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| 1 | Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease. | Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy | 2017 | World Journal of Gastroenterology2017，23，15： | 2 |
| 2 | Distinct mechanisms of action of anti - CD154 in early versus late treatment of murine lupus nephritis 显示文摘 | Quezada SA Eekert M Adeyi OA | 2003 | Arthritis Rheum2003，48，9： | 1 |
| 3 | Normothermic Acellular Ex Vivo Liver Perfusion Reduces Liver and Bile Duct Injury of Pig Livers Retrieved After Cardiac Death显示文摘 | M. U. Boehnert J. C. Yeung F. Bazerbachi J. M. Knaak N. Selzner I. D. McGilvray O. D. Rotstein O. A. Adeyi S. M. Kandel P. Rogalla P. M. Yip G. A. Levy S. Keshavjee D. R. Grant M. Selzner | 2013 | American Journal of Transplantation2013，，6： | 1 |
| 4 | Liver biopsy interpretation for causes of late liver allograft dysfunction显示文摘 | Banff Working Group Demetris AJ Adeyi O | 2006 | Hepatology2006，44，2： | 1 |
| 5 | CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance显示文摘 | Jarvinen L Z Blazar B R Adeyi O A | | 0，，09： | 1 |
| 6 | Antiviral Treatment of Recurrent Hepatitis C After Liver Transplantation: Predictors of Response and Long-Term Outcome显示文摘 | Nazia Selzner Eberhard L. Renner Markus Selzner Oyedele Adeyi Arash Kashfi George Therapondos Nigel Girgrah Chaturika Herath Gary A. Levy Leslie Lilly | 2009 | Transplantation2009，，10： | 1 |
| 7 | Rotavirus infection in adult small intestine allografts:a clinicopatho-logical study of a cohort of 23 patients显示文摘 | Adeyi OA Costa G Abu-Elmagd KM | 2010 | Am J Transplant2010，10，12： | 1 |
| 8 | Liver biopsy interpretation for causes of late liver allograft dysfunction显示文摘 | Banff Working Group Demetris AJ Adeyi O | 2006 | Hepatology2006，44，2： | 1 |
| 9 | FGL2/fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apop- tosis in mice显示文摘 | Selzner N Liu H Boehnert MU Adeyi OA Shalev I Bartczak AM | 2012 | J Hepatol2012，56，1： | 1 |
| 10 | Distinct mechanisms of action of anti - CD154 in early versus late treatment of murine lupus nephritis 显示文摘 | Quezada SA Eckert M Adeyi OA | 2003 | Arthritis Rheum2003，48，9： | 1 |
| 11 | The novel immunoregulatory molecule FGL2: A potential biomarker for severity of chronic hepatitis C virus infection显示文摘 | Katharina Foerster Ahmed Helmy Yi Zhu Ramzi Khattar Oyedele A. Adeyi Kit Man Wong Itay Shalev David A. Clark Pui-Yuen Wong Elizabeth J. Heathcote Melville J. Phillips David R. Grant Eberhard L. Renner Gary A. Levy Nazia Selzner | 2010 | Journal of Hepatology2010，，4： | 1 |
| 12 | FGL2/Fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice显示文摘 | Nazia Selzner Hao Liu Markus U. Boehnert Oyedele A. Adeyi Itay Shalev Agata M. Bartczak Max Xue-Zhong Justin Manuel Ori D. Rotstein Ian D. McGilvray David R. Grant Melville J. Phillips Gary A. Levy Markus Selzner | 2011 | Journal of Hepatology2011，，1： | 1 |
| 13 | Pathology Services in Developing Countries-The West African Experience显示文摘 | Adeyi Oyedele A | 2011 | Archives of Pathology & Laboratory Medicine2011，，： | 1 |
| 14 | Liver biopsy interpretation for causes of late liver allograft dysfunction 显示文摘 | Demetris AJ Adeyi O Bellamy CO | 2006 | Hepatology2006，44，2： | 1 |
| 15 | Human solid tumor xenografts in immunodeficient mice are vulnerable to lymphomagenesis associated with Epstein-Barr virus 显示文摘 | Chen K Ahmed S Adeyi O | 2012 | PLoS One2012，7，39： | 1 |
| 16 | Importance of river biopsy findings in immunosuppression management: biop- sy monitoring and working criteria for patients with operational tolerance显示文摘 | ADEYI O ALEXANDER G BAIOCCHI L | 2012 | Liver Transpl2012，18，10： | 1 |
| 17 | Serum analysis after transplant nephrectomy reveals restricted antibody specificity patterns against structurally defined HLA class I mismatches 显示文摘 | Adeyi O A Girnita A L Howe J | 2005 | Transpl Immunol2005，14，1： | 1 |
| 18 | Induction and activity of glutathione S-transferases extracted from Zonoeerus variegatus (Orthoptera: Pyrgomorphidae) exposed to insecticides显示文摘 | ADEYI A O AKOZI G O ADELEKE M A | 2015 | Int J Trop Insect Sci2015，35，1： | 1 |
| 19 | Performance Evaluation of a Maize Cob Thresher显示文摘Threshing is one of the most critical parts of post-harvest operation which affects the quality and quantity of maize production.It could be done manually or mechanically.However,the objective of this study was to evaluate the performance of a maize cob thresher fabricated at National Centre for Agricultural Mechanization(NCAM)Ilorin at three different moisture contents and analyze the result using ANOVA and bar chart as statistical tools.The average values of parameters evaluated at three different stages of moisture content(15.81%,16.79%and 17.10%)of maize cob are as follow:threshing capacity 754.20,737.38 and 720.23 kg/h;threshing efficiency 99.73%,99.63%and 99.16%;cleaning efficiency 89.82%,89.45%and 88.34%;broken grains ratio 0.84%,0.79%and 0.70%;time taken 43,44 and 45 s,respectively.The total amount of maize cob fed into the machine was 9 kg in three replicates for each of the moisture content and the average values of threshed maize of 8.08,8.05 and 7.95 kg was recovered,respectively.There was significant difference in threshing efficiency,amount of chaffs in the threshed maize and the percentage broken ration.At 17.10%moisture content,the percentage broken grain ratio was minimal.At high moisture content,more force,energy and time is required to thresh certain amount of maize cob.Also,at minimal moisture content less force and energy is required for maximum output.Therefore,considering the previous work on performance evaluation of maize cob thresher,this machine performed satisfactorily and is far better than manual method.The machine is effective,efficient,affordable and available for the small and medium scale farmers in Nigeria. | Adeyi Abdulrasaq Mashood Willoughby Fouad Ayinde Shehu Muhammed Yusuf Ola Olalekan Abiola Faleye Tope | 2019 | Journal of Agricultural Science and Technology(A)2019，9，1： | 0 |
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