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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Animal models of migraine:looking at the component parts of a complex disorder显示文摘 | Bergerot A Holland PR Akerman S | 2006 | Eur J Neurosci2006，24，： | 1 |
| 3 | Pyramidal techniques for multi-sensor fusion 显示文摘 | Akerman A | 1992 | Senor Fu- sion1992，，： | 1 |
| 4 | Pyram idal techniques formulti-sensor fusion显示文摘 | Akerman A | 1992 | SPIE1992，1828，： | 1 |
| 5 | Isolation of a cDNA encoding human holocarboxylase synthetase by functional complementation of a biotin auxotroph of Escherichia coli显示文摘 | LEON-DEL-RIO A LECLERC D AKERMAN B | 1995 | Proceedings of the National Academy of Sciences USA1995，92，10： | 1 |
| 6 | The splicing fac- tor SRSF1 regulates apoptosis and proliferation to promote mam- mary epithelial cell transformation显示文摘 | Anczukow O Rosenberg A Z Akerman M | 2012 | Nat Struct Mol Biol2012，19，2： | 1 |
| 7 | Pyramidal techniques for multisensor fusion 显示文摘 | AKERMAN A | 1992 | Proc SPIE1992，1828，： | 1 |
| 8 | Ezrin expression predicts loal recurrence and development of metastases in soft tissue sarcomas 显示文摘 | Carneiro A Bendahl PO Akerman M | 2011 | J Clin Pathol2011，64，8： | 1 |
| 9 | Blood vessel maturation and response to vascular-disrupting therapy in single vascular endothelial growth factor-A isoform-producing tumors显示文摘 | Tozer G M Akerman S Cross N A | 2008 | Cancer Res2008，68，： | 1 |
| 10 | In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene显示文摘 | Lambert D M Mamer O A Akerman B R | 2001 | Mol Genet Metab2001，73，3： | 1 |
| 11 | Gene expression profiles and genetic damage in benzo(a) pyrene diol epoxide-exposed TK6 cells 显示文摘 | AKERMAN G S OSENZWEIG B A DOMON O E | 2004 | Mutat Res2004，549，： | 1 |
| 12 | Studies on the absorption,distribution and metabolism of labelled prilocaine and lidocaine in some animal species显示文摘 | AKERMAN B ASTROM A ROSS S | 1966 | Acta Pharmacol Toxicol1966，24，4： | 1 |
| 13 | Pyramidal techniques for multi - soasor fusion显示文摘 | Akerman A | 1992 | Proc SPIE1992，1828，12： | 1 |
| 14 | Isolation of a cDNA encoding human holocarboxylase synthethase by functional comple mentation of a biotin auxotroph of Escherichia coli显示文摘 | Leorr Del- Rio A Leclerc D Akerman B | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 15 | Estimation of the probabilities of 3D clusters in functional brain images显示文摘 | Ledberg A Akerman S Roland PE | 1998 | Neuroimage1998，8，： | 1 |
| 16 | Clinical experience and incidence of ventilator - associated pneumonia using closed versus open suction - system 显示文摘 | Akerman E Larsson C Ersson A | 2014 | Nurs Crit Care2014，19，1： | 1 |
| 17 | Architecture Decisions:Demystifying Architecture显示文摘 | Tyree J Akerman A | 2005 | IEEE Software2005，22，2： | 1 |
| 18 | Postharvest retention of the red colour of litchi fruit pericarp显示文摘 | Zauberman G Ronen R Akerman M Weksler A Rot I Fuchs Y | | 0，，： | 1 |
| 19 | Estimation of the probabilities of 3D clusters in functional brain images显示文摘 | Ledberg A Akerman S Roland PE | 1998 | Neuroimage1998，8，2： | 1 |
| 20 | Architecture decisions: demystifying architecture显示文摘 | Tyree J Akerman A | 2005 | IEEE Software2005，22，2： | 1 |
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