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| 1 | Toll样受体参与小鼠肝脏缺血再灌注损伤显示文摘目的 探讨Toll样受体是否参与小鼠肝脏缺血再灌注损伤及其机制。方法 用Toll样受体缺损小鼠(C3H/Hej,Hej组)和野生型(C3H/Heouj,Heouj组)小鼠复制部分肝脏缺血再灌注损伤模型,于缺血45min,再灌注1h和3h处死动物,检测血清天门冬氨酸氨基转移酶(AST)和血清肿瘤坏死因子α(TNFα)的含量;并以northern blot及髓过氧化物酶(MPO)试验分别检测缺血肝组织TNFα mRNA的表达和MPO的含量。结果(1)再灌注1、3h,与假手术组相比,小鼠血浆AST明显升高,但Hej组明显低于Heouj组(661.83U/L±106.09U/L和1215.5U/L±174.03U/L,t=-6.65,P<0.01;1145.17U/L±132.43U/L和2958.17U/L±186.81U/L,t=-5.57,P<0.01);(2)再灌注3h时,与假手术组相比,Hej组和Heouj组小鼠血清TNFα浓度明显升高,且前者明显低于后者(152.39pg/ml±43.3pg/ml和249.12pg/ml±51.89pg/ml,t=-3.13,P<0.05);(3)再灌注1h,除假手术组外,Hej组和Heouj组小鼠缺血肝组织内可见TNFα mRNA的表达,但前者的表达水平明显低于后者,杂交带密度分析显示两者之间差异有显著性(80.3±28.8与189.4±24.6,t=-3.25,P<0.05);(4)再灌注3h,与假手术组相比,Hej组和Heouj组小鼠缺血肝组织内MPO含量明显升高,且前者含量明显低于后者(0.059±0.004和0.173±0.025,F=33.49,P<0.01)。结? | 吴河水 王琳 田元 Ori Rotstein | 2003 | 中华肝脏病杂志2003，11，7： | 14 |
| 2 | Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice显示文摘BACKGROUND: Toll-like receptor 4 (TLR4) is involved in innate immunity by recognizing endotoxin resulting in a burst of inflammatory cascade. We investigated the relation between activation of TLR4 and liver injury in partial hepa- tic ischemia/reperfusion (I/R) injury in mice. METHODS: TLR4-deficient mice ( C3H/Hej) and wild type mice (WT, C3H/Heouj) were used in the model of I/R injury. Partial hepatic ischemia was produced by oc- clusion of inflow to the median and left lobes for 45 mi- nutes. Blood was drawn at 1 and 3 hours after reperfusion. The blood was analyzed for aspartate aminotransferase (AST) and tumor necrosis factor alpha (TNF-α). TNF-α mRNA expression and myeloperoxidase (MPO) level in the ischemic lobes were examined by northern blot and myeloperoxidase assay respectively. RESULTS: AST levels were significantly decreased in TLR4- deficient mice compared with WT mice at both time points (WT: 1215.5 ±174. 03, 2958. 17 ± 186. 81 IU/L at 1 and 3 hours respectively vs TLR4def: 661.83±106.09, 1145.17± 132.43 IU/L at 1 and 3 hours, mean ± SD, 6 mice/group, (=-6.65 and -5.57, P <0.001). Consistent with the role of TNF-α in hepatic I/R, serum TNF-α was decreased in TLR4 deficient mice at 3 hours after reperfusion compared with WT (152.39±43.3 vs 249.12 ± 51.89, n=6, t=-3.13, P<0.05). MPO level in the ischemic lobes in TLR4 defi- cient mice at 3 hours after reperfusion was significantly low- er than that in WT mice (0.059±0.004 vs 0.173±0.025, n=6, F=33.49, P<0.001). This difference appears to be mediated at the gene level since TLR4 deficient mice had decreased TNF-α mRNA expression at 1 hour after reperfu- sion compared with WT mice (80.3±28.8 vs 189.4±24.6, t=-3.25, P<0.05). CONCLUSIONS: Compared with WT mice, TLR4-defi- cient mice appear to have a mild I/R injury. Regulation of TNF-a at mRNA level seems to have a critical effect. These suggest TLR4 be involved in the mechanism of he-patic I/R injury in mice. | Ori Rotstein | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 9 |
| 3 | Effect of acid etching on marginal adaptation of mineral trioxide aggregate to apical dentin:microcomputed tomography and scanning electron microscopy analysis显示文摘The present investigation assessed the effect of acid etching on marginal adaptation of white- and gray-colored mineral trioxide aggregate (MTA) to apical dentin using microcomputed tomography (micro-CT) and scanning electron microscopy (SEM). Sixty-four extracted single-rooted human maxillary teeth were used. Following root-end resection and apical preparation, the teeth were equally divided into four groups according to the following root end filling materials: (i) white-colored MTA (WMTA), (ii) etched WMTA (EWMTA), (iii) gray-colored MTA (GMTA) and (iv) etched GMTA (EGMTA). After 48 h, the interface between root-end filling materials and the dentinal walls was assessed using micro-CT and SEM. Data were statistically analyzed using the Kruskal-Wallis and Dunn tests. Micro-CT analysis revealed gap volumes between the apical cavity dentin walls and EGMTA, GMTA, EWMTA and WMTA of (0.007 160.004) mm 3 , (0.05360.002) mm 3 , (0.003 660.001) mm 3 and (0.005 960.002) mm 3 respectively. SEM analysis revealed gap sizes for EGMTA, WMTA, EWMTA and GMTA to be (492.3613.8) mm, (594.5617.12) mm, (543.1615.33) mm and (910.7626.2) mm respectively. A significant difference in gap size between root end preparations filled with GMTA and EGMTA was found (P,0.05). No significance difference in gap size between WMTA and EWMTA were found in either SEM or micro-CT analysis. In conclusion, pre-etching of apical dentin can provide a better seal for GMTA but not for WMTA. | Khalid Al-Fouzan Ziad Al-Garawi Khalid Al-Hezaimi Fawad Javed Thakib Al-Shalan Ilan Rotstein | 2012 | International Journal of Oral Science2012，4，4： | 3 |
| 4 | Remote Ischemic Preconditioning by Hindlimb Occlusion Prevents Liver Ischemic/Reperfusion Injury: The Role of High Mobility Group-Box 1显示文摘 | Feng Wang Simone E. Birch Ruijan He Patrick Tawadros Katalin Szaszi Andras Kapus Ori D. Rotstein | 2010 | Annals of Surgery2010，，2： | 2 |
| 5 | Strategic supply chain optimization for the pharmaceutical industries显示文摘 | Lazaros G Papageorgiou Guillermo E Rotstein Nilay Shah | 2001 | Ind Eng Chem Res2001，40，1： | 2 |
| 6 | Hypertonic resuscitation of hemorrhagic shock prevents alveolar macrophage activation by preventing systemic oxidative stress due to gut ischemia/reperfusion显示文摘 | K.A. Powers J. Zurawska K. Szaszi R.G. Khadaroo A. Kapus O.D. Rotstein | 2005 | Surgery2005，，1： | 2 |
| 7 | Computer-assisted evoked electromyography with stimulating surgical instruments for recurrent/external laryngeal nerve identification and preservation in thyroid and parathyroid operation 显示文摘 | I)ackiw AP Rotstein LE Clark OH | 2002 | Surgery2002，132，6： | 1 |
| 8 | Single-Input-Single-Output H∞ Control with Time Domain Constrains 显示文摘 | SIDERIS A ROTSTEIN H | 1993 | Automatica1993，29，4： | 1 |
| 9 | ALLOGENEIC AND XENOGENEIC HEPATOCYTE TRANSPLANTATION IN EXPERIMENTAL HEPATIC FAILURE显示文摘 | LEONARD MAKOWKA LORNE E. ROTSTEIN RUDOLPH E. FALK JUDITH A. FALK NATALIE A. NOSSAL BERNARD LANGER LAURENCE M. BLENDIS M. JAMES PHILLIPS | 1980 | Transplantation1980，，6： | 1 |
| 10 | Bactericidal and cytotoxic effects of sodium hypochlorite and sodium dichloroisocyanurate solutions iv vitro 显示文摘 | Heling I Rotstein I Dinur T | 2001 | J Endod2001，27，4： | 1 |
| 11 | Ultrasound characteristics of histologically proven grade 3 invasive duetal breast carcinoma显示文摘 | Rotstein AH Neerhut PK | 2005 | Australas Radiol2005，49，6： | 1 |
| 12 | Regional versus systemic cherno-therapy in the treat ment of colonectal carcinoma metastatic to the liver:is there a survival difference meta analysis of the published literature 显示文摘 | Harnmas A Rotstein LE Langer B | 1996 | Cancer1996，78，8： | 1 |
| 13 | Oxidants and antioxidant therapy显示文摘 | Rotstein OD | 2001 | Crit Care Clin2001，17，： | 1 |
| 14 | Micafungin versus caspo- fungin for treatment of candidemia and other forms of invasive candi diasis 显示文摘 | Pappas PG Rotstein CM Betts RF | 2007 | Clin Infect Dis2007，45，7： | 1 |
| 15 | Shrinkage,porosityand bulk density of foodstuffs at changing moisture contents 显示文摘 | Lozano J E Rotstein E Urbicain M J | 1983 | Food Science1983，48，： | 1 |
| 16 | Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults显示文摘 | Rotstein C Evans G Born A | 2008 | Can J Infect Dis Med Microbiol2008，19，： | 1 |
| 17 | Ceftizoxime: a third-generation cefhalosporin active against anaerobic bacteria显示文摘 | Rotstein C | 1990 | Can Med Assoc1990，142，11： | 1 |
| 18 | H2/H∞filtering theory and an aerospace application显示文摘 | Hector Rotstein Mario Sznaier Moshe ldan | 1996 | International Journal of Robust and Nonlinear Control1996，6，： | 1 |
| 19 | Comparison of caspofungin and Amphotericin B for invasive candidiasis显示文摘 | Mora-Duarte J Betts R Rotstein C | 2002 | N Engl J Med2002，347，25： | 1 |
| 20 | Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress; rela- tion with docosahexaenoic acid 显示文摘 | Chucair A J Rotstein NP Sanqiovanni JP | 2007 | Invest Oph- thalmol Vis Sci2007，48，11： | 1 |
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