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| 1 | A unique sequence in the N-terminal regulatory region controls the nuclear localization of KLF8 by cooperating with the C-terminal zinc-fingers显示文摘Kr 眉 p 像像素的因素 8 (KLF8 ) 抄写因素在房间周期前进起一个关键作用, oncogenic 转变,对间充质的转变和侵略上皮。然而,它的原子本地化信号(NLS ) 没被识别。有另外的 KLF monopartite NLS (mNLS ) 和 C2H2 锌手指(ZF ) 的 KLF8 份额,哪个被显示了是为一些另外的 KLF 的 NLS。在这份报告,用指导 PCR 的 mutagenesis 和 immunofluorescent 显微镜学,我们显示出 mNLSs,任何单个 ZF 的删除,或变化的那混乱 Zn2+ 有约束力或联系 DNA 主题没影响 KLF8 的原子本地化。删除 > 然而,从 C 终点的 1.5 ZF 引起了 KLF8 的细胞质的累积。令人惊讶地,氨基酸(aa ) 的删除 151-200 区域几乎从原子核消除了 KLF8。有 PKC 禁止者的 S165A, K171E 或 K171R 变化,或处理导致了部分细胞质的累积。Co-immunoprecipitation 证明 KLF8 与 importin- 交往了,这个相互作用要求了 ZF 主题。aa 1-150 或 201-261 区域的删除独自没改变原子本地化。BrdU 加入和 cyclin D1 倡导者酶试金作为野类型的 KLF8 证明在原子本地化的 KLF8 异种有缺陷者不能支持 DNA 合成或 cyclin D1 倡导者激活。一起拿,这些结果建议 KLF8 有二 NLS,一包围 S165 和 K171 并且另外的是二双人脚踏车 ZF,它为 KLF8 原子本地化和它的细胞的功能的规定是批评的。 | Tina S Mehta Heng Lu Xianhui Wang Alison M Urvalek Kim-Hang H Nguyen Farah Monzur Jojo D Hammond Jameson Q Ma Jihe Zhao | 2009 | Cell Research2009，19，9： | 10 |
| 2 | Imagining Stereotypes Away: The Moderation of Implicit Stereotypes Through Mental Imagery 显示文摘 | Irene V Blair Jennifer E Ma Alison P Lenton | 2001 | Journal of Personality and Social Psychology2001，，81： | 1 |
| 3 | Association between the ankle-brachial index and future coronary calcium (the Rancho Bemardo study) 显示文摘 | ALISON MA LAUGHLIN GA BARRETT-CONNOR E | 2006 | Am J Cardiol2006，97，2： | 1 |
| 4 | Evalution of nutritional support in acute pancreatitis 显示文摘 | Lobo DN Memon MA Alison SP | 2000 | Br J Surg2000，87，6： | 1 |
| 5 | Non–Risk-Adapted Surveillance in Clinical Stage I Nonseminomatous Germ Cell Tumors: The Princess Margaret Hospital’s Experience显示文摘 | Jeremy F. Sturgeon Malcolm J. Moore David M. Kakiashvili Ignacio Duran Lynn C. Anson-Cartwright Dominik R. Berthold Padraig R. Warde Mary K. Gospodarowicz Ruth E. Alison Justin Liu Clement Ma Greg R. Pond Michael A. Jewett | 2010 | European Urology2010，，4： | 1 |
| 6 | Non–Risk-Adapted Surveillance in Clinical Stage I Nonseminomatous Germ Cell Tumors: The Princess Margaret Hospital’s Experience显示文摘 | Jeremy F. Sturgeon Malcolm J. Moore David M. Kakiashvili Ignacio Duran Lynn C. Anson-Cartwright Dominik R. Berthold Padraig R. Warde Mary K. Gospodarowicz Ruth E. Alison Justin Liu Clement Ma Greg R. Pond Michael A. Jewett | 2010 | European Urology2010，，4： | 1 |
| 7 | A Large Study of Androgen Receptor Germline Variants and Their Relation to Sex Hormone Levels and Prostate Cancer Risk. Results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium显示文摘 | Sara Lindstr?m Jing Ma David Altshuler Edward Giovannucci Elio Riboli Demetrius Albanes Naomi E. Allen Sonja I. Berndt Heiner Boeing H. Bas Bueno-de-Mesquita Stephen J. Chanock Alison M. Dunning Heather Spencer Feigelson J. Michael Gaziano Christopher A. | 2010 | The Journal of Clinical Endocrinology & Metabolism2010，，9： | 1 |
| 8 | Intra--flap thrombosis secondary to acute sickle crisis: a case report显示文摘 | Alison MA Frederick D Gergory D | 2012 | Microsurgery2012，32，58： | 1 |
| 9 | Genetic control of wheat quality: interactions between chromosomal regions determining protein content and composition, dough rheology, and sponge and dough baking properties显示文摘 | Gulay Mann Simon Diffey Brian Cullis Fermin Azanza David Martin Alison Kelly Lynne McIntyre Adele Schmidt Wujun Ma Zena Nath Ibrahim Kutty P. Emmett Leyne Lynette Rampling Ken J. Quail Matthew K. Morell | 2009 | Theoretical and Applied Genetics2009，，8： | 1 |
| 10 | PROGRESS ON IMPROVING AGRICULTURAL NITROGEN USE EFFICIENCY: UK−CHINA VIRTUAL JOINT CENTERS ON NITROGEN AGRONOMY显示文摘Two virtual joint centers for nitrogen agronomy were established between the UK and China to facilitate collaborative research aimed at improving nitrogen use efficiency(NUE)in agricultural production systems and reducing losses of reactive N to the environment.Major focus areas were improving fertilizer NUE,use of livestock manures,soil health,and policy development and knowledge exchange.Improvements to fertilizer NUE included attention to application rate in the context of yield potential and economic considerations and the potential of improved practices including enhanced efficiency fertilizers,plastic film mulching and cropping design.Improved utilization of livestock manures requires knowledge of the available nutrient content,appropriate manure processing technologies and integrated nutrient management practices.Soil carbon,acidification and biodiversity were considered as important aspects of soil health.Both centers identified a range of potential actions that could be taken to improve N management,and the research conducted has highlighted the importance of developing a systemslevel approach to assessing improvement in the overall efficiency of N management and avoiding unintended secondary effects from individual interventions.Within this context,the management of fertilizer emissions and livestock manure at the farm and regional scales appear to be particularly important targets for mitigation. | Tom MISSELBROOK Zhaohai BAI Zejiang CAI Weidong CAO Alison CARSWELL Nicholas COWAN Zhenling CUI David RCHADWICK Bridget EMMETT Keith GOULDING Rui JIANG Davey LJONES Xiaotang JU Hongbin LIU Yuelai LU Lin MA David POWLSON Robert MREES Ute SKIBA Pete SMITH Roger SYLVESTER-BRADLEY John WILLIAMS Lianhai WU Minggang XU Wen XU Fusuo ZHANG Junling ZHANG Jianbin ZHOU Xuejun LIU | 2022 | Frontiers of Agricultural Science and Engineering2022，9，3： | 0 |
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