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| 1 | 某些剧毒有机废料在高温至超临界水中的处理实验显示文摘为了探索毒害有机废料的处理条件和反应机制,用二氨基乙二肟,氨基氰和蜜胺作初始试料,在温度150—400℃,压力100—700×105Pa的条件下进行了水热实验研究,部分密胺实验还添加了H2O2.实验结果表明,在水热条件下,尤其在超临界水中,二氨基乙二肟和氨基氰既可以通过热解作用而聚合成较高分子量的氮杂环混合物,进而水解转化成CO2和NH3,也可以直接发生水解作用,生成CO2和NH3.添加氧化剂可以大大提高对高热稳定性的有机废料如密胺的处理速度.水解反应的可能机制是水的亲核加合. | 李统锦 Brill,TB | 1998 | 环境科学1998，19，4： | 19 |
| 2 | 靶向Jak/Stat通路作为Akt/β-联蛋白诱导的肝细胞癌SP/CD44+肿瘤细胞的治疗策略显示文摘【据《J Hepatol》2019年9月报道】题:靶向Jak/Stat通路作为Akt/β-联蛋白诱导的肝细胞癌SP/CD44+肿瘤细胞的治疗策略(作者Toh TB等)肝切除和肝移植以及辅助放化疗是肝细胞癌(HCC)治疗的主要手段。由于其频繁复发和肝内转移,HCC患者5年生存率仍然很差。目前仅索拉非尼和仑伐替尼被批准用于晚期、非切除的HCC的一线治疗,但其生存获益有限。因此需要确定新的治疗靶点以改进目前HCC治疗方式。 | 丁梦梦 高沿航 TOH TB LIM JJ HOOI L | 2020 | 临床肝胆病杂志2020，36，3： | 16 |
| 3 | Purification of melibiose-binding lectins from two cultivars of Chinese black soybeans显示文摘一二聚 50 kDa melibiose 有约束力的 lectin 从大豆(Glycine 最大) 的栽培变种的种子被孤立,叫了小光滑的黑大豆。隔离过程在胶化过滤在 Superdex 75 上跟随的 Q Sepharose, SP Sepharose 和单音的 Q 上包括了离子交换层析。lectin 在所有三离子 exchangers 上被吸附,并且它展出了与大豆 lectin 的相同的一个 N 终端序列。测试的所有糖, melibiose 最 potently 禁止了 lectin 的 hemagglutinating 活动,它在 pH 3-12 和 0-70 ° C 之间是稳定的。lectin 唤起了最大的 mitogenic 反应在大约象反对 A 的一样的臼齿的集中。然而,反应弱得多。大豆 lectin 分别地与 2.82 μM, 2.6 μM 和 4.1 μM 的 IC 50 象乳癌 MCF7 房间和 hepatoma HepG2 房间的增长一样禁止了 HIV-1 反向的 transcriptase 的活动。没有抗真菌的活动。另一 lectin 从称为很少黑大豆的大豆的不同栽培变种被孤立。lectin 除了一个更大的子单元实质上类似于小光滑的黑大豆 lectin 分子的质量(31 kDa ) ,一项更多的有势力 mitogenic 活动和更低的 thermostability。结果显示大豆的不同栽培变种生产不在每个方面是相同的 lectins。 | Peng Lin Xiujuan Ye TB Ng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，12： | 7 |
| 4 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 5 | SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS显示文摘SYNTHESIS OF N-ARYL-4-METHYLPHENOXYACETAMIDES BY MEANS OF LIQUID-LIQUID PHASE TRANSFER CATALYSIS￥TaiBaoWEI;JiChouCHEN;YouMing... | Wei, TB Chen, JC Zhang, YM Wang, LL | 1995 | Chinese Chemical Letters1995，6，3： | 4 |
| 6 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 3 |
| 7 | Effects of soy isoflavones on atherosclerosis:potential mechanisms显示文摘 | Anthony MS Clarkson TB Williams JK | 1998 | Am J Clin Nutr1998，68，6： | 2 |
| 8 | 年龄和靶器官损害对24h动态血压预后价值的影响显示文摘靶器官损害标志物和测量24h动态血压可以改善心血管风险分层。随着年龄的增长,靶器官损害和血压升高的发病率增加。该研究目的是评估年龄和靶器官损害对动态血压预测预后价值的影响。 | 黄洁 叶鹏 Olesen TB Stidsen JV Blicher MK Pareek M Rasmussen S Vishram-Nielsen JKK Olsen MH | 2017 | 中华高血压杂志2017，25，10： | 2 |
| 9 | A case-control study of riskfactors of nasopharyngeal carcinoma显示文摘 | Chen DL Huang TB | 1997 | Cancer Lett1997，117，： | 2 |
| 10 | Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis显示文摘 | V Arroyo P Gines AL Gerbes FJ Dudley P Gentilini G Laffi TB Reynolds H Ring-Larsen J Scholmerich | 1996 | Hepatology1996，，1： | 2 |
| 11 | Transplanted fetal striatum in Huntington's disease:phenotypic development and lack of pathology显示文摘 | Freeman TB Cicchettif Hauser RA | 2000 | Proc Natl Acad Sci USA2000，97，13： | 1 |
| 12 | Reduced dopamine transporter binding in patients with juvenile myoclonic epilepsy 显示文摘 | Ciumas C Wahlin TB Jucaite A | 2008 | Neurology2008，71，11： | 1 |
| 13 | A case of cortical vein thrombosis with the cord sign显示文摘 | Ahn TB Roh JK | 2003 | Arch Neurol2003，60，： | 1 |
| 14 | Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study显示文摘 | Nieto F J Young TB Lind BK Shahar E Samet JM Redline S D’ Agostino RB Newman AB Lebowitz MD Picketing TG | 2000 | JAMA2000，283，： | 1 |
| 15 | Prolactin levels in schizophrenia and sehizoaffective disorder patients treated with elozapine, olanzapine, risperidone, or haloperidol显示文摘 | Volavka J Czobor P Cooper TB | 2004 | J Clin Psychiatry2004，65，1： | 1 |
| 16 | Protective effect of L-camitine on renal ischaemia - reperfusion injury in the rat 显示文摘 | Sadik G Ozlen TB Gurbuz P | 2005 | Cell Biochem Funct2005，23，3： | 1 |
| 17 | An eight-year study of epidemiologic features of enterovims 71 infection in Taiwan显示文摘 | Chen SO Chang HL Yan TB | 2007 | Am J Trop Med Hyg2007，77，1： | 1 |
| 18 | A xylanase from roots of sanchi ginseng( Partax notoginseng) wigh inhibitory effects on human immynodeficiency Virus-1 reverse transcriptase 显示文摘 | Lam SK Ng TB | 2002 | Life Sci2002，70，25： | 1 |
| 19 | Anesthesia for intraoperative neurophysiologic monitoring ofthe spinal cord显示文摘 | Sloan TB Heyer EJ | 2002 | J Clin Neurophysiol2002，19，5： | 1 |
| 20 | A distinctive clinical EEG profile in herpes simplex encephalitis显示文摘 | SMITH TB WESTMORELAND BF REAGAN TJ | 1975 | Mayo Clinic Proc1975，50，： | 1 |
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