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| 1 | Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver-related morbidity and mortality. It can develop secondary to numerous causes but a great majority of NAFLD cases occur in patients who are obese or present with other components of metabolic syndrome (hypertension, dyslipidemia, diabetes). This is called primary NAFLD and insulin resistance plays a key role in its pathogenesis. Obesity is characterized by expanded adipose tissue, which is under a state of chronic inflammation. This disturbs the normal storage and endocrine functions of adipose tissue. In obesity, the secretome (adipokines, cytokines, free fatty acids and other lipid moieties) of fatty tissue is amplified, which through its autocrine, paracrine actions in fat tissue and systemic effects especially in the liver leads to an altered metabolic state with insulin resistance (IR). IR leads to hyperglycemia and reactive hyperinsulinemia, which stimulates lipid-accumulating processes and impairs hepatic lipid metabolism. IR enhances free fatty acid delivery to liver from the adipose tissue storage due to uninhibited lipolysis. These changes result in hepatic abnormal fat accumulation, which may initiate the hepatic IR and further aggravate the altered metabolic state of whole body. Hepatic steatosis can also be explained by the fact that there is enhanced dietary fat delivery and physical inactivity. IR and NAFLD are also seen in various lipodystrophic states in contrary to popular belief that these problems only occur due to excessive adiposity in obesity. Hence, altered physiology of adipose tissue is central to development of IR, metabolic syndrome and NAFLD. | Kamran Qureshi Gary A Abrams | 2007 | World Journal of Gastroenterology2007，13，26： | 52 |
| 2 | Gemcitabine-based or capecitabine-based chemoradiotherapy for locally advanced pancreatic cancer (SCALOP): a multicentre, randomised, phase 2 trial显示文摘 | Somnath Mukherjee Christopher N Hurt John Bridgewater Stephen Falk Sebastian Cummins Harpreet Wasan Tom Crosby Catherine Jephcott Rajarshi Roy Ganesh Radhakrishna Alec McDonald Ruby Ray George Joseph John Staffurth Ross A Abrams Gareth Griffiths Tim Maugh | 2013 | Lancet Oncology2013，，4： | 4 |
| 3 | Fulminant myocarditis in adults: a narrative review显示文摘Fulminant myocarditis(FM)is an uncommon syndrome characterized by sudden and severe hemodynamic compromise secondary to acute myocardial inflammation,often presenting as profound cardiogenic shock,life-threatening ventricular arrhythmias and/or electrical storm.FM may be refractory to conventional therapies and require mechanical circulatory support(MCS).The immune system has been recognized as playing a pivotal role in the pathophysiology of myocarditis,leading to an increased focus on immunosuppressive treatment strategies.Recent data have highlighted not only the fact that FM has significantly worse outcomes than non-FM,but that prognosis and management strategies of FM are heavily dependent on histological subtype,placing greater emphasis on the role of endomyocardial biopsy in diagnosis.The impact of subtype on severity and prognosis will likewise influence how aggressively the myocarditis is managed,including whether MCS is warranted.Many patients with refractory cardiogenic shock secondary to FM end up requiring MCS,with venoarterial extracorporeal membrane oxygenation demonstrating favorable survival rates,particularly when initiated prior to the development of multiorgan failure.Among the challenges facing the field are the need to more precisely identify immunopathophysiological pathways in order to develop targeted therapies,and the need to better optimize the timing and management of MCS to minimize complications and maximize outcomes. | Santiago Montero Darryl Abrams Enrico Ammirati Florent Huang Dirk WDonker Guillaume Hekimian Cosme García-García Antoni Bayes-Genis Alain Combes Matthieu Schmidt | 2022 | Journal of Geriatric Cardiology2022，19，2： | 3 |
| 4 | Pulmonary Dysfunction in Chronic Liver Disease显示文摘 | Michael B Fallon Gary A Abrams | 2000 | Hepatology2000，，4： | 2 |
| 5 | Inability of interferon and aminogunidine to alter Cryptosporidium parvum infection in mice with severe combined immunodeficiency显示文摘 | Kuhls T L Mosier D A Abrams V L | 1994 | Journal of Parasitology1994，80，3： | 2 |
| 6 | Pancreatic cancer显示文摘 | Theresa Pluth Yeo Ralph H Hruban Steven D Leach Robb E Wilentz Taylor A Sohn Scott E Kern Christine A Iacobuzio-Donahue Anirban Maitra Michael Goggins Marcia I Canto Ross A Abrams Daniel Laheru Elizabeth M Jaffee Manuel Hidalgo Charles J Yeo | 2002 | Current Problems in Cancer2002，，4： | 2 |
| 7 | Physical activity and nutrition attitudes in obese Hispanic children with non-alcoholic steatohepatitis显示文摘AIM:To assess nutrition,physical activity and health-ful knowledge in obese children with biopsy-proven nonalcoholic steatohepatitis(NASH or NA)compared to children without liver disease.METHODS:Children with biopsy-proven NASH comprised the NASH group.Age,sex and ethnicity matched control groups consisted of obese(OB)and lean(CO) children with no liver disease.Subjects were adminis-tered the School Physical Activity and Nutrition Survey and one blood draw was obtained.RESULTS:Fifty-seven patients were enrolled with a mean age of 12.1±2.1 years,and all were Hispanic.Even though the OB and NA had a similar increased body mass index(%),35%of the NA group always read nutrition labels compared to none in the OB(P<0.05),and more NA children felt their diet is'less healthy'.NA consumed the least amount of fruits with only 25%having≥1 fruit/d vs 45%in OB and 64.7% in CO(P<0.05 NA vs CO).Only 15%of NA subjects performed light exercise vs 35%and 59%of OB and CO groups,respectively(P=0.02).The mean physical activity score was lowest in the NA group(P<0.05).Amongst the subjects with NASH,we found that 100% of patients with grade 2 or 3 fibrosis had a sedentary score>2 compared to only 63.6%of those with grade 1 or no fibrosis(P<0.05).CONCLUSION:Children with NASH had increased sedentary behavior,decreased activity,and fruit intake.Larger studies may determine the benefit of changing these behaviors as treatment for NASH. | Lana N Hattar Theresa A Wilson Leanel A Tabotabo E O'Brian Smith Stephanie H Abrams | 2011 | World Journal of Gastroenterology2011，17，39： | 2 |
| 8 | Changes in ABA turnover and sensitivity that accompany dormancy termination of yellow-cedar ( Chamaecyparis nootkatensis ) seeds 显示文摘 | Schmitz N Abrams S R Kermode A R | 2002 | Journal of Experimental Botany2002，53，366： | 1 |
| 9 | Resonator theory for hollow waveguide lasers显示文摘 | ABRAMS R CHESTER A | 1974 | Appl Opt1974，13，： | 1 |
| 10 | Assembly of foot-and- mouth disease virus empty capids synthesized by a vaccinia virus expression system显示文摘 | Abrams C C King A M Belsham G J | 1995 | J Gen Virol1995，76，： | 1 |
| 11 | Standing wave en- hancement of red absorbance and photocurrent in dye-sen- sitized titanium dioxide photoelectrodes coupled to photon- ic crystals 显示文摘 | Nishimura S Abrams N Lewis B A | 2003 | J Am Chem Soe2003，125，20： | 1 |
| 12 | Applying big GWAS data to clarify the role of obesity in Barrett's esophagus and esophageal adenocarcinoma显示文摘 | Abrams JA Chak A | 2014 | Journal of the National Cancer Institute2014，106，11： | 1 |
| 13 | Diuretics:1,2,4-Benzothiadiazine-1,1-Dioxides显示文摘 | NoveUo F C Bell S C Abram s E L A | 1960 | J Org Chem1960，25，6： | 1 |
| 14 | Mineral metabolism in children with dermatomyositis 显示文摘 | Maria D Perez Steven A Abrams Gaye Koenning | 1994 | J Rheumatol1994，21，： | 1 |
| 15 | Using stable isotopes to assoss mineral absorption and utilization by children显示文摘 | ABRAMS S A | 1999 | Am J Clin Nutr1999，70，12： | 1 |
| 16 | New advances in the treatment of adult chronic immune thrombocytopenic purpura: role of thrombopoietin recepter-stimulating agents 显示文摘 | METJIAN A ABRAMS CS | 2009 | Biologics2009，3，： | 1 |
| 17 | Tamsulosin: efficacy and safety in patients with neurogenic lower urinary tract dys?function due to suprasacral spinal cord injury 显示文摘 | Abrams P Amarenco G Bakke A | 2003 | J Urol2003，170，4： | 1 |
| 18 | Vacuum electronics for the 21st Century 显示文摘 | Abram R H Mondeli A A Parker R K | 2001 | IEEE Microwave Magazine2001，2，3： | 1 |
| 19 | Synthesis and Reactivity of2+ Formation and Structural Characterization of the Clusters andby Alkaline Titration显示文摘 | Alberto R Egli A Abram U | 1994 | J Chem Soc Dalton Trans1994，，： | 1 |
| 20 | Assembly of foot- and-mouth disease virus empty capsids synthesized by a vaccinia virus expression system 显示文摘 | Abrams C C King A M Q Belsharn G J | 1995 | J Gen Virol1995，76，12： | 1 |
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