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| 1 | Characterisation and risk assessment of venous thromboembolism in gastrointestinal cancers显示文摘AIM To characterise venous thromboembolism(VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal(GO) cancer and 1299 colorectal cancer(CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival.VTE risk scores were calculated using the Khorana index. Patients were classified as low risk(0 points), intermediate risk(1 to 2 points) or high risk(3 points). Data was analysed to determine the sensitivity of the Khorana score to predict VTE. RESULTS The incidence of VTE was 8.9% for CRC patients and 9.7% for GO cancer patients. Pulmonary emboli(PE) were more common in advanced than in localised CRC(50% vs 21% of events respectively) and lower limb deep vein thrombosis(DVT) were more common in localised than in advanced CRC(62% vs 39% of events respectively). The median time to VTE from cancer diagnosis was 8.3 mo for CRC patients compared to 6.7 mo in GO cancer. In localised CRC median time to VTE was 7.1 mo compared with 10.1 mo in advanced CRC. In contrast in GO cancer, the median time to VTE was 12.5 mo in localised disease and 6.8 mo in advanced disease. No survival difference was seen between patients with and without VTE in this cohort. The majority of patients with CRC in whom VTE was diagnosed had low or intermediate Khorana risk score(94% for localised and 97% in advanced CRC). In GO cancer, all patients scored either intermediate or high risk due to the primary site demonstrating a limitation of the risk assessment score in discriminating high and low risk patients with GO cancers. Additional risk factors were identified in this cohort including surgery, chemotherapy or hospital admission. Overall, 81% of patients with CRC and 77% of patients with GO cancer had one or more of these factors within 4 wk prior to diagnosis VTE. These should be factored into clinical risk assessment scores. CONCLUSION The Khorana score has low sensitivity for thrombotic events in CRC and cannot discriminate low risk patients in high risk cancer sites such as GO cancer. | Robert L Metcalf Eamon Al-Hadithi Nicholas Hopley Thomas Henry Clare Hodgson Antony McGurk Wasat Mansoor Jurjees Hasan | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 10 |
| 2 | Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach显示文摘 | Susan K. Lutgendorf Elizabeth Mullen-Houser Daniel Russell Koen DeGeest Geraldine Jacobson Laura Hart David Bender Barrie Anderson Thomas E. Buekers Michael J. Goodheart Michael H. Antoni Anil K. Sood David M. Lubaroff | 2010 | Brain Behavior and Immunity2010，，8： | 2 |
| 3 | Supercritical water medium for chemistry显示文摘 | Shaw R W Thomas B B Antony A C | 1991 | C&EN1991，23，11： | 1 |
| 4 | The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors显示文摘 | Thomas P.J. Garrett Neil M. McKern Meizhen Lou Thomas C. Elleman Timothy E. Adams George O. Lovrecz Michael Kofler Robert N. Jorissen Edouard C. Nice Antony W. Burgess Colin W. Ward | 2003 | Molecular Cell2003，，2： | 1 |
| 5 | Detection of Transients in 1/f Noise with the Undecimated Discrete Wavelet Transform 显示文摘 | Thomas T L Antony C S | 2000 | IEEE Transactions on Signal Processing2000，48，5： | 1 |
| 6 | Formation of DNA nanoparticles in the presence of novel polyamine analogues:a laser light scattering and atomic force microscopic study显示文摘 | VIJAYANATHAN VEENA THOMAS THRESIA ANTONY THOMAS | 2004 | Nucleic Acids Res2004，32，1： | 1 |
| 7 | Experimental Characterization of FRP Composite -Wood Pile Structural Response by Bending Tests显示文摘 | Roberto Lopez-Anido Antonis P Michael Thomas C Sandford | 2003 | Marine Structures2003，，4： | 1 |
| 8 | Freeze-thaw Resistance of Fiber-reinforced Polymer Composites Adhesive Bonds with Under Water Curing Epoxy 显示文摘 | Roberto Lopez-Anido Antonis p Michael Thomas C Sandford | 2004 | Journal of Materials In Civil Engineering2004，16，3： | 1 |
| 9 | Detection of transients in 1/f noise with the undecimated discrete wavelet transform显示文摘 | Antony C S | 2000 | IEEE Transactions on Signal Processing2000，48，5： | 1 |
| 10 | 查看详情显示文摘 | Antony Mary Grace Thomas Ryan J | | 0，，08： | 1 |
| 11 | Laser light scattering immunoassay: An improved data analysis by CONTIN method显示文摘 | Thomas Antony Anita Saxena | 1998 | J Biochem Biophy Methods1998，36，23： | 1 |
| 12 | Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease显示文摘Alzheimer’s disease(AD)is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles.Prior to the development of these characteristic pathological hallmarks of AD,anterograde axonal transport is impaired.However,the key proteins that initiate these intracellular impairments remain elusive.The collapsin response mediator protein-2(CRMP-2)plays an integral role in kinesin-1-dependent axonal transport and there is evidence that phosphorylation of CRMP-2releases kinesin-1.Here,we tested the hypothesis that amyloid-beta(Aβ)-dependent phosphorylation of CRMP-2 disrupts its association with the kinesin-1(an anterograde axonal motor transport protein)in AD.We found that brain sections and lysates from AD patients demonstrated elevated phosphorylation of CRMP-2 at the T555 site.Additionally,in the transgenic Tg2576 mouse model of familial AD(FAD)that exhibits Aβaccumulation in the brain with age,we found substantial co-localization of p T555CRMP-2and dystrophic neurites.In SH-SY5Y differentiated neuronal cultures,Aβ-dependent phosphorylation of CRMP-2 at the T555 site was also elevated and this reduced the CRMP-2 association with kinesin-1.The overexpression of an unphosphorylatable form of CRMP-2 in neurons promoted the re-establishment of CRMP-2-kinesin association and axon elongation.These data suggest that Aβ-dependent phosphorylation of CRMP-2 at the T555 site may directly impair anterograde axonal transport protein function,leading to neuronal defects. | Sara H.Mokhtar Min Joung Kim Kylie A.Magee Pei Mun Aui Speros Thomas Maha M.Bakhuraysah Amani A.Alrehaili Jae Young Lee David L.Steer Rachel Kenny Catriona Mc Lean Michael F.Azari Antonis Birpanagos Ewlina Lipiec Philip Heraud Bayden Wood Steven Petratos | 2018 | Neural Regeneration Research2018，13，6： | 1 |
| 13 | Detection of transients in 1/f noise with the undecimated discrete wavelet transform显示文摘 | THOMAS T L ANTONY C S | 2000 | IEEE Transactions on Signal Processing2000，48，5： | 1 |
| 14 | Effects of Phytoestrogen Extracts Isolated from Pumpkin Seeds on Estradiol Production and ER/PR Expression in Breast Cancer and Trophoblast Tumor Cells显示文摘 | Dagmar Richter Sibylle Abarzua Mareike Chrobak Thomas Vrekoussis Tobias Weissenbacher Christina Kuhn Sandra Schulze MarkusS. Kupka Klaus Friese Volker Briese Birgit Piechulla Antonis Makrigiannakis Udo Jeschke Darius Dian | 2013 | Nutrition and Cancer2013，，5： | 1 |
| 15 | Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodie5ter and phosphorothicate o1igodeoxyribonuc1eotides显示文摘 | Antony T Thomas T Shirahata A | 1999 | Biochemistry1999，38，10： | 1 |
| 16 | Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodiester and phosphorothicate oligodeoxyribonucleotides显示文摘 | Antony T Thomas T Shirahata A | 1999 | Biochemistry1999，38，10： | 1 |
| 17 | Supercritical water:a medium for chemistry显示文摘 | SHAW R W THOMAS B B ANTONY A C | 1991 | Chem Eng News1991，69，： | 1 |
| 18 | Farm management systems and the Future Internet era显示文摘 | Alexandros Kaloxylos Robert Eigenmann Frederick Teye Zoi Politopoulou Sjaak Wolfert Claudia Shrank Markus Dillinger Ioanna Lampropoulou Eleni Antoniou Liisa Pesonen Huether Nicole Floerchinger Thomas Nancy Alonistioti George Kormentzas | 2012 | Computers and Electronics in Agriculture2012，，： | 1 |
| 19 | Selectivity of polyamines on the stability of RNA-DNA hybrids containing phosphodiestor and phosphorothioate oligodeoxyribonucleotides 显示文摘 | Antony T Thomas T Shirahata A | 1999 | Biochemistry1999，28，10： | 1 |
| 20 | A Comparative Analysis of the Taguchi and Shainin DOE Techniques in an Aerospace Environ- ment 显示文摘 | Thomas A J Antony J | 2005 | International Journal of Productivity and Performance Management2005，54，8： | 1 |
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