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		题名	作者	年代	出处	被引量
	1	Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis显示文摘AIM To determine the effect of overexpression of fibrinogenlike protein 2(FGL2) on regulatory T cell(Treg) and effector T(Teff) cell function on T cell-induced colitis in Rag1-/-mice.METHODS Treg and Teff cells from fgl2-/-, fgl2+/+, and fgl2 Tg mice were purified by FACS. They were studied in vitro for immunosuppressive activity and cell proliferation and in vivo for their effects on the development and prevention of T cell-induced colitis in Rag1-/-mice. RESULTS In vitro, fgl2 Tg Treg had enhanced immunosuppressive activity, and fgl2 Tg Teff had reduced proliferation to alloantigen stimulation. Transfer of Teff from C57Bl/6J mice(fgl2+/+) into Rag1-/-mice produced both clinical and histologic colitis with dense infiltrates of CD3+ T cells, crypt abscesses and loss of goblet cells. Fgl2 Tg Treg prevented the development of T cell-induced colitis, whereas fgl2+/+ and fgl2-/-Treg were only partially protective. In mice that received fgl2 Tg Treg, the ratio of Foxp3+ to CD3+ cells was increased both in the colon and in mesenteric lymph nodes, and Teff cell proliferation as determined by staining with Ki67 was reduced. Teff cells from fgl2 Tg mice did not produce colitis. CONCLUSION Here we show that fgl2 Tg Teff are hypoproliferative and do not induce colitis. We further demonstrate that fgl2 Tg Treg prevent colitis in contrast to fgl2+/+ Treg, which were only partially protective. These studies collectively provide a rationale for exploring the use of FGL2 or Treg expressing high levels of FGL2 in the treatment of inflammatory bowel disease.	Agata Bartczak Jianhua Zhang Oyedele Adeyi Achiya Amir David Grant Reginald Gorczynski Nazia Selzner Andrzej Chruscinski Gary A Levy	2017	World Journal of Gastroenterology2017，23，15：	2
	2	Antiviral Treatment of Recurrent Hepatitis C After Liver Transplantation: Predictors of Response and Long-Term Outcome显示文摘	Nazia Selzner Eberhard L. Renner Markus Selzner Oyedele Adeyi Arash Kashfi George Therapondos Nigel Girgrah Chaturika Herath Gary A. Levy Leslie Lilly	2009	Transplantation2009，，10：	1
	3	The novel immunoregulatory molecule FGL2: A potential biomarker for severity of chronic hepatitis C virus infection显示文摘	Katharina Foerster Ahmed Helmy Yi Zhu Ramzi Khattar Oyedele A. Adeyi Kit Man Wong Itay Shalev David A. Clark Pui-Yuen Wong Elizabeth J. Heathcote Melville J. Phillips David R. Grant Eberhard L. Renner Gary A. Levy Nazia Selzner	2010	Journal of Hepatology2010，，4：	1
	4	FGL2/Fibroleukin mediates hepatic reperfusion injury by induction of sinusoidal endothelial cell and hepatocyte apoptosis in mice显示文摘	Nazia Selzner Hao Liu Markus U. Boehnert Oyedele A. Adeyi Itay Shalev Agata M. Bartczak Max Xue-Zhong Justin Manuel Ori D. Rotstein Ian D. McGilvray David R. Grant Melville J. Phillips Gary A. Levy Markus Selzner	2011	Journal of Hepatology2011，，1：	1
	5	Pathology Services in Developing Countries-The West African Experience显示文摘	Adeyi Oyedele A	2011	Archives of Pathology & Laboratory Medicine2011，，：	1

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