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| 1 | Early stage colon cancer: Current treatment standards, evolving paradigms, and future directions显示文摘Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies.The majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for cure.The current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a cure.Surgery alone is curative for the vast majority of colon cancer patients.Currently,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal involvement.Adjuvant chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical trials.Contemporary research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor biology.In this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes. | Sakti Chakrabarti Carrie Y Peterson Deepika Sriram Amit Mahipal | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 4 |
| 2 | Graphical templates for model registration显示文摘 | Kong A | 1996 | IEEE Transactions on pattern analysis and machine intelligence1996，18，3： | 1 |
| 3 | Axin-mediated CKI phosphorylation of beta -catenin at Set 45:a molecular switch for the Wnt pathway显示文摘 | Amit S Hatzubai A Birman Y Andersen J S Ben Shushan E Mann M | 2002 | Genes Dev2002，16，： | 1 |
| 4 | Repeated aspiration of ovarian follicles and early corpus luteum cysts in an in-vitro fertilisation programme reduces the risk of ovarian hyperstimulation syndrome in high responders显示文摘 | Amit A Yaron Y Yovel I | 1993 | Hum Reprod1993，8，8： | 1 |
| 5 | Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigalloeateehin-3-gallate neuroprotective action显示文摘 | LEVITES Y AMIT T YOUDIM MB | 2002 | J Biol Chem2002，277，30： | 1 |
| 6 | Effects of tobacco smoke on immunity, inflammation and autoimmunity 显示文摘 | Arnson Y Shoenfeld Y Amital H | 2010 | J Autoimmun2010，34，3： | 1 |
| 7 | A coarse-to t'ine strate gy for multi class shape detection显示文摘 | AMIT Y GEMAN D FAN X | 2004 | IEEE Transac- tions on Pattern Analysis and Machine Intelligence2004，26，12： | 1 |
| 8 | Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action 显示文摘 | Levites Y Amit T Youdim MB | 2002 | J Biol Chem2002，277，30： | 1 |
| 9 | Effects of tobacco smoke on immunity, inflammation and autoimmunity 显示文摘 | Arnson Y Shoenfeld Y Amital H | 2010 | J Autoimmun2010，34，3： | 1 |
| 10 | Growth hormone-binding protein in partially hepatectomized rats 显示文摘 | Amit T Hertz P | 1993 | Horm Res1993，40，56： | 1 |
| 11 | Age-dependent sensitivity of cultured rat glial cells to bilirubin toxicity显示文摘 | Amit Y Brenner T | 1993 | Exp Neurol1993，121，： | 1 |
| 12 | Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action 显示文摘 | LEVITES Y AMIT T YOUDIM M B | 2002 | J Biol Chem2002，277，30： | 1 |
| 13 | The commonimmunogenic etiology of chronic fatigue syndrome:from in-fections to vaccines via adjuvants to the ASIA syndrome显示文摘 | Rosenblum H Shoenfeld Y Amital H | 2011 | Infect Dis Clin North Am2011，25，： | 1 |
| 14 | Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by,green tea polyphenol (-)-epigallocatechin-3-gallate显示文摘 | Levites Y Amit T Mandel S Youdim MB | 2003 | FASEB J2003，17，8： | 1 |
| 15 | Effects of tobacco smoke on immunity, inflammation and autoimmunity显示文摘 | Amson Y Shoenfeld Y Amital H | 2010 | J Autoimmun2010，34，3： | 1 |
| 16 | Studies of bilirubin toxicity at the synaaptosome and cellular levels显示文摘 | Amit Y Cashores W Schiff D | 1992 | Semin Perinatol1992，17，2： | 1 |
| 17 | Immunomodulation of murine experimental SLE-like disease by interferon-γ显示文摘 | Levi Y Barak V | 1998 | Lupus1998，7，： | 1 |
| 18 | Genomic and proteomic study to survey the mechanism of action of the antiParkinson’s disease drug,rasagiline compared with selegiline,in the rat midbrain显示文摘 | Weinreb O Amit T Saqi Y | 2009 | Neural Transm2009，116，11： | 1 |
| 19 | TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity显示文摘 | Kleiner Y Bar-Am O Amit T | 2008 | J Cardiovasc Pharmacol2008，52，3： | 1 |
| 20 | Axin-mediated CKI phosphorylation of beta-catenin at Ser 45 : a molecular switch for the Wnt pathway 显示文摘 | Amit S Hatzubai A Birman Y | 2002 | Genes Dev2002，16，9： | 1 |
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