维普期刊资源整合服务平台（V6.5）

维普中文期刊产品整合服务

11篇 您的检索式：作者名="Lynnette J"

选中清除导出查看参考文献查看引证文献引用追踪共1页首页上一页第1页下一页末页 /1 跳转

		题名	作者	年代	出处	被引量
	1	Why interleukin-10 supplementation does not work in Crohn's disease patients显示文摘Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) or ulcerative colitis are chronic intestina disorders, which are on the increase in 'Westernised' countries. IBD can be caused by both genetic and environmental factors. Interleukin-10 (IL-10) is an immunoregulatory cytokine that has been identified as being involved in several diseases including IBD. Studies have shown that polymorphisms in the promoter region reduce serum levels of IL-10 and this reduction has been associated with some forms of IBD. Mouse models have shown promising results with IL-10 supplementation, as such IL-10 supplementation has been touted as being a possible alternative treatment for CD in humans. Clinical trials have shown that recombinant human IL-10 is safe and well tolerated up to a dose o 8 μg/kg. However, to date, the results of the clinica trials have been disappointing. Although CD activity was reduced as measured by the CD activity index IL-10 supplementation did not result in significantly reduced remission rates or clinical improvements when compared to placebo. This review discusses why IL-10supplementation is not effective in CD patients currently and what can be addressed to potentially make IL-10 supplementation a more viable treatment option in the future. Based on the current research we conclude that IL-10 supplementation is not a one size fits all treatment and if the correct population of patients is chosen then IL-10 supplementation could be of benefit.	Gareth J Marlow Dominique van Gent Lynnette R Ferguson	2013	World Journal of Gastroenterology2013，19，25：	9
	2	Candidate gene association studies of the α4 ( CHRNA4 ) and b2 ( CHRNB2 ) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease 显示文摘	Lynnette J Luk W Alison E	2004	Neurosci Lett2004，358，：	1
	3	The Hypothalamic-pituitary-adrenal axis in pregnancy: challenges in disease detection and treatment显示文摘	John R Lindsay J Lynnette KN	2005	Endonr Rev2005，26，6：	1
	4	Dietary fibres may protect or enhance carcinogenesis显示文摘	Philip J Harris Lynnette R Ferguson	1999	Mut.Res.-Genetic Toxicology and Environmental Mutagenesis1999，，1：	1
	5	Dietary fibre: Its composition and role in protection against coloreetal cancer 显示文摘	Philip J Harris Lynnette R Ferguson		Mutation Re search/Fundamental and Molecular Mechanisms of Mutagenesis0，290，1：	1
	6	Effects of two contrasting dietaryfibers on starch digestion,short-chain fatty acid production and transit time in rats显示文摘	Philip J Harris Clifford Tasman-Jones Lynnette R Ferguson	2000	Journal of the Science of Food and Agriculture2000，80，：	1
	7	Com- parative effects in rats of intact wheat bran and two wheat bran fractions on the disposition of the mutagen 2-amino-3-methylimid- azo quino-line 显示文摘	Lynnette R Ferguson Philip J Harris Philip Kestell	2011	Mut Res2011，716，：	1
	8	Estrogen replacement in perimenopause related depression:A Preliminary report显示文摘	Peter J Sshmidt MD Lynnette Nieman MD	2000	Am J Obstect Gynecal2000，183，2：	1
	9	Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat 显示文摘	Charles W Pemble Lynnette C Johnsonl Steven J Kridel	1998	Nature Structural & Molecular Biology1998，14，8：	1
	10	Estroge replacement inperimenopause related depression: a preliminary report 显示文摘	Peter J Scbmidt Lynnette Nieman	2010	Am J Obster Gynecal2010，183，2：	1
	11	Dietary fibre:Its composition and role in protection against colorectal cancer显示文摘	Philip J Harris Lynnette R Ferguson	1993	Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis1993，290，1：	1

返回顶部每页显示：

共1页首页上一页第1页下一页末页 /1 跳转

goolge学术搜索-维普

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费