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| 1 | 青藏高原20世纪后40年潜在蒸散趋势及其空间分布(英文)显示文摘气候变化研究主要集中在温度和降水的长期变化趋势及其影响方面,对于控制陆地生态系统和大气之间的质能交换的重要气候因子——蒸散,研究相对较少。蒸散在气候系统中扮演着重要角色,它是多个气候因子综合作用的结果,如日照、温度、风速、湿度等。蒸散也是陆地和大气间能量、水汽传送和气候变化监测的敏感因子。蒸散的变化趋势更能反映气候变化的状况,并对农业生产、流域开发和人民生活产生重要影响。论文分析了青藏高原及其周边的101个气象台站在20世纪后40年Penman-Monteith潜在蒸散(PET)的变化趋势及其空间分布。研究显示青藏高原PET在所有季节呈现减少的趋势,年平均PET倾向率为-13.1mm/10年或年总量的2.0%。在PET整体负的趋势下,1970和1980年代在平均值上的波动幅度大约是在600到700mm范围。青藏高原空间性的趋势分布随季节性波动全年仍保持稳定。PET减小趋势的台站冬春(80%)多于夏秋(58%)。尽管总体趋势是负的,但有些台站PET表现还是正的趋势,最大年的正负PET趋势台站在柴达木盆地的南部,分别是84.8mm/10年和-79.5mm/10年。论文还进一步探索了青藏高原不同气候因子对PET趋势的影响。在青藏高原,风速是影响PET趋势最重要的因子,相对湿度次之,而日照时数的变化作用不明显。由于青藏高原上稳定的日间温度限制了温度趋势对PET的影响。因此,负蒸散趋势被认为与地区性季风环流强度的降低有关,而非日照时间的减少。也就是说,降低的PET趋势显示出与全球变暖情景中预测的水文循环增强相反。由于不均匀的青藏高原气象台站分布,进一步的探索最好增加遥感方法获取没有台站地区的PET数据,以便对整个青藏高原PET的时空分布进行深入研究。 | 陈沈斌 刘允芬 Axel Thomas | 2008 | 自然资源学报2008，23，6： | 15 |
| 2 | Deep-learning based denoising and reconstruction of super-resolution structured illumination microscopy images显示文摘Super-resolution structured illumination microscopy(SR-SIM) provides an up to twofold enhanced spatial resolution of fluorescently labeled samples. The reconstruction of high-quality SR-SIM images critically depends on patterned illumination with high modulation contrast. Noisy raw image data(e.g., as a result of low excitation power or low exposure time), result in reconstruction artifacts. Here, we demonstrate deep-learning based SR-SIM image denoising that results in high-quality reconstructed images. A residual encoding–decoding convolutional neural network(RED-Net) was used to successfully denoise computationally reconstructed noisy SR-SIM images.We also demonstrate the end-to-end deep-learning based denoising and reconstruction of raw SIM images into high-resolution SR-SIM images. Both image reconstruction methods prove to be very robust against image reconstruction artifacts and generalize very well across various noise levels. The combination of computational image reconstruction and subsequent denoising via RED-Net shows very robust performance during inference after training even if the microscope settings change. | ZAFRAN HUSSAIN SHAH MARCEL MÜLLER TUNG-CHENG WANG PHILIP MAURICE SCHEIDIG AXEL SCHNEIDER MARK SCHÜTTPELZ THOMAS HUSER WOLFRAM SCHENCK | 2021 | Photonics Research2021，9，5： | 11 |
| 3 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Definitions and diagnosis显示文摘 | Gert Van Assche Axel Dignass Julian Panes Laurent Beaugerie John Karagiannis Mathieu Allez Thomas Ochsenkühn Tim Orchard Gerhard Rogler Edouard Louis Limas Kupcinskas Gerassimos Mantzaris Simon Travis Eduard Stange | 2009 | Journal of Crohn’s and Colitis2009，，1： | 10 |
| 4 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 5 | TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis显示文摘 | Charles Thomas Antimo Gioiello Lilia Noriega Axelle Strehle Julien Oury Giovanni Rizzo Antonio Macchiarulo Hiroyasu Yamamoto Chikage Mataki Mark Pruzanski Roberto Pellicciari Johan Auwerx Kristina Schoonjans | 2009 | Cell Metabolism2009，，3： | 4 |
| 6 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Sü? Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，6： | 3 |
| 7 | Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients显示文摘Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC afterNAC.Although spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with NSCLC.We evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine learning.Methods:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with NSCLC.The specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%accuracy.By contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,respectively.The combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic classifier.In multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic factors.Using Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non-responders(P<0.001).Conclusions:Our findings indicate that the metabolic constitutions of both tumor cells and the stroma are valuable additions to the classical histomorphology-based assessment of tumor response. | Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska Axel Walch | 2022 | Cancer Communications2022，42，6： | 3 |
| 8 | MicroRNAs in the Human Heart: A Clue to Fetal Gene Reprogramming in Heart Failure显示文摘 | Thomas Thum Paolo Galuppo Christian Wolf Jan Fiedler Susanne Kneitz Linda W. van Laake Pieter A. Doevendans Christine L. Mummery Jürgen Borlak Axel Haverich Carina Gross Stefan Engelhardt Georg Ertl Johann Bauersachs | 2007 | Circulation2007，，3： | 3 |
| 9 | Contrast-enhanced coronary artery visualization by dual-source computed tomography—Initial experience显示文摘 | Stephan Achenbach Dieter Ropers Axel Kuettner Thomas Flohr Bernd Ohnesorge Herbert Bruder Heike Theessen Meri Karakaya Werner G. Daniel Werner Bautz Willi A. Kalender Katharina Anders | 2005 | European Journal of Radiology2005，，3： | 3 |
| 10 | Inhaled nitric oxide versus aerosolized iloprost for the treatment of pulmonary hypertension with left heart disease显示文摘 | Ning Yin Stephanie Kaestle Jun Yin Thomas Hentschel Axel R. Pries Hermann Kuppe Wolfgang M. Kuebler | 2009 | Critical Care Medicine2009，，3： | 2 |
| 11 | High-pitch spiral acquisition: A new scan mode for coronary CT angiography显示文摘 | Stephan Achenbach Mohamed Marwan Tiziano Schepis Tobias Pflederer Herbert Bruder Thomas Allmendinger Martin Petersilka Katharina Anders Michael Lell Axel Kuettner Dieter Ropers Werner G. Daniel Thomas Flohr | 2009 | Journal of Cardiovascular Computed Tomography2009，，2： | 2 |
| 12 | Global review and synthesis of trends in observed terrestrial near-surface wind speeds: Implications for evaporation显示文摘 | Tim R. McVicar Michael L. Roderick Randall J. Donohue Ling Tao Li Thomas G. Van Niel Axel Thomas Jürgen Grieser Deepak Jhajharia Youcef Himri Natalie M. Mahowald Anna V. Mescherskaya Andries C. Kruger Shafiqur Rehman Yagob Dinpashoh | 2011 | Journal of Hydrology2011，，： | 2 |
| 13 | Primary malignant melanoma of the esophagus显示文摘 | Axel W. Joob G. Kenneth Haines Merrill S. Kies Thomas W. Shields | 1995 | The Annals of Thoracic Surgery1995，，1： | 2 |
| 14 | Reduction and carburization of iron oxides for Fischer–Tropsch synthesis显示文摘The activation of iron oxide Fischer–Tropsch Synthesis(FTS) catalysts was investigated during pretreatment: reduction in hydrogen followed by carburization in either CO or syngas mixture, or simultaneously reduction and carburization in syngas. A combination of different complementary in situ techniques was used to gain insight into the behavior of Fe-based FTS catalysts during activation. In situ XRD was used to identify the crystalline structures present during both reduction in hydrogen and carburization. An increase in reduction rate was established when increasing the temperature. A complete reduction was demonstrated in the ETEM and a grain size dependency was proven, i.e. bigger grains need higher temperature in order to reduce. XPS and XAS both indicate the formation of a small amount of carbonaceous species at the surface of the bulk metallic iron during carburization. | Monia Runge Nielsen Asger Barkholt Moss Anton Simon Bjrnlund Xi Liu Axel Knop-Gericke Alexander YuKlyushin Jan-Dierk Grunwaldt Thomas LSheppard Dmitry EDoronkin Anna Zimina Thomas Eric Lyck Smitshuysen Christian Danvad Damsgaard Jakob Birkedal Wagner Thomas Willum Hansen | 2020 | Journal of Energy Chemistry2020，29，12： | 2 |
| 15 | Prospectively ECG-triggered high-pitch spiral acquisition for coronary CT angiography using dual source CT: technique and initial experience显示文摘 | Michael Lell Mohamed Marwan Tiziano Schepis Tobias Pflederer Katharina Anders Thomas Flohr Thomas Allmendinger Willi Kalender Dirk Ertel Carsten Thierfelder Axel Kuettner Dieter Ropers Werner G. Daniel Stephan Achenbach | 2009 | European Radiology2009，，11： | 2 |
| 16 | Reversal of Central Nervous System and Cardiac Toxicity After Local Anesthetic Intoxication by Lipid Emulsion Injection显示文摘 | Rainer J. Litz Thomas Roessel Axel R. Heller Sebastian N. Stehr | 2008 | Anesthesia & Analgesia2008，，： | 2 |
| 17 | Immobilizing glycopyranose on mesoporous silica via 'click-chemistry' for borate adsorption显示文摘 | Dorothee I Fried Axel Schlossbauer Thomas Bein | 2010 | Microporous and Mesoporous Materials2010，8，6： | 1 |
| 18 | Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis显示文摘 | Jonathan Mill Thomas Tang Zachary Kaminsky Tarang Khare Simin Yazdanpanah Luigi Bouchard Peixin Jia Abbas Assadzadeh James Flanagan Axel Schumacher Sun-Chong Wang Arturas Petronis | 2008 | The American Journal of Human Genetics2008，，3： | 1 |
| 19 | First performance evaluation of a dual-source CT (DSCT) system显示文摘 | Thomas G. Flohr Cynthia H. McCollough Herbert Bruder Martin Petersilka Klaus Gruber Christoph Süβ Michael Grasruck Karl Stierstorfer Bernhard Krauss Rainer Raupach Andrew N. Primak Axel Küttner Stefan Achenbach Christoph Becker Andreas Kopp Bernd M. Ohnes | 2006 | European Radiology2006，，2： | 1 |
| 20 | Interrelation of immunity and tissue repair or regeneration显示文摘 | Sabine A. Eming Matthias Hammerschmidt Thomas Krieg Axel Roers | 2009 | Seminars in Cell and Developmental Biology2009，，5： | 1 |
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