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| 1 | Changing face of hepatic encephalopathy:Role of inflammation and oxidative stress显示文摘The face of hepatic encephalopathy(HE) is changing.This review explores how this neurocognitive disorder,which is associated with both acute and chronic liver injury,has grown to become a dynamic syndrome that spans a spectrum of neuropsychological impairment,from normal performance to coma.The central role of ammonia in the pathogenesis of HE remains incontrovertible.However,over the past 10 years,the HE community has begun to characterise the key roles of inflammation,infection,and oxidative/nitrosative stress in modulating the pathophysiological effects of ammonia on the astrocyte.This review explores the current thoughts and evidence base in this area and discusses the potential role of existing and novel therapies that might abrogate the oxidative and nitrosative stresses inflicted on the brain in patients with,or at risk of developing,HE. | Amit S Seyan Robin D Hughes Debbie L Shawcross | 2010 | World Journal of Gastroenterology2010，16，27： | 23 |
| 2 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 3 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 4 | Effect of hydroalcoholic extract of Hibiscus rosa sinensis Linn.leaves in experimental colitis in rats显示文摘Objective:To elucidate the ameliorative effect of liydrualcuholic extract of leaves of Hibiscus rosa sinensis(HRS) in acetic acid induced experimental colitis in male wistar rats.Methods: The animals were administered with 2 mL acetic acid(4%) via intra rectal.The animals were divided into various treatment groups(n=6).Prednisolone was used as standard drug and HRS was administered at a dose of 50,100 and 200 mg/kg p.o.The control group of animals received 1 mL of vehicle(distilled water).Ulcer area,ulcer index,spleen weight,colon weight to length ratio, macroscopic score,haemalological parameters,colonic superoxide dismutase(SOD),glutathione(GSH),myeloperoxidase(MPO),malondialdchyde(MDA),tumor necrosis factor-α(TNK- α), nitric oxide(NO) and histological changes were recorded after the treatment regimen of 11 days. Results:Intrarectal instillation of acetic acid caused enhanced ulcer area,ulcer index,spleen weight,colon weight to length ratio,colonic MPO,MDA,NO and TNF-α It caused significant decreased level of SOD and GSH.Pretreatment with HRS for 7 days exhibited significant effect in lowering of oxidative stress,colonic NO,TNF- α and elevation of SOD and GSH at a dose of 100 and 200 mg/kg in acetic acid induced colilis.Conclusions:The present investigation demonstrates HRS is of potent therapeutic value in the amelioration of expcrimenlal colilis in laboralory animals by inhibiting the proinflammatory mediator like NO and TNK-α. | Amit D Kandhare Kiran S Raygude Pinaki Ghosh Arvindkumar E Ghule Tejas P Gosavi Sachin L Badole Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 2 |
| 5 | In vitro anti- Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action显示文摘 | Mannanthendil Kumaran Asha Debnath Debraj D’souza Prashanth Jothie Richard Edwin H.S. Srikanth Nithyanantham Muruganantham Shekhar Michael Dethe Bhaskar Anirban Balachandran Jaya Mundkinajeddu Deepak Amit Agarwal | 2012 | Journal of Ethnopharmacology2012，，： | 2 |
| 6 | α-Glucosidase i nhibitory activity of Mangifera indica bark显示文摘 | Prashanth D Amit A Samiulla D S | 2001 | Fitoterapia2001，72，6： | 1 |
| 7 | Red meat and poultry intake, polymorphisms in the nueleotide excision repair and mismatch repair pathways and colorectal cancer risk显示文摘 | Amit D Joshi Roma'n Corral | 2009 | Carcinogenesis2009，30，3： | 1 |
| 8 | Transcriptional targeting of glioblastoma by diphtheria toxin-A driven by both H19 and IGF2-P4 promoters显示文摘 | Amit D Matouk IJ Lavon I | 2012 | Int J Clin Exp Med2012，5，2： | 1 |
| 9 | the basic and applied aspects of superoxide dismutase显示文摘 | Amit B Som D Arun K | 2011 | Journal of Molecular Catalysis B:Enzymatic2011，68，3： | 1 |
| 10 | A coarse-to t'ine strate gy for multi class shape detection显示文摘 | AMIT Y GEMAN D FAN X | 2004 | IEEE Transac- tions on Pattern Analysis and Machine Intelligence2004，26，12： | 1 |
| 11 | Surface modifications and cell-materials interactions with anodized Ti显示文摘 | KAKOLI D SUSMITA B AMIT B | 2007 | Acta Biomaterialia2007，3，： | 1 |
| 12 | Cationic transfer- somes based topical genetic vaccine against hepatitis B 显示文摘 | SUNIL M AMIT R PRAVEEN K D | 2007 | lnt J Pharm2007，340，12： | 1 |
| 13 | linkage Disequilibrium between the Human Leukocyte Antigen Class Ⅱ Region of the Major Histocompatibility Complex and Graves' Disease: Replication Using a Population Case Control and Family-Based Study 显示文摘 | Joanne M H Amit A Jacquie D | 1998 | J Clin Endocrinol Metab1998，83，： | 1 |
| 14 | Studies of bilirubin toxicity at the synaaptosome and cellular levels显示文摘 | Amit Y Cashores W Schiff D | 1992 | Semin Perinatol1992，17，2： | 1 |
| 15 | Reclaiming of Ground Rubber Tire (GRT) by a Novel Reclaiming Agent显示文摘 | Debapriya D Amit D Debasish D | 2006 | Euro- pean Polymer Journal2006，42，4： | 1 |
| 16 | Molecular targets of the muhifunctional iron chelating drug, M30 in the brains of mouse of type2 diabetes mellitus显示文摘 | Mechlovich D Amit T Bar-Am O | 2014 | Br J Pharmacol2014，171，24： | 1 |
| 17 | Automatic kernel clustering with a multi-elitist particle swarm optimization algorithm显示文摘 | SWAGATAM D AJ1TH A AMIT K | 2008 | Pattern Recognition Letters2008，29，5： | 1 |
| 18 | The use of cardic troponins in acute coronary syndromes显示文摘 | Amit G Gilutz H Zahger D | 2003 | J Harefush2003，142，2： | 1 |
| 19 | Modification of decellularized goat- lung scaffold with chi- tosan/ ing ap 2013 : nanohydroxyapatite plications 显示文摘 | Sweta K Gupta Amit K Dinda Pravin D Potdar | 2013 | Bio 651945 composite for bone tissue engineer- Med research international2013，，： | 1 |
| 20 | Nondestructive testing of asphalt pavements for structural condition evaluation: a state of the art显示文摘 | Amit G Animesh D | 2008 | Nondestructive Testing and Evaluation2008，23，2： | 1 |
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