|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PredSL: A Tool for the N-terminal Sequence-based Prediction of Protein Subcellular Localization显示文摘The ability to predict the subcellular localization of a protein from its sequence is of great importance, as it provides information about the protein’s function. We present a computational tool, PredSL, which utilizes neural networks, Markov chains, profile hidden Markov models, and scoring matrices for the prediction of the subcellular localization of proteins in eukaryotic cells from the N-terminal amino acid sequence. It aims to classify proteins into five groups: chloroplast, thylakoid, mitochondrion, secretory pathway, and “other”. When tested in a five- fold cross-validation procedure, PredSL demonstrates 86.7% and 87.1% overall accuracy for the plant and non-plant datasets, respectively. Compared with Tar- getP, which is the most widely used method to date, and LumenP, the results of PredSL are comparable in most cases. When tested on the experimentally verified proteins of the Saccharomyces cerevisiae genome, PredSL performs com- parably if not better than any available algorithm for the same task. Further- more, PredSL is the only method capable for the prediction of these subcellu- lar localizations that is available as a stand-alone application through the URL: http://gffzz369e93cb0ab44f9fh6qpo900b0fvk6ncp.ffgz.tsg.suse.edu.cn/PredSL/. | Evangelia I. Petsalaki Pantelis G. Bagos Zoi I. Litou Stavros J. Hamodrakas | 2006 | Genomics, Proteomics & Bioinformatics2006，4，1： | 5 |
| 2 | Steatosis and steatohepatitis in postmortem material from Northwestern Greece显示文摘AIM: To determine the prevalence of steatosis and steatohepatitis in a series of autopsies in Northwestern Greece. METHODS: Liver biopsy material from a total of 600 autopsies performed over a period of 2 years (2006-2008) to def ine the cause of death was subjected to histological examination. Patient demographic data were also collected. Tissue sections were stained with different dyes for the evaluation of liver architecture, degree of fibrosis and other pathological conditions when necessary. RESULTS: Satisfactory tissue samples for histological evaluation were available in 498 cases (341 male, 157 female) with a mean age of 64.51 ± 17.78 years. In total, 144 (28.9%) had normal liver histology, 156 (31.3%) had evidence of steatosis, and 198 (39.8%) had typical histological findings of steatohepatitis. The most common causes of death were ischemic heart disease with or without myocardial infarction (43.4%), and traffic accidents (13.4%). CONCLUSION: A high prevalence of steatosis and steatohepatitis was detected in postmortem biopsies from Northwestern Greece. Since both diseases can have serious clinical consequences, they should be considered as an important threat to the health of the general population in Greece. | Christos D Zois Gerasimos H Baltayiannis Anna Bekiari Anna Goussia Peter Karayiannis Michalis Doukas Demetrios Demopoulos Antigoni Mitsellou Theodoros Vougiouklakis Vasiliki Mitsi Epameinondas V Tsianos | 2010 | World Journal of Gastroenterology2010，16，31： | 4 |
| 3 | Scalable nanomanufacturing of surfactant-free carbon nanotube inks for spray coatings with high conductivity显示文摘Spray-coated carbon nanotube films offer a simple and printable solution for fabricating low cost, lightweight, and flexible thin-film electronics. However, current nanotube spray inks require either a disruptive surfactant or destructive surface functionalization to stabilize dispersions at the cost of the electrical properties of the deposited film. We demonstrate that high-purity few-walled carbon nanotubes may be stabilized in isopropanol after surface functionalization and that optimizing the ink stability dramatically enhances the conductivity of subsequent spray-coated thin films. We consequently report a surfactant-free carbon nanotube ink for spray-coated thin films with conductivities reaching 2,100 S/cm. Zeta-potential measurements, used to quantify the nanotube ink dispersion quality, directly demonstrate a positive correlation with the spray- coated film conductivity, which is the key metric for high-performance printed electronics. | Colin Preston Da Song Jaiqi Dai Zois Tsinas John Bavier John Cumings Vince Ballarotto Liangbing Hu | 2015 | Nano Research2015，8，7： | 4 |
| 4 | Recent Developments in the Treatment of Wet Age-related Macular Degeneration显示文摘Age-related macular degeneration(AMD)is the most common cause of irreversible blindness and visual impairment in individuals over the age of 50 years in western societies.More than 25 million people currently suffer from this illness in the world,with an additional 500000 every year,approximately.It is a multifactorial ocular disease that affects the maculae due to a late-onset progressive neurodegeneration and dysfunction of photoreceptors and retinal pigment epithelium(RPE).There are many subtypes of AMD but basically two broad forms:the nonneovascular(dry,nonexudative)and neovascular(wet,exudative).Exudative AMD is the less common form(about 15%)but tends to progress more rapidly.At the moment,wet AMD is treated primarily on the basis of anti-vascular endothelial growth factor(VEGF)agents,which have led to massive improvement in the prognosis of the disease since they were first introduced.This article focuses on the latest treatment approaches to neovascular AMD.An extensive literature review was performed in order to illustrate the effectiveness of current and future anti-VEGF agents as well as the landmark clinical studies that have been carried out to establish these drugs as a gold standard in the therapy of wet AMD. | Zois Papadopoulos | 2020 | Current Medical Science2020，40，5： | 4 |
| 5 | Applications of biosensors for bacteria and virus detection in food and water–A systematic review显示文摘Biosensors for sensitive and specific detection of foodborne and waterborne pathogens are particularly valued for their portability,usability,relatively low cost,and real-time or near real-time response.Their application is widespread in several domains,including environmental monitoring.The main limitation of currently developed biosensors is a lack of sensitivity and specificity in complex matrices.Due to increased interest in biosensor development,we conducted a systematic review,complying with the PRISMA guidelines,covering the period from January 2010 to December 2019.The review is focused on biosensor applications in the identification of foodborne and waterborne microorganisms based on research articles identified in the Pubmed,Science Direct,and Scopus search engines.Efforts are still in progress to overcome detection limitations and to provide a rapid detection system which will safeguard water and food quality.The use of biosensors is an essential tool with applicability in the evaluation and monitoring of the environment and food,with great impact in public health. | Zoi Kotsiri Jasmina Vidic Apostolos Vantarakis | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 6 | Evidence of neutrophil functional defect despite inflammation in stable cirrhosis显示文摘 | Giovanni Tritto Zois Bechlis Vanessa Stadlbauer Nathan Davies Rubén Francés Naina Shah Rajeshwar P. Mookerjee Jose Such Rajiv Jalan | 2011 | Journal of Hepatology2011，，3： | 2 |
| 7 | Translation and validation of the Greek chronic liver disease questionnaire显示文摘AIM:To translate into Greek and validate the chronic liver disease questionnaire (CLDQ).METHODS:Two hundred and six consecutive adult patients with the diagnosis of a chronic liver disease from 2 general hospitals in Athens were enrolled in the study from May to September 2008.In order to assess their quality of life (QOL) the CLDQ was applied.The instrument was translated from English,back translated and reviewed in focus groups within the framework of a large multicenter study.The measurements that were performed included:2 independent sample t tests,oneway analysis of variance,reliability coefficients,explanatory factor analysis using a varimax rotation and the principal components method.RESULTS:One hundred and twenty five (61%) patients were men,half were aged 40-59 years and > 33% were > 60 years old.Among the patients,48 (23%) were hospitalized and 97 (47%) were cirrhotic according to the Child-Pugh score.The internal consistency of the Greek CLDQ version using Cronbach's alpha coefficient was found to be 0.93.Exploratory factor analysis identified 7 domains accounting for 65% of the variance of CLDQ items and only partially overlapping with those found in the original version.The area under the receiver operating characteristics curve was calculated at 0.813 and the logistic estimate for the threshold score of 167.50 provided a sensitivity of 74.3% and a specificity of 71.6% for the model.CONCLUSION:Our data confirmed the validity of the Greek version of the CLDQ in identifying the QOL among patients with chronic liver disease. | Zoi Kollia Evridiki Patelarou Victoria Vivilaki Eleni Kollia Florentia Kefou Ioannis Elefsiniotis Spyros P Dourakis Hero Brokalaki | 2010 | World Journal of Gastroenterology2010，16，46： | 2 |
| 8 | Widespread occurrence of the JAK2V617F mutation in chronic myeloproliferative disorders 显示文摘 | Jones AV Kreil S Zoi K | 2005 | Blood2005，106，6： | 1 |
| 9 | The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes显示文摘 | Tokmakidis S Zois C Volaklis K | 2004 | Eur J Appl Physiol2004，92，： | 1 |
| 10 | Combined estrogen receptor α and estrogen receptor β genotypes influence the age of menarche显示文摘 | Stavrou I Zois C Chatzikyriakidou A | | 0，，02： | 1 |
| 11 | Lipoprotein profile,glycemic control and physical fitness after strength and aerobic training in post-menopausal women with type 2 diabetes显示文摘 | Zois C Tokmakidis S Volaklis K | 2009 | Eur J Appl Physiol2009，106，6： | 1 |
| 12 | Adjuvant chemotherapy and acute toxicity in hypofractionated radiotherapy for early breast cancer显示文摘AIM: To evaluate the effect of chemotherapy to the acute toxicity of a hypofractionated radiotherapy(HFRT) schedule for breast cancer. METHODS: We retrospectively analyzed 116 breast cancer patients with T1, 2N0 Mx. The patients received3-D conformal radiotherapy with a total physical dose of 50.54 Gy or 53.2 Gy in 19 or 20 fractions according to stage, over 23-24 d. The last three to four fractions were delivered as a sequential tumor boost. All patients were monitored for acute skin toxicity according to the European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group criteria. The maximum monitored value was taken as the final grading score. Multivariate analysis was performed for the contribution of age, chemotherapy and 19 vs 20 fractions to the radiation acute skin toxicity.RESULTS: The acute radiation induced skin toxicity was as following: grade Ⅰ 27.6%, grade Ⅱ 7.8% and grade Ⅲ 2.6%. No significant correlation was noted between toxicity grading and chemotherapy(P = 0.154, χ2 test). The mean values of acute toxicity score in terms of chemotherapy or not, were 0.64 and 0.46 respectively(P = 0.109, Mann Whitney test). No significant correlation was also noted between acute skin toxicity and radiotherapy fractions(P = 0.47, χ2test). According to univariate analysis, only chemotherapy contributed significantly to the development of acute skin toxicity but with a critical value of P = 0.05. However, in multivariate analysis, chemotherapy lost its statistical significance. None of the patients during the 2-years of follow-up presented any locoregional relapse.CONCLUSION: There is no clear evidence that chemotherapy has an impact to acute skin toxicity after an HFRT schedule. A randomized trial is needed for definite conclusions. | Vassilis Kouloulias Anna Zygogianni Efrosini Kypraiou John Georgakopoulos Zoi Thrapsanioti Ivelina Beli Eftychia Mosa Amanta Psyrri Christos Antypas Christina Armbilia Maria Tolia Kalliopi Platoni Christos Papadimitriou Nikolaos Arkadopoulos Costas Gennatas George Zografos George Kyrgias Maria Dilvoi George Patatoucas Nikolaos Kelekis John Kouvaris | 2014 | World Journal of Clinical Cases2014，2，11： | 1 |
| 13 | Radiation-induced autophagy in normal and cancer ceils: towards novel cytoprotection and radio- sensitization policies? 显示文摘 | Zois CE Koukourakis MI | 2009 | Autophagy2009，5，4： | 1 |
| 14 | Widespread Occurrence of the JAK2V617F Mutation in Chronic Myeloproliferative Disorders 显示文摘 | Jones A V Kreil S Zoi K | 2005 | Blood2005，106，6： | 1 |
| 15 | Molecular pathogenesis of atypical CML, CMML and MDS/MPN-unclassifiable显示文摘 | Zoi K Cross NC | 2015 | Int J Hematol2015，101，3： | 1 |
| 16 | Electrochemical behaviour of cermet coatings with a bond coat on Al7075: Pseudopassivity, localized corrosion and galvanic effect considerations in a saline environment显示文摘 | A. Lekatou D. Zois A.E. Karantzalis D. Grimanelis | 2010 | Corrosion Science2010，，8： | 1 |
| 17 | Microphase separation in ioncontaining polyurethanes studied by dielectric measurements 显示文摘 | Tsonos C Apekis L Zois C | 2004 | Acta Materialia2004，52，5： | 1 |
| 18 | Widespread oc-currence of the JAK2V617Fmutation in chronic my-eloproliferative disorders显示文摘 | JONES A V KREIL S ZOI K | 2005 | Blood2005，106，： | 1 |
| 19 | Widespread occurrence of the JAK2 V617F mutation in chronic myeloprolifcrative disorders显示文摘 | Jones AV Kreil S Zoi K | 2005 | Blood2005，106，6： | 1 |
| 20 | Combined estrogen receptor alpha and estrogen receptor beta genotypes influence the age of menarche 显示文摘 | Stavrou I Zois C Chatzikyriakidou A | 2007 | Hum Reprod ( Oxf Engl )2007，21，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员