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| 1 | Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis显示文摘 | Pierre-Alain Clavien M.D. Ph.D. F.A.C.S. Koo Jeong Kang M.D. Nazia Selzner M.D. Michael A. Morse M.D. Paul V. Suhocki M.D | 2002 | Journal of Gastrointestinal Surgery2002，，1： | 4 |
| 2 | Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease. | Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy | 2017 | World Journal of Gastroenterology2017，23，15： | 2 |
| 3 | 一氧化碳通过调节CD36表面表达控制小胶质细胞的红细胞吞噬作用减轻出血性损伤显示文摘小胶质细胞的红细胞吞噬作用在出血性卒中后的损伤反应中至关重要。我们假设通过HO-1/CO调节小胶质细胞的红细胞吞噬作用依赖于涉及活性氧(ROS)和CD36表面表达的信号通路。我们在有/无血液和有/无一氧化碳(CO)暴露条件下孵育小胶质细胞BV-2细胞系和原代小胶质细胞(PMG)。我们用从组织特异性HO-1缺陷(LyzM-Cre-Hmoxlfl/fl)和CD36-/-小鼠中分离出的PMG,或针对AMPK(AMP激活的蛋白激酶)的siRNA来检验我们的假设。在鼠蛛网膜下腔出血(SAH)模型中,我们比较了野生型和CD36-/-小鼠的神经元损伤。观察指标包括血管痉挛、小胶质细胞活化、神经元凋亡和空间记忆。我们观察到在血液暴露后,小胶质细胞HO-1表达增加。CO暴露后,ROS产生显著增加,导致磷酸化的AMPK数量增加,随后CD36表面表达增强。来自LyzM-CreHmoxlfl/fl小鼠的PMG表现出ROS产生和CD36表面表达均降低,并且CO不能诱导其CD36表面表达增加。缺乏HO-1和CD36导致的红细胞吞噬作用降低无法用CO逆转。在存在外源性CO的情况下,BV-2细胞的红细胞吞噬作用增强,而在经AMPK的siRNA处理的细胞中没有发现该现象。经历SAH的CD36-/-小鼠神经元细胞死亡增加,空间记忆功能受损。我们证明,小胶质细胞的吞噬功能部分与HO-1相关通路有关,该通路涉及ROS产生、磷酸化的AMPK和CD36的表面表达的变化。CD36为出血后血液清除的关键因子之一,与神经元的预后密切相关。这些结果需要进一步研究以明确CO潜在的神经保护特性。 | Sandra Kaiser Lisa Selzner JanickWeber Nils Schallner 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，6： | 2 |
| 4 | Fatty Liver in Liver Transplantation and Surgery显示文摘 | Markus Selzner Pierre-Alain Clavien | 2001 | Semin Liver Dis2001，，01： | 2 |
| 5 | Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism显示文摘 | Nazia Selzner Markus Selzner Wolfram Jochum Pierre-Alain Clavien | 2003 | Journal of Hepatology2003，，1： | 2 |
| 6 | Virological response for recurrent hepatitis C improves long‐term survival in liver transplant recipients显示文摘 | Tomohiro Tanaka Nazia Selzner George Therapondos Eberhard L. Renner Leslie B. Lilly | 2012 | Transplant International2012，，1： | 1 |
| 7 | Induction of apoptotic cell death and pre- vention of tumor growth by ceramide analogues in metastatic human colon cancer显示文摘 | Selzner M Bielawska A Morse M A Radiger H A Sindram D Hannun Y A | 2001 | Cancer Res2001，61，： | 1 |
| 8 | Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver显示文摘 | Kohli V Selzner M Madden JF | 1999 | Transplantation1999，67，8： | 1 |
| 9 | Transgenic mice overexpressing human Bcl-2 are resistant to hepatic ischemia and reperfusion 显示文摘 | Selzner M Rudiger HA Selzner N | 2002 | J Hepatol2002，36，2： | 1 |
| 10 | Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis显示文摘 | Selzner N Selzner M Jochum W | 2006 | J Hepatol2006，44，4： | 1 |
| 11 | Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver显示文摘 | Kohli V Selzner M Madden J F | 1999 | Transplantation1999，67，12： | 1 |
| 12 | Protective strategies against ischemic injury of the liver 显示文摘 | Selzner N Rudiger H Graf R | 2003 | Gastroenterology2003，125，： | 1 |
| 13 | A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning显示文摘 | Clavien PA Selzner M Rudiger Ha | 2003 | Ann Surg2003，238，6： | 1 |
| 14 | Increased ischemic iniury in old mouse liver: an ATP dependent mechanism 显示文摘 | SELZNER M SELZNER N JOCHUM W | 2007 | Liver Transpl2007，13，3： | 1 |
| 15 | Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis显示文摘 | SELZNER N SELZNER M JOCHUM W | 2006 | J Hepatol2006，44，4： | 1 |
| 16 | Immune-mediated complications of the graft in interferon-treated hepatitis C positive liver transplant recipients 显示文摘 | Selzner N Guindi M Renner EL | 2011 | J Hepatol2011，55，1： | 1 |
| 17 | Antiviral treatment of Recurrent Hepatitis C After Liver Transplantation: Predic- tors of Response and Long TermOutcome 显示文摘 | Selzner N Renner E L Selzner M | 2009 | Transplanta- tion2009，88，10： | 1 |
| 18 | How should transection of the liver be performed? A prospective randomized study in 100 consecutive patients:comparing four different transection strategies显示文摘 | Lesurtel M Selzner M Petmwsky H | | 0，，06： | 1 |
| 19 | How should transection of the liver be performed? A prospective randomized study in 100 consecutive patients:comparing four different transection strategies显示文摘 | Lesurtel M Selzner M Petrowsky H | 2005 | Ann Surg2005，242，6： | 1 |
| 20 | Liver metastases from breast cancer: long-term survival after curative resection 显示文摘 | Selzner M Morse MA Vredenburgh J J | 2000 | Surgery2000，127，4： | 1 |
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