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| 1 | 浅谈葛根素对β细胞的保护作用显示文摘近年来世界各国糖尿病发病率呈现急剧增加的趋势,因此,进一步加强对糖尿病发病机制的研究,拓展糖尿病治疗药物研发新思路,治疗的新策略,是目前医药界面临的一项迫切任务。中医药治疗糖尿病历史悠久,其中葛根被应用于众多经典降糖方,如葛根芩连汤。葛根素是葛根的主要活性成分,可以促进胰岛β细胞增殖、生长,并减少凋亡,保护胰岛β细胞功能,使受损胰岛细胞得以修复并恢复功能。基于β细胞功能衰竭是引起糖尿病的重要病因,保护胰岛β细胞成为治疗糖尿病的有效方法。文章将着重对葛根素保护胰岛β细胞的作用机制进行探讨。 | 杨蕾 舒娈 姚冬冬 贾晓斌 余嗣明 | 2014 | 中华中医药杂志2014，29，11： | 10 |
| 2 | Naringin ameliorates acetic acid induced colitis through modulation of endogenous oxido-nitrosative balance and DNA damage in rats显示文摘The aim of this study was to evaluate the effect of naringin on experimentally induced inflammatory bowel disease in rats.Naringin(20,40 and 80 mg/kg) was given orally for 7 days to Wistar rats before induction of colitis by intrarectal instillation of 2 mL of 4%(v/v) acetic acid solution.The degree of colonic mucosal damage was analyzed by examining mucosal damage,ulcer area,ulcer index and stool consistency.Intrarectal administration of 4%acetic acid resulted in significant modulation of serum alkaline phosphatase,lactate dehydrogenase,superoxide dismutase(SOD),glutathione(GSH),malondialdehyde(MDA) and myeloperoxidase(MPO) content along with colonic nitric oxide(NO),xanthine oxidase(XO) level and protein carbonyl content in the colonic tissue as well as in blood.Naringin(40 and 80 mg/kg) exerted a dose dependent(P < 0.05) ameliorative effect,as it significantly increased hematological parameter as well as colonic SOD and GSH.There was a significant(P < 0.05)and dose dependant inhibition of macroscopical score,ulcer area along with colonic MDA,MPO activity by the7 days of pretreatment of naringin(40 and 80 mg/kg).Biochemical studies revealed a significant(P < 0.05) dose dependant inhibition in serum alkaline phosphatase(ALP) and lactate dehydrogenase(LDH) levels by pretreatment of naringin.Increased levels of colonic NO,XO,protein carbonyl content and DNA damage were also significantly decreased by naringin pretreatment.The findings of the present investigation propose that naringin has an anti-inflammatory,anti-oxidant and anti-apoptotic potential effect at colorectal sites as it modulates the production and expression of oxidative mediators such as MDA,MPO,NO and XO,thus reducing DNA damage. | Venkatashivam Shiva Kumar Anuchandra Ramchandra Rajmane Mohammad Adil Amit Dattatraya Kandhare Pinaki Ghosh Subhash Laxman Bodhankar | 2014 | The Journal of Biomedical Research2014，28，2： | 8 |
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