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| 1 | 慢性丙型肝炎合并肾脏疾病的抗病毒治疗显示文摘丙型肝炎病毒(Hepatitis C virus infection,HCV)感染在肾脏疾病患者中并不少见,尤其是终末期肾病进行透析的患者中,感染率明显高于一般人群。两种疾病互相影响,导致疾病进展,影响患者生存质量。抗HCV治疗在我国现有治疗条件下仍以干扰素联合利巴韦林(ribavirin,RBV)为主要治疗方案,在肾功能不全患者不论干扰素还是RBV均需要进行剂量调整。未来直接抗病毒药物(direct antiviral drugs,DAAs)将是这类患者的主要治疗方案。现阶段HCV感染在终末期肾病和肾移植患者中的治疗仍面临挑战。 | 张琳 | 2016 | 中国实用内科杂志2016，36，3： | 2 |
| 2 | Kidney transplantation from donors with hepatitis C infection显示文摘The increasing demand for organ donors to supply the increasing number of patients on kidney waiting lists has led to most transplant centers developing protocols that allow safe utilization from donors with special clini cal situations which previously were regarded as contra indications.Deceased donors with previous hepatitis C infection may represent a safe resource to expand the donor pool.When allocated to serology-matched recipi ents,kidney transplantation from donors with hepatitis C may result in an excellent short-term outcome and a significant reduction of time on the waiting list.Specia care must be dedicated to the pre-transplant evaluation of potential candidates,particularly with regard to live functionality and evidence of liver histological damage such as cirrhosis,that could be a contraindication to transplantation.Pre-transplant antiviral therapy could be useful to reduce the viral load and to improve the long-term results,which may be affected by the progression of liver disease in the recipients.An accurate selection of both donor and recipient is mandatory to achieve a satisfactory long-term outcome. | Massimiliano Veroux Daniela Corona Nunziata Sinagra Alessia Giaquinta Domenico Zerbo Burcin Ekser Giuseppe Giuffrida Pietro Caglià Riccardo Gula Vincenzo Ardita Pierfrancesco Veroux | 2014 | World Journal of Gastroenterology2014，20，11： | 1 |
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