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| 1 | Generalized megaviscera of lupus:Refractory intestinal pseudo-obstruction,ureterohydronephrosis and megacholedochus显示文摘Dilated dysfunction involving multiple visceral organs has been reported in patients with systemic lupus erythematosus(SLE).Chronic intestinal pseudo-obstruction(CIPO) resulting from intestinal smooth muscle damage has presented in conjunction with ureterohydronephrosis and, more rarely, biliary dilatation(megacholedochus).While the molecular pathogenesis is largely unknown, observed histo-pathologic features include widespread myositis, myocyte necrosis in the intestinal muscularis propria with subsequent atrophy and fibrosis, preserved myenteric innervations and little vasculitis.High dose immunosuppression usually results in resolution of symptoms with recovery of smooth muscle function, indicative of an autoimmune etiology.We report a patient with SLE who presented with intestinal pseudo-obstruction, ureterohydronephrosis and megacholedochus, and present images that illustrate megaviscera simultaneously involving all 3 visceral organs.Since the co-manifestation of all 3 is unusual and has been reported only once previously, wehave termed this rare clinical syndrome generalized megaviscera of lupus(GML).Although the SLE disease-activity parameters responded to aggressive immunomodulative therapy in our patient, clinical evidence of peristaltic dysfunction persisted in all involved viscera.This is a variation from the favorable outcomes reported previously in SLE patients with GML and we attribute this poor clinical outcome to disease severity and, most importantly, delayed clinical presentation.Since inflammation followed by atrophy and fibrosis are key aspects in the pathogenesis and natural history of GML, the poor response in our patient who presented late in the clinical course may be the result of ‘burnt out' inflammation with irreversible end-stage flbrosis.Thus, early recognition and timely initiation of treatment may be the key to recover visceral peristaltic function in patients with GML. | Frederick D Park Jeffrey K Lee Ganga D Madduri Pradipta Ghosh | 2009 | World Journal of Gastroenterology2009，15，28： | 20 |
| 2 | Mechanism of mechanical failure of sapphire at high temperature 显示文摘 | Harris D C Sehmid Frederick Mecholsky J J | 1994 | Proc SPIE1994，2286，： | 1 |
| 3 | Structura1 comparison of anticancer drug- DNA complexes:adriamycin and daunomycin显示文摘 | Wi11iams L D Ughetto G | 1990 | Biochemistry1990，29，10： | 1 |
| 4 | Seed yield and agronomic traits of old and modem soybean cultivars under irrigation and soil water-deficit显示文摘 | Frederick J R Woolley J T Hesketh J D Peters D B | 1991 | Field Crops Research1991，27，： | 1 |
| 5 | Standards for nutrition support: home care patients 显示文摘 | Kovacevich DS Frederick A Kelly D | 2005 | Nutr Clin Pract2005，20，5： | 1 |
| 6 | Human Error:A Concept Analysis显示文摘 | Frederick D H | 2006 | Journal of AirTransportation2006，11，3： | 1 |
| 7 | A randomized trial of two types of nurse-assisted home care for patients with COPD显示文摘 | Coultas D Frederick J Barnett B | 2005 | Chest2005，128，4： | 1 |
| 8 | Fac tors that influence mechanical failure of sapphire at high temperature显示文摘 | Harris D C Schmid Frederick Black David R | 1997 | Proc SPIE1997，3060，： | 1 |
| 9 | The continuum theory of lattice defects显示文摘 | Eshelby J D Turnbull Frederick Seitz | | 0，，： | 1 |
| 10 | Diabetes and behavioral medicine: The second decade 显示文摘 | Gonder- Frederick LA Cox D J Ritterband LM | 2002 | J Consult Clin Psychol2002，70，3： | 1 |
| 11 | Quality of life in persons with irritable bowel syndrome: development and validation of a new measure显示文摘 | Patrick D Drossman DA Frederick IQ | 1998 | Dig Dis Sci1998，43，： | 1 |
| 12 | Intrinsic mo tivations and exercise adherence显示文摘 | RYAN R M FREDERICK C M LEPES D | 1997 | Int J Sport Psychol1997，28，： | 1 |
| 13 | Pollen-mediated gene flow in California cotton depends on pollinator activity显示文摘 | ALLEN E V D Frederick J S Kent J B | 2005 | Crop Science2005，45，4： | 1 |
| 14 | Combustion effects of C6osoot in ammonium nitrate propellants显示文摘 | Greiner B E Frederick R A Maser M D | | 0，，4： | 1 |
| 15 | Seed yield and agronomic traits of old and modern soybean cultivars under irrigation and soil water-deficit显示文摘 | Frederick J R Woolley J T Hesketh J D | 1991 | Field Crops Research1991，27，： | 1 |
| 16 | Elaborating a Simpler theory of anchoring显示文摘 | Frederick S Kahneman D Mochon D | | 0，，01： | 1 |
| 17 | Temporal contiguity between food ingestion and toxicosis affects the acquisition of food aversions in sheep显示文摘 | Frederick D Provenza John V Nolan Justin J Lynch | 1993 | Applied Animal Behaviour Science1993，38，12： | 1 |
| 18 | Physical distribution service:a neglected aspect of marketing management 显示文摘 | William D Perreault Frederick A Russ | 1974 | MSU Business Topics1974，22，2： | 1 |
| 19 | Epidemics of soybean rust ( Phakopsora pachyrhizi ) in Brazil and Paraguay from 2001 to 2003 显示文摘 | Yorinorl J T Paiva W M Frederick R D | 2005 | Plant Disease2005，89，： | 1 |
| 20 | Benefit of transferring ST segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increase显示文摘 | Pinto D S Frederick P D Chakrabarti A K | 2011 | Circulation2011，124，23： | 1 |
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