | 2001 | Surgical Endoscopy2001，，3： | 1 |
| 14 | Association be- tween 2 angiographic subtypes of renal artery fibromus- cular dysplasia and clinical characteristics显示文摘 | Savard S Steichen 0 Azarine A | 2012 | Circulation2012，126，25： | 1 |
| 15 | Gonococcal cervicitis: a role for biofilm in pathogenesis显示文摘 | Steichen CT Shao JQ Ketterer MR | 2008 | J Infect Dis2008，198，： | 1 |
| 16 | Radical nephreetomy for renal cell carcinoma 30 mm or less:long term follow results显示文摘 | ESCHWEGE P SAUSSINE C STEICHEN G | 1996 | J Urol1996，155，4： | 1 |
| 17 | Sulfide tolerance of four marine species used to evaluate sediment and pore - wayer toxicity 显示文摘 | Steichen DJ Jelinshi JA | 1996 | Bull Environ Toxicol1996，57，3： | 1 |
| 18 | Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporium显示文摘 | Steichen C Chen P Kearney JF | 2003 | J Bacteriol2003，185，6： | 1 |
| 19 | Gonococcal cervi- citisza role for biofilm in pathogenesis显示文摘 | Steichen CT Shao JQ Ketterer MR | 2008 | J Infect Dis2008，198，12： | 1 |
| 20 | Optimal timingfor diagnostic cravial ultra sound in low-birth-weight infamts;detection of intracraninal hemorrhage and Ventricular2dilation显示文摘 | Partride JC Babcock DS Steichen JJ | 1983 | J Pediatr1983，102，： | 1 |
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