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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Dietary approach in the treatment of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) has been identified as one of the most prevalent chronic liver disease in adults and children populations. NAFLD is usually associated with the metabolic syndrome(MS), which is chiefly related to insulin resistance and its consequences. Insulin resistance has a crucial role in the pathogenesis of hepatic steatosis and potentially nonalcoholic steatohepatitis(NASH). Because of the contemporary epidemics of MS and obesity, the burden of NAFLD is also expected to rise. Unhealthy diets, such as the so-called western diet, are enriched in fructose, trans-fatty acids and saturated fat and seem to be associated with the development of NAFLD. In human studies, certain dietary sugars, particularly fructose, are used as a substrate for lipogenesis leading to hepatic fatty infiltration, inflammation, and possibly fibrosis. Other investigations have shown that fat consumption especially cholesterol and trans/saturated fatty acids are also steatogenic and seem to increase visceral adiposity. The identification of specific dietary components that favor the development of NASH could be important for the management of this disorder. This review focuses on the effects of different dietary approaches to prevent and treat NAFLD emphasizing the macronutrients and energy composition. | Silvia Marinho Ferolla Luciana Costa Silva Maria de Lourdes Abreu Ferrari Aloísio Sales da Cunha Flaviano dos Santos Martins Cláudia Alves Couto Teresa Cristina Abreu Ferrari | 2015 | World Journal of Hepatology2015，7，24： | 2 |
| 4 | Streptococcus agalactiae:Identification methods,antimicrobial susceptibility, and resistance genes in pregnant women显示文摘BACKGROUND Group B Streptococcus(GBS)is a normal component of the gastrointestinal and genital microbiota in humans and can lead to important infections in newborns.AIM To compare GBS isolation and identification methods as well as to assess the antibiotic susceptibility and to identify resistance genes in GBS strains from pregnant women attended in healthcare services from the city of Vitória da Conquista,in Bahia State,Brazil.METHODS From January 2017 to February 2018,vaginorectal swabs were obtained from 186 participants and the samples were seeded onto chromogenic agar for GBS before and after inoculation in selective broth.Confirmatory identification using 3 CAMP and latex tests was performed in samples with GBS-suggestive colonies.Then,disk diffusion antibiograms were performed in GBS-positive samples,and the detection of the resistance genes ermB,ermTR,mefA,and linB in the clindamycin and/or erythromycin-resistant samples was carried out.RESULTS Thirty-two samples(17.2%)were GBS-positive.The culture in chromogenic agar after sample incubation in selective broth was the most sensitive method(96.9%)for GBS detection.All isolates were susceptible to penicillin,ampicillin,cefotaxime,and vancomycin.Clindamycin resistance was observed in 6 samples(18.8%),while 8 samples(25%)were erythromycin-resistant.All erythromycin and/or clindamycin-resistant GBS strains had negative D-tests.Two strains(25%)presented an M phenotype and 6 isolates(75%)presented a cMLSB phenotype.The ermB gene was identified in 4 samples(44.4%),the mefA gene was also found in 4 samples(44.4%),the ermTR gene was identified in 1 isolate(11.1%),and the linB gene was not found in any isolate.CONCLUSION This study evidenced that the screening for SGB can be performed by means of various methods,including chromogenic media,and that the chemoprophylaxis for pregnant women who cannot use penicillin must be susceptibility-guided. | Fabrícia Almeida Fernandes Santana Tais Viana Ledo de Oliveira Marcelo Barreto de Souza Filho Lucas Santana Coelho da Silva Breno Bittencourt de Brito Fabrício Freire de Melo Cláudio Lima Souza Lucas Miranda Marques Márcio Vasconcelos Oliveira | 2020 | World Journal of Clinical Cases2020，8，18： | 2 |
| 5 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum‐/xeno‐free culture media显示文摘 | Irina N. Sim?es Joana S. Boura Francisco dos Santos Pedro Z. Andrade Carla M. P. Cardoso Jeffrey M. Gimble Cláudia L. da Silva Joaquim M. S. Cabral | 2013 | Biotechnology Journal2013，，4： | 1 |
| 6 | Investigation of preconcentration strategies for the trace analysis of multi-residue pesticides in real samples by capillary electrophoresis 显示文摘 | da Silva CL de Lima EC Tavares MF | 2003 | J Chromatogr A2003，1014，12： | 1 |
| 7 | Chemical Composition, Leishmanicidal and Cytotoxic Activities of the Essential Oils from Mangifera indica L. var. Rosa and Espada显示文摘 | Eduardo H. S. Ramos Marcílio M. Moraes Laís L. de A. Nerys Silene C. Nascimento Gardênia C. G. Milit?o Regina C. B. Q. de Figueiredo Cláudio A. G. da Camara Teresinha Gon?alves Silva Silvia R. B. Uliana | 2014 | BioMed Research International2014，，： | 1 |
| 8 | Human mesenchymal stem cell expression program upon extended ex-vivo cultivation,as revealed by 2-DE-Based q Quantitative proteomics显示文摘 | Madeira A da Silva CL dos Santos F | 2012 | Plos One2012，7，43： | 1 |
| 9 | A quantitative enzymelinked immunosorbent assay (ELISA) for the immunodiagnosis of neuroeystieereosis using a purified fraction from Taenia solium cysticerci显示文摘 | Da Silva AD Quagliato EM Rossi CL | 2000 | Diagn Microbiol Infect Dis2000，37，2： | 1 |
| 10 | Separation technologies for stem cell bioprocessing显示文摘 | Maria Margarida Diogo Cláudia Lobato da Silva Joaquim M.S. Cabral | 2012 | Biotechnol Bioeng2012，，11： | 1 |
| 11 | Stem cell cultivation in bioreactors显示文摘 | Carlos A.V. Rodrigues Tiago G. Fernandes Maria Margarida Diogo Cláudia Lobato da Silva Joaquim M.S. Cabral | 2011 | Biotechnology Advances2011，，6： | 1 |
| 12 | Nuclear medicineannual external occupational dose distribution : Rio de Janeiro,Brazil, year 2005 显示文摘 | Mauricio CL Lima AL DA Silva HL | 2011 | Radiat Prot Dosimetry2011，144，14： | 1 |
| 13 | Variants of Human Papillomavirus Types 53, 58 and 66 Identified in Central Brazil显示文摘 | Daniela Marreco Cerqueira Geni Noceti de Lima Camara Márcio Rojas da Cruz Evandro Oliveira Silva Marcelo de Macedo Brígido Luciano Gon?alves de Souza Carvalho Cláudia Renata Fernandes Martins | 2003 | Virus Genes2003，，1： | 1 |
| 14 | A quantitative enzymelinked immunsorbent assay(ELISA) for the immumodiagnosis of neurocysticercosis using a purified fraction from taenia solium cysticerci显示文摘 | Quag Iialo EM Rossi CL | 2000 | Diagn Microbiol Infect Dis2000，37，2： | 1 |
| 15 | Mycobacteri- um tuberculosis culture filtrate proteins plus CpG oligode- oxynucleotides confer protection to mycobacterium bovis BCG-primed mice by inhibiting interleukin-4 secretion显示文摘 | da Fonseca DM Silva CL Wowk PF | 2009 | Infectlmmun2009，77，12： | 1 |
| 16 | Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro suseeptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America显示文摘 | Dalla Costa ER Ribeiro MO Silva MS Arnold LS Rostirolla DC Cafrune PI Espinoza RC Palaci M Telles MA Ritaeeo V Suffys PN Lopes ML Campelo CL Miranda SS Kremer K da Silva PE Fonseea Lde S Ho JL Kritski AL Rossetti ML | 2009 | BMC Microbiol2009，9，： | 1 |
| 17 | Enterobacter hormaechei bloodstream infection at three neonatal intensive care units in Brazil显示文摘 | da Silva CL Miranda LE Moreira BM | 2002 | Pediatr Infect Dis J2002，21，2： | 1 |
| 18 | Soil compressibility and least limiting water range of a constructed soil under cover crops after coal mining in Southern Brazil显示文摘 | Cláudia Liane Rodrigues de Lima Ezequiel Cesar Carvalho Miola Luis Carlos Timm Eloy Antonio Pauletto Alvaro Pires da Silva | 2012 | Soil & Tillage Research2012，，： | 1 |
| 19 | The effect of a minor constituent of essential oil from Citrus aurantium : The role of β-myrcene in preventing peptic ulcer disease显示文摘 | Flavia Bonamin Thiago M. Moraes Raquel C. dos Santos Hélio Kushima Felipe M. Faria Marcos A. Silva Ivan V. Junior Leonardo Nogueira Tais M. Bauab Alba R.M. Souza Brito Lucia R.M. da Rocha Clélia A. Hiruma-Lima | 2014 | Chemico-Biological Interactions2014，，： | 1 |
| 20 | A quantitative enzyme- linked immunosorbent assay (ELISA) for the immunodiagnosis of neu- rocysticercosis using a purified fraction from Taenia solium cysticerci 显示文摘 | Da Silva AD Quagliato EM Roll CL | 2000 | Diagn Microbiol Infect Dis2000，37，2： | 1 |
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