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| 1 | Accuracy and responses of genomic selection on key traits in apple breeding显示文摘The application of genomic selection in fruit tree crops is expected to enhance breeding eficiency by increasing prediction accuracy,increasing selection intensity and decreasing generation interval.The objectives of this study were to assess the accuracy of prediction and selection response in commercial apple breeding programmes for key traits.The training population comprised 977 individuals derived from 20 pedigreed fllsib families.Historic phenotypic data were available on 10 traits related to productivity and fruit external appearance and genotypic data for 7829 SNPs obtained with an llumina 20K SNP array.From these data,a genome-wide prediction model was built and subsequently used to calculate genomic breeding values of five application fllsib families.The application families had genotypes at 364 SNPs from a dedicated 512 SNP array,and these genotypic data were extended to the high-density level by imputation.These five families were phenotyped for 1 year and their phenotypes were compared to the predicted breeding values.Accuracy of genomic prediction across the 10 traits reached a maximum value of 0.5 and had a median value of 0.19.The accuracies were strongly affected by the phenotypic distribution and heritability of traits.In the largest family,significant selection response was observed for traits with high heritability and symmetric phenotypic distribution.Traits that showed non-significant response often had reduced and skewed phenotypic variation or low heritability.Among the five application families the accuracies were uncorrelated to the degree of relatedness to the training population.The results underline the potential of genomic prediction to accelerate breeding progress in outbred fruit tree crops that still need to overcome long generation intervals and extensive phenotyping costs. | Hélène Muranty Michela Troggio Inès Ben Sadok Mehdi Al Rifaï Annemarie Auwerkerken Elisa Banchi Riccardo Velasco Piergiorgio Stevanato W.Eric van de Weg Mario Di Guardo Satish Kumar François Laurens Marco C.A.M.Bink | 2015 | Horticulture Research2015，2，1： | 14 |
| 2 | Fatty liver without a large“belly”:Magnified review of nonalcoholic fatty liver disease in non-obese patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is well described as a common cause of chronic liver disease, mostly in the obese population. It refers to a spectrum of chronic liver disease that starts with simple steatosis than progresses to nonalcoholic steatohepatitis and cirrhosis in patients without significant alcohol consumption. NAFLD in the non-obese population has been increasingly reported and studied recently. The pathogenesis of nonobese NAFLD is poorly understood and is related to genetic predisposition, most notably patatin-like phospholipase domain-containing 33 G allele polymorphism that leads to intrahepatic triglyceride accumulation and insulin resistance. Nonobese NAFLD is associated with components of metabolic syndrome and, especially, visceral obesity which seems to be an important etiological factor in this group. Dietary factors and, specifically, a high fructose diet seem to play a role. Cardiovascular events remain the main cause of mortality and morbidity in NAFLD, including in the nonobese population. There is not enough data regarding treatment in non-obese NAFLD patients, but similar to NAFLD in obese subjects, lifestyle changes that include dietary modification, physical activity, and weight loss remain the mainstay of treatment. | Mohamad H Yousef Alhareth Al Juboori Abdulmajeed A Albarrak Jamal A Ibdah Veysel Tahan | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，3： | 9 |
| 3 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 4 | 中心和外周动脉脉搏波传导速度测量的重复性:社区动脉粥样硬化风险研究显示文摘通过脉搏波传导速度(pulsewavevelocity,PwV)检测动脉硬化程度是当前对高血压和心血管病风险评估和分层所日渐常用的方式。颈股动脉脉搏波传导速度(catroidfemoralarteryPWV,cfPWV)是一项公认的测定中心动脉硬化程度的方式。 | Meyer ML Tanaka H Palta P Patel MD Camplain R Couper D Cheng S Al Qunaibet A Poon AK Heiss G 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，5： | 6 |
| 5 | Transradial approach for acute stroke intervention: technical procedure and clinical outcomes显示文摘background and purpose Radial artery catheterisation is an alternate route of access that has recently started to gain more widespread use for neuroendovascular procedures,including acute stroke intervention.In this small case series,we present our institution’s outcomes in patients undergoing acute stroke interventions via transradial access.Materials and methods We present a retrospective study of 15 patients who underwent acute stroke intervention via radial artery access.We analyse these patients’periprocedural and clinical outcomes after undergoing mechanical thrombectomy.results A total of 15 consecutive patients were included in the study(9 males and 6 females),and all patients were able to successfully undergo mechanical thrombectomy via radial artery access.The mean time of arterial puncture to reperfusion was 50±28 min(range:15-104).A TICI 2b/3 revascularisation was achieved in 13/15 patients(87%);a TICI 1 and TICI 2a outcome was achieved on the other two patients.One patient incurred an iatrogenic vessel dissection during the procedure.Eight of out 15 patients(53%)had favourable mRS(0-3)at the time of discharge from the hospital.Conclusion Radial artery catheterisation is technically feasible for performing acute stroke interventions with favourable time to revascularisation and good overall clinical outcomes. | Omaditya Khanna Nikolaos Mouchtouris Ahmad Sweid Nohra Chalouhi Ritam Ghosh Fadi Al Saiegh Michael R Gooch Stavropoula Tjoumakaris Robert H Rosenwasser Victor Romo Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 4 |
| 6 | Resurgence of Fentanyl as a Drug of Abuse显示文摘Fentanyl,a powerful opioid analgesic introduced over 50 years ago,has a major role in modern anesthesia and chronic pain relief but has also gained a major role in illicit use.After a spike in fentanyl abuse between 2005 and 2007,fentanyl deaths decreased until 2010,with the introduction of“abuse‑deterrent”OxyContin.Our data indicate a recent rise in fentanyl‑related deaths beginning in 2013,which follows national trends.With the re‑emergence of the synthetic narcotic analgesic of high potency as a popular drug of abuse and the alarmingly increasing mortality associated with its abuse,there are profound implications for public health,health care providers,law enforcement,and the society in general. | Lauren P Tamburro Jenan H Al‑Hadidi Ljubisa Jovan Dragovic | 2016 | Journal of Forensic Science and Medicine2016，2，2： | 3 |
| 7 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 3 |
| 8 | Defining the specific physiological requirements for c- Myc in T cell development显示文摘 | Douglas NC Jacobs H Bothwell AL | 2001 | Nat Immunol2001，2，4： | 2 |
| 9 | Purified hematopoietic stem cells can differentiate into hepatocytes in vivo显示文摘 | Lagasse E Connors H Al - Dhalimy M | | 0，，： | 2 |
| 10 | Platelet volume,ggregation and adenosine triphosphate release in cerebral thrombosis 显示文摘 | Toghi H uzuki H amura K t al | 1991 | Stroke1991，2，： | 2 |
| 11 | A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain Ⅱ of bikunin efficiently inhibits tumor cell invasion and metastasis显示文摘 | Kobayashi H Sugino D She MY ct al | 1998 | Eur J Biochem1998，253，3： | 2 |
| 12 | Factors affecting mortality in biliary tract surgery显示文摘 | Pitt H amero JL ostier RG t al | 1981 | Am J Surg1981，141，： | 2 |
| 13 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 2 |
| 14 | Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): an open-label randomised trial显示文摘 | Caroline AH Klazen Paul NM Lohle Jolanda de Vries Frits H Jansen Alexander V Tielbeek Marion C Blonk Alexander Venmans Willem Jan J van Rooij Marinus C Schoemaker Job R Juttmann Tjoen H Lo Harald JJ Verhaar Yolanda van der Graaf Kaspar J van Everdingen Al | 2010 | 2010 (9746)2010，，9746： | 2 |
| 15 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 16 | Rapid, high throughput prenatal detection ofaneuploidy using a novel quantitative method (MLPA) 显示文摘 | Slater H R Bruno D L Ren H at al | 2003 | J Med Genet2003，40，12： | 1 |
| 17 | Comparison of magnetic resonance and endoscopic retrograde cholangiopancreatography in malignant pancreaficobiliary obstruction显示文摘 | STEVE K LAWRENCE H WILLIAM R el al | 1999 | Arch Surg1999，134，： | 1 |
| 18 | The Strong Chromatic Index of Graphs显示文摘 | Fardree R J Schelp R H Gyfirrfis A at al | 1990 | Ars Co mbin1990，29，： | 1 |
| 19 | Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway显示文摘 | PENG H SHINTANI S KIM Y al | 2006 | Neoplasia2006，8，： | 1 |
| 20 | Short-term effects of intravitreal bevacizumab for subfoveal choroidal neovascularization in pathologic myopia 显示文摘 | Herndndez-Rojas ML Quiroz-Mercado H Dalma-Weiszhausz J et al | 2007 | Retina2007，27，6： | 1 |
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