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| 1 | 欧洲呼吸病学会/美国胸科学会官方研究共识:自身免疫特征的间质性肺炎显示文摘在临床工作中,有一类患者被诊断为特发性间质性肺炎(idiopathic interstitial pneumonia,IIP),值得注意的是,实际上这类患者与真正的IIP有所差异,他们除了间质性肺炎的表现外,还具备一些或临床特征、或血清学特征、或影像学特征提示其存在潜在的自身免疫性紊乱,但这些表现又不足以达到某些已知结缔组织病(connective tisslie disease,CTD)的既定诊断标准。 | 宋宁 段林 Fischer A Antoniou KM Brown KK | 2015 | 临床荟萃2015，30，10： | 41 |
| 2 | Intestinal barrier in inflammatory bowel disease显示文摘A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal microorganisms.In this review,we provide an overview about the major components of this protective system as for example an intact epithelium,the synthesis of various antimicrobial peptides(AMPs)and the formation of the mucus layer.We highlight the crucial importance of their correct functioning for the maintenance of a proper intestinal function and the prevention of dysbiosis and disease.Barrier disturbances including a defective production of AMPs,alterations in thickness or composition of the intestinal mucus layer,alterations of pattern-recognition receptors,defects in the process of autophagy as well as unresolved endoplasmic reticulum stress result in an inadequate host protection and are thought to play a crucial role in the pathogenesis of the inflammatory bowel diseases Crohn’s disease and ulcerative colitis. | Lena Antoni Sabine Nuding Jan Wehkamp Eduard F Stange | 2014 | World Journal of Gastroenterology2014，20，5： | 33 |
| 3 | Drought Responses of Leaf Tissues from Wheat Cultivars of Differing Drought Tolerance at the Metabolite Level显示文摘干旱在谷物庄稼的生理学上有严肃的效果。在细胞并且明确地代谢物水平,许多单个混合物被增加提供 osmoprotective 功能,并且减少,阻止酶的分离在房间在场的反应的氧种类的数字。我们使用了一条指向的 GCMS 途径识别在忍耐的不同层次在干旱应力下面描绘到干旱的面包小麦的三不同栽培变种不同的混合物(反曲刀的一种,偏狭;Excalibur 和 RAC875,容忍) 。氨基酸,最尤其是脯氨酸,色氨酸,和分叉的链氨基酸白氨酸,异白氨酸,和缬氨酸的层次在所有栽培变种在干旱应力下面被增加。在二容忍的栽培变种,在很多器官的酸的小减少也是明显的。Excalibur,栽培变种 genotypically 与反曲刀的一种有关,显示出更类似于在浇得好的条件下面的反曲刀的一种的反应的一个模式。在干旱应力下面, Excalibur 和 RAC875 有类似的回答;然而, Excalibur 没有象 RAC875 的反应的一样的大小。这里,结果在以前的工作的上下文被讨论在生理并且在干旱应力下面的这些栽培变种的 proteomic 分析。 | Jairus B. Bowne Tim A. Erwin Juan Juttner Thorsten Schnurbusch Peter Langridge Antony Bacic Ute Roessner | 2012 | Molecular Plant2012，5，2： | 25 |
| 4 | 新版Bethesda指南、微卫星不稳定性检测和免疫组化检查诊断遗传性非息肉性结直肠癌的准确性显示文摘背景:挑选适当个体进行遗传性非息肉性结直肠癌(hereditary nonpolyposis colorectal cancer,HNPCC)基因检测有一定难度。最近,美国国立癌症研究所(National Cancer Institute)在新版Bethesda指南中给出了一套新的推荐方案,以明确哪些HNPCC个体应行微卫星不稳定性检测。 | Virginia Pinol, MD Antoni Castells, MD Montserrat Andreu, MD 许峰(译) 祝学光(校) | 2005 | 美国医学会杂志(中文版)2005，24，6： | 23 |
| 5 | A study of internal solitary waves observed on the continental shelf in the northwestern South China Sea显示文摘Based on in-situ time series data from the acoustic Doppler current profiler (ADCP) and thermistor chain in Wenchang area, a sequence of internal solitary wave (ISW) packets was observed in September 2005, propagating northwest on the continental shelf of the northwestern South China Sea (SCS). Corresponding to different stratification of the water column and tidal condition, both elevation and depression ISWs were observed at the same mooring location with amplitude of 35 m and 25 m respectively in different days. Regular arrival of the remarkable ISW packets at approximately the diurnal tidal period and the dominance of diurnal internal waves in the study area, strongly suggest that the main energy source of the waves is the diurnal tide. Notice that the wave packets were all riding on the troughs and shoulders of the internal tides, they were probably generated locally from the shelf break by the evolution of the internal tides due to nonlinear and dispersive effects. | XU Zhenhua YIN Baoshu HOU Yijun FAN Zhisong Antony K LIU | 2010 | Acta Oceanologica Sinica2010，29，3： | 17 |
| 6 | Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients显示文摘AIM:To investigate the comparative effect of laparoscopic and open cholecystectomy in elderly patients.METHODS:Laparoscopic cholecystectomy has induced a revolution in the treatment of gallbladder disease.Nevertheless,surgeons have been reluctant to implement the concepts of minimally invasive surgery in older patients.A systematic review of Medline was embarked on,up to June 2013.Studies which provided outcome data on patients aged 65 years or older,subjected to laparoscopic or open cholecystectomy were considered.Mortality,morbidity,cardiac and pulmonary complications were the outcome measures of treatment effect.The methodological quality of selected studies was appraised using valid assessment tools.Τhe random-effects model was applied to synthesize outcome data.RESULTS:Out of a total of 337 records,thirteen articles(2 randomized and 11 observational studies)reporting on the outcome of 101559 patients(48195in the laparoscopic and 53364 in the open treatment group,respectively)were identified.Odds ratios(OR)were constantly in favor of laparoscopic surgery,in terms of mortality(1.0%vs 4.4%,OR=0.24,95%CI:0.17-0.35,P<0.00001),morbidity(11.5%vs 21.3%,OR=0.44,95%CI:0.33-0.59,P<0.00001),cardiac(0.6%vs 1.2%,OR=0.55,95%CI:0.38-0.80,P=0.002)and respiratory complications(2.8%vs 5.0%,OR=0.55,95%CI:0.51-0.60,P<0.00001).Critical analysis of solid study data,demonstrated a trend towards improved outcomes for the laparoscopic concept,when adjusted for age and co-morbid diseases.CONCLUSION:Further high-quality evidence is necessary to draw definite conclusions,although bestavailable evidence supports the selective use of laparoscopy in this patient population. | Stavros A Antoniou George A Antoniou Oliver O Koch Rudolph Pointner Frank A Granderath | 2014 | World Journal of Gastroenterology2014，20，46： | 17 |
| 7 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 8 | Prognostic value of increased carbohydrate antigen in patients with heart failure显示文摘AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) patients.METHODS:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to 2011.Patients were included in the study if they had a previous documented episode of HF and received HF treatment.CA125 and NT-proBNP concentrations were measured.The independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) index.RESULTS:The mean age of the 156 patients was 72 ± 12 years.During follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for HF.Higher CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P < 0.05),and 94 ± 121 KU/L in those who died or needed urgent heart transplantation vs 45 ± 78 KU/L in survivors(P < 0.01).After adjusting for propensity scores,the highest risk was observed when both biomarkers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P < 0.001) and intermediate when only NT-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P < 0.01).Moreover,when CA125 was added to the clinical model with NT-proBNP,a 4%(P < 0.05) improvement in the IDI was found.CONCLUSION:CA125 > 60 KU/L identified patients in stable HF with poor survival.Circulating CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes. | Ana B Méndez Jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig | 2014 | World Journal of Cardiology2014，6，4： | 13 |
| 9 | 三株克里米亚刚果出血热病毒中国分离株糖蛋白基因的全序列测定与比较分析显示文摘目的 测定克里米亚 刚果出血热病毒 (CCHFV)中国分离株 (即新疆出血热病毒 ,XH FV)BA6 6 0 19、BA840 2及BA8816 6糖蛋白 (M)基因的全部序列并分析各毒株之间的相互关系。方法 病毒RNA在只与其保守末端互补的特异引物PCM Tag和随机引物的共同引发下逆转录成cDNA ,以单一PCM Tag和高保真DNA聚合酶扩增出完整的M基因。扩增产物纯化后作为模板进行序列测定 ,并将所得序列经计算机辅助分析其种系发生与编码策略。结果 XHFV代表株BA6 0 19的M基因与国际原型株IbAr10 2 0 0的M基因比较多 5个碱基 ,为 5 36 5bp ;比BA840 2、BA8816 6多 4个碱基 ,即5 36 4bp。 3株XHFV长ORF起始于M基因的第 78位碱基 ,比IbAr10 2 0 0株提前 15bp。编码的前体蛋白共 16 89个氨基酸 ,比IbAr10 2 0 0株多 6个。 4株病毒之间核苷酸序列的同源性分别为 :80 9%(IbAr10 2 0 0 BA6 6 0 19) ,80 2 % (IbAr10 2 0 0 BA840 2 ) ,80 2 % (IbAr10 2 0 0 BA8816 6 ) ,83 7% (BA6 6 0 19 BA840 2 ) ,83 6 % (BA6 6 0 19 BA8816 6 ) ,99 0 % (BA840 2 BA8816 6 ) ;对应的氨基酸序列的同源性分别为85 1% ,86 3 % ,86 6 % ,87 8% ,88 0 % ,98 8%。它们与Dugbe病毒在核苷酸和氨基酸的同源性较低 ,大约是 5 5 %和 37 7%。 | 马本江 杭长寿 Papa Anna 唐青 Antoniadis Antonis | 2001 | 中华实验和临床病毒学杂志2001，15，2： | 12 |
| 10 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 11 | Hypoxia inducible factor-1αaccumulation in steatotic liver preservation:Role of nitric oxide显示文摘AIM:To examine the relevance of hypoxia inducible factor(HIF-1)and nitric oxide(NO)on the preservation of fatty liver against cold ischemia-reperfusion injury(IRI). METHODS:We used an isolated perfused rat liver model and we evaluated HIF-1αin steatotic and non-steatotic livers preserved for 24 h at 4℃in University of Wisconsin and IGL-1 solutions,and then subjected to 2 h of normothermic reperfusion.After normoxic reperfusion,liver enzymes,bile production,bromosulfophthalein clearance,as well as HIF-1αand NO[endothelial NO synthase(eNOS)activity and nitrites/nitrates]were also measured.Other factors associated with the higher susceptibility of steatotic livers to IRI,such as mitochondrial damage and vascular resistance were evaluated. RESULTS:A significant increase in HIF-1αwas found in steatotic and non-steatotic livers preserved in IGL-1 after cold storage.Livers preserved in IGL-1 showed a significant attenuation of liver injury and improvement in liver function parameters.These benefits were enhanced by the addition of trimetazidine(an antiischemic drug),which induces NO and eNOS activation, to IGL-1 solution.In normoxic reperfusion,the presence of NO favors HIF-1αaccumulation,promoting also the activation of other cytoprotective genes,such as hemeoxygenase-1. CONCLUSION:We found evidence for the role of the HIF-1α/NO system in fatty liver preservation,especially when IGL-1 solution is used. | Mohamed Amine Zaouali Ismail Ben Mosbah Eleonora Boncompagni Hassen Ben Abdennebi Maria Teresa Mitjavila Ramon Bartrons Isabel Freitas Antoni Rimola Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，28： | 11 |
| 12 | ^(14)-C菲在“植物-火山石-营养液-空气”系统中的迁移和转化显示文摘利用放射性同位素示踪技术 ,研究14 C 菲在“植物 火山石 营养液 空气”封闭系统中的迁移转化 .结果表明 ,菲在该系统中降解较快 ,实验进行到 2 3d时 ,营养液中的放射性含量仅为施入时的 2 5 % .实验结束 (46d)时 ,14 C放射性在该系统各部分间的分布顺序为根 (38.5 5 % ) >挥发性有机代谢产物 (VOCs ,17.6 8% ) >火山石(14 .35 % ) >CO2 (11.42 % ) >茎 (2 % ) ;植物体内的放射性物质主要以结合态 (根 4.6 8% ;茎叶 0 .6 8% )与植物组织结合和以极性代谢产物 (根 2 3 .14 % ;茎 0 .78% )形式存在 . | 姜霞 区自清 应佩峰 Ayfer Yediler Antonious Kettrup | 2001 | 应用生态学报2001，12，3： | 11 |
| 13 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 14 | Characterisation and risk assessment of venous thromboembolism in gastrointestinal cancers显示文摘AIM To characterise venous thromboembolism(VTE) in gastrointestinal cancer and assess the clinical utility of risk stratification scoring. METHODS We performed a retrospective analysis using electronic patient records of 910 gastro-oesophageal(GO) cancer and 1299 colorectal cancer(CRC) patients referred to a tertiary cancer centre to identify the incidence of VTE, its relationship to chemotherapy and impact on survival.VTE risk scores were calculated using the Khorana index. Patients were classified as low risk(0 points), intermediate risk(1 to 2 points) or high risk(3 points). Data was analysed to determine the sensitivity of the Khorana score to predict VTE. RESULTS The incidence of VTE was 8.9% for CRC patients and 9.7% for GO cancer patients. Pulmonary emboli(PE) were more common in advanced than in localised CRC(50% vs 21% of events respectively) and lower limb deep vein thrombosis(DVT) were more common in localised than in advanced CRC(62% vs 39% of events respectively). The median time to VTE from cancer diagnosis was 8.3 mo for CRC patients compared to 6.7 mo in GO cancer. In localised CRC median time to VTE was 7.1 mo compared with 10.1 mo in advanced CRC. In contrast in GO cancer, the median time to VTE was 12.5 mo in localised disease and 6.8 mo in advanced disease. No survival difference was seen between patients with and without VTE in this cohort. The majority of patients with CRC in whom VTE was diagnosed had low or intermediate Khorana risk score(94% for localised and 97% in advanced CRC). In GO cancer, all patients scored either intermediate or high risk due to the primary site demonstrating a limitation of the risk assessment score in discriminating high and low risk patients with GO cancers. Additional risk factors were identified in this cohort including surgery, chemotherapy or hospital admission. Overall, 81% of patients with CRC and 77% of patients with GO cancer had one or more of these factors within 4 wk prior to diagnosis VTE. These should be factored into clinical risk assessment scores. CONCLUSION The Khorana score has low sensitivity for thrombotic events in CRC and cannot discriminate low risk patients in high risk cancer sites such as GO cancer. | Robert L Metcalf Eamon Al-Hadithi Nicholas Hopley Thomas Henry Clare Hodgson Antony McGurk Wasat Mansoor Jurjees Hasan | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 10 |
| 15 | Whole-Genome Resequencing of a Worldwide Collection of Rapeseed Accessions Reveals the Genetic Basis of Ecotype Divergence显示文摘Rapeseed (Brassica napus),an important oilseed crop,has adapted to diverse climate zones and latitudes by forming three main ecotype groups,namely winter,semiwinter,and spring types. However,genetic variations underlying the divergence of these ecotypes are largely unknown. Here,we report the global pattern of genetic polymorphisms in rapeseed determined by resequencing a worldwide collection of 991 germplasm accessions.A total of 5.56 and 5.53 million singlenucleotide polymorphisms (SNPs)as Well as 1.86 and 1.92 million InDels were identified by mapping reads to the reference genomes of 'Darmor-bzh'and 'Tapidor,'respectively.We generated a map of allelic drift paths that shows splits and mixtures of the main populations,and revealed an asymmetric evolution of the two subgenomes of B.napus by calculating the genetic diversity and linkage disequilibrium parameters.Selective-sweep analysis revealed genetic changes in genes orthologous to those regulating various aspects of plant development and response to stresses.A genome-wide association study identified SNPs in the promoter regions of FLOWERING LOCUS T and FLOWERING LOCUS C orthologs that corresponded to the different rapeseed ecotype groups. Our study provides important insights into the genomic footprints of rapeseed evolution and flowering-time divergence among three ecotype groups,and will facilitate screening of molecular markers for accelerating rapeseed breeding. | Dezhi Wu Zhe Liang Tao Yan Ying Xu Lijie Xuan Juan Tang Gang Zhou Ulrike Lohwasser Shuijin Hua Haoyi Wang Xiaoyang Chen Qian Wang Le Zhu Antony Maodzeka Nazim Hussain Zhilan Li Xuming Li Imran Haider Shamsi Ghulam Jilani Linde Wu Hongkun Zheng Guoping Zhang Boulos Chalhoub Lisha Shen Hao Yu Lixi Jiang | 2019 | Molecular Plant2019，12，1： | 10 |
| 16 | Effects of laparoscopic cholecystectomy on lung function:A systematic review显示文摘AIM:To present and integrate findings of studies investigating the effects of laparoscopic cholecystectomy on various aspects of lung function.METHODS:We extensively reviewed literature of the past 24 years concerning the effects of laparoscopic cholecystectomy in comparison to the open procedure on many aspects of lung function including spirometricvalues,arterial blood gases,respiratory muscle performance and aspects of breathing control,by critically analyzing physiopathologic interpretations and clinically important conclusions.A total of thirty-four articles were used to extract information for the meta-analysis concerning the impact of the laparoscopic procedure on lung function and respiratory physiopathology.The quality of the literature reviewed was evaluated by the number of their citations and the total impact factor of the corresponding journals.A fixed and random effect meta-analysis was used to estimate the pooled standardized mean difference of studied parameters for laparoscopic(LC)and open(OC)procedures.A crude comparison of the two methods using all available information was performed testing the postoperative values expressed as percentages of the preoperative ones using the Mann-Whitney two-sample test.RESULTS:Most of the relevant studies have investigated and compared changes in spirometric parameters.The median percentage and interquartile range(IQR)of preoperative values in forced vital capacity(FVC),forced expiratory volume in 1 s and forced expiratory flow(FEF)at 25%-75%of FVC(FEF25%-75%)expressed as percentage of their preoperative values 24 h after LC and OC were respectively as follows:[77.6(73.0,80.0)L vs 55.4(50.0,64.0)L,P<0.001;76.0(72.3,81.0)L vs 52.5(50.0,56.7)L,P<0.001;and 78.8(68.8,80.9)L/s vs 60.0(36.1,66.1)L/s,P=0.005].Concerning arterial blood gases,partial pressure of oxygen[Pa O2(k Pa)]at 24 or 48 h after surgical treatment showed reductions that were significantly greater in OC compared with LC[LC median 1.0,IQR(0.6,1.3);OC median 2.4,IQR(1.2,2.6),P=0.019].Fewer studies have investigated the effect of LC on respiratory muscle performance showing less impact of this surgical method on maximal respiratory pressures(P<0.01);and changes in the control of breathing after LC evidenced by increase in mean inspiratory impedance(P<0.001)and minimal reduction of duty cycle(P=0.01)compared with preoperative data.CONCLUSION:Laparoscopic cholecystectomy seems to be associated with less postoperative derangement of lung function compared to the open procedure. | George D Bablekos Stylianos A Michaelides Antonis Analitis Konstantinos A Charalabopoulos | 2014 | World Journal of Gastroenterology2014，20，46： | 10 |
| 17 | The evolution of corneal and refractive surgery with the femtosecond laser显示文摘The use of femtosecond lasers has created an evolution in modern corneal and refractive surgery.With accuracy,safety,and repeatability,eye surgeons can utilize the femtosecond laser in almost all anterior refractive procedures;laser in situ keratomileusis(LASIK),small incision lenticule extraction(SMILE),penetrating keratoplasty(PKP),insertion of intracorneal ring segments,anterior and posterior lamellar keratoplasty(Deep anterior lamellar keratoplasty(DALK)and Descemet's stripping endothelial keratoplasty(DSEK)),insertion of corneal inlays and cataract surgery.As the technology matures,it will push surgical limits and open new avenues for ophthalmic intervention in areas not yet explored.As we witness the transition from femto-LASIK to femto-cataract surgery it becomes obvious that this innovation is here to stay.This article presents some of the most relevant advances of femtosecond lasers to modern corneal and refractive surgery. | Antonis Aristeidou Elise V.Taniguchi Michael Tsatsos Rodrigo Muller Colm McAlinden Roberto Pineda Eleftherios I.Paschalis | 2015 | Eye and Vision2015，2，1： | 9 |
| 18 | Characterization of Ion Contents and Metabolic Responses to Salt Stress of Different Arabidopsis AtHKT1;1 Genotypes and Their Parental Strains显示文摘植物采用几策略在咸度应力下面维持细胞的离子动态平衡,包括由 transmembrane 运输蛋白质的调停的离子流动并且调整由积累 osmolytes 的渗透的压力。HKT (高亲密关系的钾 transporter ) 基因家庭在多样的植物种类包括 Na+ 和 Na+/K+ transporters,与 HKT1;在 Arabidopsis thaliana 的 1 个同样唯一的成员。AtHKT1 的 Cell-type-specific overexpression; 1 被显示了在咸度应力下面阻止射击 Na+ overaccumulation。这里,我们在不同 AtHKT1 的射击和根分析了大量代谢物和元素;在咸度应力前后的 1 遗传型和他们的父母紧张,揭示 AtHKT1 之间的代谢物差别的一种相互的关系; 1 根猛烈的线( hkt1 ; 1 )并且 AtHKT1 ; 1 根 overexpressing 线( E2586 UAS GAL4 : HKT1 ; 1 并且 J2731 *UAS GAL4 : HKT1 ; 1 )。尽管根糖的层次在两 AtHKT1 在盐应力以后被增加; 1 overexpressing 排队, E2586 UAS GAL4 : HKT1 ; osmoprotectants trehalose , gentiobiose ,和 melibiose 的 1 显示出的更高的累积,而 J2731 *UAS GAL4 : HKT1 ;蔗糖和棉白糖的 1 显示出的高水平,与他们的父母线相比,分别地。相反,猛烈的线 hkt1; tricarboxylic 酸(TCA ) 的层次的 1 显示出的猛烈增加骑车在在盐处理以后的射击的中介。这与糖的重要弄空与一致,建议有进以从周期的 C 流出的经常的率的 TCA 周期的碳流入的增加的率,它可能被需要在盐应力期间支持植物幸存。用关联分析,我们识别了在 Na+ 内容和几糖之间的协会,建议糖新陈代谢的那条规定在对咸度应力的植物回答是重要的。 | Camilla B. Hill Deepa Jha Antony Bacic Mark Tester Ute Roessner | 2013 | Molecular Plant2013，6，2： | 8 |
| 19 | Functional Characterization and RNAi-Mediated Suppression Reveals Roles for Hexose Transporters in Sugar Accumulation by Tomato Fruit显示文摘Hexoses 积累到高集中(200 ? 公里) 在西红柿的存储实质房间水果。Hexoses 作为进口韧皮部的蔗糖的水解作用产品从水果 apoplasm 被采购。三 hexose transporters (LeHT1, LeHT2, LeHT3 ) ,在水果存储实质房间表示了,可以由这些房间贡献 hexose 举起。他们的全身的序列的分析证明所有三 transporters 属于 monosaccharide transporters 的 STP 亚科本地化到血浆膜。LeHT1 的 Heterologous 表示(并且以前 LeHT2,齿轮等, 2000 ) ,然而并非 LeHT3,救了 hexose 损害运输的酵母异种当在葡萄糖上涨了时或象唯一的碳来源果糖。生物化学地, LeHT1,同样到 LeHT2,与高亲密关系的 glucose/H+ symporter 一致的展出运输性质。显著地, LeHT1 和 LeHT2 也与水果纸巾的与那些同量的明显的 Km 价值作为低亲密关系的 fructose/H+ symporters 工作了。在所有 LeHT 基因由的水果表示层次的实质的减小(8090%)调停 RNAi 击倒在水果 hexose 累积引起了 55% 减少。相反,由来源叶子的 photoassimilate 生产和到水果的韧皮部运输能力由 transporter 是未受影响的击倒。一起,这些调查结果证明 LeHTs 玩在在西红柿水果开发期间驾驶 hexoses 的累积进存储实质房间给角色调音。 | David W. McCurdy Stephen Dibley Ricky Cahyanegara Antony Martin John W. Patrick | 2010 | Molecular Plant2010，3，6： | 7 |
| 20 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
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