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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Gastric food retention at endoscopy is associated with severity of liver cirrhosis显示文摘BACKGROUND Gastrointestinal symptoms are prevalent in patients with cirrhosis.Cirrhotic patients have a known predilection to delayed gastric emptying compared to those without cirrhosis.However,the contributing factors have not been fully elucidated.Retained gastric food on esophagogastroduodenoscopy(EGD)has been used as a surrogate marker for delayed gastric emptying with reasonably high specificity.Therefore,we hypothesize that the frequency of retained gastric food contents at EGD will be higher in a cirrhotic population compared to a control population without liver disease.Additionally,we hypothesize that increased frequency of gastric food contents will be associated with increased severity of cirrhosis.AIM To determine the relative frequency of delayed gastric emptying among cirrhotics as compared to non-cirrhotics and to identify associated factors.METHODSWe performed a retrospective case-control study of cirrhotic subjects whounderwent EGD at an academic medical center between 2000 and 2015. Threehundred sixty-four patients with confirmed cirrhosis, who underwent a total of1044 EGDs for the indication of esophageal variceal screening or surveillance,were identified. During the same period, 519 control patients without liverdisease, who underwent a total of 881 EGDs for the indication of anemia, wereidentified. The presence of retained food on EGD was used as a surrogate fordelayed gastric emptying. The relative frequency of delayed gastric emptyingamong cirrhotics was compared to non-cirrhotics. Characteristics of patients withand without retained food on EGD were compared using univariable andmultivariable logistic regression analysis to identify associated factors.RESULTSOverall, 40 (4.5%) patients had evidence of retained food on EGD. Cirrhotics weremore likely to have retained food on EGD than non-cirrhotics (9.1% vs 1.4%, P <0.001). Characteristics associated with retained food on univariable analysisincluded age less than 60 years (12.6% vs 5.2%, P = 0.015), opioid use (P = 0.004),Child-Pugh class C (24.1% Child-Pugh class C vs 6.4% Child-Pugh class A, P =0.007), and lower platelet count (P = 0.027). On multivariate logistic regressionanalysis, in addition to the presence of cirrhosis (adjusted OR = 5.83;95%CI: 2.32-14.7, P < 0.001), diabetes mellitus (types 1 and 2 combined) (OR = 2.34;95%CI:1.08-5.06, P = 0.031), opioid use (OR = 3.08;95%CI: 1.29-7.34, P = 0.011), andChild-Pugh class C (OR = 4.29;95%CI: 1.43-12.9, P = 0.01) were also associatedwith a higher likelihood of food retention on EGD.CONCLUSIONCirrhotics have a higher frequency of retained food at EGD than non-cirrhotics.Decompensated cirrhosis, defined by Child-Pugh class C, is associated with ahigher likelihood of delayed gastric emptying. | David B Snell Shirley Cohen-Mekelburg Russell Weg Gaurav Ghosh Adam P Buckholz Amit Mehta Xiaoyue Ma Paul J Christos Arun B Jesudian | 2019 | World Journal of Hepatology2019，11，11： | 2 |
| 3 | Low cost flexible printed circuit technology based microelectrode array for extraeellular stimulation of the invertebrate locomotory system 显示文摘 | ALPER B AMIT L | 2011 | Sensors and Actuators A : Physical2011，169，1： | 1 |
| 4 | the basic and applied aspects of superoxide dismutase显示文摘 | Amit B Som D Arun K | 2011 | Journal of Molecular Catalysis B:Enzymatic2011，68，3： | 1 |
| 5 | Clinical, environmental, and gene- tic determinants of multiple sclerosis in children with acute demyelination : a prospective national cohort study显示文摘 | Brenda B Amit BO Arnold DL | 2011 | Lancet Neuro12011，10，5： | 1 |
| 6 | Surface modifications and cell-materials interactions with anodized Ti显示文摘 | KAKOLI D SUSMITA B AMIT B | 2007 | Acta Biomaterialia2007，3，： | 1 |
| 7 | Influence of processing parameters on PZT thick films显示文摘 | Oliver H Amit B Susmita B | 2005 | Mater Sci Eng B2005，116，： | 1 |
| 8 | Bitumen surface energy characterization using a contact angle approach 显示文摘 | HEFER A W AMIT B DALLAS N | 2006 | Journal of Materials in Civil Engineering2006，18，6： | 1 |
| 9 | Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective action 显示文摘 | LEVITES Y AMIT T YOUDIM M B | 2002 | J Biol Chem2002，277，30： | 1 |
| 10 | Compositionally graded hydroxyapatite/tricalcium phosphate coating on Ti by laser and induction plasma 显示文摘 | Mangal R Vamsi KB Amit B | 2011 | Acta Biomaterialia2011，7，2： | 1 |
| 11 | Feedback linearization based control of a variable air volume air conditioning system for cooling applications显示文摘 | ARCHANA T AMIT P SOUVIK B | 2008 | ISA Trans2008，47，3： | 1 |
| 12 | Comprehensive analysis of surface free energy of asphalts and aggregates and the effects of changes in Ph 显示文摘 | JONATHAN H EYAD M AMIT B | 2011 | Construction and Building Materials2011，25，5： | 1 |
| 13 | How do family ownership,control,and management affect firm value?显示文摘 | Villalonga B Amit R | 2006 | Journal of Financial Economics2006，80，2： | 1 |
| 14 | Sudden death due to rupture esophageal varices:a case report显示文摘 | Amit S Jyoti B | | 0，，02： | 1 |
| 15 | How do family ownership, control, and management affect firm value显示文摘 | Villalonga B Amit R | 2006 | Journal of Financial Economics2006，80，2： | 1 |
| 16 | Micromachining of PZT-based MEMS显示文摘 | TOBB B M SUSMITA B AMIT B | 2003 | Amer Ceram Soc Bull2003，82，1： | 1 |
| 17 | Extending surface temperature and emissivity retrieval to the mid-infrared(3 -5 Ixm)using the Multispectral Thermal Imager (MTI) 显示文摘 | Amit M Lee K B Alan R G | 2005 | Remote Sensing of Environment2005，98，23： | 1 |
| 18 | How do family ownership, control and management affect firm value? 显示文摘 | Villalonga B and Amit R | 2006 | Journal of Financial Economics2006，80，2： | 1 |
| 19 | Family control of firms and industries显示文摘 | Villalonga B Amit R | 2010 | Financial Management2010，39，3： | 1 |
| 20 | Extend surface temperature and emissivity retrieval to the mid-infrared (3-5)using the Muhispectral Thermal Imager (MTI) 显示文摘 | AMIT M A LEE K BALICK B | 2005 | Remote Sensing of Environment2005，98，： | 1 |
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